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Kidney transplant donor glomerular filtration rate by iohexol clearance during computerized tomographic angiography of the kidneys.

Abstract：

BACKGROUND:Pre-transplantation living-donor kidney function determines remaining donor kidney function and significantly affects post-transplantation allograft function in the recipient. Few transplantation centers perform donor kidney function measurement owing to patient burden. A simplified method of glomerular filtration rate (GFR) measurement after angiographic procedures may facilitate more precise measurement of donor kidney function. METHODS:We evaluated the agreement between a simplified method of GFR measurement after renal computerized tomographic (CT) angiography (index GFR, 100 mL iohexol [350 mg/mL iodine]) and the reference GFR measurement with the use of iodinated radiocontrast media (5 mL bolus of iohexol [300 mg/mL iodine]) among 19 potential living kidney transplant donors. The 24-hour creatinine clearance and GFR estimation equations were additionally examined. Kidney lengths and total and segmented cortical kidney volumes were also measured. RESULTS:The index CT angiography GFR performed best with respect to the reference GFR with minimal bias (mean difference, -4 mL/min/1.73 m(2)), good precision (SD of the difference, 9.8 mL/min/1.73 m(2)), coefficient of determination (R(2)) of 0.74, narrow mean coefficient of variation (5% [range 1%-15%]), and high accuracy, with 100% of the values for the index test within 30% of the reference test. The 24-hour urine creatinine clearance values performed poorly. Kidney volumes and length did not significantly correlate with measured GFR. CONCLUSIONS:The CT angiographic GFR measurement could be a useful and more convenient method of donor kidney function evaluation and maintains minimal bias, high precision, and accuracy compared with the reference GFR measurement.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Hu SL,Igari M,Walle NL,Steffes MW,Beland MD,Collins SA,Gohh RY

doi

10.1016/j.transproceed.2013.05.010

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

3229-33

issue

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(13)00738-0

journal_volume

pub_type

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Kidney transplant donor glomerular filtration rate by iohexol clearance during computerized tomographic angiography of the kidneys.