Electromagnetic redesign of the HYPERcollar applicator: toward improved deep local head-and-neck hyperthermia.

Abstract:

:Accumulating evidence shows that hyperthermia improves head-and-neck cancer treatment. Over the last decade, we introduced a radiofrequency applicator, named HYPERcollar, which enables local heating also of deep locations in this region. Based on clinical experience, we redesigned the HYPERcollar for improved comfort, reproducibility and operator handling. In the current study, we analyze the redesign from an electromagnetic point of view. We show that a higher number of antennas and their repositioning allow for a substantially improved treatment quality. Combined with the much better reproducibility of the water bolus, this will substantially minimize the risk of underexposure. All improvements combined enable a reduction of hot-spot prominence (hot-spot to target SAR quotient) by 32% at an average of 981 W, which drastically reduces the probability for system power to become a treatment limiting source. Moreover, the power deposited in the target selectively can be increased by more than twofold. Hence, we expect that the HYPERcollar redesign currently under construction allows us to double the clinically applied power to the target while reducing the hot-spots, resulting in higher temperatures and, consequently, better clinical outcome.

journal_name

Phys Med Biol

authors

Togni P,Rijnen Z,Numan WC,Verhaart RF,Bakker JF,van Rhoon GC,Paulides MM

doi

10.1088/0031-9155/58/17/5997

subject

Has Abstract

pub_date

2013-09-07 00:00:00

pages

5997-6009

issue

17

eissn

0031-9155

issn

1361-6560

journal_volume

58

pub_type

杂志文章
  • Enhancement of subharmonic emission from encapsulated microbubbles by using a chirp excitation technique.

    abstract::Subharmonic contrast imaging promises to improve ultrasound-imaging quality by taking advantage of an increased contrast to tissue signal. However, acoustic pressures beyond the subharmonic generation threshold using common ultrasound pulses may induce significant contrast microbubble destruction. In this work, a chir...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/18/005

    authors: Zhang D,Gong Y,Gong X,Liu Z,Tan K,Zheng H

    更新日期:2007-09-21 00:00:00

  • Measurement of effective detective quantum efficiency for a photon counting scanning mammography system and comparison with two flat panel full-field digital mammography systems.

    abstract::Effective detective quantum efficiency (eDQE) describes the resolution and noise properties of an imaging system along with scatter and primary transmission, all measured under clinically appropriate conditions. Effective dose efficiency (eDE) is the eDQE normalised to mean glandular dose and has been proposed as a us...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aaa307

    authors: Wood TJ,Moore CS,Saunderson JR,Beavis AW

    更新日期:2018-01-16 00:00:00

  • Exploration of tradeoffs in intensity-modulated radiotherapy.

    abstract::The purpose of this study is to calculate Pareto surfaces in multi-criteria radiation treatment planning and to analyse the dependency of the Pareto surfaces on the objective functions used for the volumes of interest. We develop a linear approach that allows us to calculate truly Pareto optimal treatment plans, and w...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/24/007

    authors: Craft D,Halabi T,Bortfeld T

    更新日期:2005-12-21 00:00:00

  • Single spectrum three-material decomposition with grating-based x-ray phase-contrast CT.

    abstract::Grating-based x-ray phase-contrast imaging provides three simultaneous image channels originating from a single image acquisition. While the phase signal provides direct access to the electron density in tomography, there is additional information on sub-resolutional structural information which is called dark-field s...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab9704

    authors: Braig EM,Pfeiffer D,Willner M,Sellerer T,Taphorn K,Petrich C,Scholz J,Petzold L,Birnbacher L,Dierolf M,Pfeiffer F,Herzen J

    更新日期:2020-09-18 00:00:00

  • The inverse problem of a Gaussian convolution and its application to the finite size of the measurement chambers/detectors in photon and proton dosimetry.

    abstract::A Gaussian convolution kernel K is deduced as a Green's function of a Lie operator series. The deconvolution of a Gaussian kernel is developed by the inverse Green's function K(-1). A practical application is the deconvolution of measured profiles Dm(x) of photons and protons with finite detector size to determine the...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/48/6/302

    authors: Ulmer W,Kaissl W

    更新日期:2003-03-21 00:00:00

  • Investigation of real tissue water equivalent path lengths using an efficient dose extinction method.

