当前位置： SCI文献检索 > VIROLOGY期刊下所有文献 > Friend murine leukemia virus and spleen focus-forming virus expression in highly malignant interferon-sensitive and interferon-resistant Friend leukemia cells.

Friend murine leukemia virus and spleen focus-forming virus expression in highly malignant interferon-sensitive and interferon-resistant Friend leukemia cells.

Abstract：

:Analysis of expression of the Friend murine leukemia virus (F-MuLV) and of the spleen focus forming virus (SFFV) has been undertaken in highly malignant interferon (IFN)-sensitive (745) and IFN-resistant (3Cl-8) Friend leukemia cells (FLC), serially passaged intraperitoneally in DBA/2 mice. In vivo passaged 745 cells, as well as the clones derived thereof, did not release Friend virus (FV). Western blot analysis of the plasma membrane fractions of the virus nonproducer 745 cells revealed the lack of gp69/70 glycoprotein expression. At least 10 intraperitoneal passages of virus producer in vitro passaged of virus producer in vitro passaged 745 cells were necessary to obtain the selection of the virus nonproducer phenotype. In contrast in vivo passaged 3Cl-8 cells continued to produce FV even after 100 in vivo passages and expressed gp69/70 antigens to a similar extent as the original in vitro passaged FLC. The expression of F-MuLV and SFFV RNAs in virus producer and virus nonproducer FLC clones has been investigated by means of Northern blot technique using probes specific for either F-MuLV or SFFV. No F-MuLV specific RNA sequences were detected in virus nonproducer 745 clones. SFFV specific RNA transcripts and gp52/55 glycoprotein production could be revealed in all the FLC tested. Southern blot analysis showed the presence of F-MuLV specific sequences in the cellular DNA of virus nonproducer 745 clones. As both in vivo passaged F-MuLV producer 3Cl-8 and F-MuLV nonproducer 745 cells were equally barely immunogenic and highly malignant when injected into syngeneic DBA/2 mice, these results indicate that F-MuLV expression does not result per se in a high immunogenic potential of tumor cells. For the time being, as a specific property of 3Cl-8 versus 745 cells is the interferon-resistant phenotype, it is tempting to speculate that the selection of virus nonproducer cell variants after in vivo passages of interferon-sensitive 745 cells could depend on the presence of low levels of endogenous interferon in normal young mice.

journal_name

Virology

journal_title

Virology

authors

Oppi C,Fiorucci G,Ferrantini M,Battistini A,Belardelli F

doi

10.1016/0042-6822(86)90304-1

subject

Has Abstract

pub_date

1986-04-30 00:00:00

pages

390-401

issue

2

eissn

0042-6822

issn

1096-0341

journal_volume

150

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • High dose of plasmid IL-15 inhibits immune responses in an influenza non-human primates immunogenicity model.

    abstract：:Interleukin (IL)-15, is a cytokine that is important for the maintenance of long-lasting, high-avidity T cell response to invading pathogens and has, therefore, been used in vaccine and therapeutic platforms as an adjuvant. In addition to pure protein delivery, plasmids encoding the IL-15 gene have been utilized. Howe...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2009.07.017

    authors： Yin J,Dai A,Laddy DJ,Yan J,Arango T,Khan AS,Lewis MG,Andersen H,Kutzler MA,Draghia-Akli R,Weiner DB,Boyer JD

    更新日期：2009-10-10 00:00:00

  • In vitro fidelity of the prototype primate foamy virus (PFV) RT compared to HIV-1 RT.

    abstract：:We compared the in vitro fidelity of wild-type human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT) and the prototype foamy virus (PFV) RT. Both enzymes had similar error rates for single nucleotide substitutions; however, PFV RT did not appear to make errors at specific hotspots, like HIV-1 RT. In a...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.05.034

    authors： Boyer PL,Stenbak CR,Hoberman D,Linial ML,Hughes SH

    更新日期：2007-10-25 00:00:00

  • Temporal and spatial expression of the E5a protein during the differentiation-dependent life cycle of human papillomavirus type 31b.

