Concentrations of oral lomefloxacin in serum and bronchial mucosa.


:The bronchial mucosal concentrations of lomefloxacin were determined for specimens obtained by fiber-optic bronchoscopy and compared with simultaneous concentrations in serum. The 23 patients studied were given an oral dose of 400 mg once daily for 4 days to achieve steady-state levels. The median concentration in serum was 2.5 micrograms/ml (range, 1.0 to 5 micrograms/ml), and the median bronchial mucosal concentration was 5.0 micrograms/g (range, 0.7 to 18.6 micrograms/g). The median percent penetration was 177% (range, 69 to 541%). The concentrations in serum and mucosa exceeded the MIC for 90% of strains of organisms causing bronchial infections but not sufficiently to recommend lomefloxacin for the routine treatment of pneumococcal infections.


Baldwin DR,Honeybourne D,Andrews JM,Ashby JP,Wise R




Has Abstract


1990-06-01 00:00:00












  • Forging New Antibiotic Combinations under Iron-Limiting Conditions.

    abstract::Pseudomonas aeruginosa is a multidrug-resistant nosocomial pathogen. We showed previously that thiostrepton (TS), a Gram-positive thiopeptide antibiotic, is imported via pyoverdine receptors and synergizes with iron chelator deferasirox (DSX) to inhibit the growth of P. aeruginosa and Acinetobacter baumannii clinical ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Chan DCK,Guo I,Burrows LL

    更新日期:2020-02-21 00:00:00

  • Xenograft model for identifying chemotherapeutic agents against papillomaviruses.

    abstract::The report describes the establishment and characterization of a mouse xenograft transplantation model for the study of papillomavirus infection of bovine skin. Calf scrotal skin was inoculated with bovine papillomavirus type 2 before grafting it to the dorsum of severe combined immunodeficient mice. The grafted skin ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Pawellek A,Hewlett G,Kreuter J,Rübsamen-Waigmann H,Weber O

    更新日期:2001-04-01 00:00:00

  • Hydrogenosome metabolism is the key target for antiparasitic activity of resveratrol against Trichomonas vaginalis.

    abstract::Metronidazole (MDZ) and related 5-nitroimidazoles are the recommended drugs for treatment of trichomoniasis, a sexually transmitted disease caused by the protozoan parasite Trichomonas vaginalis. However, novel treatment options are needed, as recent reports have claimed resistance to these drugs in T. vaginalis isola...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Mallo N,Lamas J,Leiro JM

    更新日期:2013-06-01 00:00:00

  • Efficacy of amphotericin B or itraconazole in a murine model of central nervous system Aspergillus infection.

    abstract::Given the greater than 90% lethality of clinical central nervous system (CNS) aspergillosis despite current therapies, there is a need for an animal model to study therapeutic strategies. We previously established a model of CNS aspergillosis by intracerebral infection and report here the results of treatment with the...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Chiller TM,Sobel RA,Luque JC,Clemons KV,Stevens DA

    更新日期:2003-02-01 00:00:00

  • Effect of fluconazole on the steady-state pharmacokinetics of delavirdine in human immunodeficiency virus-positive patients.

    abstract::Fluconazole, an inhibitor of certain human cytochrome P-450 isozymes, is used for the prevention and treatment of a broad range of fungal infections that predominantly affect immunocompromised individuals. This study evaluated the influence of fluconazole on the steady-state pharmacokinetics of delavirdine, a nonnucle...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Borin MT,Cox SR,Herman BD,Carel BJ,Anderson RD,Freimuth WW

    更新日期:1997-09-01 00:00:00

  • Comparison of hydrogen peroxide contact lens disinfection systems and solutions against Acanthamoeba polyphaga.

    abstract::Acanthamoeba is a free-living amoeba causing a potentially blinding infection of the cornea. Contact lens wearers are most at risk and account for some 95% of cases. Hydrogen peroxide is used for contact lens disinfection due to its broad antimicrobial activity. Lenses must be neutralized before use to avoid pronounce...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hughes R,Kilvington S

    更新日期:2001-07-01 00:00:00

  • Susceptibility of Helicobacter pylori to bactericidal properties of medium-chain monoglycerides and free fatty acids.

    abstract::Previous studies have shown that various short- and medium-chain free fatty acids (FFAs) and their corresponding monoacylglycerol esters (MGs) have antibacterial activity in vitro against primarily gram-positive bacteria. More recent studies have also shown that the growth of Helicobacter spp. is inhibited by linoleic...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Petschow BW,Batema RP,Ford LL

