Abstract:
:Genetic modifier screens offer a powerful, indeed a uniquely powerful tool for the analysis and identification of elements capable of modulating specific cellular functions in development. Here, we describe the methodology that allowed us to explore the genetic circuitry that affects a Notch mutant phenotype caused by the abnormal endosomal trafficking of the Notch receptor. Endosomal trafficking events are increasingly appreciated to play a major role in controlling Notch signaling in development.
journal_name
Methods Enzymoljournal_title
Methods in enzymologyauthors
Hori K,Sen A,Artavanis-Tsakonas Sdoi
10.1016/B978-0-12-397926-1.00016-0subject
Has Abstractpub_date
2014-01-01 00:00:00pages
283-99eissn
0076-6879issn
1557-7988pii
B978-0-12-397926-1.00016-0journal_volume
534pub_type
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