    abstract：:Human papillomaviruses (HPVs) are epitheliotropic viruses, and their life cycle is intimately linked to the stratification and differentiation state of the host epithelial tissues. Defining a role for the E5 gene product in the differentiation-dependent viral life cycle has been difficult due to the lack of a suitable...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1998.9262

    authors： Mayer TJ,Meyers C

    更新日期：1998-09-01 00:00:00

  • Rescue of a 7502-nucleotide (49.3% of full-length) synthetic analog of respiratory syncytial virus genomic RNA.

    abstract：:A cDNA was constructed to encode an internally-truncated version of negative-sense genomic RNA (vRNA) of respiratory syncytial virus (RSV) containing (in 3' to 5' order) the 3' vRNA leader region, the complement of the open reading frame for bacterial chloramphenicol acetyl transferase (CAT) under the control of RSV g...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1993.1368

    authors： Collins PL,Mink MA,Hill MG 3rd,Camargo E,Grosfeld H,Stec DS

    更新日期：1993-07-01 00:00:00

  • Characterization of a nonhemagglutinating mutant of canine parvovirus.

    abstract：:A nonhemagglutinating mutant of a 1978 isolate of canine parvovirus (CPV) was derived after repeated passages in the NLFK feline kidney cell line. The mutant CPV was antigenically indistinguishable from wild-type virus when tested with 82 monoclonal antibodies, and it replicated in cat and dog cell lines in culture. S...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(88)90255-3

    authors： Parrish CR,Burtonboy G,Carmichael LE

    更新日期：1988-03-01 00:00:00

  • Paramyxovirus Sendai virus-like particle formation by expression of multiple viral proteins and acceleration of its release by C protein.

    abstract：:Envelope viruses maturate by macromolecule assembly and budding. To investigate these steps, we generated virus-like particles (VLPs) by co-expression of structural proteins of Sendai virus (SeV), a prototype of the family Paramyxoviridae. Simultaneous expression of matrix (M), nucleo- (N), fusion (F), and hemagglutin...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2004.04.019

    authors： Sugahara F,Uchiyama T,Watanabe H,Shimazu Y,Kuwayama M,Fujii Y,Kiyotani K,Adachi A,Kohno N,Yoshida T,Sakaguchi T

    更新日期：2004-07-20 00:00:00

  • Primary structure of brome mosaic virus coat protein.

    abstract：:The amino acid sequence of BMV (brome mosaic virus) coat protein is presented and compared with the sequence derived from RNA structure. Apart from removal of the N-terminal methionine residue and acetylation of the following serine residue, no post-translational modifications occur. ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(83)90193-9

    authors： Moosic JP,McKean DJ,Shih DS,Kaesberg P

    更新日期：1983-09-01 00:00:00

  • Identification and characterization of a novel gene encoding an RGD-containing protein in large yellow croaker iridovirus.

    abstract：:Many virus-encoded RGD-containing proteins have been reported to play important roles in virus attachment and entry. Here we report the identification and functional characterization of a gene encoding an RGD-containing protein (037L) from large yellow croaker iridovirus (LYCIV), a causative agent of epizootics among ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.07.004

    authors： Ao J,Chen X

    更新日期：2006-11-25 00:00:00

  • Do hemagglutinin genes of highly pathogenic avian influenza viruses constitute unique phylogenetic lineages?

    abstract：:Avian influenza A viruses of the H5 and H7 subtypes periodically cause severe outbreaks of disease in poultry. The question we wished to address in this study is whether these highly pathogenic strains constitute unique lineages or whether they and related nonpathogenic viruses are derived from common ancestors in the...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1301

    authors： Röhm C,Horimoto T,Kawaoka Y,Süss J,Webster RG

    更新日期：1995-06-01 00:00:00

  • The outer capsid protein VP4 of murine rotavirus strain Eb represents a tentative new P type.

