Concentrations of oral lomefloxacin in serum and bronchial mucosa.

Abstract:

:The bronchial mucosal concentrations of lomefloxacin were determined for specimens obtained by fiber-optic bronchoscopy and compared with simultaneous concentrations in serum. The 23 patients studied were given an oral dose of 400 mg once daily for 4 days to achieve steady-state levels. The median concentration in serum was 2.5 micrograms/ml (range, 1.0 to 5 micrograms/ml), and the median bronchial mucosal concentration was 5.0 micrograms/g (range, 0.7 to 18.6 micrograms/g). The median percent penetration was 177% (range, 69 to 541%). The concentrations in serum and mucosa exceeded the MIC for 90% of strains of organisms causing bronchial infections but not sufficiently to recommend lomefloxacin for the routine treatment of pneumococcal infections.

authors

Baldwin DR,Honeybourne D,Andrews JM,Ashby JP,Wise R

doi

10.1128/aac.34.6.1017

subject

Has Abstract

pub_date

1990-06-01 00:00:00

pages

1017-9

issue

6

eissn

0066-4804

issn

1098-6596

journal_volume

34

pub_type

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