Abstract:
:Neuroimaging plays an important role in assessing axonal pathology after traumatic spinal cord injury. However, coexisting inflammation confounds imaging assessment of the severity of axonal injury. Herein, we applied diffusion basis spectrum imaging (DBSI) to quantitatively differentiate and quantify underlying pathologies in traumatic spinal cord injury at 3 days post-injury. Results reveal that DBSI was capable of detecting and differentiating axonal injury, demyelination, and inflammation-associated edema and cell infiltration in contusion-injured spinal cords. DBSI was able to detect and quantify axonal loss in the presence of white matter tract swelling. The DBSI-defined apparent axonal volume correlated with the corresponding histological markers. DBSI-derived pathological metrics could serve as neuroimaging biomarkers to differentiate and quantify coexisting white matter pathologies in spinal cord injury, providing potential surrogate outcome measures to assess spinal cord injury progression and response to therapies.
journal_name
J Neurotraumajournal_title
Journal of neurotraumaauthors
Lin TH,Sun P,Hallman M,Hwang FC,Wallendorf M,Ray WZ,Spees WM,Song SKdoi
10.1089/neu.2018.6016subject
Has Abstractpub_date
2019-08-01 00:00:00pages
2308-2315issue
15eissn
0897-7151issn
1557-9042journal_volume
36pub_type
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