    abstract：:The nucleotide and deduced amino acid sequence of the gene 4 of murine rotavirus strain Eb were determined. The gene is 2359 nucleotides in length and encodes for a protein of 775 amino acids. Comparison of the VP4 amino acid sequence of the Eb strain with several human and animal rotavirus strains which represent all...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1994.1153

    authors： Sereno MM,Gorziglia MI

    更新日期：1994-03-01 00:00:00

  • Two cellular microRNAs, miR-196b and miR-1290, contribute to HIV-1 latency.

    abstract：:Understanding the mechanism of HIV-1 latency is crucial to the viral reservoir eradication. Human cellular miRNAs can modulate HIV-1 expression by targeting of viral RNAs or host gene transcripts. To identify miRNAs modulating HIV-1 latency, we determined the miRNA expression profiles of HIV-1 latently infected and pr...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2015.09.016

    authors： Wang P,Qu X,Zhou X,Shen Y,Ji H,Fu Z,Deng J,Lu P,Yu W,Lu H,Zhu H

    更新日期：2015-12-01 00:00:00

  • A variant of CRPV DNA preferentially maintained as a plasmid in NIH 3T3 cells and characterization of its transcripts in nude mouse tumors.

    abstract：:Rabbit and human papillomaviruses are strictly epitheliotropic and their DNA replicates extrachromosomally in benign lesions (warts) of their natural host. Their tissue and host specificity is thought to be genetically controlled and may account for the inefficiency in transforming heterologous cells. In our hands, CR...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(87)90149-8

    authors： Nasseri M,Wettstein FO

    更新日期：1987-12-01 00:00:00

  • MHV-A59 enters polarized murine epithelial cells through the apical surface but is released basolaterally.

    abstract：:Coronaviruses have a marked tropism for epithelial cells. Entry and release of the porcine transmissible gastroenteritis virus (TGEV) is restricted to apical surfaces of polarized epithelial cells, as we have recently shown (J. W. A. Rossen, C. P. J. Bekker, W. F. Voorhout, G. J. A. M. Strous, A. van der Ende, and P. ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1316

    authors： Rossen JW,Voorhout WF,Horzinek MC,van der Ende A,Strous GJ,Rottier PJ

    更新日期：1995-06-20 00:00:00

  • Expression of the large 5'-proximal cistron of tobacco mosaic virus by 70 S ribosomes during cotranslational disassembly in a prokaryotic cell-free system.

    abstract：:In vitro translation of pH 8-washed particles of tobacco mosaic virus (TMV; vulgare, common, or U1 strain) in a cell-free system derived from Escherichia coli (MRE 600) results in a broad size range of TMV RNA-encoded products, including significant amounts of the distinctive 126-kDa polypeptide which is encoded by th...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(86)90394-6

    authors： Wilson TM

    更新日期：1986-07-15 00:00:00

  • Virus neutralising activity of African fruit bat (Eidolon helvum) sera against emerging lyssaviruses.

    abstract：:It is likely that phylogroup 2 lyssaviruses circulate within bat reservoirs. We adapted a pseudotype (pt) neutralisation assay (PNA) to a multiplex format enabling serosurveillance for Lagos bat virus (LBV), Mokola virus (MOKV) and West Caucasian bat virus (WCBV) in a potential reservoir, the African straw-coloured fr...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.09.014

    authors： Wright E,Hayman DT,Vaughan A,Temperton NJ,Wood JL,Cunningham AA,Suu-Ire R,Weiss RA,Fooks AR

    更新日期：2010-12-20 00:00:00

  • Deletion analysis of a replication origin of human cytomegalovirus by a novel assay system with a combination of microinjection and polymerase chain reaction.

    abstract：:We have developed a sensitive assay for DNA replication in mammalian cells that enables us to detect replicated DNA fragments of human cytomegalovirus. A 1/100 portion of DNA extracted from 1000 microinjected cells was subjected to polymerase chain reaction after digestion with appropriate restriction enzymes to diffe...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1993.1038

    authors： Watanabe S,Yamaguchi N

    更新日期：1993-01-01 00:00:00

  • Subcellular distribution of the foot-and-mouth disease virus 3A protein in cells infected with viruses encoding wild-type and bovine-attenuated forms of 3A.