    更新日期:1996-02-01 00:00:00

  • Stronger activity of human immunodeficiency virus type 1 protease inhibitors against clinical isolates of Plasmodium vivax than against those of P. falciparum.

    abstract::Recent studies using laboratory clones have demonstrated that several antiretroviral protease inhibitors (PIs) inhibit the growth of Plasmodium falciparum at concentrations that may be of clinical significance, especially during human immunodeficiency virus type 1 (HIV-1) and malaria coinfection. Using clinical isolat...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Lek-Uthai U,Suwanarusk R,Ruengweerayut R,Skinner-Adams TS,Nosten F,Gardiner DL,Boonma P,Piera KA,Andrews KT,Machunter B,McCarthy JS,Anstey NM,Price RN,Russell B

    更新日期:2008-07-01 00:00:00

  • Development of a cell-based high-throughput specificity screen using a hepatitis C virus-bovine viral diarrhea virus dual replicon assay.

    abstract::The hepatitis C virus (HCV) replicon is a unique system for the development of a high-throughput screen (HTS), since the analysis of inhibitors requires the quantification of a decrease in a steady-state level of HCV RNA. HCV replicon replication is dependent on host cell factors, and any toxic effects may have a sign...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: O'Boyle DR 2nd,Nower PT,Lemm JA,Valera L,Sun JH,Rigat K,Colonno R,Gao M

    更新日期:2005-04-01 00:00:00

  • Effects of the Chinese traditional medicine mao-bushi-saishin-to on therapeutic efficacy of a new benzoxazinorifamycin, KRM-1648, against Mycobacterium avium infection in mice.

    abstract::The Chinese traditional medicine mao-bushi-saishin-to (MBST), which has anti-inflammatory effects and has been used to treat the common cold and nasal allergy in Japan, was examined for its effects on the therapeutic activity of a new benzoxazinorifamycin, KRM-1648 (KRM), against Mycobacterium avium complex (MAC) infe...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Shimizu T,Tomioka H,Sato K,Sano C,Akaki T,Dekio S,Yamada Y,Kamei T,Shibata H,Higashi N

    更新日期:1999-03-01 00:00:00

  • Susceptibility of Haemophilus influenza to ampicillin as determined by use of a modified, one-minute beta-lactamase test.

    abstract::Fifty-seven cultures of Haemophilus influenzae were tested for production of beta-lactamase by use of a modified, 1-min test. Only the 24 cultures that were ampicillin resistant, whether type b or not, yielded positive results for the enzyme; all ampicillin-susceptible isolates were uniformly negative. The beta-lactam...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Escamilla J

    更新日期:1976-01-01 00:00:00

  • Penetration of cefotaxime into respiratory secretions.

    abstract::The objective of this study was to quantitate cefotaxime and its active metabolite, desacetyl cefotaxime, in the distal airways and to compare these levels to concentrations in plasma. Respiratory secretions were obtained from the subsegmental level in 17 adult patients undergoing fiber-optic bronchoscopy within 2 h a...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Fick RB Jr,Alexander MR,Prince RA,Kasik JE

    更新日期:1987-05-01 00:00:00

  • Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae.

    abstract::We investigated ertapenem-susceptible and -resistant extended-spectrum beta-lactamase-producing Enterobacter cloacae isolates obtained from the same patient. Gene transcription of OmpD and OmpF was diminished in the ertapenem-resistant isolate. An efflux pump inhibitor decreased the MICs of ertapenem in the resistant ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Szabó D,Silveira F,Hujer AM,Bonomo RA,Hujer KM,Marsh JW,Bethel CR,Doi Y,Deeley K,Paterson DL

    更新日期:2006-08-01 00:00:00

  • Preclinical safety assessments of UC781 anti-human immunodeficiency virus topical microbicide formulations.

    abstract::The nonnucleoside reverse transcriptase inhibitor UC781 is under development as a potential microbicide to prevent sexual transmission of human immunodeficiency virus type 1 (HIV-1). Two gel formulations of UC781 (0.1% and 1.0%) were evaluated in a range of preclinical safety assessments, including systemic absorption...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Patton DL,Sweeney YT,Balkus JE,Rohan LC,Moncla BJ,Parniak MA,Hillier SL

    更新日期:2007-05-01 00:00:00

  • Antipicornavirus flavone Ro 09-0179.