    abstract::For proton therapy, an accurate conversion of CT HU to relative stopping power (RSP) is essential. Validation of the conversion based on real tissue samples is more direct than the current practice solely based on tissue substitutes and can potentially address variations over the population. Based on a novel dose exti...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa782c

    authors: Zhang R,Baer E,Jee KW,Sharp GC,Flanz J,Lu HM

    更新日期:2017-06-23 00:00:00

  • Evidence for a significant timer error on a linear accelerator: consequences for a special therapy application.

    abstract::A significant timer error has been found on a linear accelerator used for intraoperative radiation therapy. Since typical treatment doses range up to 20 Gy, calibrations that do not account for this effect can incur a large dosimetry error. The effect is dose rate dependent, but energy independent. For a dose rate of ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/43/10/031

    authors: Biggs PJ

    更新日期:1998-10-01 00:00:00

  • Energy-resolved computed tomography: first experimental results.

    abstract::First experimental results with energy-resolved computed tomography (CT) are reported. The contrast-to-noise ratio (CNR) in CT has been improved with x-ray energy weighting for the first time. Further, x-ray energy weighting improved the CNR in material decomposition CT when applied to CT projections prior to dual-ene...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/53/20/002

    authors: Shikhaliev PM

    更新日期:2008-10-21 00:00:00

  • Effect of material property heterogeneity on biomechanical modeling of prostate under deformation.

    abstract::Biomechanical model based deformable image registration has been widely used to account for prostate deformation in various medical imaging procedures. Biomechanical material properties are important components of a biomechanical model. In this study, the effect of incorporating tumor-specific material properties in t...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/60/1/195

    authors: Samavati N,McGrath DM,Jewett MA,van der Kwast T,Ménard C,Brock KK

    更新日期:2015-01-07 00:00:00

  • The noise navigator: a surrogate for respiratory-correlated 4D-MRI for motion characterization in radiotherapy.

    abstract::Respiratory-correlated 4D-MRI can characterize respiratory-induced motion of tumors and organs-at-risk for radiotherapy treatment planning and is a necessity for image guidance of moving tumors treated on an MRI-linac. Essential for 4D-MRI generation is a robust respiratory surrogate signal. We investigated the feasib...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab5c62

    authors: Navest RJM,Mandija S,Bruijnen T,Stemkens B,Tijssen RHN,Andreychenko A,Lagendijk JJW,van den Berg CAT

    更新日期:2020-01-13 00:00:00

  • Exploration and application of phenomenological RBE models for proton therapy.

    abstract::The relative biological effectiveness (RBE) of protons varies with multiple physical and biological factors. Phenomenological RBE models have been developed to include such factors in the estimation of a variable RBE, in contrast to the clinically applied constant RBE of 1.1. In this study, eleven published phenomenol...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aad9db

    authors: Rørvik E,Fjæra LF,Dahle TJ,Dale JE,Engeseth GM,Stokkevåg CH,Thörnqvist S,Ytre-Hauge KS

    更新日期:2018-09-13 00:00:00

  • The local noise property in positron volume imaging and optimal conditions for the signal-to-noise ratio of the 3D reconstructed image.

    abstract::The local noise property of a 3D PET reconstructed image is investigated for a uniform-activity sphere distributed in a constantly attenuating spherical object. The positional dependence of the statistical noise is approximately derived and calculated for some special cases. It is suggested that a larger diameter of t...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/42/1/015

    authors: Murayama H,Nohara N

    更新日期:1997-01-01 00:00:00

  • Estimation of mean glandular dose for breast tomosynthesis: factors for use with the UK, European and IAEA breast dosimetry protocols.

    abstract::A formalism is proposed for the estimation of mean glandular dose for breast tomosynthesis, which is a simple extension of the UK, European and IAEA protocols for dosimetry in conventional projection mammography. The formalism introduces t-factors for the calculation of breast dose from a single projection and T-facto...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/2/011

    authors: Dance DR,Young KC,van Engen RE

    更新日期:2011-01-21 00:00:00

  • Monte Carlo calculations of beam quality correction factors kQ for electron dosimetry with a parallel-plate Roos chamber.

