The esophageal mucosa and submucosa: immunohistology in GERD and Barrett's esophagus.

abstract：:In the United States, some 80,000 commercial and industrial chemicals are now in use of which over 30,000 are produced or used in the Great Lakes region. Thus, the environmental quality within the Great Lakes basin has been compromised particularly with respect to persistent toxic substances (PTS). Information derived...

journal_title：Annals of the New York Academy of Sciences

authors： De Rosa CT,Hicks HE,Ashizawa AE,Pohl HR,Mumtaz MM

更新日期：2006-09-01 00:00:00

abstract：:The strategy of "manufacturing uncertainty" has been used with great success by polluters and manufacturers of dangerous products to oppose public health and environmental regulation. This strategy entails questioning the validity of scientific evidence on which the regulation is based. While this approach is most ide...

journal_title：Annals of the New York Academy of Sciences

authors： Michaels D

更新日期：2006-09-01 00:00:00

abstract：:Experimental occlusion of a brain-supplying artery triggers tissue ischemia and subsequent inflammatory events that are initiated at the blood microvessel interface. Cytokine production and molecular adhesive events occur in the early moments following cerebral blood flow reduction, which underlie the transition from ...

journal_title：Annals of the New York Academy of Sciences

authors： del Zoppo GJ

更新日期：1997-08-14 00:00:00

abstract：:Two kinds of active protein fraction, TP1 and TP2, were isolated from bovine thymus extracts. Both these fractions showed a single band in polyacrylamide gel disc electrophoresis. Though these two fractions showed a difference in potency, they both lowered serum calcium in rabbits and increased lymphocytes in mice. Mo...

journal_title：Annals of the New York Academy of Sciences

authors： Mizutani Shimizu M,Suzuki I,Mizutani T,Hayase S,Mizutani A

更新日期：1975-02-28 00:00:00

abstract：:Apoptosis protease-activating factor-1 (Apaf-1), which plays a central role in the formation of the apoptosome, is absent or poorly expressed (because of a transcriptional silencing by methylation) in a substantial percentage of metastatic melanomas and melanoma cell lines, which are unable to activate caspase-9 and e...

journal_title：Annals of the New York Academy of Sciences

authors： Del Bello B,Valentini MA,Comporti M,Maellaro E

更新日期：2003-12-01 00:00:00

abstract：:Glycosylation of alpha-fetoprotein (AFP) by human primary hepatocellular carcinoma (PHC) is abnormal. Concanavalin A (Con A)-affinity molecular variant patterns of serum AFP from patients with PHC are different from those of cord-serum AFP. Different patients with PHC exhibit different Con-A-affinity AFP molecular var...

journal_title：Annals of the New York Academy of Sciences

authors： Smith CJ,Ajdukiewicz A,Kelleher PC

更新日期：1983-01-01 00:00:00

abstract：:Acute viral infection of humans induces virus-specific serum antibody production that often persists for decades. To better understand the nature of this long-term antiviral antibody response, we studied antiviral antibody production of mice acutely infected with lymphocytic choriomeningitis virus (LCMV). Although thi...

journal_title：Annals of the New York Academy of Sciences

authors： Slifka MK,Ahmed R

更新日期：1996-10-25 00:00:00

abstract：:Alzheimer's disease (AD) is a heterogeneous and progressive neurodegenerative disease which in Western societies mainly accounts for clinical dementia. A high proportion of women are affected by this disease, especially at a very advanced age, which might to a large extent be associated with the fact that women live l...

journal_title：Annals of the New York Academy of Sciences

authors： Candore G,Balistreri CR,Grimaldi MP,Vasto S,Listì F,Chiappelli M,Licastro F,Lio D,Caruso C

更新日期：2006-11-01 00:00:00

abstract：:Murine schistosomiasis mansoni is a parasitic disease in which flukes living in the portal vein of the host produce ova that deposit in the liver and intestines. In these organs, ova release antigens that induce chronic, focal granulomatous inflammation. IFN-gamma is an inflammatory cytokine important in macrophage ac...

journal_title：Annals of the New York Academy of Sciences

authors： Weinstock JV,Elliott D

更新日期：1998-05-01 00:00:00

abstract：:Our studies have indicated that normal human placental cytosol contains a complex mixture of nucleoside kinase enzymes, some of which conform to previously characterized activities. Deoxyadenosine is phosphorylated by deoxycytidine kinase, adenosine kinase, and two as yet uncharacterized activities. Deoxyguanosine pho...

