Bayesian Modeling of Enteric Virus Density in Wastewater Using Left-Censored Data.

Abstract:

:Stochastic models are used to express pathogen density in environmental samples for performing microbial risk assessment with quantitative uncertainty. However, enteric virus density in water often falls below the quantification limit (non-detect) of the analytical methods employed, and it is always difficult to apply stochastic models to a dataset with a substantially high number of non-detects, i.e., left-censored data. We applied a Bayesian model that is able to model both the detected data (detects) and non-detects to simulated left-censored datasets of enteric virus density in wastewater. One hundred paired datasets were generated for each of the 39 combinations of a sample size and the number of detects, in which three sample sizes (12, 24, and 48) and the number of detects from 1 to 12, 24 and 48 were employed. The simulated observation data were assigned to one of two groups, i.e., detects and non-detects, by setting values on the limit of quantification to obtain the assumed number of detects for creating censored datasets. Then, the Bayesian model was applied to the censored datasets, and the estimated mean and standard deviation were compared to the true values by root mean square deviation. The difference between the true distribution and posterior predictive distribution was evaluated by Kullback-Leibler (KL) divergence, and it was found that the estimation accuracy was strongly affected by the number of detects. It is difficult to describe universal criteria to decide which level of accuracy is enough, but eight or more detects are required to accurately estimate the posterior predictive distributions when the sample size is 12, 24, or 48. The posterior predictive distribution of virus removal efficiency with a wastewater treatment unit process was obtained as the log ratio posterior distributions between the posterior predictive distributions of enteric viruses in untreated wastewater and treated wastewater. The KL divergence between the true distribution and posterior predictive distribution of virus removal efficiency also depends on the number of detects, and eight or more detects in a dataset of treated wastewater are required for its accurate estimation.

journal_name

Food Environ Virol

authors

Kato T,Miura T,Okabe S,Sano D

doi

10.1007/s12560-013-9125-1

subject

Has Abstract

pub_date

2013-08-25 00:00:00

eissn

1867-0334

issn

1867-0342

pub_type

杂志文章
  • Large-Scale Survey of Human Enteroviruses in Wastewater Treatment Plants of a Metropolitan Area of Southern Italy.

    abstract::Human enteroviruses (HEVs) occur in high concentrations in wastewater and can contaminate receiving environmental waters, constituting a major cause of acute waterborne disease worldwide. In this study, we investigated the relative abundance, occurrence, and seasonal distribution of polio and other enteroviruses at th...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-017-9331-3

    authors: Pennino F,Nardone A,Montuori P,Aurino S,Torre I,Battistone A,Delogu R,Buttinelli G,Fiore S,Amato C,Triassi M

    更新日期:2018-06-01 00:00:00

  • The Experimental Research (In Vitro) of Carrageenans and Fucoidans to Decrease Activity of Hantavirus.

    abstract::The effect of carrageenans and fucoidans on the activity of Hantavirus is studied. It has been found that among carrageenans a significant antiviral effect is exerted by the ι-type, which decreases the viral titer by 2.5 log focus forming units per mL; among fucoidans, by a preparation from Laminaria cichorioides, whi...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-016-9233-9

    authors: Pavliga SN,Kompanets GG,Tsygankov VY

    更新日期:2016-06-01 00:00:00

  • Impact of an alcohol-based hand sanitizer intervention on the spread of viruses in homes.

    abstract::The objectives of this study were to determine the movement of a virus throughout a household and the impact of an alcohol-based hand sanitizer (ABHS) on reducing the movement and exposure of the virus to household members. Bacterial virus MS-2 was used as the surrogate for human enteric and respiratory viruses. Seven...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-014-9141-9

    authors: Tamimi AH,Carlino S,Edmonds S,Gerba CP

    更新日期:2014-06-01 00:00:00

  • Hepatitis A Virus, Hepatitis E Virus, and Rotavirus in Foods of Animal Origin Traded at the Borders of Brazil, Argentina, and Uruguay.

