The pharmacokinetic evaluation of boceprevir for treatment of hepatitis C virus.

abstract：INTRODUCTION:Co-medication, gene polymorphisms and co-morbidity are main causes for high variability in expression and function of the CYP3A isoenzymes. Pharmacokinetic variability is a major source of interindividual variability of drug effect and response of CYP3A substrates. While CYP3A genotyping is of limited use,...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Hohmann N,Haefeli WE,Mikus G

更新日期：2016-05-01 00:00:00

abstract：INTRODUCTION:The pharmacokinetic properties of anti-infective drugs are a determinant part of treatment success. Pathogen replication is inhibited if adequate drug levels are achieved in target sites, whereas excessive drug concentrations linked to toxicity are to be avoided. Anti-infective distribution can be predicte...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Moss DM,Marzolini C,Rajoli RK,Siccardi M

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Drug-disease interactions include the impact of a drug and a particular disease condition on each other. However, the current practice in addressing drug-disease interaction is unbalanced and mostly limited to how the drug worsens the disease or health condition. AREAS COVERED:Aspirin and gastric ulcer in...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Nwose EU,Yee KC

更新日期：2016-09-01 00:00:00

abstract：:Three first-line antituberculosis drugs, isoniazid, rifampicin and pyrazinamide, may induce liver injury, especially isoniazid. This antituberculosis drug-induced liver injury ranges from a mild to severe form, and the associated mortality cases are not rare. The major drug-metabolizing enzyme of isoniazid is N-acetyl...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Huang YS

更新日期：2007-02-01 00:00:00

abstract：INTRODUCTION:Treatments for hepatitis C virus (HCV) infection have advanced rapidly in the last decade. Pegylated interferon alpha 2a (PEG-IFN alpha 2a) alone, in combination with ribavirin and with or without direct acting antivirals (DAAs) is modestly effective in the treatment of chronic HCV infection. Areas covered...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Maughan A,Ogbuagu O

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:Medullary thyroid carcinoma (MTC) is a rare endocrine malignancy accounting for a significant percentage of thyroid cancer-related fatal events. Traditional treatment modalities used in the other types of thyroid carcinomas have been proved largely ineffective in advanced MTC. Better understanding of the m...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Karras S,Anagnostis P,Krassas GE

更新日期：2014-03-01 00:00:00

abstract：INTRODUCTION:Painful diabetic neuropathy (PDN) is a disabling pain condition. Its pathomechanism remains unknown, but a sensitization and neuronal hyperexcitabilty have been suggested. Only symptomatic pharmacological pain management treatment is currently available. AREAS COVERED:The origin of PDN is enigmatic, and t...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Tajti J,Szok D,Majláth Z,Csáti A,Petrovics-Balog A,Vécsei L

更新日期：2016-07-01 00:00:00

abstract：INTRODUCTION:Cardiovascular disease is still the leading cause of death worldwide. There are many environmental and genetic factors that play a role in the development of cardiovascular disease. The treatment of cardiovascular disease is beginning to move in the direction of personalized medicine by using biomarkers fr...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Berinstein E,Levy A

更新日期：2017-09-01 00:00:00

abstract：INTRODUCTION:Gestational diabetes mellitus (GDM) complicates 10% of all pregnancies and is defined as hyperglycemia first noted during pregnancy. Rates of GDM are rising and untreated GDM results in complications for both mother and fetus. GDM is often managed by diet and exercise but 30-40% of women will require pharm...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Malek R,Davis SN

更新日期：2016-06-01 00:00:00

abstract：:The pharmaceutical relevance of proton-coupled peptide transporters is currently under intense investigation in many laboratories. Studies have shown that these membrane proteins, expressed in intestine, kidney, choroid plexus and other tissues, accept many peptidomimetic drugs and prodrugs as substrates. The focus of...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Brandsch M

更新日期：2009-08-01 00:00:00

abstract：INTRODUCTION:Chronic hepatitis C virus (HCV) infection has recently become a curable disease with antiviral therapy. The knowledge of drug interactions using direct-acting antivirals (DAA) may permit maximizing antiviral efficacy and avoiding drug-related toxicities. Ageing in the chronic hepatitis C population, along ...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Soriano V,Labarga P,Barreiro P,Fernandez-Montero JV,de Mendoza C,Esposito I,Benítez-Gutiérrez L,Peña JM

更新日期：2015-03-01 00:00:00

abstract：INTRODUCTION:Immunosuppressive drugs have a narrow therapeutic range and large inter-individual response variability. This has prompted pharmacogenetic studies, mostly with regard to their dose-concentration relationships, but also about proteins involved in their pharmacodynamics. Some polymorphisms of genes involved ...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Picard N,Marquet P

更新日期：2011-06-01 00:00:00

abstract：INTRODUCTION:Chemoprevention of cancer refers to the use of natural or synthetic compounds to abolish or perturb a variety of steps in tumor initiation, promotion, and progression. This can be realized through different mechanisms, including activation of free radical scavenging enzymes, control of chronic inflammation...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Ismail T,Donati-Zeppa S,Akhtar S,Turrini E,Layla A,Sestili P,Fimognari C

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Cytochrome P450 2E1 (CYP2E1) plays a central role in the metabolism and metabolic activation of a large number of small, mostly xenobiotic compounds. These qualities distinguish CYP2E1 from traditional enzymes and pose significant challenges to understanding the role and consequences of CYP2E1-mediated metab...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Miller GP

更新日期：2008-08-01 00:00:00

abstract：INTRODUCTION:Type IV drug hypersensitivity remains an important clinical problem and an obstacle to the development of new drugs. Several forms of drug hypersensitivity are associated with expression of specific HLA alleles. Furthermore, drug-specific T-lymphocytes have been isolated from patients with reactions. Despi...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Sullivan A,Watkinson J,Waddington J,Park BK,Naisbitt DJ

