Association of -2518A>G promoter polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene with type 2 diabetes and coronary artery disease.


AIMS:Inflammatory markers play an important role in the development of diseases related to metabolic syndrome, such as type 2 diabetes (T2D) and coronary artery disease (CAD). The present study evaluates the association of -2518A>G polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene with T2D and CAD. RESULTS:The frequency of the G allele is greater in CAD cases (35%) as compared to T2D (24.6%) and controls (31%), while the frequency of the A allele is higher in T2D cases (75.4%) as compared to CAD cases (65%) and controls (69%). The analysis has revealed that in comparison to T2D cases, the G allele increases the risk of CAD by 1.9-fold (p=0.008; odds ratio [OR]=1.9, 1.18-3.06 at 95% confidence interval [CI]) but in comparison to controls the G-allele provided protection against T2D (p=0.011; OR=0.55, 0.35-0.87 at 95% CI), both under the dominant model (AG+GG vs. AA). CONCLUSION:Results of the present study suggests that G-allele of MCP-1 -2518A>G polymorphism is associated with reduced risk of T2D and increased risk of CAD in the population of Punjab. The results indicate that there is a difference in the association of risk alleles with phenotypes of metabolic syndrome. Body mass index and waist circumference are important risk factors for T2D in the population of Punjab.


Kaur R,Matharoo K,Arora P,Bhanwer AJ




Has Abstract


2013-10-01 00:00:00












  • Serum Level and Gene Expression of Interleukin-15 Do Not Correlate with Villous Atrophy in Celiac Disease Patients.

    abstract:: Background and Aims: Interleukin-15 (IL-15) is a key player in the pathogenesis of celiac disease (CD). We investigated the functional role of IL-15 in the process of epithelial cell phenotypic modification at different stages of CD. Materials and ...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章


    authors: Aghamohamadi E,Kokhaei P,Rostami-Nejad M,Pak F,Rostami K,Moradi A,Pourhoseingholi MA,Chaleshi V,Masotti A,Zali MR

    更新日期:2020-08-01 00:00:00

  • The use of next-generation sequencing in molecular diagnosis of neurofibromatosis type 1: a validation study.

    abstract:AIMS:We assessed the validity of a next-generation sequencing protocol using in-solution hybridization-based enrichment to identify NF1 mutations for the diagnosis of 86 patients with a prototypic genetic syndrome, neurofibromatosis type 1. In addition, other causative genes for classic genetic syndromes were set as th...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Maruoka R,Takenouchi T,Torii C,Shimizu A,Misu K,Higasa K,Matsuda F,Ota A,Tanito K,Kuramochi A,Arima Y,Otsuka F,Yoshida Y,Moriyama K,Niimura M,Saya H,Kosaki K

    更新日期:2014-11-01 00:00:00

  • Validation of an unlabeled probe melting analysis assay combined with high-throughput extractions for genotyping of the most common variants in HFE-associated hereditary hemochromatosis, C282Y, H63D, and S65C.

    abstract::Hereditary hemochromatosis is an inherited disorder of iron metabolism, characterized by high absorption of iron by the gastrointestinal tract leading to a toxic accumulation of iron in various organs and impaired organ function. Three variants in the HFE gene (p.C282Y, p.H63D, and p.S65C) are commonly associated with...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章


    authors: Sumner K,Hubley L,Pont-Kingdon G,Mitchell S,Wayman T,Wilson A,Meadows C,Elenitoba-Johnson K,Pattison D,Dobrowolski S,Best H,Lyon E

    更新日期:2012-07-01 00:00:00

  • Screening for the GJB2 c.-3170 G>A (IVS 1+1 G>A) mutation in Brazilian deaf individuals using multiplex ligation-dependent probe amplification.

    abstract::Mutations in GJB2 gene are the most common cause of nonsyndromic sensorineural recessive hearing loss. One specific mutation, c.35delG, is the most frequent in the majority of Caucasian populations and may account for up to 70% of all GJB2 mutations. However, 10-40% of the patients carry only one pathogenic mutation i...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章


    authors: da Silva-Costa SM,Coeli FB,Lincoln-de-Carvalho CR,Marques-de-Faria AP,Kurc M,Pereira T,Pomilio MC,Sartorato EL

