Abstract:
:While temperatures in the noxious range are well-known to inhibit acute itch, the impact of temperature in the innocuous temperature range is less well understood. We investigated the effect of alternating short-term temperature changes in the innocuous range on histamine and cowhage-induced acute itch, taking into account individual differences in baseline skin temperature and sensory thresholds. Results indicate that cooling the skin to the cold threshold causes a temporary increase in the intensity of histamine-induced itch, in line with previous findings. Skin warming increased cowhage-induced itch intensity. Potential mecha-nisms of this interaction between thermosensation and pruritoception could involve cold-sensitive channels such as TRPM8, TREK-1 or TRPC5 in the case of histamine. The rapid modulation of cowhage induced itch - but not histamine-induced itch - by transient skin warming could be related to the lower temperature threshold of pruriceptive polymodal C-fibres (cowhage) as compared to the higher temperature threshold of the mechanoinsensitive C-fibres conveying histaminergic itch.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Lewis Z,George DN,Cowdell F,Holle Hdoi
10.2340/00015555-3077subject
Has Abstractpub_date
2019-02-01 00:00:00pages
188-195issue
2eissn
0001-5555issn
1651-2057journal_volume
99pub_type
杂志文章abstract::Thirty patients having mosaic warts of the soles for 2 years (range 3 months-6 years) were treated daily with a wax-based anthralin stick supplemented by weekly paring. Six patients dropped out, because they failed to appear for follow-up. Of the remaining patients 17/24 cleared, whereas the warts persisted in 7/24. A...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::A 78-year-old man is described, who over 18 years developed three different types of keratoacanthoma: multiple keratoacanthomas, keratoacanthoma centrifugum marginatum and giant keratoacanthoma. Histological examination of the different neoplasms showed similar changes, all typical of a keratoacanthoma. In situ hybrid...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555764042
更新日期:1996-01-01 00:00:00
abstract::To evaluate if whole body UVB irradiation has effects on the neutrophil function, eleven patients with mild to moderate psoriasis and 14 healthy subjects were treated with whole body UVB irradiation 3 times weekly for 4 weeks. Eight healthy untreated subjects served as controls. After 2 weeks of treatment the individu...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::Basement membrane (BM) disruption and dermal changes (elastosis, collagenolysis, vascular ectasia) have been reported in melasma. Although ultraviolet (UV) irradiation can induce these changes, UV is not always necessary for melasma development. Cadherin 11 (CDH11), which is upregulated in some melasma patients, has p...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-2315
更新日期:2016-06-15 00:00:00
abstract::Familial progressive hyperpigmentation is rarely described in the literature. We report on five patients from three different families presenting with a peculiar progressive pigmentary disorder. The patients show a progressive diffuse, partly blotchy, hyperpigmentation, intermixed with scattered small hypopigmented ma...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/00015550310005780
更新日期:2004-01-01 00:00:00
abstract::Cinnamic alcohol and cinnamic aldehyde are a cause of allergic contact dermatitis in man and give rise to similar rates of positive reactions in routine patch testing. However, data from animal models indicates that the aldehyde is the stronger sensitizer of the two. Circumstantial evidence has pointed to the conversi...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:102340/0001555572264265
更新日期:1992-08-01 00:00:00
abstract::With fluorescence-histochemical methods (FIF method) pigment-producing cells were investigated in benign and malignant skin lesions. Here, pigment cells appear predominantly dendritic, whilst they are separated from each other by keratinocytes, cells of hair follicles, or cells of sebaceous glands. In lentigo maligna ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::The association between itch and suicidal ideation has not been explored previously in the general population. The aim of the present study is to analyse the association between itch and suicidal ideation in adolescents, and to compare the findings with an expected association between pain and suicidal ideation in the...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-1251
更新日期:2012-09-01 00:00:00
abstract::We studied by immunohistochemistry the fate of factor XIIIa-positive dermal dendrocytes in Henoch-Schönlein purpura. We have observed apoptosis affecting most of the perivascular dendrocytes. Such an aspect of dendrocytoclasis has never previously been reported in inflammatory disorders in the absence of vasculitis. ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::ESR spectra of synthetic melanins formed from dopa and from 5-S-cysteinyldopa and of melanins isolated from human melanomas were studied. Alkali-soluble melanin synthesized from cysteinyldopa showed a signal similar to that of insoluble melanin synthesized from dopa, but also a simple fine structure. Trichochromes C a...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::We set out to show that the assumption is incorrect that continuous treatment with cyclosporin is necessary in psoriasis, as this tenet forms a basis for current recommended treatment regimens. Sixty patients with mild to moderate plaque psoriasis were allocated at random to treatment with oral cyclosporin 5 mg/kg/day...
journal_title:Acta dermato-venereologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2340/00015555756569
更新日期:1995-01-01 00:00:00
abstract::Normal skin and psoriatic lesions from 35 patients were investigated immunohistochemically with regard to the CD1a+ cell population (Langerhans' cells and indeterminate cells) in the epidermis as well as in the dermal infiltrate. In the normal-appearing skin, we found the regularly typical pattern of CD1a+ dendritic c...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::Eosinophilic pustular folliculitis is a rare dermatosis. Recently, in addition to oral indomethacin, other treatments have been applied for eosinophilic pustular folliculitis. The aim of this study was to assess the effectiveness of various therapies encompassing conventional to newly applied drugs for eosinophilic pu...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-0578
更新日期:2009-01-01 00:00:00
abstract::The effect on dermographic wealing of an H1 and H2 receptor antagonist was studied separately and in combination. a double-blind protocol was used and dermographism was measured as the diameter of weal response to a measured force. Both H1 and H2 antagonists had a small but non-significant effect, but the combination ...