    abstract：:Picornavirus infection induces the proliferation and rearrangement of intracellular membranes in response to the synthesis of nonstructural proteins, including 3A. We have previously shown that changes in 3A are associated with the inability of a Taiwanese strain of foot-and-mouth disease virus (FMDV) (OTai) to grow i...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2001.1035

    authors： O'Donnell VK,Pacheco JM,Henry TM,Mason PW

    更新日期：2001-08-15 00:00:00

  • CfMNPV blocks AcMNPV-induced apoptosis in a continuous midgut cell line.

    abstract：:Morphological and molecular changes produced by Autographa californica nuclear polyhedrosis virus (AcMNPV) infection in a permissive cell line, IPLB-SF-21AE (SF-21), of Spodoptera frugiperda and a nonpermissive cell line, FPMI-CF-203 (CF-203), of Choristoneura fumiferana are described. CF-203 cells inoculated with AcM...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1996.0411

    authors： Palli SR,Caputo GF,Sohi SS,Brownwright AJ,Ladd TR,Cook BJ,Primavera M,Arif BM,Retnakaran A

    更新日期：1996-08-01 00:00:00

  • Tobacco mosaic virus coat protein and the large subunit of the host protein ribulose-1,5-biphosphate carboxylase share a common antigenic determinant.

    abstract：:An immunological relationship was detected between the coat protein of the common (U1) strain of tobacco mosaic virus (TMV) and the large subunit of the ubiquitous CO2-fixing host enzyme, ribulose-1,5-biphosphate carboxylase (RuBisCo). When assayed by Western immunoblotting or indirect ELISA, polyclonal antisera to TM...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(86)90186-8

    authors： Dietzgen RG,Zaitlin M

    更新日期：1986-11-01 00:00:00

  • Identification, expression, and processing of an 87-kDa polypeptide encoded by ORF 1a of the coronavirus infectious bronchitis virus.

    abstract：:Nucleotide sequence analysis has shown previously that the genomic-length mRNA (mRNA1) of the coronavirus infectious bronchitis virus (IBV) contains two large open reading frames (ORFs), 1a and 1b, with the potential to encode polyproteins of approximately 441 and 300 kDa, respectively. We have characterized the speci...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1128

    authors： Liu DX,Tibbles KW,Cavanagh D,Brown TD,Brierley I

    更新日期：1995-04-01 00:00:00

  • Resistance and susceptibility of bovine cells expressing herpesviral glycoprotein D homologs to herpesviral infections.

    abstract：:Bovine cell lines individually expressing two related herpesviral proteins, pseudorabies virus glycoprotein 50 and herpes simplex virus type 1 glycoprotein D, were examined for their susceptibility/resistance to infection with several alphaherpesviruses. Cell lines expressing gp50 or gD-1 resisted plaque formation by ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1993.1269

    authors： Chase CC,Lohff C,Letchworth GJ 3rd

    更新日期：1993-05-01 00:00:00

  • Temperature and density dependent induction of a cytopathic effect following infection with non-cytopathic HAV strains.

    abstract：:Hepatitis A virus infection and growth in cultured cells is protracted, cell-type restricted, and generally not accompanied by the appearance of a cytopathic effect, with the exception of some culture-adapted strains. We demonstrate that the non-cytopathic HAV strain HM175/clone 1 can be induced to exhibit a cytopathi...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2012.04.010

    authors： Wales SQ,Ngo D,Hida K,Kulka M

    更新日期：2012-08-15 00:00:00

  • Assignment of the genome segments of bluetongue virus type 1 to the proteins which they encode.