    abstract::The aim of this study was to investigate hepatitis A virus (HAV), hepatitis E (HEV), and rotavirus (RV) in fresh and processed meat traded on the border of Brazil with Argentina and Uruguay. In total, 159 samples of raw and processed foods of animal origin were collected in Paso de los Libres, Argentina (n = 53 raw me...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-018-9357-1

    authors: Pereira JG,Soares VM,de Souza FG,Tadielo LE,Dos Santos EAR,Brum MCS,Henzel A,Duval EH,Spilki FR,da Silva WP

    更新日期:2018-12-01 00:00:00

  • Secretor Status is Associated with Susceptibility to Disease in a Large GII.6 Norovirus Foodborne Outbreak.

    abstract::Norovirus is commonly associated with food and waterborne outbreaks. Genetic susceptibility to norovirus is largely dependent on presence of histo-blood group antigens (HBGA), specifically ABO, secretor, and Lewis phenotypes. The aim of the study was to determine the association between HBGAs to norovirus susceptibili...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-019-09410-3

    authors: Sharma S,Hagbom M,Carlsson B,Nederby Öhd J,Insulander M,Eriksson R,Simonsson M,Widerström M,Nordgren J

    更新日期:2020-03-01 00:00:00

  • Evaluation of Two Triplex One-Step qRT-PCR Assays for the Quantification of Human Enteric Viruses in Environmental Samples.

    abstract::Human enteric viruses are responsible for waterborne and shellfish-associated disease outbreaks worldwide. Quantitative reverse transcription PCR (qRT-PCR) is often used to assess the health risks associated with shellfish and environmental water, but viral titres in sediments are less commonly investigated. In this s...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-017-9293-5

    authors: Farkas K,Peters DE,McDonald JE,de Rougemont A,Malham SK,Jones DL

    更新日期:2017-09-01 00:00:00

  • Prevalence and genetic diversity of klassevirus in wastewater in Japan.

    abstract::Klassevirus is a novel virus belonging to the family Picornaviridae. This study examined the prevalence and genetic diversity of klassevirus in wastewater. Raw sewage (100 ml) and secondary-treated sewage (2 l) were collected monthly for 14 months between January 2011 and February 2012 from a wastewater treatment plan...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-012-9098-5

    authors: Haramoto E,Otagiri M

    更新日期:2013-03-01 00:00:00

  • Prevalence and Bayesian Phylogenetics of Enteroviruses Derived From Environmental Surveillance Around Polio Vaccine Switch Period in Shandong Province, China.

    abstract::We present the results of environmental surveillance for poliovirus (PV) and non-poliovirus (NPEV) around the switch from trivalent to bivalent oral polio-vaccine (OPV) which occurred in China in May 2016. Sewage samples were collected in Jinan and Linyi city from 2015 to 2017. Enterovirus (EV) isolation, VP1 amplific...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-020-09449-7

    authors: Zhao C,Lin X,Ji F,Xiong P,Liu Y,Wang S,Chen P,Xu Q,Zhang L,Tao Z,Xu A

    更新日期:2020-12-01 00:00:00

  • Environmental Surveillance of Non-polio Enteroviruses in Poland, 2011.

    abstract::The aim of this study was to apply environmental surveillance to evaluate circulation of non-polio enteroviruses (NPEVs) in sewage in Poland. Samples of raw sewage were collected in 14 sewage disposal systems from January to December, 2011. Sewage samples were concentrated prior to analysis by RT-PCR and isolation in ...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-015-9195-3

    authors: Wieczorek M,Ciąćka A,Witek A,Kuryk Ł,Żuk-Wasek A

    更新日期:2015-09-01 00:00:00

  • Characterization, Genome Sequence, and Analysis of Escherichia Phage CICC 80001, a Bacteriophage Infecting an Efficient L-Aspartic Acid Producing Escherichia coli.

    abstract::Escherichia phage CICC 80001 was isolated from the bacteriophage contaminated medium of an Escherichia coli strain HY-05C (CICC 11022S) which could produce L-aspartic acid. The phage had a head diameter of 45-50 nm and a tail of about 10 nm. The one-step growth curve showed a latent period of 10 min and a rise period ...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-015-9218-0

    authors: Xu Y,Ma Y,Yao S,Jiang Z,Pei J,Cheng C

    更新日期:2016-03-01 00:00:00

  • Isolation and Characterization of Bacillus cereus Bacteriophages from Foods and Soil.

