Abstract：
PURPOSE:Previous studies have suggested that extreme endurance exercise may induce cardiac microdamage that could lead to subsequent myocardial fibrosis. Soluble suppression of tumorigenicity 2 (sST2) is a cardiac biomarker for assessment of myocardial fibrosis, inflammation, and strain. We evaluated baseline and exercise-induced sST2 concentrations in a heterogeneous cohort of marathon runners to identify predictors for sST2 concentrations. METHODS:Ninety-two runners supplied demographic data, health status, physical activity levels, and marathon experience. Before (baseline) and immediately after (finish) the marathon, blood was collected for analysis of sST2 and cardiac troponin I (cTnI). RESULTS:Eighty-two participants (45 ± 8 yr, 79% male) finished the race in 227 ± 28 min at 92% (88%-94%) of their predicted maximum heart rate (exercise intensity). sST2 concentrations increased in all runners, from 34 (25-46) ng·mL to 70 (53-87) ng·mL (P < 0.001), and cTnI increased from 9 (5-21) ng·L to 60 (34-102) ng·L (P < 0.001). sST2 concentrations were higher in the fastest marathon runners. Sex and marathon personal best time were associated with baseline sST2 (R = 0.27); baseline sST2, weight loss, and exercise intensity during marathon were associated with finish sST2 (R = 0.54); baseline sST2, height, sex, and weekly training hours were associated with the exercise-induced increase in sST2 (R = 0.47). We observed no association between sST2 and cTnI concentrations. CONCLUSION:An exercise-induced increase in sST2 was observed in all marathon runners with sST2 concentrations exceeding cutoff values both at baseline (48%) and finish (94%). Faster runners had higher sST2 concentrations. Our data suggest complex variables determine sST2 concentrations in marathon runners.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Aengevaeren VL,VAN Kimmenade RRJ,Hopman MTE,VAN Royen N,Snider JV,Januzzi JL,George KP,Eijsvogels TMHdoi
10.1249/MSS.0000000000001806subject
Has Abstractpub_date
2019-03-01 00:00:00pages
405-410issue
3eissn
0195-9131issn
1530-0315journal_volume
51pub_type
杂志文章abstract：PURPOSE:The objective of this study was to examine the association of screen time viewing behavior with isometric trunk muscle strength in youth. METHODS:A cross-sectional study was carried out including 606 adolescents (14-16 yr old) participating in the Danish European Youth Heart Study, a population-based study wit...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e318295af56
更新日期：2013-10-01 00:00:00
abstract：:Six adult females with normal menstrual cycles (28-31 d in length) volunteered to exercise on a bicycle ergometer on five different days of their menstrual cycles (days 2, 8, 14, 20, and 26; day 1 = onset of menstruation). Each day the subjects exercised at a maximum work load (184.4 W) and at four submaximal exercise...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：PURPOSE:The aim of this study was to assess the feasibility and the effects of a long-term training program with endurance and strength elements for patients with advanced congestive heart failure (CHF). METHODS:We studied 14 patients, mean age 57 yr, mean NYHA class 2.7, mean LVEF 29%, and mean VO2max 17.2 mL x kg(-1...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-199908000-00004
更新日期：1999-08-01 00:00:00
abstract：PURPOSE:The purpose of the current study was to investigate the associations between the GNB3 C825T polymorphism, body fatness and fitness, and blood pressure in a sample of young Korean men. METHODS:A total of 282 apparently healthy Korean men (nonobese N = 152, obese N = 130) aged 19-33 yr participated in the study....
