Abstract:
PURPOSE:Associations between the preoperative absolute neutrophil count (NC), lymphocyte count (LC), and monocyte count (MC) in the peripheral blood and the prognosis of colorectal cancer (CRC) patients have not been widely studied. METHODS:We enrolled 361 patients who underwent surgery for CRC between January 2007 and December 2013 to analyze correlations among the LC, MC, and NC and prognosis. RESULTS:Based on cut-off values determined by a receiver operating characteristic analysis, patients were subgrouped as LymphHigh or LymphLow (cut-off: LC = 1460 cells/µL); as MonoHigh or MonoLow (cut-off: MC = 421 cells/µL); and as NeutHigh or NeutLow (cut-off: NC = 3247 cells/µL). Patients were then given lymphocyte-monocyte-neutrophil (LMN) scores by adding the points of their different subgroups (1 point each for LymphLow, MonoHigh and NeutHigh; 0 points for LymphHigh, MonoLow and NeutLow). The 5-year overall survival rates significantly differed by the LMN score (0: 89.7%, 1: 80.6%, 2: 68.8%, and 3: 57.4%; P < 0.0001). In the multivariate analysis, the LMN score was found to be an independent prognostic indicator. CONCLUSIONS:The combination of the preoperative absolute number of lymphocytes, monocytes, and neutrophils is a useful prognostic indicator in CRC patients.
journal_name
Surg Todayjournal_title
Surgery todayauthors
Tanio A,Saito H,Uejima C,Takaya S,Yamamoto M,Tokuyasu N,Sakamoto T,Honjo S,Ashida K,Fujiwara Ydoi
10.1007/s00595-018-1728-6subject
Has Abstractpub_date
2019-03-01 00:00:00pages
245-253issue
3eissn
0941-1291issn
1436-2813pii
10.1007/s00595-018-1728-6journal_volume
49pub_type
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