Age-related changes in mitochondrial function of mouse colonic smooth muscle: beneficial effects of melatonin.

abstract：:Epigenetic alterations have emerged as an important mechanism involved in tumorigenesis. The epigenetic impact of DNA methylation in various types of human cancer is not completely understood. Previously, we observed melatonin-induced differential expression of miRNA and miRNA-related genes in human breast cancer cell...

journal_title：Journal of pineal research

authors： Lee SE,Kim SJ,Yoon HJ,Yu SY,Yang H,Jeong SI,Hwang SY,Park CS,Park YS

更新日期：2013-01-01 00:00:00

abstract：:Exposure of rats to light during darkness or blockade of the pineal beta-adrenoceptor in stimulated pineal glands results in a rapid fall in pineal N-acetyltransferase (NAT) activity. Maintenance of a high level of NAT activity requires continuous stimulation of the pineal beta-adrenoceptors. It is not known what fact...

journal_title：Journal of pineal research

authors： Olivieri G,Daya S

更新日期：1992-03-01 00:00:00

abstract：:The oncostatic effects of melatonin on the mammary gland have been studied in transgenic mice carrying the N-ras proto-oncogene under the control of the MMTV-LTR. Female (4-week-old) virgin mice with positive transgenic pedigrees were injected with melatonin (200 micrograms/mouse/ day, five times a week) or vehicle la...

journal_title：Journal of pineal research

authors： Mediavilla MD,Güezmez A,Ramos S,Kothari L,Garijo F,Sánchez Barceló EJ

更新日期：1997-03-01 00:00:00

abstract：:Melatonin has been shown to improve in vitro fertilization and offspring survival after bacterial infection, but its role in regulating maternal-fetal communication during early pregnancy has not been investigated. Results of this study demonstrated expression of abundant melatonin receptors in conceptus and endometri...

journal_title：Journal of pineal research

authors： Bae H,Yang C,Lee JY,Park S,Bazer FW,Song G,Lim W

更新日期：2020-09-01 00:00:00

abstract：:Excessive activity of NADPH oxidase (Nox) is considered to be of importance for the progress of diabetic nephropathy. The aim of the study was to elucidate the effect of melatonin, known for its nephroprotective properties, on Nox activity under diabetic conditions. The experiments were performed on three groups of an...

journal_title：Journal of pineal research

authors： Winiarska K,Dzik JM,Labudda M,Focht D,Sierakowski B,Owczarek A,Komorowski L,Bielecki W

更新日期：2016-01-01 00:00:00

abstract：:Seasonal day length has been linked to the prevalence of mood disorders, and however, the mechanisms underlying this relationship remain unknown. Previous work in our laboratory has shown that developmental exposure to seasonal photoperiods has enduring effects on the activity of mouse dorsal raphe serotonergic neuron...

journal_title：Journal of pineal research

authors： Giannoni-Guzmán MA,Kamitakahara A,Magalong V,Levitt P,McMahon DG

更新日期：2020-11-19 00:00:00

abstract：:The permeability of the pineal gland to lanthanum was investigated by means of transmission electron microscopy and X-ray microanalysis. Different pineal cell populations were studied. Light pinealocytes as well as glial cells were not permeated by the tracer lanthanum, which normally stays extracellularly. Dark pinea...

journal_title：Journal of pineal research

authors： Humbert W,Pévet P

更新日期：1992-03-01 00:00:00

abstract：:Previous studies proved that melatonin protected against secondary brain damage by modulating oxidative stress after experimental subarachnoid hemorrhage (SAH), but it has not been evaluated yet about its effects on inflammatory pathway and secondary cognitive dysfunction in SAH model. This study was undertaken to eva...

journal_title：Journal of pineal research

authors： Wang Z,Wu L,You W,Ji C,Chen G

更新日期：2013-11-01 00:00:00

abstract：:Melatonin is a powerful antioxidant and free radical scavenger. A large body of in vivo and in vitro evidence shows that melatonin effectively inhibits membrane lipid peroxidation; this damage was based on the measurement of malondialdehyde and/or 4-hydroxynonenal levels. In the current study, for the first time using...

journal_title：Journal of pineal research

authors： Zhang L,Wei W,Xu J,Min F,Wang L,Wang X,Cao S,Tan DX,Qi W,Reiter RJ

更新日期：2006-05-01 00:00:00

abstract：:Autophagy is an important survival pathway and participates in the host response to infection. Beneficial effects of melatonin have been previously reported in an animal model of acute liver failure (ALF) induced by the rabbit hemorrhagic disease virus (RHDV). This study was aimed to investigate whether melatonin prot...

journal_title：Journal of pineal research

authors： San-Miguel B,Crespo I,Vallejo D,Álvarez M,Prieto J,González-Gallego J,Tuñón MJ

