Dendritic SK channels convert NMDA-R-dependent LTD to burst timing-dependent plasticity.

Abstract:

:Feedback and descending projections from higher to lower brain centers play a prominent role in all vertebrate sensory systems. Feedback might be optimized for the specific sensory processing tasks in their target brain centers, but it has been difficult to connect the properties of feedback synapses to sensory tasks. Here, we use the electrosensory system of a gymnotiform fish (Apteronotus leptorhynchus) to address this problem. Cerebellar feedback to pyramidal cells in the first central electrosensory processing region, the electrosensory lateral line lobe (ELL), is critical for canceling spatially and temporally redundant electrosensory input. The ELL contains four electrosensory maps, and we have previously analyzed the synaptic and network bases of the redundancy reduction mechanism in a map (centrolateral segment; CLS) believed to guide electrolocation behavior. In the CLS, only long-term depression was induced by pairing feedback presynaptic and pyramidal cell postsynaptic bursts. In this paper, we turn to an ELL map (lateral segment; LS) known to encode electrocommunication signals. We find remarkable differences in synaptic plasticity of the morphologically identical cerebellar feedback input to the LS. In the LS, pyramidal cell SK channels permit long-term potentiation (LTP) of feedback synapses when pre- and postsynaptic bursts occur at the same time. We hypothesize that LTP in this map is required for enhancing the encoding of weak electrocommunication signals. We conclude that feedback inputs that appear morphologically identical in sensory maps dedicated to different tasks, nevertheless display different synaptic plasticity rules contributing to differential sensory processing in these maps.

journal_name

J Neurophysiol

authors

Harvey-Girard E,Maler L

doi

10.1152/jn.00506.2013

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

2689-703

issue

12

eissn

0022-3077

issn

1522-1598

pii

jn.00506.2013

journal_volume

110

pub_type

杂志文章
  • LFP power spectra in V1 cortex: the graded effect of stimulus contrast.

    abstract::We recorded local field potentials (LFPs) and single-unit activity simultaneously in the macaque primary visual cortex (V1) and studied their responses to drifting sinusoidal gratings that were chosen to be "optimal" for the single units. Over all stimulus conditions, the LFP spectra have much greater power in the low...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00919.2004

    authors: Henrie JA,Shapley R

    更新日期:2005-07-01 00:00:00

  • Sensory processing in a thermal afferent pathway.

    abstract::Extracellular recordings were made from cold-receptive afferent fibers in the trigeminal ganglion of rats anesthetized with halothane. By applying a standardized series of steady or changing temperatures to the receptive fields, we recorded the static and dynamic responses of the afferents. Comparable recordings were ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1985.53.2.429

    authors: Davies SN,Goldsmith GE,Hellon RF,Mitchell D

    更新日期:1985-02-01 00:00:00

  • Analysis of muscle receptor connections by spike-triggered averaging. 1. Spindle primary and tendon organ afferents.

    abstract::1. The synaptic connections of 44 single identified muscle spindle Ia afferents and of 21 Golgi tendon organ (Ib) afferents from medial gastrocnemius (MG) were studied in 46 cats by the spike-triggered averaging of synaptic noise in 803 motoneurons of various types. 2. The well-known monosynaptic Ia excitatory connect...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1976.39.6.1375

    authors: Watt DG,Stauffer EK,Taylor A,Reinking RM,Stuart DG

    更新日期:1976-11-01 00:00:00

  • Transformation in the neural code for whisker deflection direction along the lemniscal pathway.

    abstract::A prominent characteristic of neurons in the whisker system is their selectivity to the direction in which a whisker is deflected. The aim of this study was to determine how information about whisker direction is encoded at successive levels of the lemniscal pathway. We made extracellular recordings under identical co...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00636.2009

    authors: Bale MR,Petersen RS

    更新日期:2009-11-01 00:00:00

  • Activity-related calcium dynamics in motoneurons of the nucleus hypoglossus from mouse.

    abstract::A quantitative analysis of activity-related calcium dynamics was performed in motoneurons of the nucleus hypoglossus in the brain stem slice preparation from mouse by simultaneous patch-clamp and microfluorometric calcium measurements. Motoneurons were analyzed under in vitro conditions that kept them in a functionall...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.82.6.2936

    authors: Lips MB,Keller BU

    更新日期:1999-12-01 00:00:00

  • The motor inhibitory system operating during active sleep is tonically suppressed by GABAergic mechanisms during other states.

