Noninvasive Quantification of Axonal Loss in the Presence of Tissue Swelling in Traumatic Spinal Cord Injury Mice.


:Neuroimaging plays an important role in assessing axonal pathology after traumatic spinal cord injury. However, coexisting inflammation confounds imaging assessment of the severity of axonal injury. Herein, we applied diffusion basis spectrum imaging (DBSI) to quantitatively differentiate and quantify underlying pathologies in traumatic spinal cord injury at 3 days post-injury. Results reveal that DBSI was capable of detecting and differentiating axonal injury, demyelination, and inflammation-associated edema and cell infiltration in contusion-injured spinal cords. DBSI was able to detect and quantify axonal loss in the presence of white matter tract swelling. The DBSI-defined apparent axonal volume correlated with the corresponding histological markers. DBSI-derived pathological metrics could serve as neuroimaging biomarkers to differentiate and quantify coexisting white matter pathologies in spinal cord injury, providing potential surrogate outcome measures to assess spinal cord injury progression and response to therapies.


J Neurotrauma


Journal of neurotrauma


Lin TH,Sun P,Hallman M,Hwang FC,Wallendorf M,Ray WZ,Spees WM,Song SK




Has Abstract


2019-08-01 00:00:00












  • Mechanisms of calpain proteolysis following traumatic brain injury: implications for pathology and therapy: implications for pathology and therapy: a review and update.

    abstract::Much recent research has focused on the pathological significance of calcium accumulation in the central nervous system (CNS) following cerebral ischemia, spinal cord injury (SCI), and traumatic brain injury (TBI). Disturbances in neuronal calcium homeostasis may result in the activation of several calcium-sensitive e...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章,评审


    authors: Kampfl A,Posmantur RM,Zhao X,Schmutzhard E,Clifton GL,Hayes RL

    更新日期:1997-03-01 00:00:00

  • Impaired arpeggio movement in skilled reaching by rubrospinal tract lesions in the rat: a behavioral/anatomical fractionation.

    abstract::Spinal cord injury damaging the rubrospinal tract (RST) interferes with skilled forelimb movement, but identification of the precise role of the RST in this behavior is impeded by the difficulty of surgically isolating the RST from other pathways running within the lateral funiculus (LF). The present study used a skil...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Morris R,Tosolini AP,Goldstein JD,Whishaw IQ

    更新日期:2011-12-01 00:00:00

  • Activation of JNK in the inner ear following impulse noise exposure.

    abstract::Noise exposure is known to induce cell death signaling in the cochlea. Since c-Jun N-terminal kinase (JNK) signaling is known to induce both cell survival and apoptosis, the present study focused on early changes (within 24 h) after impulse noise exposure, inquiring whether cell death is always related to phosphorylat...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Murai N,Kirkegaard M,Järlebark L,Risling M,Suneson A,Ulfendahl M

    更新日期:2008-01-01 00:00:00

  • Monitoring recovery after injury: procedures for deriving the optimal test window.

    abstract::Researchers studying the impact of treatments designed to facilitate recovery after neural injury face competing demands. On the one hand, because treatment effects often emerge slowly over days, and because researchers seek evidence of stable long-term effects, it is common practice to observe experimental subjects f...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Hook MA,Ferguson AR,Garcia G,Washburn SN,Koehly LM,Grau JW

    更新日期:2004-01-01 00:00:00

  • Relative risk of mortality after traumatic brain injury: a population-based study of the role of age and injury severity.

    abstract::To test if observed vs. expected mortality differs by age among traumatic brain injury (TBI) cases, a population-based, historical cohort study was conducted in Olmsted County, Minnesota. From all residents with any diagnosis suggestive of TBI 1985-1999, we randomly sampled 7,800 and reviewed their medical records to ...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Flaada JT,Leibson CL,Mandrekar JN,Diehl N,Perkins PK,Brown AW,Malec JF

    更新日期:2007-03-01 00:00:00

  • Age Moderates the Effects of Traumatic Brain Injury on Beta-Amyloid Plaque Load in APP/PS1 Mice.

    abstract::Traumatic brain injury (TBI) has been identified as a risk factor for Alzheimer's disease (AD). However, how such neural damage contributes to AD pathology remains unclear; specifically, the relationship between the timing of a TBI relative to aging and the onset of AD pathology is not known. In this study, we have ex...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Collins JM,King AE,Woodhouse A,Kirkcaldie MTK,Vickers JC

