Drug concentrations in post-mortem femoral blood compared with therapeutic concentrations in plasma.

abstract：:The use of corticosteroids, such as betamethasone, in performance horses is tightly regulated. The objective of the current study was to describe the plasma pharmacokinetics of betamethasone as well as time-related urine and synovial fluid concentrations following intra-articular administration to horses. Twelve racin...

journal_title：Drug testing and analysis

authors： Knych HK,Stanley SD,Harrison LM,Mckemie DS

更新日期：2017-09-01 00:00:00

abstract：:Synthetic cathinones continue to proliferate in clandestine drug markets worldwide. N-ethylnorpentylone (also known as N-ethylpentylone or ephylone) is a popular emergent cathinone, yet little information is available about its toxicology and pharmacology. Here we characterize the analytical quantification, clinical p...

journal_title：Drug testing and analysis

authors： Costa JL,Cunha KF,Lanaro R,Cunha RL,Walther D,Baumann MH

更新日期：2019-03-01 00:00:00

abstract：:Xenon is a modern inhalative anaesthetic with a very low solubility in tissues providing rapid elimination and weaning from anaesthesia. Besides its anaesthetic properties, Xenon promotes the endogenous erythropoietin biosynthesis and thus has been enlisted as prohibited substance by the World Anti-Doping Agency (WADA...

journal_title：Drug testing and analysis

authors： Schaefer MS,Piper T,Geyer H,Schneemann J,Neukirchen M,Thevis M,Kienbaum P

更新日期：2017-05-01 00:00:00

abstract：:A novel poly (vinyl chloride) PVC membrane sensor for Fe(2+) ions is described. The sensor is based on the use of newly synthesized chiral 2,6-bis-(carboxamide methyl ester)pyridine derivative as neutral ionophore in plasticized PVC membrane. The sensor display a fast, stable and near-Nernstian response over a relativ...

journal_title：Drug testing and analysis

authors： Abounassif MA,Al-Omar MA,Amr AG,Mostafa GA

更新日期：2011-06-01 00:00:00

abstract：:This work presents an analytical procedure for the identification and characterization of liposome-entrapped haemoglobins, based on flow cytofluorimetry. Flow cytofluorimetric detection is carried out following labelling by two distinct fluorescent reagents, an anti-haemoglobin antibody, fluorescein isothiocyanate con...

journal_title：Drug testing and analysis

authors： Esposito S,Colicchia S,de la Torre X,Donati F,Mazzarino M,Botrè F

更新日期：2017-02-01 00:00:00

abstract：:According to French law, the roadside testing for drugs of abuse (DOA) should be performed in oral fluid (OF) using an immunological screening kit. If the screening is positive, confirmation has to be done in OF collected by a special swab, called the FLOQSwab™ (FS). Unlike other sampling kits, this device was not des...

journal_title：Drug testing and analysis

authors： Fabresse N,Aouad H,Knapp A,Mayer C,Etting I,Larabi IA,Alvarez JC

更新日期：2019-06-01 00:00:00

abstract：:Designer drugs belong to a group of legally or illegally produced substances that are structurally and pharmacologically very similar to illicit drugs. In the past, designer drugs were often used during all-night dance parties, but they are now consumed in multiple settings from college bars to parks to private house ...

journal_title：Drug testing and analysis

authors： Karila L,Reynaud M

更新日期：2011-09-01 00:00:00

abstract：:In vitro and in vivo experiments are widely used for studying the metabolism of new psychoactive substances (NPS). The availability of such data is required for toxicological risk assessments and development of urine screening approaches. This study investigated the in vitro metabolism of the 5 pyrrolidinophenone-deri...

journal_title：Drug testing and analysis

authors： Manier SK,Richter LHJ,Schäper J,Maurer HH,Meyer MR

更新日期：2018-01-04 00:00:00

abstract：:The present study was designed to provide preliminary information on the potential impact of metabolic drug-drug interaction on the effectiveness of doping control strategies currently followed by the anti-doping laboratories to detect the intake of prohibited agents. In vitro assays based on the use of human liver mi...

journal_title：Drug testing and analysis

authors： Mazzarino M,de la Torre X,Fiacco I,Botrè F

更新日期：2014-10-01 00:00:00

abstract：:Lysergic acid diethylamide (LSD) is a prototypical serotonergic psychedelic drug and the subject of many clinical investigations. In recent years, a range of lysergamides has emerged with the production of some being inspired by the existing scientific literature. Others, for example various 1-acyl substituted lyserga...

journal_title：Drug testing and analysis

authors： Brandt SD,Kavanagh PV,Westphal F,Stratford A,Odland AU,Klein AK,Dowling G,Dempster NM,Wallach J,Passie T,Halberstadt AL