    abstract::The present study was undertaken to explore the neuronal mechanisms responsible for muscle atonia that occurs after the microinjection of bicuculline into the nucleus pontis oralis (NPO). Specifically, we wished to test the hypothesis that motoneurons are postsynaptically inhibited after the microinjection of bicucull...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.86.4.1908

    authors: Xi MC,Morales FR,Chase MH

    更新日期:2001-10-01 00:00:00

  • Ocular responses to brief motion of textured backgrounds during smooth pursuit in humans.

    abstract::We studied the effects of horizontal smooth pursuit on the ocular responses to brief vertical perturbations of textured backgrounds in humans. When the subject was fixating on a stationary target, a brief vertical perturbation of the background elicited a small tracking response. When the subject was pursuing a target...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00430.2009

    authors: Miura K,Kobayashi Y,Kawano K

    更新日期:2009-09-01 00:00:00

  • Mg2+-malate co-transport, a mechanism for Na+-independent Mg2+ transport in neurons of the leech Hirudo medicinalis.

    abstract::Mg2+-extrusion from Mg2+-loaded neurons of the leech, Hirudo medicinalis, is mediated mainly by Na+/Mg2+ antiport. However, in a number of leech neurons, Mg2+ is extruded in the nominal absence of extracellular Na+, indicating the existence of an additional, Na+-independent Mg2+ transport mechanism. This mechanism was...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01221.2004

    authors: Günzel D,Hintz K,Durry S,Schlue WR

    更新日期:2005-07-01 00:00:00

  • A unifying model of concurrent spatial and temporal modularity in muscle activity.

    abstract::Modularity in the central nervous system (CNS), i.e., the brain capability to generate a wide repertoire of movements by combining a small number of building blocks ("modules"), is thought to underlie the control of movement. Numerous studies reported evidence for such a modular organization by identifying invariant m...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00245.2013

    authors: Delis I,Panzeri S,Pozzo T,Berret B

    更新日期:2014-02-01 00:00:00

  • Heptanol but not fluoroacetate prevents the propagation of spreading depression in rat hippocampal slices.

    abstract::We investigated whether heptanol and other long-chain alcohols that are known to block gap junctions interfere with the generation or the propagation of spreading depression (SD). Waves of SD were triggered by micro-injection of concentrated KCl solution in stratum (s.) radiatum of CA1 of rat hippocampal tissue slices...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.77.1.9

    authors: Largo C,Tombaugh GC,Aitken PG,Herreras O,Somjen GG

    更新日期:1997-01-01 00:00:00

  • Whole-cell voltage-clamp study of the fading of GABA-activated currents in acutely dissociated hippocampal neurons.

    abstract::The lability of the responses of mammalian central neurons to gamma-aminobutyric acid (GABA) was studied using neurons acutely dissociated from the CA1 region of the adult guinea pig hippocampus as a model system. GABA was applied to the neuronal somata by pressure ejection and the resulting current (IGABA) recorded u...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1986.56.1.1

    authors: Huguenard JR,Alger BE

    更新日期:1986-07-01 00:00:00

  • Quantitative analysis and biophysically realistic neural modeling of the MEG mu rhythm: rhythmogenesis and modulation of sensory-evoked responses.

    abstract::Variations in cortical oscillations in the alpha (7-14 Hz) and beta (15-29 Hz) range have been correlated with attention, working memory, and stimulus detection. The mu rhythm recorded with magnetoencephalography (MEG) is a prominent oscillation generated by Rolandic cortex containing alpha and beta bands. Despite its...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00535.2009

    authors: Jones SR,Pritchett DL,Sikora MA,Stufflebeam SM,Hämäläinen M,Moore CI

    更新日期:2009-12-01 00:00:00

  • Statistics of visual responses in primate inferotemporal cortex to object stimuli.

    abstract::We have characterized selectivity and sparseness in anterior inferotemporal cortex, using a large data set. Responses were collected from 674 monkey inferotemporal cells, each stimulated by 806 object photographs. This 806 × 674 matrix was examined in two ways: columnwise, looking at responses of a single neuron to al...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00990.2010

    authors: Lehky SR,Kiani R,Esteky H,Tanaka K

    更新日期:2011-09-01 00:00:00

  • Plateau pattern of afferent discharge rate from frog muscle spindles.

