Genome-wide DNA copy number analysis of desmoplastic infantile astrocytomas and desmoplastic infantile gangliogliomas.


:Little is known about the molecular features of desmoplastic infantile ganglioglioma (DIG) and desmoplastic infantile astrocytoma (DIA). We performed a genome-wide DNA copy number analysis in combination with a multiplex ligation-dependent probe amplification-based analysis of copy number changes of candidate genes in 4 DIAs and 10 DIGs. Molecular inversion probe (MIP) assay showed that large chromosomal alterations were rare among DIG and DIA. Focal recurrent genomic losses were observed in chromosome regions such as 5q13.3, 21q22.11, and 10q21.3 in both DIA and DIG. Principal component analysis did not show any significant differences between the molecular profiles of DIG and DIA, and a hierarchical cluster analysis did not clearly separate the 2 tumor groups according to their molecular profiles. In 6 cases, gain of genomic material at 7q31 (corresponding to MET gene) was found in multiplex ligation-dependent probe amplification (MLPA) analysis. Furthermore, two cases showed gain at 4q12, and a single case showed BRAF mutation. In agreement with previous analyses, this study demonstrates the absence of consistent recurrent chromosomal alterations in DIA and DIG and overall rarity of the BRAF mutation in these tumors. Notably, these results suggest that DIA and DIG represent a histologic spectrum of the same tumor rather than 2 separate entities.


Gessi M,Zur Mühlen A,Hammes J,Waha A,Denkhaus D,Pietsch T




Has Abstract


2013-09-01 00:00:00












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    abstract::The role of anti-myelin antibodies in the pathogenesis of experimental autoimmune neuritis (EAN) induced in the Lewis rat by immunization with peripheral nerve myelin has been assessed. Passive transfer with lymph node cells (LNC) or purified serum immunoglobulin from rats with EAN was employed to directly measure the...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Taylor JM,Pollard JD

    更新日期:2001-06-01 00:00:00

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    abstract::Pilocytic astrocytoma (PA) is the most common glioma of childhood. Despite their relatively high incidence, the molecular mechanisms responsible for tumorigenesis and growth of PA are poorly understood. Previous in vitro studies in our laboratory showed that despite the absence of ErbB1, PA was sensitive to ErbB1 tyro...

    journal_title:Journal of neuropathology and experimental neurology

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    authors: Addo-Yobo SO,Straessle J,Anwar A,Donson AM,Kleinschmidt-Demasters BK,Foreman NK

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    abstract::Sibling concurrence of pathologically confirmed prion disease has only been reported in association with pathogenic mutation of the prion protein gene (PRNP). Here, we report 2 siblings with classic neuropathologic features of sporadic Creutzfeldt-Jakob disease unexplained by PRNP mutation or known risk factors for ia...

    journal_title:Journal of neuropathology and experimental neurology

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    authors: Webb TE,Pal S,Siddique D,Heaney DC,Linehan JM,Wadsworth JD,Joiner S,Beck J,Wroe SJ,Stevenson V,Brandner S,Mead S,Collinge J

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    abstract::In 63 patients with malabsorption syndromes, 16 with congenital biliary atresia (BA) and 47 with cystic fibrosis (CF), axonal dystrophy in the gracile nucleus (ADG) was studied. Of the 16 patients with BA, ADG of considerable severity was observed in all 10 over one year of age. Of the 47 patients with CF, it was obse...

    journal_title:Journal of neuropathology and experimental neurology

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    authors: Sung JH,Park SH,Mastri AR,Warwick WJ

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    journal_title:Journal of neuropathology and experimental neurology

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    authors: Raedler E,Raedler A

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    journal_title:Journal of neuropathology and experimental neurology

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    authors: Fuller CE,Schmidt RE,Roth KA,Burger PC,Scheithauer BW,Banerjee R,Trinkaus K,Lytle R,Perry A

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    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Kastanauskaite A,Alonso-Nanclares L,Blazquez-Llorca L,Pastor J,Sola RG,DeFelipe J

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    journal_title:Journal of neuropathology and experimental neurology

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    authors: Fuller CE,Wang H,Zhang W,Fuller GN,Perry A

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    journal_title:Journal of neuropathology and experimental neurology

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    journal_title:Journal of neuropathology and experimental neurology

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    authors: Low HL,Nogradi A,Vrbová G,Greensmith L

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    authors: Watanabe T,Yokoo H,Yokoo M,Yonekawa Y,Kleihues P,Ohgaki H

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    authors: Snyder DH,Valsamis MP,Stone SH,Raine CS

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    authors: De Simone R,Ajmone-Cat MA,Tirassa P,Minghetti L

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    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Knobler RL,Marini JC,Goldowitz D,Lublin FD

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    pub_type: 杂志文章


    authors: Kim SU,Rizzuto N

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    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


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    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


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