    abstract::Current dosimetry protocols (AAPM, IAEA, DIN) recommend the use of parallel-plate ionization chambers for the measurement of absorbed dose-to-water in clinical electron beams. For well-guarded plane-parallel chambers, it is assumed that the perturbation correction pQ is unity for all electron energies. In this study, ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/53/6/006

    authors: Zink K,Wulff J

    更新日期:2008-03-21 00:00:00

  • Effect on tumour control of time interval between surgery and postoperative radiotherapy: an empirical approach using Monte Carlo simulation.

    abstract::In this work, a procedure, based on Monte Carlo techniques, to analyse the effect on the tumour control probability of the time interval between surgery and postoperative radiotherapy is presented. The approach includes the tumour growth as well as the survival of tumour cells undergoing fractionated radiotherapy. Bot...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/49/13/005

    authors: Al-Dweri FM,Guirado D,Lallena AM,Pedraza V

    更新日期:2004-07-07 00:00:00

  • Calculation of positron range and its effect on the fundamental limit of positron emission tomography system spatial resolution.

    abstract::Developments in positron emission tomography (PET) technology have resulted in systems with finer detector elements designed to further improve spatial resolution. However, there is a limit to what extent reducing detector element size will improve spatial resolution in PET. The spatial resolution of PET imaging is li...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/44/3/019

    authors: Levin CS,Hoffman EJ

    更新日期:1999-03-01 00:00:00

  • Measurement of patient entrance surface dose rates for fluoroscopic x-ray units.

    abstract::Measurements of patient entrance surface dose rate provide valuable data for interpreting results from dose-area product studies on fluoroscopic x-ray equipment. Methods for measurement of entrance surface dose rate with backscatter and incident dose rate without backscatter have been investigated. Entrance surface do...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/40/5/008

    authors: Martin CJ

    更新日期:1995-05-01 00:00:00

  • Absorbed dose determination at short distance from 60Co and 192Ir brachytherapy sources.

    abstract::This paper presents two methods for absorbed dose determination with ionization chambers at short distance from 60Co and 192Ir brachytherapy sources. The methods are modifications of the Bragg-Gray and large cavity principles given in the IAEA code of practice for high- and medium-energy photon beams. A non-uniformity...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/43/11/002

    authors: Tölli H,Johansson KA

    更新日期:1998-11-01 00:00:00

  • Cascaded systems analysis of anatomic noise in digital mammography and dual-energy digital mammography.

    abstract::In x-ray based imaging of the breast, contrast between fibroglandular (Fg) tissue and adipose (Ad) tissue is a source of anatomic noise. The goal of this work was to validate by simulation and experiment a mathematical framework for modelling the Fg component of anatomic noise in digital mammograpy (DM) and dual-energ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab3fcd

    authors: Tanguay J,Lalonde R,Bjarnason TA,Yang CJ

    更新日期:2019-10-23 00:00:00

  • Evaluation of a ferrous benzoic xylenol orange transparent PVA cryogel radiochromic dosimeter.

    abstract::A stable cryogel dosimeter was prepared using ferrous benzoic xylenol orange (FBX) in a transparent poly-(vinyl alcohol) (PVA) cryogel matrix. Dose response was evaluated for different numbers of freeze-thaw cycles (FTCs), different concentrations of PVA, and ratios of water/dimethyl sulfoxide. Linear relationships be...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/7/1773

    authors: Eyadeh MM,Farrell TJ,Diamond KR

    更新日期:2014-04-07 00:00:00

  • Photoluminescent thermometry based on europium-activated calcium sulphide.

    abstract::A photoluminescent thermometer, based on the transient emission response of a europium-activated calcium sulphide phosphor, is described in detail. This optical thermometry system has special advantages for temperature measurements in microwave and RF fields and potential application in electromagnetically induced cli...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/27/1/011

    authors: Samulski TV,Chopping PT,Haas B

    更新日期:1982-01-01 00:00:00

  • Integral equations and boundary-element solution for static potential in a general piece-wise homogeneous volume conductor.

    abstract::Boundary element methods (BEM) are used for forward computation of bioelectromagnetic fields in multi-compartment volume conductor models. Most BEM approaches assume that each compartment is in contact with at most one external compartment. In this work, I present a general surface integral equation and BEM discretiza...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/61/22/N606

    authors: Stenroos M

    更新日期:2016-11-21 00:00:00

  • Three-dimensional FDTD simulation of biomaterial exposure to electromagnetic nanopulses.