    abstract::Ro 09-0179 (4',5-dihydroxy-3,3',7-trimethoxyflavone), isolated from a Chinese medicinal herb, was found to have potent antiviral activity. It selectively inhibited the replication of human picornaviruses, such as rhinoviruses and coxsackieviruses in tissue culture, but not other DNA and RNA viruses. Ro 09-0298 (4',5-d...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ishitsuka H,Ohsawa C,Ohiwa T,Umeda I,Suhara Y

    更新日期:1982-10-01 00:00:00

  • Synergistic in vitro antimalarial activity of omeprazole and quinine.

    abstract::Previous studies have shown that the proton pump inhibitor omeprazole has antimalarial activity in vitro. The interactions of omeprazole with commonly used antimalarial drugs were assessed in vitro. Omeprazole and quinine combinations were synergistic; however, chloroquine and omeprazole combinations were antagonistic...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Skinner-Adams T,Davis TM

    更新日期:1999-05-01 00:00:00

  • Effects of ionenes on interferon induction by poly(inosinic acid) . poly(cytidylic acid).

    abstract::Depending on the spacing of their positive charges, ionenes, a class of quaternary ammonium polymers, increased the interferon-inducing activity of poly(inosinic acid).poly(cytidylic acid) in mouse L-929 cells, whereas they did not enhance poly(inosinic acid).poly(cytidylic acid) induced interferon production in prima...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Clercq ED,Janik B,Sommer RG

    更新日期:1977-04-01 00:00:00

  • Diminished macrophage inflammatory response to Staphylococcus aureus isolates exposed to daptomycin versus vancomycin or oxacillin.

    abstract::Exposure of any of six clinical isolates of Staphylococcus aureus to daptomycin alone or in combination with vancomycin or oxacillin (compared with vancomycin or oxacillin alone) led to a dampened macrophage inflammatory response with diminished tumor necrosis factor secretion and reduced accumulation of inducible nit...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: English BK,Maryniw EM,Talati AJ,Meals EA

    更新日期:2006-06-01 00:00:00

  • Randomized pilot trial of eight weeks of bedaquiline (TMC207) treatment for multidrug-resistant tuberculosis: long-term outcome, tolerability, and effect on emergence of drug resistance.

    abstract::The 2-year follow-up results for a randomized placebo-controlled study of 47 patients with multidrug-resistant pulmonary tuberculosis treated with either the new diarylquinoline TMC207, recently renamed bedaquiline, or placebo, added to the first 8 weeks of a background regimen, are presented. Bedaquiline significantl...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,随机对照试验


    authors: Diacon AH,Donald PR,Pym A,Grobusch M,Patientia RF,Mahanyele R,Bantubani N,Narasimooloo R,De Marez T,van Heeswijk R,Lounis N,Meyvisch P,Andries K,McNeeley DF

    更新日期:2012-06-01 00:00:00

  • In vitro effects of antimicrobial agents on Mycobacterium leprae in mouse peritoneal macrophages.

    abstract::Mycobacterium leprae synthesizes large quantities of a specific phthiocerol-containing phenolic glycolipid in vivo. We have shown earlier that viable M. leprae readily incorporates radiolabeled palmitic acid into phenolic glycolipid I when residing in cultured macrophages in vitro and that this process is inhibited by...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ramasesh N,Krahenbuhl JL,Hastings RC

    更新日期:1989-05-01 00:00:00

  • Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity.

    abstract::Genome studies suggest that DNA gyrase is the sole type II topoisomerase and likely the unique target of quinolones in Mycobacterium tuberculosis. Despite the emerging importance of quinolones in the treatment of mycobacterial disease, the slow growth and high pathogenicity of M. tuberculosis have precluded direct pur...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Aubry A,Pan XS,Fisher LM,Jarlier V,Cambau E

    更新日期:2004-04-01 00:00:00

  • Susceptibility Testing of Antibiotics That Degrade Faster than the Doubling Time of Slow-Growing Mycobacteria: Ertapenem Sterilizing Effect versus Mycobacterium tuberculosis.

    abstract::Drug susceptibility tests (DSTs) for Mycobacterium tuberculosis require at least 7 days of incubation. Drugs that are unstable at 37°C, such as ertapenem, are likely to be degraded before killing or inhibiting slow-growing bacteria. This would alter the MICs of these drugs, including ertapenem, leading to falsely high...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Srivastava S,van Rijn SP,Wessels AM,Alffenaar JW,Gumbo T

    更新日期:2016-04-22 00:00:00

  • Concentration-dependent synergy and antagonism within a triple antifungal drug combination against Aspergillus species: analysis by a new response surface model.

