Abstract:
:Arthritogenic alphaviruses, including Ross River virus (RRV), Chikungunya virus (CHIKV), Sindbis virus (SINV), Mayaro virus (MAYV), O'nyong-nyong virus (ONNV), and Barmah Forest virus (BFV), cause incapacitating and long lasting articular disease/myalgia. Outbreaks of viral arthritis and the global distribution of these diseases point to the emergence of arthritogenic alphaviruses as an important public health problem. This review discusses the molecular mechanisms involved in alphavirus-induced arthritis, exploring the recent data obtained with in vitro systems and in vivo studies using animal models and samples from patients. The factors associated to the extension and persistence of symptoms are highlighted, focusing on (a) virus replication in target cells, and tissues, including macrophages and muscle cells; (b) the inflammatory and immune responses with recruitment and activation of macrophage, NK cells and T lymphocytes to the lesion focus and the increase of inflammatory mediators levels; and (c) the persistence of virus or viral products in joint and muscle tissues. We also discuss the importance of the establishment of novel animal models to test new molecular targets and to develop more efficient and selective drugs to treat these diseases.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Assunção-Miranda I,Cruz-Oliveira C,Da Poian ATdoi
10.1155/2013/973516subject
Has Abstractpub_date
2013-01-01 00:00:00pages
973516eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
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journal_title:BioMed research international
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pub_type: 杂志文章,meta分析
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doi:10.1155/2017/7097580
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journal_title:BioMed research international
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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doi:10.1155/2013/297093
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