Abstract:
OBJECTIVES:Currently, there is a debate regarding the roles of two functional fibrinogen-related variants (rs6050 and rs1800790) and ischemic stroke (IS). MATERIALS AND METHODS:A total of 1402 subjects (834 cases and 568 controls) were genotyped for single-nucleotide polymorphisms rs6050 and rs1800790 with the ligation detection reaction method. RESULTS:We found that the homozygous minor allele genotype (GG) of rs6050 significantly increased IS risk by 66%, whereas that of rs1800790 reduced risk by 59% (rs6050: odds ratio [OR]=1.660, 95% confidence intervals [CI]: 1.141-2.415, p=0.008; rs1800790: OR=0.413, 95% CI: 0.228-0.747, p=0.003). After stratifying IS by three common subtypes, consistent results were found in IS cases with large-artery atherosclerosis (rs6050: OR=2.116, 95% CI: 1.327-3.376, p=0.002; rs1800790: OR=0.191, 95% CI: 0.085-0.430, p=0.000), and we also observed that the homozygous minor allele genotype of rs6050 increased risk by 86% in IS cases with cardioembolism (OR=1.859, 95% CI: 1.243-2.782, p=0.003). However, a paradox of association was shown between these two sites and fibrinogen levels. In haplotype analysis, we found that those with haplotype AA (major allele of rs6050 and minor allele of rs1800790) could reduce susceptibility to IS by 35% (OR=0.650, 95% CI: 0.493-0.858, p=0.002). CONCLUSION:Our study suggested that minor allele G of rs6050 is a significant risk factor, which can increase IS risk in the Chinese Han population, while minor allele A of rs1800790 and the haplotype AA lower such risk.
journal_name
Genet Test Mol Biomarkersjournal_title
Genetic testing and molecular biomarkersauthors
Zhang J,Yu L,Yin Y,Lu Q,Lei L,Xiao J,Guo J,Zhao J,Wang Y,He G,Xu Y,He Ldoi
10.1089/gtmb.2013.0131subject
Has Abstractpub_date
2013-11-01 00:00:00pages
789-93issue
11eissn
1945-0265issn
1945-0257journal_volume
17pub_type
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pub_type: 临床试验,杂志文章,评审
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pub_type: 临床试验,杂志文章
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journal_title:Genetic testing and molecular biomarkers
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doi:10.1089/gtmb.2015.0272
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journal_title:Genetic testing and molecular biomarkers
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journal_title:Genetic testing and molecular biomarkers
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doi:10.1089/gtmb.2020.0069
更新日期:2020-07-01 00:00:00
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journal_title:Genetic testing and molecular biomarkers
pub_type: 杂志文章,评审
doi:10.1089/gtmb.2017.0105
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journal_title:Genetic testing and molecular biomarkers
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doi:10.1089/gtmb.2019.0265
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journal_title:Genetic testing and molecular biomarkers
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journal_title:Genetic testing and molecular biomarkers
pub_type: 临床试验,杂志文章
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journal_title:Genetic testing and molecular biomarkers
pub_type: 杂志文章
doi:10.1089/gtmb.2011.0354
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journal_title:Genetic testing and molecular biomarkers
pub_type: 杂志文章
doi:10.1089/gtmb.2010.0106
更新日期:2011-01-01 00:00:00
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journal_title:Genetic testing and molecular biomarkers
pub_type: 杂志文章,meta分析
doi:10.1089/gtmb.2013.0493
更新日期:2014-06-01 00:00:00
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journal_title:Genetic testing and molecular biomarkers
pub_type: 杂志文章
doi:10.1089/gtmb.2009.0095
更新日期:2010-02-01 00:00:00
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journal_title:Genetic testing and molecular biomarkers
pub_type: 杂志文章
doi:10.1089/gtmb.2012.0244
更新日期:2012-12-01 00:00:00
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journal_title:Genetic testing and molecular biomarkers
pub_type: 杂志文章
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journal_title:Genetic testing and molecular biomarkers
pub_type: 杂志文章
doi:10.1089/gtmb.2011.0085
更新日期:2012-02-01 00:00:00
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journal_title:Genetic testing and molecular biomarkers
pub_type: 杂志文章
doi:10.1089/gtmb.2008.0123
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pub_type: 杂志文章
doi:10.1089/gtmb.2012.0100
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