    更新日期:2009-10-01 00:00:00

  • Molecular Prognostic Value of Circulating Epstein-Barr Viral DNA in Nasopharyngeal Carcinoma: A Meta-Analysis of 27,235 Cases in the Endemic Area of Southeast Asia.

    abstract:: Aims: This meta-analysis evaluated the value of using Epstein-Barr virus (EBV) DNA titers as a predictive factor in assessing the clinical course of nasopharyngeal carcinoma (NPC) patients in Southeast Asia. Methods: A systemat...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章,meta分析


    authors: Xie X,Ren Y,Wang K,Yi B

    更新日期:2019-07-01 00:00:00

  • Distribution of killer cell immunoglobulin-like receptor (KIR) genotypes in patients with familial Mediterranean fever.

    abstract::Genotypic profiles of the natural killer cell immunoglobulin-like receptors (KIR) have been reported to vary among different ethnic groups and variable clinical entities. This study represents the first report on its distribution among patients with familial Mediterranean fever (FMF). We studied 56 unrelated Lebanese ...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章


    authors: Mahfouz RA,Sabbagh AS,Shamseddine W,Bazarbachi A,Ibrahim G,Arayssi T,El Hajj N,Rayes R,Zaatari GS,Khazen G,Khalaf RA

    更新日期:2009-02-01 00:00:00

  • Using Cost-Effectiveness Analysis to Quantify the Value of Genomic-Based Diagnostic Tests: Recommendations for Practice and Research.

    abstract:AIMS:New sequencing technologies allow increased opportunities to use genomic-based diagnostic tests (genomic tests) in routine clinical practice, which will impact healthcare budgets and patients' outcomes. This article aims to generate a list of recommendations on how the principles and methods of cost-effectiveness ...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章,评审


    authors: Spackman E,Hinde S,Bojke L,Payne K,Sculpher M

    更新日期:2017-12-01 00:00:00

  • Polymorphisms in the ERCC1 and XPF genes and risk of breast cancer in a Chinese population.

    abstract::Inherited functional single-nucleotide polymorphisms (SNPs) in DNA repair genes may influence the capability of DNA repair and contribute to the risk of breast cancer. We therefore performed a case-control study to investigate the association of three in excision repair cross-complimentary group 1 (ERCC1) and three in...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Yang Z,Fang X,Pei X,Li H

    更新日期:2013-09-01 00:00:00

  • PARP-1 rs3219073 polymorphism may contribute to susceptibility to lung cancer.

    abstract:OBJECTIVE:To investigate the relationship between the PARP-1 rs3219073 C>G polymorphism and susceptibility to lung cancer in Chinese people. METHODS:In accordance with the case-control study principle, 645 of the patients had histologically recognized primary lung cancer, among them 240 had squamous carcinoma, 217 had...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 临床试验,杂志文章


    authors: Wang HT,Gao Y,Zhao YX,Yu H,Wang TL,Bai L,Chen YZ,Zhang HB,Zhou BS,Qu YL,Liu D,Chen Y

    更新日期:2014-11-01 00:00:00

  • The Half-Life of Serum Thymidine Kinase 1 Concentration Is an Important Tool for Monitoring Surgical Response in Patients with Lung Cancer: A Meta-Analysis.

    abstract:AIMS:In this meta-analysis, we evaluated the usefulness of serum thymidine kinase 1 concentration (STK1c) for monitoring the outcome of extensive open surgery in patients with lung cancer. We also compared STK1c between a healthy population and patients with benign and malignant lung tumors to assess its potential valu...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章,meta分析


    authors: Lou X,Zhou J,Ma H,Xu S,He E,Skog S,Wang H

    更新日期:2017-08-01 00:00:00

  • An Association Study of the SLC19A1 Gene Polymorphisms/Haplotypes with Idiopathic Recurrent Pregnancy Loss in an Iranian Population.

