Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer.

Abstract:

:We have identified in and around the immunoglobulin heavy-chain enhancer two apparently distinct negative regulatory elements which repress immunoglobulin H enhancer, simian virus 40 enhancer, and heterologous promoter activity in fibroblasts but not in myeloma cells. We propose that in nonlymphoid cells, negative regulatory elements prevent activation of the immunoglobulin H enhancer by ubiquitous stimulatory trans-acting factors.

journal_name

Mol Cell Biol

authors

Imler JL,Lemaire C,Wasylyk C,Wasylyk B

doi

10.1128/mcb.7.7.2558

subject

Has Abstract

pub_date

1987-07-01 00:00:00

pages

2558-67

issue

7

eissn

0270-7306

issn

1098-5549

journal_volume

7

pub_type

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