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.mss.0000170096.96662.05
更新日期：2005-07-01 00:00:00
abstract：PURPOSE:The cold pain sensitivity in fighter pilots was studied by using a cold pressor test. METHODS:The pilots were divided into two groups: one group consisting of eight pilots (N = 8) who had experienced several acute in-flight neck pain attacks, and the control group (N = 8) who had not experienced these pain con...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-199804000-00016
更新日期：1998-04-01 00:00:00
abstract：:Eight older (52 to 62 yr old) post-menopausal and 8 younger (20 to 30 yr old) women were matched with respect to body size, fatness, and maximal oxygen consumption, heat-acclimated, and then exercised at 35 to 40% maximal oxygen consumption in a warm-humid (37 degrees C, 60% relative humidity) environment. Results wer...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/00005768-198820020-00009
更新日期：1988-04-01 00:00:00
abstract：:This randomized study compared the fibrinolytic circadian rhythm of healthy older men and older women (average age 66 +/- 5), before and after 6 months of endurance training versus stretching controls. Compared with men, women at baseline had similar rhythms for tissue plasminogen activator (t-PA) activity and plasmin...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00005768-199606000-00001
更新日期：1996-06-01 00:00:00
abstract：INTRODUCTION:Regular exercise can reduce the risk of developing cardiovascular disease through risk factor modification, with high-intensity exercise and more recently small muscle mass training providing alternatives to moderate-intensity exercise. METHODS:This study randomly assigned 53 healthy middle-age adults (ag...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1249/MSS.0000000000002053
更新日期：2019-11-01 00:00:00
abstract：PURPOSE:The increased physiological demand of pregnancy results in profound adaptation of the maternal cardiovascular system, reflected by greater resting cardiac output and left ventricular (LV) deformation. Whether the increased resting demand alters acute cardiac responses to exercise in healthy pregnant women is no...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000002554
更新日期：2020-11-03 00:00:00
abstract：:We provide an updated version of the Compendium of Physical Activities, a coding scheme that classifies specific physical activity (PA) by rate of energy expenditure. It was developed to enhance the comparability of results across studies using self-reports of PA. The Compendium coding scheme links a five-digit code t...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200009001-00009
更新日期：2000-09-01 00:00:00
abstract：PURPOSE:Apnea divers hyperinflate the lung by taking a deep breath followed by glossopharyngeal insufflation. The maneuver can lead to symptomatic arterial hypotension. We tested the hypotheses that glossopharyngeal insufflation interferes with cardiac function further reducing cardiac output (CO) using cardiac magneti...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e31821ff294
更新日期：2011-11-01 00:00:00
abstract：PURPOSE:To determine whether a low-cost, commercially available global positioning system (GPS) can be used to study outdoor walking of healthy subjects, allowing the detection of walking and resting (nonwalking) periods and the accurate estimation of speed and distance of each walking periods. METHODS:The same EGNOS-...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/mss.0b013e3180cc20c7
更新日期：2007-09-01 00:00:00
abstract：:Ingestion of fluids providing carbohydrate and electrolytes extends endurance times during prolonged exercise. To understand the contribution of these factors, we examined hormonal, physiologic, and metabolic responses to ingesting water (W) or a 7% glucose polymer/fructose/electrolyte solution (GPFE) in 10 men (age: ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：INTRODUCTION:The vascular endothelium plays an important role in the maintenance of vascular health and the modulation of vascular tone and blood pressure. Recently, it has been demonstrated that blood pressure reactivity to physical activity is greater in the morning, and possibly, diurnal variation in vascular functi...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e318195109c
更新日期：2009-06-01 00:00:00
abstract：PURPOSE:Tibial stress fracture is a common overuse running injury that results from the interplay of repetitive mechanical loading and bone strength. This research project aimed to determine whether female runners with a history of tibial stress fracture (TSF) differ in ground reaction force (GRF) parameters during run...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.mss.0000117116.90297.e1
更新日期：2004-03-01 00:00:00
abstract：PURPOSE:The Compendium of Physical Activities was developed to enhance the comparability of results across studies using self-report physical activity (PA) and is used to quantify the energy cost of a wide variety of PA. We provide the second update of the Compendium, called the 2011 Compendium. METHODS:The 2011 Compe...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e31821ece12
更新日期：2011-08-01 00:00:00
abstract：:Recently, Sarna et al. (Med. Sci. Sports Exerc. 25:237-244, 1993) reported increased mean life expectancy in former world class athletes. Because lifestyle is associated with longevity, we have examined whether health habits of former Finnish male athletes (N = 1274; present mean age: 57.5, range: 36-94 yr) differed f...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/00005768-199402000-00013
