Abstract：
OBJECTIVE:Maternal prenatal symptoms of depression and anxiety have been associated with altered neurodevelopmental outcomes in the child. These effects may be mediated in part by altered placental function, with increased fetal 5-hydroxytryptamine (5-HT) exposure being one possible mechanism. The current study aimed to determine whether maternal symptoms of depression or anxiety were associated with decreased placental expression of monoamine oxidase A (MAO A), the enzyme which metabolises 5-HT into 5-hydroxyindoleacetic acid. The localisation of MAO A in the placenta was also investigated. METHODS:Pregnant women were recruited one day prior to elective caesarean and assessed using psychometric tests for symptoms of depression (Edinburgh Depression Scale) and anxiety (Spielberger State/Trait Index). Villous trophoblast tissue was extracted from each placenta and used for subsequent gene expression analysis (N=62). Localisation was studied using immunohistochemistry, with a specific polyclonal antibody. RESULTS:Increasing symptoms of maternal depression were associated with a reduction in placental MAO A expression (r=-0.339, p=0.007, N=62). There was a trend for a similar correlation with symptoms of maternal trait anxiety, but not with state anxiety. MAO A was localised to the syncytiotrophoblast, the tissue between maternal and fetal blood. CONCLUSIONS:These findings support the hypothesis that maternal mood is associated with altered placental function. A reduction in placental MAO A expression is consistent with a subsequent increase in fetal exposure to 5-HT.
journal_name
J Psychosom Resjournal_title
Journal of psychosomatic researchauthors
Blakeley PM,Capron LE,Jensen AB,O'Donnell KJ,Glover Vdoi
10.1016/j.jpsychores.2013.07.002subject
Has Abstractpub_date
2013-10-01 00:00:00pages
341-5issue
4eissn
0022-3999issn
1879-1360pii
S0022-3999(13)00268-7journal_volume
75pub_type
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journal_title：Journal of psychosomatic research
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journal_title：Journal of psychosomatic research
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pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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