    abstract::1. A characteristic plateau pattern was observed in the rate of afferent discharges during ramp-and-hold stretch of spindles isolated from semitendinosus muscles of frogs. The plateau pattern was more frequent in summer frogs (84%) than winter frogs (11%). 2. The plateau pattern consisted of a discharge rate around 12...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.70.1.275

    authors: Sokabe M,Nunogaki K,Naruse K,Soga H,Fujitsuka N,Yoshimura A,Ito F

    更新日期:1993-07-01 00:00:00

  • A cGMP-dependent protein kinase (PKG) controls synaptic transmission tolerance to acute oxidative stress at the Drosophila larval neuromuscular junction.

    abstract::Increasing evidence demonstrates that modulating the cGMP-dependent protein kinase G (PKG) pathway produces an array of behavioral phenotypes in the fruit fly, Drosophila melanogaster. Altering PKG activity, either genetically via the foraging (for) gene or using pharmacology modifies tolerance to acute abiotic stress...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00784.2011

    authors: Caplan SL,Milton SL,Dawson-Scully K

    更新日期:2013-02-01 00:00:00

  • Efficient estimation of phase-response curves via compressive sensing.

    abstract::The phase-response curve (PRC), relating the phase shift of an oscillator to external perturbation, is an important tool to study neurons and their population behavior. It can be experimentally estimated by measuring the phase changes caused by probe stimuli. These stimuli, usually short pulses or continuous noise, ha...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00919.2011

    authors: Hong S,Robberechts Q,De Schutter E

    更新日期:2012-10-01 00:00:00

  • Conductance-based model of the voltage-dependent generation of a plateau potential in subthalamic neurons.

    abstract::Because the subthalamic nucleus (STN) acts as a driving force of the basal ganglia, it is important to know how the activities of STN neurons are regulated. Previously, we have reported that a subset of STN neurons generates a plateau potential in a voltage-dependent manner. These plateau potentials can be evoked only...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00508.2003

    authors: Otsuka T,Abe T,Tsukagawa T,Song WJ

    更新日期:2004-07-01 00:00:00

  • Pain enhances functional connectivity of a brain network evoked by performance of a cognitive task.

    abstract::Experimental and clinical evidence indicates that pain can affect cognitive processes, but the cortical networks involved in pain-cognition interactions are unclear. In this study, we determined the effect of pain on the activity of cortical areas involved in cognition acting as a whole (i.e., a network). Subjects und...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01210.2006

    authors: Seminowicz DA,Davis KD

    更新日期:2007-05-01 00:00:00

  • A reduced somatosensory gating response in individuals with multiple sclerosis is related to walking impairment.

    abstract::When identical stimuli are presented in rapid temporal succession, neural responses to the second stimulation are often weaker than those observed for the first. This phenomenon is termed sensory gating and is believed to be an adaptive feature that helps prevent higher-order cortical centers from being flooded with u...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00260.2017

    authors: Arpin DJ,Gehringer JE,Wilson TW,Kurz MJ

    更新日期:2017-10-01 00:00:00

  • Intended arm use influences interhemispheric correlation of β-oscillations in primate medial motor areas.

    abstract::To investigate the role of interhemispheric β-synchronization in the selection of motor effectors, we trained two monkeys to memorize and perform multiple two-movement sequences that included unimanual repetition and bimanual switching. We recorded local field potentials simultaneously in the bilateral supplementary m...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00379.2016

    authors: Nakajima T,Arisawa H,Hosaka R,Mushiake H

    更新日期:2017-11-01 00:00:00

  • β2-Adrenergic receptor supports prolonged theta tetanus-induced LTP.

    abstract::The widespread noradrenergic innervation in the brain promotes arousal and learning by molecular mechanisms that remain largely undefined. Recent work shows that the β(2)-adrenergic receptor (β(2)AR) is linked to the AMPA-type glutamate receptor subunit GluA1 via stargazin and PSD-95 (Joiner ML, Lise MF, Yuen EY, Kam ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00374.2011

    authors: Qian H,Matt L,Zhang M,Nguyen M,Patriarchi T,Koval OM,Anderson ME,He K,Lee HK,Hell JW

    更新日期:2012-05-01 00:00:00

  • Localized adenosine signaling provides fine-tuned negative feedback over a wide dynamic range of neocortical network activities.