    更新日期:2019-06-01 00:00:00

  • Concussive brain trauma in the mouse results in acute cognitive deficits and sustained impairment of axonal function.

    abstract::Concussive brain injury (CBI) accounts for approximately 75% of all brain-injured people in the United States each year and is particularly prevalent in contact sports. Concussion is the mildest form of diffuse traumatic brain injury (TBI) and results in transient cognitive dysfunction, the neuropathologic basis for w...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Creed JA,DiLeonardi AM,Fox DP,Tessler AR,Raghupathi R

    更新日期:2011-04-01 00:00:00

  • Morphological characterization of photochemical graded spinal cord injury in the rat.

    abstract::This study characterizes the histological and immunohistochemical changes in the adult rat spinal cord following photochemically induced spinal cord lesions. The spinal cord was exposed by laminectomy (T12-L1 vertebrae) and bathed with 1.5% rose bengal solution for 10 min. The excess dye was removed by saline rinse an...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


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    更新日期:2003-05-01 00:00:00

  • tPA-S481A prevents neurotoxicity of endogenous tPA in traumatic brain injury.

    abstract::Traumatic brain injury (TBI) is associated with loss of autoregulation due to impaired responsiveness to cerebrovascular dilator stimuli, which leads to cerebral hypoperfusion and neuronal impairment or death. Upregulation of tissue plasminogen activator (tPA) post-TBI exacerbates loss of cerebral autoregulation and N...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Armstead WM,Riley J,Yarovoi S,Cines DB,Smith DH,Higazi AA

    更新日期:2012-06-10 00:00:00

  • The uncoupling agent 2,4-dinitrophenol improves mitochondrial homeostasis following striatal quinolinic acid injections.

    abstract::It is now generally accepted that excitotoxic cell death involves bioenergetic failure resulting from the cycling of Ca2+ and the generation of reactive oxygen species (ROS) by mitochondria. Both Ca2+ cycling and ROS formation by mitochondria are dependent on the mitochondrial membrane potential (Deltapsi(m)) that res...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Korde AS,Sullivan PG,Maragos WF

    更新日期:2005-10-01 00:00:00

  • Is there a cartesian renaissance of the mind or is it time for a new taxonomy for low responsive states?

    abstract::The mass media have recently pointed out the likelihood of diagnostic errors in post-coma patients. Late recoveries of consciousness, even after 20 years, might indicate hidden misdiagnoses that are not corrected over a long period of time. The rate of misdiagnoses of patients in a vegetative state is very high when b...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Pistoia F,Sarà M

    更新日期:2012-09-01 00:00:00

  • Traumatic brain injury-associated coagulopathy.

    abstract::Traumatic injury is a common cause of coagulopathy, primarily due to blood loss and hemodilution secondary to fluid resuscitation. Traumatic injury-associated coagulopathy often follows a course of transition from hyper- to hypocoagulable state exemplified in disseminated intravascular coagulation. The incidence of co...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章,评审


    authors: Zhang J,Jiang R,Liu L,Watkins T,Zhang F,Dong JF

    更新日期:2012-11-20 00:00:00

  • Post-acute brain injury urinary signature: a new resource for molecular diagnostics.

    abstract::Heterogeneity within brain injury presents a challenge to the development of informative molecular diagnostics. Recent studies show progress, particularly in cerebrospinal fluid, with biomarker assays targeting one or a few structural proteins. Protein-based assays in peripheral fluids, however, have been more challen...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Ottens AK,Stafflinger JE,Griffin HE,Kunz RD,Cifu DX,Niemeier JP

    更新日期:2014-04-15 00:00:00

  • Cardiometabolic risk factors in experimental spinal cord injury.

    abstract::Cardiometabolic risk factors are sorely underreported after spinal cord injury (SCI), despite the high prevalence of metabolic disorders and cardiovascular mortality in this population. Body-composition analysis and serum-lipid profiling are two assessments that are beginning to be more widely used to document metabol...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Inskip J,Plunet W,Ramer L,Ramsey JB,Yung A,Kozlowski P,Ramer M,Krassioukov A

    更新日期:2010-01-01 00:00:00

  • Phosphorylation and cleavage of the family of collapsin response mediator proteins may play a central role in neurodegeneration after CNS trauma.