更新日期：2014-04-01 00:00:00

abstract：:The purpose of this study was to determine whether melatonin treatment would mitigate retinal ganglion cell (RGC) death in the developing retina following a hypoxic insult. Lipid peroxidation (LPO), glutathione (GSH), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) concentrations, expression of vascular end...

journal_title：Journal of pineal research

authors： Kaur C,Sivakumar V,Robinson R,Foulds WS,Luu CD,Ling EA

更新日期：2013-03-01 00:00:00

abstract：:In the current study, a fundamental question, that is, the mechanisms related to the beneficial effects of melatonin on mammalian embryonic development, was addressed. To examine the potential beneficial effects of melatonin on bovine embryonic development, different concentrations of melatonin (10(-11), 10(-9), 10(-7...

journal_title：Journal of pineal research

authors： Wang F,Tian X,Zhang L,Gao C,He C,Fu Y,Ji P,Li Y,Li N,Liu G

更新日期：2014-04-01 00:00:00

abstract：:The purpose of the present studies using artificial light was to determine how the timing and duration of exposure influence the light-induced suppression of pineal melatonin levels in hamsters. An 8-min exposure to 0.186 microW/cm2 of cool white fluorescent light caused a continued depression of pineal melatonin even...

journal_title：Journal of pineal research

authors： Brainard GC,Richardson BA,Hurlbut EC,Steinlechner S,Matthews SA,Reiter RJ

更新日期：1984-01-01 00:00:00

abstract：:Rat pineal hydroxyindole-O-methyltransferase (HIOMT; EC 2.1.1.4) was purified by affinity chromatography using an S-adenosyl-L-homocysteine agarose column. This single-step procedure, which is rapid, simple, and applicable to small quantities of tissue, gave a large enrichment of a protein (Mr approximately 38,000) id...

journal_title：Journal of pineal research

authors： Sugden D,Voisin P,Klein DC

更新日期：1986-01-01 00:00:00

abstract：:N-nitrosomelatonin (NOMela) is well-known for its capabilities of transnitrosating nucleophiles such as thiols and ascorbate, thereby generating nitric oxide (NO)-releasing compounds. It is unknown, however, whether NOMela can be successfully applied as a precursor of NO in a complex biological environment like a cell...

journal_title：Journal of pineal research

authors： Berchner-Pfannschmidt U,Tug S,Trinidad B,Becker M,Oehme F,Flamme I,Fandrey J,Kirsch M

更新日期：2008-11-01 00:00:00

abstract：:The circadian clock plays a vital role in physiology and behavior such as the sleep-wake cycle and blood pressure and hormone levels. Immune responses also display circadian rhythmicity and particularly pineal melatonin contributes to immunological processes. Little attention, however, is given to mechanisms underlyin...

journal_title：Journal of pineal research

authors： Ren DL,Li YJ,Hu BB,Wang H,Hu B

更新日期：2015-05-01 00:00:00

abstract：:Four-week-old male hamsters, born and raised in total darkness or in LD 14:10 (hr) were exposed to several low levels of illumination for 14 weeks. Analyses showed that testicular weights were significantly affected by both photic history and illuminance levels. Animals born in the dark possessed larger testes than th...

journal_title：Journal of pineal research

authors： Hoffman RA,Johnson LB

更新日期：1985-01-01 00:00:00

abstract：:Melatonin, a neurohormone that binds to two G protein-coupled receptors MT1 and MT2, is involved in pain regulation, but the distinct role of each receptor has yet to be defined. We characterized the nociceptive responses of mice with genetic inactivation of melatonin MT1 (MT1-/- ), or MT2 (MT2-/- ), or both MT1 /MT2 ...

journal_title：Journal of pineal research

authors： Posa L,Lopez-Canul M,Rullo L,De Gregorio D,Dominguez-Lopez S,Kaba Aboud M,Caputi FF,Candeletti S,Romualdi P,Gobbi G

更新日期：2020-10-01 00:00:00

abstract：:Hypochlorous acid (HOCl) is a potent cytotoxic oxidant generated by the enzyme myeloperoxidase (MPO) in the presence of hydrogen peroxide (H2 O2 ) and chloride (Cl- ). Elevated levels of HOCl play an important role in various pathological conditions through oxidative modification of several biomolecules. Recently, we ...

journal_title：Journal of pineal research

authors： Jeelani R,Maitra D,Chatzicharalampous C,Najeemuddin S,Morris RT,Abu-Soud HM

更新日期：2018-04-01 00:00:00

abstract：:The association of seasonal changes in health and disease has been known for centuries. The prevalence of psychopathological symptoms with seasonal fluctuations and the use of melatonin as a biological marker of circadian and circannual rhythms is well documented. The aim of this work was to study the variability of m...

journal_title：Journal of pineal research

authors： Morera AL,Abreu P

更新日期：2006-10-01 00:00:00

abstract：:GPR50 is an orphan seven transmembrane protein related to the melatonin receptor subfamily comprising MT(1) and MT(2) receptors. In the absence of any known ligand for GPR50, other tools are critical for the characterization of this protein. Here, we describe the generation, purification and characterization of the fi...