    abstract:AIMS:The genetics of folate metabolism is one of the most significant mechanisms influencing fetal growth and may underlie some cases of unexplained recurrent miscarriage. Reduced folate carrier 1, encoded by the SLC19A1 gene, is a transporter of folate. Folate deficiency and elevated levels of homocysteine could be di...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章


    authors: Mohtaram S,Sheikhha MH,Honarvar N,Sazegari A,Maraghechi N,Feizollahi Z,Ghasemi N

    更新日期:2016-05-01 00:00:00

  • The Association Between the FTO rs9939609 Variant and Malignant Pleural Mesothelioma Risk: A Case-Control Study.

    abstract:AIMS:Despite the established link between malignant pleural mesothelioma (MPM) and asbestos exposure, genetic risk factors may play a key role in MPM pathogenesis. The rs9939609 polymorphism in the FTO gene has recently been implicated as a risk factor for some types of cancer, such as breast, pancreatic, and prostate ...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章


    authors: Khella MS,Salem AM,Abdel-Rahman O,Saad AS

    更新日期:2018-02-01 00:00:00

  • Exploration of the Serum Interleukin-17 and Interleukin-27 Expression Levels in Children with Bronchial Asthma and Their Correlation with Indicators of Lung Function.

    abstract:: Aims: To investigate the expression levels of serum interleukin-17 (IL-17) and interleukin-27 (IL-27) in children with bronchial asthma and to correlate these expression levels with lung function indicators. Methods: A total of...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章


    authors: Liu Z,Niu C,Ying L,Zhang Q,Long M,Fu Z

    更新日期:2020-01-01 00:00:00

  • Analysis of CLCN2 as candidate gene for megalencephalic leukoencephalopathy with subcortical cysts.

    abstract::Mutations in the gene MLC1 are found in approximately 80% of the patients with the inherited childhood white matter disorder megalencephalic leukoencephalopathy with subcortical cysts (MLC). Genetic linkage studies have not led to the identification of another disease gene. We questioned whether mutations in CLCN2, co...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章


    authors: Scheper GC,van Berkel CG,Leisle L,de Groot KE,Errami A,Jentsch TJ,Van der Knaap MS

    更新日期:2010-04-01 00:00:00

  • Association between the CTLA-4 +49A/G polymorphism and type 1 diabetes: a meta-analysis.

    abstract:BACKGROUND:+49A/G polymorphism of the cytotoxic T-lymphocyte-associated antigen-4 gene (CTLA-4) has been associated with type 1 diabetes (T1D). However, results were inconsistent. The aim of this study was to quantitatively summarize the evidence for CTLA-4 +49A/G polymorphism and T1D. METHODS:Electronic search of Pub...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章,meta分析


    authors: Si X,Zhang X,Luo Y,Tang W

    更新日期:2012-11-01 00:00:00

  • Applications of Next-Generation Sequencing in Neoantigen Prediction and Cancer Vaccine Development.

    abstract::Next-generation sequencing has changed the face of cancer immunotherapy research by making tumor-specific cancer vaccines a reality. Whole exome sequencing and RNA sequencing combined with bioinformatic pipelines allow the prediction of neoantigen targets for cancer vaccines. In this review, we discuss the preclinical...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章,评审


    authors: Lancaster EM,Jablons D,Kratz JR

    更新日期:2020-02-01 00:00:00

  • The Frequency of the Minor Polymorphisms in the CYP2C19, VEGFR-2 Genes, and Clinical Outcomes in Russian and Buryat Patients with Acute Coronary Syndrome.

    abstract::Aim: To determine the differences in the frequencies of polymorphic variants at the rs4244285(*2), rs4986893 (*3), rs12248560 (*17), loci of the CYP2C19 gene, and the rs2305948 locus of the VEGFR-2 gene in patients receiving clopidogrel treatment as part of a 30-day clinical outcome trial in the Russian and Buryat reg...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章


    authors: Zelenskaya EM,Lifshits GI,Nikolaev KY,Donirova OS,Altayev VD,Apartsin KA,Voronina EN,Protasov KV,Sychev DA

