Protective effect of sildenafil on liver injury induced by intestinal ischemia/reperfusion.

Abstract:

BACKGROUND:This study evaluated the protective effect of sildenafil on liver injury induced by intestinal ischemia-reperfusion. METHODS:Forty female Sprague Dawley rats were divided into 4 groups: sham-control (SC), ischemia (I), ischemia-reperfusion (IR), and ischemia-reperfusion+sildenafil (SIL; sildenafil gavaged at 50mg/kg before operating). A 2-h ischemia-reperfusion was performed by clamping the superior mesenteric artery. Liver function, plasma alanine (ALT) and aspartate (AST) aminotransferase, and intestinal and liver malondialdehyde (MDA) were measured at the end of the experiment. Intestinal and liver tissue damage was examined by histology. Liver samples were immunologically stained for endothelial nitric oxide synthase (eNOS) and proliferating cell nuclear antigen (PCNA). RESULTS:The ALT and AST levels were highest in the IR group and were lower in the SIL group (p<0.05). Intestinal MDA levels were statistically higher in the IR group than in the SC, I and SIL groups. Liver MDA levels were significantly higher in the IR group than in the I and SC groups (p<0.05) and higher than in the SIL group (p>0.05). Intestinal damage based on Chiu scoring was more severe in the IR than in the SIL group (p<0.05). Sildenafil reduced damage and also increased eNOS and PCNA immunoreactivity in liver tissue. CONCLUSIONS:Sildenafil shows a protective effect on intestinal ischemia-reperfusion-induced liver injury, possibly by decreasing vascular resistance through increased nitric oxide levels.

journal_name

J Pediatr Surg

authors

Inan M,Uz YH,Kizilay G,Topcu-Tarladacalisir Y,Sapmaz-Metin M,Akpolat M,Aydogdu N

doi

10.1016/j.jpedsurg.2012.12.054

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

1707-15

issue

8

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(13)00085-7

journal_volume

48

pub_type

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