更新日期：2018-03-01 00:00:00

abstract：:The human ether-a-go-go-related gene (hERG) encodes the pore-forming alpha-subunit of a voltage-gated potassium (K(+)) channel. A variety of unrelated compounds reduce K(+ )current in the heart by blocking the pore or disrupting trafficking of the hERG channel to the membrane surface. This induces a syndrome known as ...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Stansfeld PJ,Sutcliffe MJ,Mitcheson JS

更新日期：2006-02-01 00:00:00

abstract：:Knowledge of pharmacokinetics and the use of a mechanistic-based approach can improve our ability to predict the effects of pregnancy for medications when data are limited. Despite the many physiological changes that occur during pregnancy that could theoretically affect absorption, bioavailability does not appear to ...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Anderson GD

更新日期：2006-12-01 00:00:00

abstract：:The burden of seasonal influenza in children is poorly recognized, in spite of the potential for severe and even life-threatening illness and common secondary complications. Children are a primary reservoir for the spread of influenza to both family members and the community, which imposes a sizeable social and econom...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Whitley RJ

更新日期：2007-10-01 00:00:00

abstract：INTRODUCTION:Various trials have attempted to develop gene expression profiles (GEPs) that may provide a better predictor of clinical outcome over traditional clinicopathological criteria. AREAS COVERED:The review focuses on two main areas: trials examining chemotherapy-induced GEP changes pre- and post-treatment, and...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Tan SH,Lee SC

更新日期：2012-09-01 00:00:00

abstract：:With the progressive ageing of the population, an increasing number of elderly patients are being exposed to multiple drugs because of co-existing morbidity states requiring pharmacological management. However, the knowledge of the effects of ageing on the pharmacokinetics and pharmacodynamics of individual drugs is f...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Mangoni AA

更新日期：2007-06-01 00:00:00

abstract：INTRODUCTION:Despite initial patient benefit, drug resistance to first-generation EGFR tyrosine kinase inhibitors (TKIs) is inevitable. One of the key mechanisms responsible for the development of acquired drug resistance is the secondary T790M missense mutation in exon 20 of the EGFR kinase domain. Afatinib is an ATP-...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Yap TA,Popat S

更新日期：2013-11-01 00:00:00

abstract：:The interaction between drug-metabolising enzymes and active transporters is an emerging concept in pharmacokinetics. In the gut mucosa, P-glycoprotein and cytochrome P450 (CYP)3A functionally interact in three ways: i) drugs are repeatedly taken up and pumped out of the enterocytes by P-glycoprotein, thus increasing ...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Christians U,Schmitz V,Haschke M

更新日期：2005-12-01 00:00:00

abstract：INTRODUCTION:Nucleosidic analogs such as pyrimidine and purine derivatives are mainstay in the field of treating cancers, both in adults and in children. All these drugs act as antimetabolite compounds, that is, they interfere with the ability of cancer cells to synthesize the nucleosides or the nucleotides necessary f...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Serdjebi C,Milano G,Ciccolini J

更新日期：2015-05-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:There are few true international meetings dedicated to covering multiple areas of toxicology. The XII International Congress of Toxicology (IUTOX) held from 19 to 23 July 2010 in Barcelona, Spain is one such meeting. The IUTOX is important as its emphasis is on chemical safety and integrating ap...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Anadón A,Valerio LG Jr

更新日期：2010-11-01 00:00:00

abstract：:In adapting to the challenge to make more informed selection of compounds for development, the pharmaceutical industry is increasingly embracing the application of mechanism-based models and prediction tools for prediction of pharmacokinetic parameters. This review first outlines the concepts and application of the ma...

journal_title：Expert opinion on drug metabolism & toxicology

authors： De Buck SS,Mackie CE

更新日期：2007-12-01 00:00:00

abstract：INTRODUCTION:Variations in the human genome sequence sometimes play an important role in pharmacokinetics and/or pharmacodynamics. Previous studies have demonstrated a high degree of variation both between and within different ethnic populations. Areas covered: This review sought to summarize key SNPs in CYP2B6, CYP3A ...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Neary M,Owen A

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Anticancer drugs are characterized by a narrow therapeutic window and significant inter-patient variability in therapeutic and toxic effects. Current body surface area (BSA)-based dosing fails to standardize systemic anticancer drug exposure and other alternative dosing strategies also have their limitations...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Gao B,Klumpen HJ,Gurney H

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:CYP enzymes from the CYP2C and CYP2J subfamilies metabolize arachidonic acid in a regiospecific and stereoselective manner to eight epoxyeicosatrienoic acids (EETs). Various EETs have been detected in the liver, as well as in many extrahepatic tissues, and have been implicated in numerous physiological funct...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Kaspera R,Totah RA

更新日期：2009-07-01 00:00:00

abstract：INTRODUCTION:Extensive within-population variability is the essence of neonatal pharmacology. Despite this, infants remain one of the last therapeutic orphans. Together with additional legal initiatives, tailoring of already available tools (modeling, covariates, pharmacovigilance) may significantly improve pharmacothe...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Allegaert K

更新日期：2014-08-01 00:00:00

abstract：INTRODUCTION:Epigenetics is a rapidly growing field describing heritable alterations in gene expression that do not involve DNA sequence variations. Advances in epigenetics and epigenomics have influenced pharmacology, leading to the development of a new specialty, pharmacoepigenetics, the study of the epigenetic basis...

journal_title：Expert opinion on drug metabolism & toxicology

authors： Majchrzak-Celińska A,Baer-Dubowska W

更新日期：2017-04-01 00:00:00