Abstract:
:Multiple myeloma (MM) is a heterogeneous disease for which several new treatments are available. Much has been learned about its biology over the past 15 years. We now understand that there are various subtypes of the disease, each one associated with different outcomes and clinical pathological features. While a detailed classification of the disease into at least seven or eight major subtypes is possible, a practical clinical approach classifies the disease into high-risk and not-high-risk MM. This classification has allowed for tailored approaches to therapy and treatment planning. Furthermore, the discussion of outcomes with patients should include risk stratification, as the prospects for survival are quite different depending on whether the patient has high-risk MM or not. The tools for measuring risk subcategory are widely available and now routinely employed in the clinic. The continued search for genetic abnormalities that underlie the biology of MM may allow for even better precision therapy in the future.
journal_name
Semin Oncoljournal_title
Seminars in oncologyauthors
Fonseca R,Monge Jdoi
10.1053/j.seminoncol.2013.07.002subject
Has Abstractpub_date
2013-10-01 00:00:00pages
554-66issue
5eissn
0093-7754issn
1532-8708pii
S0093-7754(13)00126-7journal_volume
40pub_type
杂志文章,评审abstract::The goal of this National Cancer Institute-sponsored phase I trial is to determine the feasibility, toxicity, and pharmacokinetics of continuous-infusion (24 hr/d, 7 d/wk, 7 weeks total) intravenous paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) when combined with standard, curative-intent radiation t...
journal_title:Seminars in oncology
pub_type: 临床试验,杂志文章
doi:
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abstract::The current resurgence in the use of nomograms as diagnostic and prognostic tools has legitimate roots in their effectiveness in facilitating communication between the doctor and patient. By returning to a more classical approach to nomography, graphical insights can further enlighten the patient beyond what can be ac...
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abstract::Colorectal cancer (CRC) is a common malignancy in the elderly. Randomized trials have demonstrated that adjuvant and palliative chemotherapy for CRC improves survival and quality of life. Unfortunately, there is a lack of evidence-based data about elderly patients to guide decisions regarding therapy. Clinical trials ...
journal_title:Seminars in oncology
pub_type: 杂志文章,评审
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更新日期:2008-12-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
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更新日期:2016-02-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
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journal_title:Seminars in oncology
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
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更新日期:2016-08-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
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journal_title:Seminars in oncology
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journal_title:Seminars in oncology
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journal_title:Seminars in oncology
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-10-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:1998-04-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
doi:10.1053/j.seminoncol.2006.04.001
更新日期:2006-08-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章
doi:10.1053/j.seminoncol.2014.09.009
更新日期:2014-10-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
doi:10.1053/j.seminoncol.2004.11.013
更新日期:2005-04-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
doi:10.1053/j.seminoncol.2009.06.002
更新日期:2009-08-01 00:00:00
abstract::Etoposide phosphate (Etopophos; Bristol-Myers Squibb Company, Princeton, NJ) is a water-soluble prodrug of etoposide that is converted in vivo by endogenous phosphatases to the active drug etoposide. This conversion process is efficient and not saturable in humans at doses between 50 and 1,600 mg/m2. The resultant eto...
journal_title:Seminars in oncology
pub_type: 杂志文章,评审
doi:
更新日期:1996-12-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
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更新日期:2007-12-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Seminars in oncology
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journal_title:Seminars in oncology
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journal_title:Seminars in oncology
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journal_title:Seminars in oncology
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