    abstract::The family of the collapsin response mediator proteins (CRMPs) plays a significant physiological role in neuronal cell bodies and axons within the integrated mammalian central nervous system (CNS). Trauma-induced damage to the CNS results in variable degrees of axonal degeneration, and this may lead to neuronal cell d...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Taghian K,Lee JY,Petratos S

    更新日期:2012-06-10 00:00:00

  • Platelet dysfunction in patients with severe traumatic brain injury.

    abstract::Coagulopathy is a common phenomenon in traumatic brain injury (TBI) and a major contributor to a poor outcome. Thrombocytopenia is a strong negative prognostic factor in TBI, but bleeding tendency can be present even with a normal platelet count. We investigated platelet function in patients with TBI by means of modif...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Nekludov M,Bellander BM,Blombäck M,Wallen HN

    更新日期:2007-11-01 00:00:00

  • Acute pharmacological DVT prophylaxis after spinal cord injury.

    abstract::A systematic review of the literature was performed to address pertinent clinical questions regarding deep vein thrombosis (DVT) prophylaxis in the setting of acute spinal cord injury (SCI). Deep vein thromboses are a common occurrence following SCI. Administration of low-molecular-weight heparin (LMWH) within 72 h of...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章,评审


    authors: Christie S,Thibault-Halman G,Casha S

    更新日期:2011-08-01 00:00:00

  • Traumatic brain injury induces prolonged accumulation of cyclooxygenase-1 expressing microglia/brain macrophages in rats.

    abstract::Inflammatory cellular responses to brain injury are promoted by proinflammatory messengers. Cyclooxygenases (prostaglandin endoperoxide H synthases [PGH]) are key enzymes in the conversion of arachidonic acid into prostanoids, which mediate immunomodulation, mitogenesis, apoptosis, blood flow, secondary injury (lipid ...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Schwab JM,Seid K,Schluesener HJ

    更新日期:2001-09-01 00:00:00

  • Relationship between intracranial pressure and cortical spreading depression following fluid percussion brain injury in rats.

    abstract::Traumatic brain injury (TBI) is known to be accompanied by an increase in intracranial pressure (ICP) and in some cases, by spontaneous generation of cortical spreading depression (CSD) cycles. However, the role of CSD in the pathophysiology of cerebral contusion is still unknown. A multiparametric monitoring assembly...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Rogatsky GG,Sonn J,Kamenir Y,Zarchin N,Mayevsky A

    更新日期:2003-12-01 00:00:00

  • Lack of Standardization in the Use of the Glasgow Coma Scale: Results of International Surveys.

    abstract::The Glasgow Coma Scale (GCS) was introduced 40 years ago and has received world-wide acceptance. The GCS rates eye, motor, and verbal responses to assess the level of consciousness. Concerns have been expressed with regard to reliability and consistency of assessments. We considered that lack of standardization in app...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Reith FC,Brennan PM,Maas AI,Teasdale GM

    更新日期:2016-01-01 00:00:00

  • Correlation between diffusion-tensor magnetic resonance imaging and motor-evoked potential in chronic severe diffuse axonal injury.

    abstract::We conducted a study to evaluate the degree of corticospinal tract (CST) dysfunction associated with diffuse axonal injury (DAI) through analyses of both diffusion-tensor magnetic resonance imaging (DTMRI) and motor-evoked potential (MEP). Using DTMRI and MEP with transcranial magnetic stimulation, we evaluated 138 in...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Yasokawa YT,Shinoda J,Okumura A,Nakayama N,Miwa K,Iwama T

    更新日期:2007-01-01 00:00:00

  • Modeling the Kinetics of Serum Glial Fibrillary Acidic Protein, Ubiquitin Carboxyl-Terminal Hydrolase-L1, and S100B Concentrations in Patients with Traumatic Brain Injury.

    abstract::Glial fibrillary acidic protein (GFAP), ubiquitin carboxyl-terminal hydrolase-L1 (UCH-L1), and S100B have been shown to be predictive of patients with brain injury. Kinetics of these biomarkers in injured humans have not been extensively examined. This prospective multi-center study included patients with mild-to-mode...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章,多中心研究


    authors: Welch RD,Ellis M,Lewis LM,Ayaz SI,Mika VH,Millis S,Papa L

    更新日期:2017-06-01 00:00:00

  • Investigating white matter tract microstructural changes at 6-12 weeks following mild traumatic brain injury: a combined DTI and NODDI study.