    abstract：:The purified genomic dsRNA of bluetongue virus type 1 (BTV 1) was separated into 10 size classes by polyacrylamide gel electrophoresis. These genome segments were recovered individually from the gel, denatured with methylmercuric hydroxide and translated in vitro in a rabbit reticulocyte lysate system. The virus-speci...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(84)90131-4

    authors： Mertens PP,Brown F,Sangar DV

    更新日期：1984-05-01 00:00:00

  • Nucleotide sequence and transcriptional analysis of molecular clones of CAEV which generate infectious virus.

    abstract：:The lentivirus caprine arthritis-encephalitis virus (CAEV) is closely related by nucleotide sequence homology to visna virus and other sheep lentiviruses and shows less similarity to the other animal and human lentiviruses. The genomic organization of CAEV is very similar to that of visna virus and the South African o...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(90)90303-9

    authors： Saltarelli M,Querat G,Konings DA,Vigne R,Clements JE

    更新日期：1990-11-01 00:00:00

  • Infection and cellular activation by human T-cell leukemia viruses, types I and II.

    abstract：:Resting peripheral blood mononuclear cells (PBMC) or purified T-cells can be induced to proliferate when cocultured in vitro with fixed HTLV-infected T-cells. This process of HTLV-dependent cellular activation and induction of proliferation has been considered distinctive because of an apparent independence from conve...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1996.0389

    authors： Martin TC,Southern PJ

    更新日期：1996-07-15 00:00:00

  • An infectious West Nile virus that expresses a GFP reporter gene.

    abstract：:West Nile virus is a mosquito-borne, neurotropic flavivirus that causes encephalitis in humans and animals. Since being introduced into the Western hemisphere in 1999, WNV has spread rapidly across North America, identifying this virus as an important emerging pathogen. In this study, we developed a DNA-launched infec...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2005.01.021

    authors： Pierson TC,Diamond MS,Ahmed AA,Valentine LE,Davis CW,Samuel MA,Hanna SL,Puffer BA,Doms RW

    更新日期：2005-03-30 00:00:00

  • Immunolocalization of the dengue virus nonstructural glycoprotein NS1 suggests a role in viral RNA replication.

    abstract：:Although many workers have investigated the maturation and processing of the flavivirus nonstructural glycoprotein NS1 in infected cells, these studies have provided little insight into a possible function for NS1. In this study we investigated the subcellular localization of NS1 both by immunofluorescence and cryo-im...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1996.0307

    authors： Mackenzie JM,Jones MK,Young PR

    更新日期：1996-06-01 00:00:00

  • A human T-cell line resistant to cytopathic effects of the human immunodeficiency virus (HIV).

    abstract：:Infection of human helper T lymphocytes with the human immunodeficiency virus (HIV) results in a rapid induction of cytopathic effects and cell lysis. We isolated a variant of the human T-lymphoblastoid cell line, CEM, that is fully susceptible to HIV infection but resistant to virally induced cytopathic effects. Expo...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(87)90434-x

    authors： Casareale D,Stevenson M,Sakai K,Volsky DJ

    更新日期：1987-01-01 00:00:00

  • Autophagy sustains the replication of porcine reproductive and respiratory virus in host cells.

    abstract：:In this study, we confirmed the autophagy induced by porcine reproductive and respiratory syndrome virus (PRRSV) in permissive cells and investigated the role of autophagy in the replication of PRRSV. We first demonstrated that PRRSV infection significantly results in the increased double-membrane vesicles, the accumu...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2012.03.022

    authors： Liu Q,Qin Y,Zhou L,Kou Q,Guo X,Ge X,Yang H,Hu H

    更新日期：2012-08-01 00:00:00

  • Transcriptional activation by the E1A regions of adenovirus types 40 and 41.

    abstract：:In order to establish whether the poor growth of the two fastidious adenoviruses types 40 and 41 (Ad40 and Ad41) in HeLa cells is due to a reduced trans-activation by the early region 1A (E1A), we have determined the trans-activating effect of this region on the expression of the chloramphenicol acetyltransferase (CAT...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(87)90080-8

    authors： van Loon AE,Gilardi P,Perricaudet M,Rozijn TH,Sussenbach JS

    更新日期：1987-09-01 00:00:00