journal_title:Acta dermato-venereologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1983-01-01 00:00:00
abstract::Terfenadine is a safe non-sedative H1-receptor antagonist. This study aimed to quantify the relative reduction in weal and flare area, thickness and erythema at 4, 8, 12 and 24 h following a single but variable oral dose of terfenadine compared with pre-treatment measurements, in order to compare the dose-effect relat...
journal_title:Acta dermato-venereologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1991-01-01 00:00:00
abstract::In a case of epidermodysplasia verruciformis with impaired cell-mediated immunity and multiple skin cancers human papillomavirus type 5 (HPV5) DNA sequences were demonstrated in a cutaneous squamous cell carcinoma. HPV5 and HPV8 were detected in the benign disseminated skin lesions together with three newly characteri...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::We used T-cell receptor excision circles (TREC) to evaluate thymic function in adult patients with atopic dermatitis and psoriasis. We observed that men, but not women, with atopic dermatitis had a significantly faster decline in TREC content with increasing age compared with healthy men. In contrast, both men and wom...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-0550
更新日期:2008-01-01 00:00:00
abstract::Twenty female patients with late onset acne and idiopathic hyperprolactinemia--but without increased levels of androgens or decreased levels of SHBG--were treated with bromocriptine. All patients had a fall of basal prolactin levels to normal and a great improvement in or even disappearance of their acne. ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::Human leukocytes and fibroblasts were cultured in medium containing 3H-8-methoxypsoralen (10(-6) M and 3.3 X 10(-6) M). At different stages during the culturing period the cells were exposed to ultraviolet light (1, 2, and 10 J/cm2). After the culture period the slides for chromosome analysis and smears of the cells w...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::Demonstrating T-cell clonality has become an important approach supporting a diagnosis of malignant T-cell neoplasms. A comparative study between Genescan analysis, polyacrylamide gel and agarose gel electrophoresis in visualizing T-cell receptor gamma gene rearrangement was performed on 25 biopsy specimens from 18 pa...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/00015550310015798
更新日期:2004-01-01 00:00:00
abstract::Irritant dermatitis after application of experimental irritants was studied by means of contact thermography. Sixteen healthy persons were patch-tested, using the following irritants: Sodium lauryl sulphate, benzalkonium chloride, nonanoic acid, hydrochloric acid, croton oil, sapo kalinus and sodium hydroxide. A main ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::Different scoring systems have been developed to determine the severity of atopic dermatitis. The SCORAD (SCORing Atopic Dermatitis), one of the best validated systems, is suited for clinical trials, but is too complicated and time consuming for routine clinical use. The TIS score (Three Item Severity score), a simpli...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/000155599750010256
更新日期:1999-09-01 00:00:00
abstract::The defined, serum-free media used in the cultivation of skin equivalents are liable to inter-laboratory variations, require the preparation of multiple additives, and are potentially difficult to replicate. In this study, we assessed the use of standardized, serum-free and bovine pituitary extract-free keratinocyte c...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-1092
更新日期:2011-06-01 00:00:00
abstract::An observational, questionnaire-based, cross-sectional study was performed to assess whether differences in coping behaviour (positive and negative strategies) between patients with either a recent diagnosis of malignant melanoma (MM) or with benign dermatological disease, were predictive of the diagnosis. Coping stra...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-1351
更新日期:2012-11-01 00:00:00
abstract::The immunological activity in the cerebrospinal fluid (CSF) was studied in 47 patients with early syphilis. The immunoglobulin production within the central nervous system (CNS) was estimated by analysing immunoglobulin G and albumin in CSF and serum and constructing an IgG index according to Tibbling et al. and calcu...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract::Penicillin concentration in serum and cerebrospinal fluid (CSF) were estimated in 19 syphilitic patients given three different regimens: Penicillin G, 10 MIU i.v. three times a day (3 patients); procaine penicillin, 600 000 IU i.m. (11 patients); and penicillin V, 1.2 MIU by mouth four times a day (5 patients). Intrav...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract::Psychological stress and atopic dermatitis (AD) symptoms appear to form a vicious cycle. This study compared the degree of stress and impairment of dermatology life quality between patients with AD and healthy controls, and examined for neuropeptides and neurotrophins associated with stress in AD. Questionnaires, comp...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-0933
更新日期:2010-11-01 00:00:00
abstract::The effect of five corticosteroid ointments on epidermal thickness was studied using occlusive chamber application. Thinning of the epidermis and telangiectasia were noted 3 weeks after application of betamethasone-17-valerate (BV), budesonide (BD), clobetasol-17-propionate (CP), and fluocinolone acetonide (FA), but n...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract::Sympathetic dysfunction and skin microvascular arteriovenous shunting with insufficient nutritive perfusion and tissue hypoxia have been reported in patients with erythromelalgia. The objective of this study was to determine whether iloprost, a synthetic prostacyclin analogue--primarily a vasodilator and inhibitor of ...
journal_title:Acta dermato-venereologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/00015550310015031
更新日期:2003-01-01 00:00:00
abstract::Although recent therapeutic developments raise hope, melanoma remains a devastating disease with a need for new treatment targets. In other tumours prohormone convertases have been shown to be pro-tumourigenic as they are involved in processing preforms of matrix-metalloproteinases, growth factors and adhesion molecul...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-3525
更新日期:2020-05-28 00:00:00