journal_title：Journal of pineal research

authors： Hamouda HO,Chen P,Levoye A,Sözer-Topçular N,Daulat AM,Guillaume JL,Ravid R,Savaskan E,Ferry G,Boutin JA,Delagrange P,Jockers R,Maurice P

更新日期：2007-08-01 00:00:00

abstract：:Dim light exposure of the mother during pregnancy has been proposed as one of the environmental factors that affect the fetal brain development in schizophrenia. Melatonin circulating levels are regulated by the environmental light/dark cycle. This hormone stimulates neuronal differentiation in the adult brain. Howeve...

journal_title：Journal of pineal research

authors： Galván-Arrieta T,Trueta C,Cercós MG,Valdés-Tovar M,Alarcón S,Oikawa J,Zamudio-Meza H,Benítez-King G

更新日期：2017-10-01 00:00:00

abstract：:A link between endotoxemia and nonalcoholic fatty liver disease (NAFLD) has been demonstrated in human and rodent animals. Nevertheless, the molecular mechanisms of endotoxin-evoked NAFLD remain poorly understood. We hypothesize that reactive oxygen species (ROS) mediate lipopolysaccharide (LPS)-evoked hepatic lipid a...

journal_title：Journal of pineal research

authors： Chen X,Zhang C,Zhao M,Shi CE,Zhu RM,Wang H,Zhao H,Wei W,Li JB,Xu DX

更新日期：2011-11-01 00:00:00

abstract：:Previously it has been found that pinealectomy in rats was associated with increased small bowel crypt cell proliferation. The hypothalamus is thought to play a role in the neural control of crypt cell proliferation and the pineal gland is known to be functionally connected with this component of the autonomic nervous...

journal_title：Journal of pineal research

authors： Callaghan BD

更新日期：1991-01-01 00:00:00

abstract：:Melatonin, a molecule produced in the pineal gland and retina of vertebrates, plays a major role in day-night circadian rhythms and other physiological processes, including the immune responses. Because little is known in this respect in fish, we have evaluated the in vivo role of melatonin in the main innate immune a...

journal_title：Journal of pineal research

authors： Cuesta A,Cerezuela R,Esteban MA,Meseguer J

更新日期：2008-08-01 00:00:00

abstract：:An interaction between melatonin and adrenocorticotropin (ACTH) seems to occur in humans and both hormones respond to beta-adrenergic stimulation. As in lower animal species, human pineal gland also contains alpha2-adrenergic receptors as does the hypothalamus-pituitary axis. In this study the response of the pineal g...

journal_title：Journal of pineal research

authors： Muñóz-Hoyos A,Fernández-García JM,Molina-Carballo A,Macías M,Escames G,Ruiz-Cosano C,Acuña-Castroviejo D

更新日期：2000-08-01 00:00:00

abstract：:Melatonin as a potent antioxidant exhibits important nutritional and medicinal values. To produce melatonin-enriched milk will benefit the consumers. In this study, a sheep bioreactor which generates melatonin-enriched milk has been successfully developed by the technology that combined CRISPR/Cas9 system and microinj...

journal_title：Journal of pineal research

authors： Ma T,Tao J,Yang M,He C,Tian X,Zhang X,Zhang J,Deng S,Feng J,Zhang Z,Wang J,Ji P,Song Y,He P,Han H,Fu J,Lian Z,Liu G

更新日期：2017-08-01 00:00:00

abstract：:Irradiation of the melatonin metabolite N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) with UV light of 254 nm causes the release of carbon monoxide (CO) and, thus, deformylation to N(1)-acetyl-5-methoxykynuramine (AMK). Liberation of CO was demonstrated by reduction of PdCl(2) to metallic palladium, under avoidan...

journal_title：Journal of pineal research

authors： Seever K,Hardeland R

更新日期：2008-05-01 00:00:00

abstract：:Oxidative stress is involved in ischemia-reperfusion injury and allograft rejection after transplantation. We studied two well-known antioxidants, melatonin and ascorbic acid (AA), in relation to the survival of a pancreas transplantation model without immunosuppression. Forty-eight Landrace pigs were divided into thr...

journal_title：Journal of pineal research

authors： García-Gil FA,Albendea CD,Escartín J,Lampreave F,Fuentes-Broto L,Roselló-Catafau J,López-Pingarrón L,Reiter RJ,Alvarez-Alegret R,García JJ

更新日期：2011-11-01 00:00:00

abstract：:The aim of this study was to determine, in the rat, the interaction between melatonin and cholecystokinin in the regulation of the ileal interdigestive motility. This was analyzed by the chronic electromyography technique. Ileal motility was defined by the presence of intermittent spike bursts corresponding to the con...

journal_title：Journal of pineal research

authors： Bonouali-Pellissier S

更新日期：1994-09-01 00:00:00