Abstract:
:In this study, the protective effects of EGCG on L-3,4-dihydroxyphenylalanine (L-DOPA)-induced oxidative cell death in catecholaminergic PC12 cells, the in vitro model of Parkinson's disease, were investigated. Treatment with L-DOPA at concentrations higher than 150 µM caused cytotoxicity in PC12 cells, as determined using the 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and flow cytometry detection. The apoptotic ratio was similar in cells treated with 100 µM EGCG plus 150 µM L-DOPA (5.02%) and the control (0.96%) (P > 0.05), and was lower than that of cells treated with L-DOPA only (32.24%, P < 0.05). The generation level of ROS (% of control) in cells treated with EGCG plus L-DOPA was lower than that in cells treated with L-DOPA only (123.90% vs 272.32%, P < 0.05). The optical density in production of TBARS in cells treated with L-DOPA only was higher than that in the control (0.27 ± 0.05 vs 0.08 ± 0.04, P < 0.05), and in cells treated with EGCG only (0.14 ± 0.02, P < 0.05), and EGCG plus L-DOPA (0.13 ± 0.02, P < 0.05). The intracellular level of GSH in cells treated with EGCG plus L-DOPA was higher than that in cells treated with L-DOPA only (233.25 ± 16.44 vs 119.23 ± 10.25, P < 0.05). These results suggest that EGCG protects against L-DOPA-induced oxidative apoptosis in PC12 cells, and might be a potent neuroprotective agent.
journal_name
Nutr Res Practjournal_title
Nutrition research and practiceauthors
Lee MY,Choi EJ,Lee MK,Lee JJdoi
10.4162/nrp.2013.7.4.249subject
Has Abstractpub_date
2013-08-01 00:00:00pages
249-55issue
4eissn
1976-1457issn
2005-6168journal_volume
7pub_type
杂志文章abstract::Inadequate dietary intakes and poor health behaviors are of concern among rural residents in Korea. This study is conducted to compare dietary intakes, dietary diversity score (DDS), mean nutrient adequacy ratio (MAR) and health related behaviors by rural, factory and urban areas in Asan. A total of 930 adults (351 me...
journal_title:Nutrition research and practice
pub_type: 杂志文章
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abstract::In this study, we investigated that consumers could differentiate between levels of claims and clarify how a visual aid influences consumer understanding of the different claim levels. We interviewed 2,000 consumers in 13 shopping malls on their perception of and confidence in different levels of health claims using s...
journal_title:Nutrition research and practice
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journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2010.4.4.259
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abstract:BACKGROUND/OBJECTIVES:Over the past few decades, Malaysia has been experiencing an increased prevalence of overweight and obesity that threatens the health of Malaysians. Poor dietary intake is one of the major contributors to the development of obesity and many non-communicable diseases. The dietary intakes of adults ...
journal_title:Nutrition research and practice
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更新日期:2019-04-01 00:00:00
abstract::Dietary inorganic sulfur is the minor component in our diet, but some studies suggested that inorganic sulfur is maybe effective to treat cancer related illness. Therefore, this study aims to examine the effects of inorganic sulfur on cell proliferation and gene expression in MDA-MB-231 human breast cancer cells. MDA-...
journal_title:Nutrition research and practice
pub_type: 杂志文章
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journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2008.2.4.204
更新日期:2008-01-01 00:00:00
abstract::The purposes of this study were to determine phenolic compounds and to evaluate antioxidant activities of plums (Soldam, Oishiwase and Formosa). Soldam contains the highest amount of total phenolics among cultivars (Formosa: 4.0%, Oishiwase: 3.3%, Soldam: 6.4% for total phenolic) as well as the total flavonoids of whi...
