Genomic African and Native American Ancestry and 15-Year Cognitive Trajectory: Bambui Study, Brazil.

Abstract:

OBJECTIVES:To investigate the association between African and Native American genomic ancestry and long-term cognitive trajectories in admixed Brazilians. DESIGN:Population-based longitudinal study. SETTING:Bambui-Epigen (Brazil) cohort study. PARTICIPANTS:Adults aged 60 and older (N=1,215) MEASUREMENTS: Participants were followed from January 1997 to December 2011. Cognitive function was assessed annually using the Mini-Mental State Examination (MMSE), totaling 12,208 measurements. We used linear mixed-effects pattern models to assess MMSE score trajectories. Ancestry was assessed using a genome-wide approach. RESULTS:After adjustments for covariates, the highest quintile of African ancestry was associated with poorer baseline cognitive performance (β=-0.73, 95% confidence interval (CI)=-1.36 to -0.11) but not with cognitive trajectory. Educational level modified the baseline association between highest African ancestry and cognitive performance in that the association was observed only in those with very low (<4 years) education (β=-1.13, 95% CI=-2.02 to -0.23). No association was found between Native American ancestry and baseline cognitive function or its trajectory. CONCLUSION:Genomic African and Native American ancestry levels had no prognostic value for age-related cognitive decline in this admixed population.

journal_name

J Am Geriatr Soc

authors

Lima-Costa MF,Gouveia MH,Cesar CC,Tarazona-Santos E,Stewart R,Ferri CP,Castro-Costa E

doi

10.1111/jgs.15504

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

1956-1962

issue

10

eissn

0002-8614

issn

1532-5415

journal_volume

66

pub_type

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