    abstract::Using diffusion-weighted imaging (DWI), research has demonstrated changes suggestive of damage to white matter tracts (WMT) following mild traumatic brain injury (mTBI). Yet due to the predominant use of the diffusion tensor imaging (DTI) model, which has numerous well-established limitations, it has not yet been poss...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Oehr LE,Yang JY,Chen J,Maller J,Seal M,Anderson J

    更新日期:2020-12-14 00:00:00

  • 150 years of treating severe traumatic brain injury: a systematic review of progress in mortality.

    abstract::Considerable effort and resources have been devoted to preserving life in patients with severe closed traumatic brain injury (TBI). We sought to identify temporal trends in mortality rates of these patients from the late 1800s to the present. We searched the literature for articles on severe TBI, abstracting numbers o...

    journal_title:Journal of neurotrauma

    pub_type: 历史文章,杂志文章,评审


    authors: Stein SC,Georgoff P,Meghan S,Mizra K,Sonnad SS

    更新日期:2010-07-01 00:00:00

  • Provider Perspectives on Early Psychosocial Interventions after Pediatric Severe Traumatic Brain Injury: An Implementation Framework.

    abstract::This study created a framework incorporating provider perspectives of best practices for early psychosocial intervention to improve caregiver experiences and outcomes after severe pediatric traumatic brain injury (TBI). A purposive sample of 23 healthcare providers from the emergency, intensive care, and acute care de...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Erlick MR,Vavilala MS,Jaffe KM,Blayney CB,Moore M

    更新日期:2020-11-09 00:00:00

  • Norepinephrine and serotonin release upon impact injury to rat spinal cord.

    abstract::Microdialysis sampling was used to characterize the release of norepinephrine and serotonin upon impact injury to the rat spinal cord. Increases in extracellular norepinephrine concentrations in response to injury were small and of short duration. In contrast, serotonin concentrations quickly rose 35-90 times followin...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Liu DX,Valadez V,Sorkin LS,McAdoo DJ

    更新日期:1990-01-01 00:00:00

  • Body weight, limb size, and muscular properties of early paraplegic mice.

    abstract::Patients with spinal cord injury (SCI) typically experience body weight loss, motor function deficits, and a general decline of physical fitness. Animal models with these characteristics can serve to study the detailed adaptive changes following SCI. In the present study, we report the use of an adult paraplegic mouse...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Landry E,Frenette J,Guertin PA

    更新日期:2004-08-01 00:00:00

  • Caspase pathways, neuronal apoptosis, and CNS injury.

    abstract::Caspases are a family of mammalian proteases related to the ced-3 gene of Caenorhabditis elegans. They mediate many of the morphological and biochemical features of apoptosis, including structural dismantling of cell bodies and nuclei, fragmentation of genomic DNA, destruction of regulatory proteins, and propagation o...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章,评审


    authors: Eldadah BA,Faden AI

    更新日期:2000-10-01 00:00:00

  • Progression of traumatic intracerebral hemorrhage: a prospective observational study.

    abstract::ABSTRACT Preliminary evidence has shown that intracerebral hemorrhages, either spontaneous (sICH) or traumatic (tICH) often expand over time. An association between hemorrhage expansion and clinical outcomes has been described for sICH. The intent of this prospective, observational study was to characterize the tempor...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章,多中心研究


    authors: Narayan RK,Maas AI,Servadei F,Skolnick BE,Tillinger MN,Marshall LF,Traumatic Intracerebral Hemorrhage Study Group.

    更新日期:2008-06-01 00:00:00

  • New CNS-specific calcium antagonists.

    abstract::Ischemic insults to the brain in stroke or traumatic brain injury produce excessive release of glutamate from depolarized nerve terminals. This excessive glutamate release in turn stimulates massive calcium entry into nerve cells, activating a biochemical cascade that results in cell death. A major pathway of calcium ...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章,评审


    authors: McBurney RN,Daly D,Fischer JB,Hu LY,Subbarao K,Knapp AG,Kobayashi K,Margolin L,Reddy NL,Goldin SM

    更新日期:1992-05-01 00:00:00