    abstract::Triple antifungal combinations are used against refractory invasive aspergillosis without an adequate understanding of their pharmacodynamic interactions. We initially studied the in vitro triple combination of voriconazole, amphotericin B, and caspofungin against Aspergillus fumigatus, A. flavus, and A. terreus by a ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Meletiadis J,Stergiopoulou T,O'Shaughnessy EM,Peter J,Walsh TJ

    更新日期:2007-06-01 00:00:00

  • In vitro and in vivo pharmacokinetics-pharmacodynamics of GV143253A, a novel trinem.

    abstract::The aim of the present study was to characterize the pharmacokinetic-pharmacodynamic relationship of GV143253A, a novel trinem anti-methicillin-resistant Staphylococcus aureus (MRSA) agent active against gram-positive cocci, including multidrug-resistant clinical isolates. An in vitro pharmacodynamic study with methic...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ferrari L,Iavarone L,Braggio S,Di Modugno E

    更新日期:2003-02-01 00:00:00

  • Polyamine transport as a target for treatment of Pneumocystis pneumonia.

    abstract::Polyamine levels are greatly increased in alveolar macrophages (AMs) during Pneumocystis pneumonia (PCP), leading to increased production of H(2)O(2), which causes AMs to undergo apoptosis. One of the mechanisms by which polyamine levels in AMs are elevated is enhanced uptake of exogenous polyamines. In this study, th...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Liao CP,Phanstiel O 4th,Lasbury ME,Zhang C,Shao S,Durant PJ,Cheng BH,Lee CH

    更新日期:2009-12-01 00:00:00

  • Nephrotoxicity in Patients with or without Cystic Fibrosis Treated with Polymyxin B Compared to Colistin.

    abstract::Nephrotoxicity is the primary adverse effect of the polymyxins. The relative rates of toxicity of polymyxin B and colistin have not been fully elucidated, especially in patients with cystic fibrosis (CF). A retrospective cohort study of adults treated with polymyxin B or colistin for at least 48 h was conducted. The p...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Crass RL,Rutter WC,Burgess DR,Martin CA,Burgess DS

    更新日期:2017-03-24 00:00:00

  • A zidovudine-resistant simian immunodeficiency virus mutant with a Q151M mutation in reverse transcriptase causes AIDS in newborn macaques.

    abstract::The simian immunodeficiency virus (SIV)-newborn rhesus macaque model of AIDS can be used to study directly the virulence of viral mutants which are resistant to antiviral drugs. A viral mutant called SIVmac79A6.1, isolated from an SIV-infected macaque after prolonged zidovudine treatment, was found to have a double-ba...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Van Rompay KK,Greenier JL,Marthas ML,Otsyula MG,Tarara RP,Miller CJ,Pedersen NC

    更新日期:1997-02-01 00:00:00

  • Structure-Activity Relationship Analysis of Benzotriazine Analogues as HIV-1 Latency-Reversing Agents.

    abstract::"Shock and kill" therapeutic strategies toward HIV eradication are based on the transcriptional activation of latent HIV with a latency-reversing agent (LRA) and the consequent killing of the reactivated cell by either the cytopathic effect of HIV or an arm of the immune system. We have recently found several benzotri...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sorensen ES,Macedo AB,Resop RS,Howard JN,Nell R,Sarabia I,Newman D,Ren Y,Jones RB,Planelles V,Spivak AM,Bosque A

    更新日期:2020-07-22 00:00:00

  • Lysogenic transfer of mef(A) and tet(O) genes carried by Phim46.1 among group A streptococci.

    abstract::We report the ex vivo lysogenic transfer of erythromycin and tetracycline resistance genes among group A streptococci (GAS). Of 42 susceptible strains, 69% acquired erythromycin/tetracycline resistance when infected with purified supernatants from strain m46 culture containing the phage Φm46.1. A significant emm-type-...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Di Luca MC,D'Ercole S,Petrelli D,Prenna M,Ripa S,Vitali LA

    更新日期:2010-10-01 00:00:00

  • Biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine.

    abstract::We have found a close correlation between viral stavudine (d4T) resistance and resistance to d4T-triphosphate at the human immunodeficiency virus type 1 reverse transcriptase (RT) level. RT from site-directed mutants with 69S-XX codon insertions and/or conventional zidovudine resistance mutations seems to be involved ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Lennerstrand J,Stammers DK,Larder BA

    更新日期:2001-07-01 00:00:00