Abstract:
:Coralyne analogues, isomers, and related alkaloids were examined as inhibitors of reverse transcriptase of RNA tumor viruses in the presence of polyriboadenylic acid-oligodeoxythymidylic acid (Poly rA.oligo dT), polydeoxyadenylic acid-oligodeoxythymidylic acid (Poly dA.oligo dT), polyribocytidylic acid-oligodeoxyguanylic acid (Poly rC.oligo dG), activated calf thymus DNA, and 70S RNA template primers. The inhibition of the reverse transcriptase exhibited by analogues, isomers, and related alkaloids of coralyne was due to the interaction of the alkaloids with the template primers and was competitive. Furthermore, the addition of the alkaloids stopped instantly the DNA polymerization processes. Comparison of the inhibition of reverse transcriptase, antileukemic activities exhibited by the alkaloids, and the structure-activity relationships have been published elsewhere.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Sethi MLdoi
10.1002/jps.2600740819subject
Has Abstractpub_date
1985-08-01 00:00:00pages
889-91issue
8eissn
0022-3549issn
1520-6017pii
S0022-3549(15)46817-0journal_volume
74pub_type
杂志文章abstract::A simple, sensitive GLC assay was developed for fusaric acid, the active metabolite of bupicomide, to follow the disposition of this investigational antihypertensive agent in patients undergoing therapy. Fusaric acid is efficiently extracted from biological samples, derivatized by on-column methylation, and chromatogr...
journal_title:Journal of pharmaceutical sciences
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