更新日期：2020-06-01 00:00:00

abstract：:Addiction is a complex disorder with interacting factors, including environmental factors, drug-induced neurobiological changes, comorbidity, personality traits and stress responsivity. Numerous genetic variants that affect these factors may work in concert to affect vulnerability and severity of addiction. Traditiona...

journal_title：Drug testing and analysis

authors： Fattore L

更新日期：2013-01-01 00:00:00

abstract：:Detection of androgenic-anabolic steroid abuse in equine sports requires knowledge of the drug's metabolism in order to target appropriate metabolites, especially where urine is the matrix of choice. Studying 'designer' steroid metabolism is problematic since it is difficult to obtain ethical approval for in vivo meta...

journal_title：Drug testing and analysis

authors： Clarke A,Scarth J,Teale P,Pearce C,Hillyer L

更新日期：2011-01-01 00:00:00

abstract：:Hair analysis is useful for documenting long-term exposure to drugs. The potential of hair analysis for therapeutic drug monitoring within the forensic field has been studied, but reference values for some antidepressants and antipsychotics in the hair of individuals undergoing chronic therapy are still lacking. In th...

journal_title：Drug testing and analysis

authors： Wang X,Zhuo Y,Tang X,Qiang H,Liu W,Wu H,Xiang P,Duan G,Shen M

更新日期：2020-04-01 00:00:00

abstract：:The detection of an intact ester of testosterone in plasma is leading towards unequivocal proof of the administration of exogenous testosterone. In the current study, a sensitive screening method for the detection of nine testosterone esters in human plasma was developed. By preparing oxime derivatives of intact testo...

journal_title：Drug testing and analysis

authors： Forsdahl G,Vatne HK,Geisendorfer T,Gmeiner G

更新日期：2013-11-01 00:00:00

abstract：:Driving under the influence of drugs (DUID) is a worldwide problem. Several countries have adopted DUID legislations which prove their deterrent effect and impact on road safety. However, the use of new psychoactive substances (NPS) and prescription drugs is not known, as the applied roadside screening tests have not ...

journal_title：Drug testing and analysis

authors： Wille SMR,Richeval C,Nachon-Phanithavong M,Gaulier JM,Di Fazio V,Humbert L,Samyn N,Allorge D

更新日期：2018-03-01 00:00:00

abstract：:Musk, the dried secretion of the musk pod (sac) of adult male musk deer, has been used as traditional Chinese Medicine (TCM) in China and south-east Asian countries for thousands of years. Due to the anabolic steroid component in this TCM, musk preparations have been included in the list of medical products containing...

journal_title：Drug testing and analysis

authors： Wang J,He Y,Liu X,Yang Z,Yang W

更新日期：2017-11-01 00:00:00

abstract：:Drug and alcohol abuse is a concern for many European companies, especially those having safety-critical jobs. It is not uncommon for European companies to establish a drug policy with little or no provision for drug testing. The European Union (EU) has launched a number of initiatives in its fight against drugs. Ther...

journal_title：Drug testing and analysis

authors： Agius R,Kintz P,European Workplace Drug Testing Society.

更新日期：2010-08-01 00:00:00

abstract：:Accurate on-site devices to screen for drug intake are critical for establishing whether an individual is driving under the influence of drugs (DUID); however, on-site oral fluid (OF) cocaine device performance is variable. We evaluated the performance of a newly developed benzoylecgonine (BE) test-strip for the Draeg...

journal_title：Drug testing and analysis

authors： Ellefsen KN,Concheiro M,Pirard S,Gorelick DA,Huestis MA

更新日期：2016-03-01 00:00:00

abstract：:Docetaxel (DTX) is an anti-cancer compound derived from 10-deacetyl baccatin III which is indicated for treatment of breast, lung, prostate, gastro-esophageal, and head and neck cancers. Epimerization of DTX at the C-7 hydroxyl position has intrigued chemists and has been implicated in loss of potency, as well as in t...

journal_title：Drug testing and analysis

authors： Mohsin S,Arellano IH,Choudhury NR,Garg S

更新日期：2014-10-01 00:00:00

abstract：:The widespread use of antibiotics in animals is causing concerns about the growing risk for development and the spread of antibiotic-resistant bacteria. Antibiotic consumption is higher in animals than in humans as reported in a joint publication of EFSA (European Food Safety Agency), ECDC (European Centre for Disease...

journal_title：Drug testing and analysis

authors： Daeseleire E,De Graef E,Rasschaert G,De Mulder T,Van den Meersche T,Van Coillie E,Dewulf J,Heyndrickx M

更新日期：2016-05-01 00:00:00

abstract：:Hemapolin (2α,3α-epithio-17α-methyl-5α-androstan-17β-ol) is a designer steroid that is an ingredient in several "dietary" and "nutritional" supplements available online. As an unusual chemical modification to the steroid A-ring could allow this compound to pass through antidoping screens undetected, the metabolism of ...