journal_title：Annals of the New York Academy of Sciences

authors： Hurley MC,Fox IH

更新日期：1985-01-01 00:00:00

abstract：:Nature has been a source of medicinal agents for thousands of years, and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional medicine. The use of herbal drugs is once more escalating in the form of complementary and alternative medicine. The past century...

journal_title：Annals of the New York Academy of Sciences

authors： Cragg GM,Newman DJ

更新日期：2001-12-01 00:00:00

abstract：:Deprivation of sympathetic neurons of their physiological neurotrophic factor, nerve growth factor (NGF), leads to degeneration of soma and neurites, followed by loss of viability. The progression of degeneration and death are dependent upon macromolecular synthesis indicating an active participation of neuronal metab...

journal_title：Annals of the New York Academy of Sciences

authors： Deckwerth TL,Johnson EM Jr

更新日期：1993-05-28 00:00:00

abstract：:We are performing genomic searches in randomly ascertained families to identify new quantitative trait loci (QTLs) that influence atherosclerosis and its risk factors. The genetic markers used for genomic searches are random microsatellite markers distributed throughout the human chromosomes. These markers are used fo...

journal_title：Annals of the New York Academy of Sciences

authors： Hixson JE,Blangero J

更新日期：2000-05-01 00:00:00

abstract：:Tocopherols and tocotrienols (vitamin E) and ascorbic acid (vitamin C) as well as the carotenoids react with free radicals, notably peroxyl radicals, and with singlet molecular oxygen (1O2), this being the basis of their function as antioxidants. RRR-alpha-tocopherol is the major peroxyl radical scavenger in biologica...

journal_title：Annals of the New York Academy of Sciences

authors： Sies H,Stahl W,Sundquist AR

更新日期：1992-09-30 00:00:00

abstract：:Considerable clinical and experimental evidence indicates that loss of vestibular function results in cognitive deficits, especially deficits in spatial memory. These studies demonstrate the importance of balance for the most fundamental of cognitive processes and suggest that information about head acceleration and o...

journal_title：Annals of the New York Academy of Sciences

authors： Smith PF,Brandt T,Strupp M,Darlington CL,Zheng Y

更新日期：2009-05-01 00:00:00

abstract：:Antigen-specific proliferative responses of peripheral blood T cells are widely used in humans to study the T cell compartment. However, responses to autoantigens are often weak and poorly reproducible. Here we show, using a test recall antigen (tetanus toxoid), that absolute levels of proliferation, minimally detecta...

journal_title：Annals of the New York Academy of Sciences

authors： Narendran P,Elsegood K,Leech NJ,Dayan CM

更新日期：2002-04-01 00:00:00

abstract：:MRI assessment of myocardial iron and function has revolutionized the treatment of thalassemia major patients. While knowledge of somatic iron stores is vital for iron chelation management, it does not adequately monitor cardiac risk. MRI monitoring of cardiac T2* allows preclinical recognition of myocardial iron, str...

journal_title：Annals of the New York Academy of Sciences

authors： Wood JC,Noetzli L

更新日期：2010-08-01 00:00:00

abstract：:The aim of this work was to study the role of glucocorticoids in the insulin-like growth factor binding protein (IGFBP)-3 response to endotoxin. Lipopolysaccharide (LPS) administration decreased IGFBP-3 serum levels as well as hepatic IGFBP-3 gene expression in both adrenalectomized and sham-operated rats. These data ...

journal_title：Annals of the New York Academy of Sciences

authors： Priego T,Ibañez De Cáceres I,Martín AI,Villanúa MA,López-Calderón A

更新日期：2002-11-01 00:00:00

abstract：:A type of unit discharge, termed "luxotonic," has been found in the striate cortex of unanesthetized squirrel monkeys and macaques.6, 21 The firing frequency of these units shows relatively little adaptation, continues indefinitely (hours), and reflects the level of diffuse illumination of the eye. The more numerous "...

journal_title：Annals of the New York Academy of Sciences

authors： Doty RW

更新日期：1977-01-01 00:00:00

abstract：:To examine whether treatment with cardiopulmonary bypass (CPB), which causes transient cellular immunity depression, influences tuberculin skin testing (TST) interpretation. The study was also aimed to assess the degree of cellular immunity depression following open heart surgery. Fifteen children from developing coun...

journal_title：Annals of the New York Academy of Sciences

authors： Stein M,Sela-Razon B,Linder I,Somekh E

更新日期：2007-08-01 00:00:00

abstract：:Since connective tissue pulleys implement Listing's law by systematically changing rectus extraocular muscle (EOM) pulling directions, non-Listing's law gaze dependence of the vestibulo-ocular reflex is currently inexplicable. Differential activation of compartments within rectus EOMs may endow the ocular motor system...