更新日期：1994-02-01 00:00:00
abstract：:To compare the physiological response to a cocaine-exercise challenge in cocaine-conditioned animals with that of acute-cocaine animals, rats were injected i.p. with either cocaine (20 mg.kg-1) or saline, twice daily for 14 consecutive days. On the 15th day (test day) cocaine-conditioned rats received an i.v. injectio...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：PURPOSE:This study was undertaken to determine whether endurance training is associated with changes in myocardial perfusion in humans. METHODS:Myocardial perfusion was measured in eleven trained and nine sedentary men at rest and during adenosine-stimulated hyperemia using positron emission tomography (PET). Left ven...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章
doi：10.1097/00005768-200206000-00007
更新日期：2002-06-01 00:00:00
abstract：PURPOSE:Investigate development of specific performance adaptions and hormonal responses every fourth week during a 12-wk high-intensity training (HIT) period in groups with different interval-training prescriptions. METHODS:Sixty-three well-trained cyclists performing a 12-wk intervention consisting of two to three H...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,多中心研究
doi：10.1249/MSS.0000000000001214
更新日期：2017-06-01 00:00:00
abstract：:The present study was designed to assess the effects of acute exercise and short-term intensive training on catechol-O-methyltransferase (COMT) activity. COMT inactivates catecholamines and converts primary catecholestrogens (CE) into their O-methylated form yielding the 2- (2-MeOE) and 4-methoxyestrogens (4-MeOE). Bl...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章
doi：10.1097/00005768-199712000-00006
更新日期：1997-12-01 00:00:00
abstract：:Although estradiol (E2) is considered primarily for its role in reproduction, it can exert numerous physiological actions on a variety of tissues. However, there are several difficulties in isolating these actions and determining its impact for in vivo situations. Despite the limitations, it does appear that E2 can al...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,评审
doi：
更新日期：1990-06-01 00:00:00
abstract：PURPOSE:Hyperventilation increases the clearance of carbon monoxide (CO) from blood; thus, we hypothesized that CO elimination would be enhanced with exercise. Accordingly, this study examined the effect of exercise on the half-life of carboxyhemolobin elimination. METHODS:Six healthy subjects (three males and three f...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/MSS.0b013e3182602a00
更新日期：2012-11-01 00:00:00
abstract：PURPOSE:To develop a protocol for isolating changes in aerodynamic and rolling resistances from field-based measures of power and velocity during level bicycling. METHODS:We assessed the effect of body position (hands on brake hoods vs drops) and tire pressure changes (414 vs 828 kPa) on aerodynamic and rolling resist...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e3181fcb140
更新日期：2011-05-01 00:00:00
abstract：UNLABELLED:High-speed auto racing has been demonstrated to produce accelerated heart rate (HR) during competition. However, it has not been determined whether the increase in HR was due to physical work efforts or a result of emotional stress. PURPOSE:The purpose of this investigation was to examine the physiological ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200212000-00033
更新日期：2002-12-01 00:00:00
abstract：:Anthropometric and demographic characteristics are important determinants of exercise performance in healthy subjects, but their influence has not yet been studied in severe chronic heart failure, although peak oxygen uptake is frequently assessed in such patients for prognostic purposes. The aim of the present analys...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-199706000-00002
更新日期：1997-06-01 00:00:00
abstract：INTRODUCTION:The purpose of this study was to identify unique organized sport trajectories from early childhood to late adolescence in an Australian pregnancy cohort, the Raine Study. METHODS:Participation in organized sport was assessed at ages 5, 8, 10, 14, and 17 yr. Physical activity, body composition, and self-ra...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000000894
更新日期：2016-07-01 00:00:00
abstract：:The purpose of this study was to investigate the association between elite endurance athlete (EEA) status and two restriction fragment length polymorphisms (RFLPs) at the muscle-specific creatine kinase (CKMM) gene locus. Genomic DNA was extracted from white blood cells or lymphoblastoid cell lines of 124 unrelated Ca...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-199711000-00009
更新日期：1997-11-01 00:00:00
abstract：PURPOSE:The purpose of this study was to examine the impact of exercise-induced metabolic stress on hormonal responses and chronic muscular adaptations. METHODS:We compared the acute and long-term effects of an "NR regimen" (no-rest regimen) and those of a "WR regimen" (regimen with rest period within a set). Twenty-s...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：2005-06-01 00:00:00
abstract：PURPOSE:Physical fitness and physical activity tracking data enhance our understanding as to when children settle into their long-term exercise and fitness patterns and, therefore. provide insight as to when programs focusing on preventing sedentary adults behaviors should be initiated. METHODS:In this paper, the trac...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200007000-00011
更新日期：2000-07-01 00:00:00
