Abstract:
BACKGROUND:Genetic testing for cancer susceptibility is an emerging technology in medicine. This study assessed the knowledge, attitudes and professional behavior of Italian physicians regarding the use of predictive genetic tests for breast and colorectal cancer, including the BRCA1/2 and APC tests. METHODS:A cross-sectional survey of a random sample of Italian physicians was performed in 2010 through a self-administered questionnaire. RESULTS:A response rate of 69.6% (1079 questionnaires) was achieved. A significant lack of knowledge was detected, particularly for APC testing. Less than half of the physicians agreed on the importance of efficacy and cost-effectiveness evidence in the selection of predictive genetic tests to be offered to the patients. Multiple logistic regression analyses showed that education had a positive influence on knowledge, attitudes and, to a lesser extent, professional use. The factor most strongly related to the physicians' use of genetic testing was patients requests for breast (odds ratio=12.65; 95% confidence interval 7.77-20.59) or colorectal cancer tests (odds ratio=7.02; 95% confidence interval 3.61-13.64). A high level of interest for specific training was reported by almost all physicians surveyed. CONCLUSIONS:Targeted educational programs are needed to improve the expertise of physicians, and, ultimately, to enhance the appropriate use of genetic tests in clinical practice.
journal_name
Prev Medjournal_title
Preventive medicineauthors
Marzuillo C,De Vito C,Boccia S,D'Addario M,D'Andrea E,Santini P,Boccia A,Villari Pdoi
10.1016/j.ypmed.2013.06.022subject
Has Abstractpub_date
2013-11-01 00:00:00pages
477-82issue
5eissn
0091-7435issn
1096-0260pii
S0091-7435(13)00214-4journal_volume
57pub_type
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journal_title:Preventive medicine
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pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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更新日期:2011-10-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Preventive medicine
pub_type: 杂志文章,meta分析
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更新日期:1999-02-01 00:00:00
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