journal_title：Annals of the New York Academy of Sciences

authors： Demer JL,Clark RA,da Silva Costa RM,Kung J,Yoo L

更新日期：2011-09-01 00:00:00

abstract：:Alexithymia has been associated with both posttraumatic stress disorder and neuroendocrine responses to stress. This study examined the relationship of alexithymia to salivary cortisol and 3-methoxy-4-hydroxy-phenylglycol (MHPG) in a sample of police academy recruits exposed to a video stress challenge. Alexithymia sc...

journal_title：Annals of the New York Academy of Sciences

authors： McCaslin SE,Inslicht SS,Neylan TC,Metzler TJ,Otte C,Lenoci M,Henn-Haase C,Best S,Yehuda R,Marmar CR

更新日期：2006-07-01 00:00:00

abstract：:We cloned a kappa 3-related opioid receptor, and although it is still not clear whether this clone corresponds to the kappa 3 receptor itself or is a related gene product, the extensive antisense mapping and the antibody immunoreactivity strongly associate this clone with the kappa 3 receptor. Our approach also indica...

journal_title：Annals of the New York Academy of Sciences

authors： Pasternak GW,Pan YX,Cheng J

更新日期：1995-05-10 00:00:00

abstract：:Aging is the outcome of the contest between chemistry and biology in living systems. Chronic, cumulative chemical modifications compromise the structure and function of biomolecules throughout the body. Proteins with long life spans serve as cumulators of exposure to chemical damage, which is detectable in the form of...

journal_title：Annals of the New York Academy of Sciences

authors： Baynes JW

更新日期：2002-04-01 00:00:00

abstract：:Studies in humans and in animal models have demonstrated that the receptor-dependent actions of 1,25-dihydroxyvitamin D are required for normal skeletal growth and maturation. Investigations were undertaken to address which consequences of vitamin D receptor deficiency are a direct result of impaired receptor-dependen...

journal_title：Annals of the New York Academy of Sciences

authors： Demay MB

更新日期：2006-04-01 00:00:00

abstract：:Agonist interactions with release processes do not validate autoreceptor operation. Instead, the data suggests that autoreceptors function as homoreceptors. Declining efficacy of agonist inhibition of transmitter release with increasing stimulation "intensity" is not assignable to competition with endogenous transmitt...

journal_title：Annals of the New York Academy of Sciences

authors： Kalsner S

更新日期：1990-01-01 00:00:00

abstract：:Starling's law and the end-systolic pressure-volume relationship (ESPVR) reflect the effect of sarcomere length (SL) on the development of stress (sigma) and shortening by myocytes in the uniform ventricle. We show here that tetanic contractions of rat cardiac trabeculae exhibit a sigma-SL relationship at saturating [...

journal_title：Annals of the New York Academy of Sciences

authors： Ter Keurs HE,Shinozaki T,Zhang YM,Wakayama Y,Sugai Y,Kagaya Y,Miura M,Boyden PA,Stuyvers BD,Landesberg A

更新日期：2008-03-01 00:00:00

abstract：:A survey of rodents and hematophagous flies was conducted on three farms located in an area endemic for vesicular stomatitis to determine the species composition of each zoological group occurring in these areas. Eleven species of small rodents were collected and identified. Individuals from forty-nine species of hema...

journal_title：Annals of the New York Academy of Sciences

authors： Jimenez AE,Vargas Herrera F,Salman M,Herrero MV

更新日期：2000-01-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) have been long proposed to reside in defined anatomical locations within bone marrow (BM) tissues in direct contact or close proximity to nurturing cell types. Imaging techniques that allow the simultaneous mapping of HSCs and interacting cell types have been central to the discovery of...

journal_title：Annals of the New York Academy of Sciences

authors： Gomariz A,Isringhausen S,Helbling PM,Nombela-Arrieta C

更新日期：2020-04-01 00:00:00

abstract：:When cells are deprived of iron, their growth is invariably inhibited. However, the mechanism involved remains largely unclear. Recently, we have reported that subcytotoxic concentration of deferoxamine mesylate (DFO), an iron chelator, specifically inhibited transition of Chang cell, a normal hepatocyte cell line, fr...

journal_title：Annals of the New York Academy of Sciences

authors： Yoon YS,Cho H,Lee JH,Yoon G

更新日期：2004-04-01 00:00:00