    更新日期:2020-06-01 00:00:00

  • Distribution of CYP2D6 and CYP2C19 polymorphisms associated with poor metabolizer phenotype in five Amerindian groups and western Mestizos from Mexico.

    abstract:BACKGROUND:The distribution of polymorphisms in the CYP2D6 and CYP2C19 genes allows inferring the potential risk for specific adverse drug reactions and lack of therapeutic effects in humans. This variability shows differences among human populations. The aim of this study was to analyze single-nucleotide polymorphisms...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章


    authors: Salazar-Flores J,Torres-Reyes LA,Martínez-Cortés G,Rubi-Castellanos R,Sosa-Macías M,Muñoz-Valle JF,González-González C,Ramírez A,Román R,Méndez JL,Barrera A,Torres A,Medina R,Rangel-Villalobos H

    更新日期:2012-09-01 00:00:00

  • Screening for AZFc partial deletions in Dravidian men with nonobstructive azoospermia and oligozoospermia.

    abstract:CONTEXT:Dravidians are the predominant population residing in South India with a diverse genetic structure. Considering various genetic discoveries taking place today, it is evident that deletions in the AZFc region are the most common cause of severe spermatogenic failure (SSF) in various populations studied. However,...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章


    authors: Vijesh VV,Nambiar V,Mohammed SI,Sukumaran S,Suganthi R

    更新日期:2015-03-01 00:00:00

  • Association of angiotensin converting enzyme (insertion/deletion) gene polymorphism with essential hypertension in northern Indian subjects.

    abstract:OBJECTIVE:Essential hypertension is a multifactorial disease in which genetic and environmental factors play an important role. The renin-angiotensin system (RAS) is known to play a critical role in the homeostasis of blood pressure. Angiotensin-I converting enzyme (ACE) is a significant component of RAS, and an insert...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章


    authors: Srivastava K,Sundriyal R,Meena PC,Bhatia J,Narang R,Saluja D

    更新日期:2012-03-01 00:00:00

  • Identification of a Novel Nonsense ASPM Mutation in a Large Consanguineous Pakistani Family Using Targeted Next-Generation Sequencing.

    abstract:AIMS:To identify the pathogenic mutation underlying microcephaly primary hereditary (MCPH) in a large consanguineous Pakistani family. METHODS:A five-generation family with an autosomal recessive transmission of MCPH was recruited. Targeted next-generation DNA sequencing was carried out to analyze the genomic DNA samp...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章


    authors: Khan A,Wang R,Han S,Ahmad W,Zhang X

    更新日期:2018-03-01 00:00:00

  • A c.1363C>T (p.R455X) nonsense mutation of RB1 gene in a southern Chinese retinoblastoma pedigree.

    abstract::Retinoblastoma (RB) is the most common malignant intraocular tumor in children. Fifty percent of RB patients are carriers of a predisposing germline mutation with high penetrance. RB1 has been identified as the only pathological gene. We present the rapid detection of an RB1 gene mutation in a Han pedigree of two RB p...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章


    authors: Chen CY,Xu CM,Du ZF,Chen XL,Ren GL,Zhang XN

    更新日期:2010-04-01 00:00:00

  • Intelligent Ratio: A New Method for Carrier and Newborn Screening in Spinal Muscular Atrophy.

    abstract:: Aim: Spinal muscular atrophy (SMA) is an inherited, autosomal recessive neuromuscular disease that causes high morbidity and mortality. The prevalence is 1-2/100,000, while the incidence is 1/6000-1/10,000 among live births. Due to the high carrier frequency (1/40-1/60) of...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章


    authors: Cavdarli B,Ozturk FN,Guntekin Ergun S,Ergun MA,Dogan O,Percin EF

    更新日期:2020-09-01 00:00:00

  • Synergistic cytogenetic and antineoplastic effects by the combined action of esteric steroidal derivatives of nitrogen mustards.

    abstract::We studied the effect of five newly synthesized steroidal derivatives of nitrogen mustards. These derivatives have as alkylators either P-N, N-bis(2-chloroethyl)aminophenyl-butyrate (CHL) or P-N, N-bis(2-chloroethyl)aminophenyl-acetate (PHE) groups esterified with different modified steroidal nuclei. We examined them ...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章


    authors: Mourelatos C,Nikolaropoulos S,Fousteris M,Pairas G,Argyraki M,Kareli D,Dafa E,Mourelatos D,Lialiaris T