    abstract::The aim of this study was to isolate and characterize Bacillus cereus bacteriophages of various origins. Twenty-seven bacteriophages against B. cereus were isolated from various Korean traditional fermented foods and soils. Plaque size, transmission electron microscopy, virulence profile, and in vitro lytic activity o...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-017-9284-6

    authors: Oh H,Seo DJ,Jeon SB,Park H,Jeong S,Chun HS,Oh M,Choi C

    更新日期:2017-09-01 00:00:00

  • Evaluation of a Porcine Gastric Mucin and RNase A Assay for the Discrimination of Infectious and Non-infectious GI.1 and GII.4 Norovirus Following Thermal, Ethanol, or Levulinic Acid Plus Sodium Dodecyl Sulfate Treatments.

    abstract::Human noroviruses (NoVs) are a major source of foodborne illnesses worldwide. Since human NoVs cannot be cultured in vitro, methods that discriminate infectious from non-infectious NoVs are needed. The purpose of this study was to evaluate binding of NoV genotypes GI.1 and GII.4 to histo-blood group antigens expressed...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-015-9219-z

    authors: Afolayan OT,Webb CC,Cannon JL

    更新日期:2016-03-01 00:00:00

  • Food-Borne Viruses in Shellfish: Investigation on Norovirus and HAV Presence in Apulia (SE Italy).

    abstract::Shellfish are an important vehicle for transmission of food-borne pathogens including norovirus (NoV) and hepatitis A virus (HAV). The risks related with consumption of shellfish are greater if these products are eaten raw or slightly cooked. As molluscs are filter-feeding organisms, they are able to concentrate patho...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-016-9273-1

    authors: La Bella G,Martella V,Basanisi MG,Nobili G,Terio V,La Salandra G

    更新日期:2017-06-01 00:00:00

  • Accumulation and Depuration Kinetics of Rotavirus in Mussels Experimentally Contaminated.

    abstract::Bivalve mollusks as filter-feeders concentrate in their digestive tissue microorganisms likely present in the harvesting water, thus becoming risky food especially if consumed raw or poorly cooked. To eliminate bacteria and viruses eventually accumulated, they must undergo a depuration process which efficacy on viruse...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-019-09413-0

    authors: Amoroso MG,Langellotti AL,Russo V,Martello A,Monini M,Di Bartolo I,Ianiro G,Di Concilio D,Galiero G,Fusco G

    更新日期:2020-03-01 00:00:00

  • Assessment of coliphage surrogates for testing drinking water treatment devices.

    abstract::Test protocols have been developed by the United States Environmental Protection Agency (USEPA) and the World Health Organization (WHO) to test water treatment devices/systems that are used at the individual and home levels to ensure the removal of waterborne viruses. The goal of this study was to assess if coliphage ...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-014-9173-1

    authors: Gerba CP,Abd-Elmaksoud S,Newick H,El-Esnawy NA,Barakat A,Ghanem H

    更新日期:2015-03-01 00:00:00

  • A rapid single-tube protocol for HAV detection by nested real-time PCR.

    abstract::Infections by food-borne viruses such as hepatitis A virus (HAV) and norovirus are significant public health concerns worldwide. Since food-borne viruses are rarely confirmed through direct isolation from contaminated samples, highly sensitive molecular techniques remain the methods of choice for the detection of vira...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-014-9152-6

    authors: Hu Y,Arsov I

    更新日期:2014-09-01 00:00:00

  • Monitoring of Extraction Efficiency by a Sample Process Control Virus Added Immediately Upon Sample Receipt.

    abstract::When analysing food samples for enteric viruses, a sample process control virus (SPCV) must be added at the commencement of the analytical procedure, to verify that the analysis has been performed correctly. Samples can on occasion arrive at the laboratory late in the working day or week. The analyst may consequently ...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-015-9214-4

    authors: Ruhanya V,Diez-Valcarce M,D'Agostino M,Cook N,Hernández M,Rodríguez-Lázaro D