    abstract::Ultra-wideband (UWB) electromagnetic pulses of nanosecond duration, or nanopulses, have recently been approved by the Federal Communications Commission for a number of different applications. They are also being explored for applications in biotechnology and medicine. The simulation of the propagation of a nanopulse t...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/21/007

    authors: Simicevic N

    更新日期:2005-11-07 00:00:00

  • The reproducibility of polyacrylamide gel dosimetry applied to stereotactic conformal radiotherapy.

    abstract::The reproducibility of polyacrylamide gel (PAG) dosimetry has been evaluated when used to verify two radiotherapy treatment plans of increasing complexity. The plans investigated were a three-field coplanar arrangement, using the linac jaws for field shaping, and a four-field, conformal, non-coplanar plan using precis...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/45/5/309

    authors: Cosgrove VP,Murphy PS,McJury M,Adams EJ,Warrington AP,Leach MO,Webb S

    更新日期:2000-05-01 00:00:00

  • Bulk optical properties of healthy female breast tissue.

    abstract::We have measured the bulk optical properties of healthy female breast tissues in vivo in the parallel plate, transmission geometry. Fifty-two volunteers were measured. Blood volume and blood oxygen saturation were derived from the optical property data using a novel method that employed a priori spectral information t...

    journal_title:Physics in medicine and biology

    pub_type: 临床试验,杂志文章

    doi:10.1088/0031-9155/47/16/302

    authors: Durduran T,Choe R,Culver JP,Zubkov L,Holboke MJ,Giammarco J,Chance B,Yodh AG

    更新日期:2002-08-21 00:00:00

  • Temporal backward projection of optoacoustic pressure transients using fourier transform methods.

    abstract::In medical imaging different techniques have been developed to gain information from inside a tissue. Optoacoustics is a method to generate tomography pictures of tissue using Q-switched laser pulses. Due to thermal and pressure confinement, a short light pulse generates a pressure distribution inside tissue, which mi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/46/7/309

    authors: Köstli KP,Frenz M,Bebie H,Weber HP

    更新日期:2001-07-01 00:00:00

  • MR-based keyhole SPECT for small animal imaging.

    abstract::The rationale for multi-modality imaging is to integrate the strengths of different imaging technologies while reducing the shortcomings of an individual modality. The work presented here proposes a limited-field-of-view (LFOV) SPECT reconstruction technique that can be implemented on a multi-modality MR/SPECT system ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/3/010

    authors: Lee KS,Roeck WW,Gullberg GT,Nalcioglu O

    更新日期:2011-02-07 00:00:00

  • Prediction of dose-volume histograms in nasopharyngeal cancer IMRT using geometric and dosimetric information.

    abstract::A method using both patient geometric and dosimetric information was proposed to predict dose-volume histograms (DVHs) of organs at risk (OARs) for a nasopharyngeal cancer (NPC) intensity-modulated radiation therapy (IMRT) plan. A total of 106 nine-field IMRT NPC plans were used in this study. Twenty-six plans were ra...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab50eb

    authors: Jiao SX,Chen LX,Zhu JH,Wang ML,Liu XW

    更新日期:2019-12-05 00:00:00

  • Efficient IMRT inverse planning with a new L1-solver: template for first-order conic solver.

    abstract::Intensity modulated radiation therapy (IMRT) inverse planning using total-variation (TV) regularization has been proposed to reduce the complexity of fluence maps and facilitate dose delivery. Conventionally, the optimization problem with L-1 norm is solved with quadratic programming (QP), which is time consuming and ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/57/13/4139

    authors: Kim H,Suh TS,Lee R,Xing L,Li R

    更新日期:2012-07-07 00:00:00

  • Dose measurements in inhomogeneous bone/tissue and lung/tissue phantoms for angiography using synchrotron radiation.

    abstract::For angiography using synchrotron radiation we measured the absorbed dose distribution in inhomogeneous phantoms with thin LiF:Mg, Cu, P, LiF:Mg, Ti thermoluminescent dosimeters (TLDs) in tissue and lung substitutes, and with Mg2SiO4:Tb TLDs in bone substitute for 33.32 keV monoenergetic photons from synchrotron radia...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/46/3/308

    authors: Nariyama N,Namito Y,Ban S,Hirayama H

    更新日期:2001-03-01 00:00:00