Artificial neural network techniques to improve the ability of optical coherence tomography to detect optic neuritis.

Abstract:

PURPOSE:To analyze the ability of Spectralis optical coherence tomography (OCT) to detect multiple sclerosis (MS) and to distinguish MS eyes with antecedent optic neuritis (ON). To analyze the capability of artificial neural network (ANN) techniques to improve the diagnostic precision. METHODS:MS patients and controls were enrolled (n = 217). OCT was used to determine the 768 retinal nerve fiber layer thicknesses. Sensitivity and specificity were evaluated to test the ability of OCT to discriminate between MS and healthy eyes, and between MS with and without antecedent ON using ANN. RESULTS:Using ANN technique multilayer perceptrons, OCT could detect MS with a sensitivity of 89.3%, a specificity of 87.6%, and a diagnostic precision of 88.5%. Compared with the OCT-provided parameters, the ANN had a better sensitivity-specificity balance. CONCLUSIONS:ANN technique improves the capability of Spectralis OCT to detect MS disease and to distinguish MS eyes with or without antecedent ON.

journal_name

Semin Ophthalmol

authors

Garcia-Martin E,Herrero R,Bambo MP,Ara JR,Martin J,Polo V,Larrosa JM,Garcia-Feijoo J,Pablo LE

doi

10.3109/08820538.2013.810277

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

11-9

issue

1

eissn

0882-0538

issn

1744-5205

journal_volume

30

pub_type

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