    abstract::Although the patterns of activity produced by neocortical networks are now better understood, how these states are activated, sustained, and terminated still remains unclear. Negative feedback by the endogenous neuromodulator adenosine may potentially play an important role, as it can be released by activity and there...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00620.2014

    authors: Wall MJ,Richardson MJ

    更新日期:2015-02-01 00:00:00

  • Innocuous warming enhances peripheral serotonergic itch signaling and evokes enhanced responses in serotonin-responsive dorsal horn neurons in the mouse.

    abstract::Itch is often triggered by warming the skin in patients with itchy dermatitis, but the underlying mechanism is largely unknown. We presently investigated if warming the skin enhances histamine- or serotonin (5-HT)-evoked itch behavior or responses of sensory dorsal root ganglion (DRG) cells, and if responses of superf...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00703.2016

    authors: Akiyama T,Nagamine M,Davoodi A,Ivanov M,Carstens MI,Carstens E

    更新日期:2017-01-01 00:00:00

  • Modulation of membrane potential in mesothoracic moto- and interneurons during stick insect front-leg walking.

    abstract::During walking, maintenance and coordination of activity in leg motoneurons requires intersegmental signal transfer. In a semi-intact preparation of the stick insect, we studied membrane potential modulations in mesothoracic (middle leg) motoneurons and local premotor nonspiking interneurons that were induced by stepp...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00493.2005

    authors: Ludwar BCh,Westmark S,Büschges A,Schmidt J

    更新日期:2005-10-01 00:00:00

  • Relationship between visual and tactile representations in cat superior colliculus.

    abstract::A stratified organization of visual, somatic and acoustic representations was observed in the cat SC. Cells of the superficial laminae were exclusively visual. Visual, somatic, and acoustic cells were observed in the intermediate laminae while the deeper laminae were predominantly nonvisual. A detailed examination of ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1976.39.2.401

    authors: Stein BE,Magalhães-Castro B,Kruger L

    更新日期:1976-03-01 00:00:00

  • Neural coupling between homologous muscles during bimanual tasks: effects of visual and somatosensory feedback.

    abstract::While the effects of sensory feedback on bimanual tasks have been studied extensively at two ends of the motor control hierarchy, the cortical and behavioral levels, much less is known about how it affects the intermediate levels, including neural control of homologous muscle groups. We investigated the effects of som...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00269.2016

    authors: Nguyen HB,Lee SW,Harris-Love ML,Lum PS

    更新日期:2017-02-01 00:00:00

  • Involvement of protein kinase C in serotonin-induced spike broadening and synaptic facilitation in sensorimotor connections of Aplysia.

    abstract::1. Plasticity at the connections between sensory neurons and their follower cells in Aplysia has been used extensively as a model system to examine mechanisms of simple forms of learning. Earlier studies have concluded that serotonin (5-HT) is a key modulatory transmitter and that it exerts its short-term actions via ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1992.68.2.643

    authors: Sugita S,Goldsmith JR,Baxter DA,Byrne JH

    更新日期:1992-08-01 00:00:00

  • Temporal limitations in object processing across the human ventral visual pathway.

    abstract::Behavioral studies have shown that object recognition becomes severely impaired at fast presentation rates, indicating a limitation in temporal processing capacity. Here, we studied whether this behavioral limit in object recognition reflects limitations in the temporal processing capacity of early visual areas tuned ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00568.2006

    authors: McKeeff TJ,Remus DA,Tong F

    更新日期:2007-07-01 00:00:00

  • Primate head-free saccade generator implements a desired (post-VOR) eye position command by anticipating intended head motion.

    abstract::Primate head-free saccade generator implements a desired (post-VOR) eye position command by anticipating intended head motion. J. Neurophysiol. 78: 2811-2816, 1997. When we glance between objects, the brain ultimately controls gaze direction in space. However, it is currently unclear how this is allocated into separat...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.78.5.2811

    authors: Crawford JD,Guitton D

    更新日期:1997-11-01 00:00:00

  • Modeling of smooth pursuit-related neuronal responses in the DLPN and NRTP of the rhesus macaque.

    abstract::The dorsolateral pontine nucleus (DLPN) and nucleus reticularis tegmenti pontis (NRTP) comprise obligatory links in the cortico-ponto-cerebellar system supporting smooth pursuit eye movements. We examined the response properties of DLPN and rNRTP neurons during step-ramp smooth pursuit of a small target moving across ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00588.2004

    authors: Ono S,Das VE,Economides JR,Mustari MJ

    更新日期:2005-01-01 00:00:00