    更新日期:2015-12-01 00:00:00

  • Environmental Surveillance of Polioviruses in Rio de Janeiro, Brazil, in Support to the Activities of Global Polio Eradication Initiative.

    abstract::Wild polioviruses still remain endemic in three countries (Afghanistan, Pakistan, and Nigeria) and re-emergency of wild polio has been reported in previously polio-free countries. Environmental surveillance has been used as a supplementary tool in monitoring the circulation of wild poliovirus (PVs) and/or vaccine-deri...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-015-9221-5

    authors: de Oliveira Pereira JS,da Silva LR,de Meireles Nunes A,de Souza Oliveira S,da Costa EV,da Silva EE

    更新日期:2016-03-01 00:00:00

  • Detection of Norovirus and Rotavirus Present in Suspended and Dissolved Forms in Drinking Water Sources.

    abstract::We investigated the present forms of genogroup II norovirus and group A rotavirus in surface water used for drinking water production. River water samples (N = 15) collected at a drinking water treatment plant (DWTP) monthly from June 2017 to August 2018 were fractioned by filtration through 10- and 0.45-μm-pore-size ...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-018-9361-5

    authors: Miura T,Gima A,Akiba M

    更新日期:2019-03-01 00:00:00

  • Quantification and genetic analysis of salivirus/klassevirus in wastewater in Arizona, USA.

    abstract::Salivirus/klassevirus sequences were identified in 7 (15%) wastewater samples collected in Arizona monthly for a year, with the highest concentration of 2.28 × 10(5) and 2.46 × 10(4) copies/L in influent and effluent, respectively. This is the first report of quantification and genetic analysis of salivirus/klasseviru...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-014-9148-2

    authors: Kitajima M,Iker BC,Rachmadi AT,Haramoto E,Gerba CP

    更新日期:2014-09-01 00:00:00

  • Detection of Hepatitis E Virus in Sewage After an Outbreak on a French Island.

    abstract::A hepatitis E outbreak, which occurred on a small isolated island, provided an opportunity to evaluate the association between the number of hepatitis E cases in the community and the concentration of virus detected in sewage. Samples were collected from the different sewage treatment plants from the island and analyz...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-016-9241-9

    authors: Miura T,Lhomme S,Le Saux JC,Le Mehaute P,Guillois Y,Couturier E,Izopet J,Abranavel F,Le Guyader FS

    更新日期:2016-09-01 00:00:00

  • Hepatitis E Virus in Domestic Pigs, Wild Boars, Pig Farm Workers, and Hunters in Estonia.

    abstract::While hepatitis E is a growing health concern in Europe, epidemiological data on hepatitis E virus (HEV) in Estonia are scarce. Along with imported HEV infections, autochthonous cases are reported from European countries. Both domestic and wild animals can be a source of human cases of this zoonosis. Here, we investig...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-015-9210-8

    authors: Ivanova A,Tefanova V,Reshetnjak I,Kuznetsova T,Geller J,Lundkvist Å,Janson M,Neare K,Velström K,Jokelainen P,Lassen B,Hütt P,Saar T,Viltrop A,Golovljova I

    更新日期:2015-12-01 00:00:00

  • Molecular Detection of Human Enteric Adenoviruses in Water Samples Collected from Lake Victoria Waters Along Homa Bay Town, Homa Bay County, Kenya.

    abstract::Lake Victoria is the primary source of water for millions of people in the Sub-Saharan Africa region. In recent years, population development around the lake has resulted in compromised sanitation standards resulting in increased faecal pollution of the lake. Consequently, this condition has increased the chances of w...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-020-09444-y

    authors: Opere WM,John M,Ombori O

    更新日期:2020-11-03 00:00:00

  • Frequent and abundant Merkel cell polyomavirus detection in urban wastewaters in Italy.