journal_title：Drug testing and analysis

authors： Waller CC,Weththasinghe SA,McClure L,Cawley AT,Suann C,Suann E,Sutherland E,Cooper E,Heather A,McLeod MD

更新日期：2020-06-01 00:00:00

abstract：:Oral fluid (OF) offers a simple, non-invasive, directly observable sample collection for clinical and forensic drug testing. Given that chronic cannabis smokers often engage in drug administration multiple times daily, evaluating OF cannabinoid pharmacokinetics during ad libitum smoking is important for practical deve...

journal_title：Drug testing and analysis

authors： Lee D,Vandrey R,Mendu DR,Murray JA,Barnes AJ,Huestis MA

更新日期：2015-06-01 00:00:00

abstract：:Zebrafish (Danio rerio) water tank (ZWT) approach was investigated as an alternative model for metabolism studies based on six different experiments with four model compounds. Sibutramine was applied for the multivariate optimization of ZWT conditions, also for the comparison of the metabolism among ZWT, humans and mi...

journal_title：Drug testing and analysis

authors： Sardela VF,Anselmo CS,Nunes IKDC,Carneiro GRA,Dos Santos GRC,de Carvalho AR,Labanca BJ,Silva Oliveira D,Ribeiro WD,de Araujo ALD,Padilha MC,de Lima CKF,de Sousa VP,de Aquino Neto FR,Gualberto Pereira HM

更新日期：2018-11-01 00:00:00

abstract：:Metal ion coordination ionspray (M(+) CIS) ionization is a powerful technique to enhance ionization efficiency and sensitivity. In this study, we developed and validated an analytical method for simultaneous ionization and analysis of 84 anabolic androgenic steroids (65 exogenous and 19 endogenous) using liquid chroma...

journal_title：Drug testing and analysis

authors： Kim SH,Cha EJ,Lee KM,Kim HJ,Kwon OS,Lee J

更新日期：2014-11-01 00:00:00

abstract：:Deschloroketamine (2-(methylamino)-2-phenyl-cyclohexanone) is a ketamine analog belonging to a group of dissociative anesthetics, which have been distributed within the illicit market since 2015. However, it was also being sold as 'ketamine' misleading people to believe that they were getting genuine ketamine. Dissoci...

journal_title：Drug testing and analysis

authors： Hájková K,Jurásek B,Čejka J,Štefková K,Páleníček T,Sýkora D,Kuchař M

更新日期：2020-03-01 00:00:00

abstract：:Prenylamine is a vasodilator of phenylalkylamine structure and was used for the treatment of angina pectoris, until reports of undesirable effects including ventricular tachycardia led to a decreasing use of the drug in the 1980s. Metabolic N-dealkylation of orally ingested prenylamine can liberate amphetamine in huma...

journal_title：Drug testing and analysis

authors： Beuck S,Sigmund G,Koch A,Schänzer W,Pokrywka A,Kwiatkowska D,Thevis M

更新日期：2012-09-01 00:00:00

abstract：:New Psychoactive Substances are now a feature of Australia's recreational drug market. Little is known, however, about the prevalence of use, the characteristics of people who use them and the relationship between the NPS and ecstasy markets. This study examined the prevalence and correlates of NPS use amongst a group...

journal_title：Drug testing and analysis

authors： Burns L,Roxburgh A,Matthews A,Bruno R,Lenton S,Van Buskirk J

更新日期：2014-07-01 00:00:00

abstract：:The synthetic tryptamine 5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT) has recently been abused as a hallucinogenic drug in Germany and Switzerland. This study presents a case of 5-MeO-MiPT intoxication and the structural elucidation of metabolites in pooled human liver microsomes (pHLM), blood, and urine. Mic...

journal_title：Drug testing and analysis

authors： Grafinger KE,Hädener M,König S,Weinmann W

更新日期：2018-03-01 00:00:00

abstract：:Rocuronium bromide is a non-depolarizing neuromuscular blocking agent that causes rapid muscle relaxation after intravenous injection. Regulatory authorities for registration of pharmaceuticals for human use require the evaluation of the stability of active compounds under various stress conditions. Forced degradation...

journal_title：Drug testing and analysis

authors： Wegener O,Harms G,Volmer DA,Hayen H

更新日期：2015-09-01 00:00:00

abstract：:A sensitive and selective ultra fast liquid chromatography (UFLC) method has been developed and validated for the determination of a potent and novel antitubercular compound S006-830 in Sprague Dawley (SD) rat plasma. Samples were extracted and processed by protein precipitation method using acetonitrile. Chromatograp...

journal_title：Drug testing and analysis

authors： Singh Y,Hidau MK,Misra A,Kushwaha HN,Tiwari A,Sharma AK,Singh SK

更新日期：2015-08-01 00:00:00