Abstract：
:The rat lateral fluid-percussion injury (FPI) model has been used extensively to study post-traumatic epilepsy (PTE). Epidemiological studies have reported that the risk of PTE is higher after more severe injury. Adult, male Wistar rats subjected to different atmospheric pressures of injury during FPI showed great variability in injury severity when functional behavior was determined based on the Neurological Severity Score (NSS) assessment. When NSS was used to select rats with the most severe FPI-induced brain injury, 63% of rats experienced at least one convulsive seizure 2-5 weeks after FPI. This same cohort of rats (i.e., selected for severe TBI based on NSS) were significantly more susceptible to PTZ-induced seizures compared to sham controls. Video/EEG recordings from a second cohort of rats with severe FPI-induced injury (based on NSS) showed a similar incidence and frequency of spike wave discharges between rats with severe TBI and sham controls. However, the rate of isolated EEG spikes was greater in rats with severe FPI-induced injury compared to sham controls. These data suggest that convulsive seizures can be obtained in FPI-treated rats when NSS is used as an inclusion criterion to select rats with severe injury. Furthermore, although spike-wave discharges were equally prevalent in rats with severe FPI and sham controls, spontaneous spikes were more prevalent in the rats with severe FPI.
journal_name
Epilepsy Resjournal_title
Epilepsy researchauthors
Smith D,Rau T,Poulsen A,MacWilliams Z,Patterson D,Kelly W,Poulsen Ddoi
10.1016/j.eplepsyres.2018.09.005subject
Has Abstractpub_date
2018-11-01 00:00:00pages
87-94eissn
0920-1211issn
1872-6844pii
S0920-1211(17)30678-2journal_volume
147pub_type
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pub_type： 杂志文章,多中心研究
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更新日期：2010-05-01 00:00:00
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更新日期：2010-03-01 00:00:00
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更新日期：2011-02-01 00:00:00
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更新日期：2017-03-01 00:00:00
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更新日期：2007-05-01 00:00:00
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journal_title：Epilepsy research
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更新日期：2008-09-01 00:00:00
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journal_title：Epilepsy research
pub_type： 杂志文章
doi：10.1016/0920-1211(90)90018-q
更新日期：1990-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：1998-11-01 00:00:00
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journal_title：Epilepsy research
pub_type： 杂志文章
doi：10.1016/j.eplepsyres.2015.03.014
更新日期：2015-07-01 00:00:00
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journal_title：Epilepsy research
pub_type： 杂志文章
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更新日期：2012-05-01 00:00:00
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journal_title：Epilepsy research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.eplepsyres.2017.02.005
更新日期：2017-03-01 00:00:00