    abstract::Viruses strongly associated with human cancer have recently been detected in urban sewages and other water environments worldwide. The aim of the present study was to assess the presence of Merkel cell polyomavirus (MCPyV), a newly discovered, potentially oncogenic human virus, in urban sewage samples collected at was...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-014-9168-y

    authors: Di Bonito P,Libera SD,Petricca S,Iaconelli M,Accardi L,Muscillo M,La Rosa G

    更新日期:2015-03-01 00:00:00

  • Harmonised investigation of the occurrence of human enteric viruses in the leafy green vegetable supply chain in three European countries.

    abstract::Numerous outbreaks have been attributed to the consumption of raw or minimally processed leafy green vegetables contaminated with enteric viral pathogens. The aim of the present study was an integrated virological monitoring of the salad vegetables supply chain in Europe, from production, processing and point-of-sale....

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-012-9087-8

    authors: Kokkinos P,Kozyra I,Lazic S,Bouwknegt M,Rutjes S,Willems K,Moloney R,de Roda Husman AM,Kaupke A,Legaki E,D'Agostino M,Cook N,Rzeżutka A,Petrovic T,Vantarakis A

    更新日期:2012-12-01 00:00:00

  • Occurrence of norovirus and hepatitis A virus in wild mussels collected from the Baltic Sea.

    abstract::The aim of the study was to define the occurrence of human noroviruses of genogroup I and II (NoV GI and NoV GII) and hepatitis A virus (HAV) in the Baltic Sea mussels. The shellfish samples were taken at the sampling sites located on the Polish coast. In total, 120 shellfish were tested as pooled samples using RT-PCR...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-014-9153-5

    authors: Bigoraj E,Kwit E,Chrobocińska M,Rzeżutka A

    更新日期:2014-09-01 00:00:00

  • Occurrence and Trend of Hepatitis A Virus in Bivalve Molluscs Production Areas Following a Contamination Event.

    abstract::The aim of this study was to assess the trend of hepatitis A virus (HAV) in a coastal zone impacted by a contamination event, providing data for the development of management strategies. A total of 352 samples, including four bivalve mollusc species (Mytilus galloprovincialis, Solen vagina, Venus gallina and Donax tru...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-017-9302-8

    authors: Suffredini E,Proroga YTR,Di Pasquale S,Di Maro O,Losardo M,Cozzi L,Capuano F,De Medici D

    更新日期:2017-12-01 00:00:00

  • Morphological and Biochemical Characteristics of Avian Faecal Droppings and Their Impact on Survival of Avian Influenza Virus.

    abstract::Environmental specimens such as faecal droppings are considered important for the detection of avian influenza viruses (AIV). In view of lower rates of AIV isolation from avian faecal droppings, characterization of droppings is imperative to elucidate contributing factors. However, there are no reports on morphologica...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-017-9323-3

    authors: Pawar SD,Pande SA,Tare DS,Keng SS,Kode SS,Singh DK,Mullick J

    更新日期:2018-03-01 00:00:00

  • Thermal Inactivation of Hepatitis A Virus, Noroviruses, and Simian Rotavirus in Cows' Milk.

    abstract::Consumption of raw or unpasteurized milk is a risk for the consumers because indirect contaminations such as fecal-cross-contamination could occur and determine the presence of enteric viruses. In this study, milk was treated with several temperature and time combinations chosen by performing a preliminary experiment ...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-020-09443-z

    authors: El-Senousy WM,Shalaby M,Deeb AMM,Alhawary II

    更新日期:2020-12-01 00:00:00

  • Evaluation of Assays to Quantify Infectious Human Norovirus for Heat and High-Pressure Inactivation Studies Using Tulane Virus.

    abstract::We compared the heat and high hydrostatic pressure (HHP) inactivation results of Tulane virus (TV), a human norovirus (HuNoV) surrogate, obtained by plaque assay, direct quantitative reverse transcription PCR (RT-qPCR), porcine gastric mucin magnetic beads (PGM-MBs) binding assay followed by RT-qPCR (PGM/PCR), and pro...

    journal_title:Food and environmental virology

    pub_type: 杂志文章

    doi:10.1007/s12560-017-9288-2

    authors: Li X,Huang R,Chen H

    更新日期:2017-09-01 00:00:00