Abstract:
OBJECTIVE:Our aim was to examine the impact of a single enteral dose of vitamin E on serum tocopherol levels. The study was undertaken to see whether a single dose of vitamin E soon after birth can rapidly increase the low α-tocopherol levels seen in very preterm infants. If so, this intervention could be tested as a means of reducing the risk of intracranial hemorrhage. METHODS:Ninety-three infants <27 weeks' gestation and <1000 g were randomly assigned to receive a single dose of vitamin E or placebo by gastric tube within 4 hours of birth. The vitamin E group received 50 IU/kg of vitamin E as dl-α-tocopheryl acetate (Aquasol E). The placebo group received sterile water. Blood samples were taken for measurement of serum tocopherol levels by high-performance liquid chromatography before dosing and 24 hours and 7 days after dosing. RESULTS:Eighty-eight infants received the study drug and were included in the analyses. The α-tocopherol levels were similar between the groups at baseline but higher in the vitamin E group at 24 hours (median 0.63 mg/dL vs. 0.42 mg/dL, P = .003) and 7 days (2.21 mg/dL vs 1.86 mg/dL, P = .04). There were no differences between groups in γ-tocopherol levels. At 24 hours, 30% of vitamin E infants and 62% of placebo infants had α-tocopherol levels <0.5 mg/dL. CONCLUSIONS:A 50-IU/kg dose of vitamin E raised serum α-tocopherol levels, but to consistently achieve α-tocopherol levels >0.5 mg/dL, a higher dose or several doses of vitamin E may be needed.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Bell EF,Hansen NI,Brion LP,Ehrenkranz RA,Kennedy KA,Walsh MC,Shankaran S,Acarregui MJ,Johnson KJ,Hale EC,Messina LA,Crawford MM,Laptook AR,Goldberg RN,Van Meurs KP,Carlo WA,Poindexter BB,Faix RG,Carlton DP,Watterberdoi
10.1542/peds.2013-1684subject
Has Abstractpub_date
2013-12-01 00:00:00pages
e1626-33issue
6eissn
0031-4005issn
1098-4275pii
peds.2013-1684journal_volume
132pub_type
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