Recent progresses on synthesized LuxS inhibitors: A mini-review.

Abstract:

:Design and synthesis of LuxS enzyme inhibitors otherwise known as S-ribosylhomocysteine analogues, to target quorum sensing in bacteria, has been considerably developed within the last decade. This review presents which molecules have been synthesized to target LuxS enzyme in other words inhibitors of S-ribosylhomocysteinase. It reports their tested biological activity as LuxS inhibitors when available. A systematic overview has been conducted by searching PubMed, Medline, and The Cochrane Library and data extraction of all synthesized S-ribosylhomocysteine analogues has been collected. This mini-review shows limited data to date on this area and should continue to be studied.

journal_name

Bioorg Med Chem

authors

Mina G,Chbib C

doi

10.1016/j.bmc.2018.11.026

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

36-42

issue

1

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(18)31701-2

journal_volume

27

pub_type

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