journal_title:Nutrition research and practice
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更新日期:2012-08-01 00:00:00
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journal_title:Nutrition research and practice
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更新日期:2014-08-01 00:00:00
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journal_title:Nutrition research and practice
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更新日期:2017-08-01 00:00:00
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journal_title:Nutrition research and practice
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更新日期:2011-02-01 00:00:00
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journal_title:Nutrition research and practice
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:This study examined the effect of nutrition labeling formats on parents' food choices for their children at different restaurant types. SUBJECTS/METHODS:An online survey was conducted with 1,980 parents of children aged 3-12 years. Participants were randomly assigned to fast food or family restau...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2018.12.3.243
更新日期:2018-06-01 00:00:00
abstract::The purpose of this study was to compare the beverage consumption by gender and season in elementary school children and to investigate the role of beverage consumption patterns on their daily nutrient intakes and BMIs. Beverage consumption and dietary energy intake in 160 elementary school students in the Gyeongnam a...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2009.3.3.234
更新日期:2009-10-01 00:00:00
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journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2016.10.3.328
更新日期:2016-06-01 00:00:00
abstract::The purpose of this study was to examine consumers' behaviors toward ready-to-eat foods and to develop ready-to-eat food market segmentation in Korea. The food-related lifestyle and purchase behaviors of ready-to-eat foods were evaluated using 410 ready-to-eat food consumers in the Republic of Korea. Four factors were...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2010.4.4.332
更新日期:2010-08-01 00:00:00
abstract::The objective of this study was to evaluate the inhibitory activity of natural products, against growth of Escherichia coli (ATCC 25922) and Salmonella typhimurium (KCCM 11862). Chitosan, epigallocatechin gallate (EGCG), and garlic were used as natural bioactives for antibacterial activity. The testing method was carr...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2007.1.4.273
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Although a lot of effort has been put into increasing fruit and vegetable intakes in preschool children, vegetable intake in this group is still low. This study investigated whether nutrition education focusing on fruit and vegetable intakes can affect preschoolers' fruit and vegetable intakes as ...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2018.12.6.521
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Diet plays an important role in growth and development of children. However, dietary intakes of children living in either rural or urban areas can be influenced by household income. This cross-sectional study examined energy, nutrient and food group intakes of 749 urban children (1-10 years old) b...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2015.9.3.278
更新日期:2015-06-01 00:00:00
abstract::Zinc is an essential trace element required for bone formation, however not much has been clarified yet for its role in osteoblast. We hypothesized that zinc would increase osteogenetic function in osteoblasts. To test this, we investigated whether zinc treatment enhances bone formation by stimulating osteoblast proli...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2010.4.5.356
更新日期:2010-10-01 00:00:00
abstract::The abnormal content of blood lipids often results in metabolic diseases, such as hyperlipidemia and obesity. Many agents, including natural sources from traditional food, have been developed to regulate the blood lipid contents. In this study, we examined the anti-hyperlipidemic activity of Rhynchosia nulubilis seeds...
journal_title:Nutrition research and practice
pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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journal_title:Nutrition research and practice
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更新日期:2015-10-01 00:00:00
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journal_title:Nutrition research and practice
pub_type: 杂志文章
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更新日期:2017-10-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Use of nutrition labels in food selection is recommended for consumers. The aim of this study is to examine factors, mainly beliefs explaining nutrition label use in female college students based on the Theory of Planned Behavior (TPB). SUBJECTS/METHODS:The subjects were female college students f...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2015.9.1.63
更新日期:2015-02-01 00:00:00
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journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2009.3.1.38
更新日期:2009-04-01 00:00:00
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journal_title:Nutrition research and practice
pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Oligonol, mainly found in lychee fruit, is an antioxidant polyphenolic compound which has been shown to have anti-inflammatory and anti-cancer properties. The detailed mechanisms by which oligonol may act as an anti-aging molecule have not been determined. MATERIALS/METHODS:In this study, we eval...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2016.10.1.3
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Epithelial-mesenchymal transition (EMT) is involved in not only cancer development and metastasis but also non-cancerous conditions. Hypoxia is one of the proposed critical factors contributing to formation of chronic rhinosinusitis or nasal polyposis. Wheatgrass (Triticum aestivum) has antioxidan...
journal_title:Nutrition research and practice
pub_type: 杂志文章,收录出版
doi:10.4162/nrp.2017.11.2.83
更新日期:2017-04-01 00:00:00
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journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.1.81
更新日期:2014-02-01 00:00:00
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journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2015.9.2.144
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The type of sweet snack incorporated into an energy-restricted diet (ERD) may produce differential effects on metabolic improvements associated with body weight (BW) loss. This study compared effects of incorporating either twice daily energy-controlled dark chocolate snacks plus once daily sugar-...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.6.695
更新日期:2014-12-01 00:00:00