    更新日期:2012-06-01 00:00:00

  • The Impact of Vitamin D Receptor Gene Polymorphisms on the Susceptibility of Diabetic Vascular Complications: A Meta-Analysis.

    abstract:: Background: To determine whether vitamin D receptor (VDR) gene polymorphisms are correlated with susceptibility to diabetic vascular complications. Methods: We included all eligible studies, and used Stata12.0 to calculate the ...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章,meta分析


    authors: Song N,Yang S,Wang YY,Tang SQ,Zhu YQ,Dai Q,Zhang H

    更新日期:2019-08-01 00:00:00

  • Association of androgen receptor, prostate-specific antigen, and CYP19 gene polymorphisms with prostate carcinoma and benign prostatic hyperplasia in a north Indian population.

    abstract::The genes involved in androgen pathway and metabolism have been reported to contribute considerably to prostate carcinoma (CaP) risk. The present study investigated the association of androgen receptor (AR), prostate-specific antigen (PSA or KLK3), and cytochrome P450 (CYP19) gene polymorphisms in CaP (n=105) and beni...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章


    authors: Soni A,Bansal A,Mishra AK,Batra J,Singh LC,Chakraborty A,Yadav DS,Mohanty NK,Saxena S

    更新日期:2012-08-01 00:00:00

  • Genotyping the GGGCGG tandem repeat promoter polymorphism in the 5-lipoxygenase enzyme gene (ALOX5) by pyrosequencing assay.

    abstract:AIMS:Efficient genotyping methods for many biologically significant repeat genetic polymorphisms, particularly in GC-rich regions of the genome, are limited. In particular, a short tandem repeat polymorphism [GGCGGG] in the promoter region of ALOX5 has been implicated as an important marker for inflammatory diseases. W...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章


    authors: Schentrup AM,Allayee H,Lima JJ,Johnson JA,Langaee TY

    更新日期:2009-06-01 00:00:00

  • Validation of Next-Generation Sequencer for 24-Chromosome Aneuploidy Screening in Human Embryos.

    abstract:BACKGROUND:Next-Generation Sequencing (NGS) is the latest approach for preimplantation genetic diagnoses (PGD). AIM:The purpose of this study was to standardize and validate an NGS method for comprehensive chromosome screening and to investigate its applicability to PGD. METHODS:Embryo biopsy, whole-genome amplificat...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章


    authors: Sachdeva K,Discutido R,Albuz F,Almekosh R,Peramo B

    更新日期:2017-11-01 00:00:00

  • A one-step prescreening for point mutations and large rearrangement in BRCA1 and BRCA2 genes using quantitative polymerase chain reaction and high-resolution melting curve analysis.

    abstract::High-resolution melting (HRM) of DNA is a versatile method for mutation scanning that monitors the fluorescence of double-strand DNA with saturating dye. Performing HRM on a real-time thermocycler enables semiquantitative analysis (quantitative polymerase chain reaction, qPCR) to be associated to HRM analysis for dete...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章


    authors: Coulet F,Pires F,Rouleau E,Lefol C,Martin S,Colas C,Cohen-Haguenauer O,Giurgea I,Fajac A,Noguès C,Demange L,Hardouin A,Lidereau R,Soubrier F

    更新日期:2010-10-01 00:00:00

  • CTLA-4 +49 G/A Polymorphism Confers Autoimmune Disease Risk: An Updated Meta-Analysis.

    abstract:BACKGROUND:Cytotoxic T lymphocyte antigen-4 (CTLA-4) plays a pivotal role in immune homeostasis. Dysregulated expression of CTLA-4 leads to many autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, and type 1 diabetes (T1D). There has been a controversial association between the CTLA-4 +49...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章,meta分析


    authors: Wang K,Zhu Q,Lu Y,Lu H,Zhang F,Wang X,Fan Y

    更新日期:2017-04-01 00:00:00