Multiple biomarker panels for early detection of breast cancer in peripheral blood.

abstract：Objective:The objective of this study is to evaluate the effect of simvastatin on the jaw bone microstructural defect and autophagy in rats with high cholesterol diet (HCD). Methods:Male Sprague-Dawley rats were fed a standard rodent chow (NC group) or a high cholesterol diet for 32 weeks and the HCD-fed rats were tre...

journal_title：BioMed research international

authors： Zhou J,Gao X,Huang S,Ma L,Cui Y,Wang H,Qiu J,Wang L,Dong Q,Chen Z,Wang X,Zhang D

更新日期：2018-06-27 00:00:00

abstract：:We investigated (a) if activation of the mitogen activated protein kinase (MAPK) pathway was linked to the stress activated protein kinase (SAPK) pathway and (b) if JNK was required for activation of c-Jun in Schwann cells of rat sciatic nerve following injury. To this aim, ERK1/2 and the transcription factors c-Jun a...

journal_title：BioMed research international

authors： Blom CL,Mårtensson LB,Dahlin LB

更新日期：2014-01-01 00:00:00

abstract：:Bacterial quorum sensing (QS) is a cell-to-cell communication in which specific signals are activated to coordinate pathogenic behaviors and help bacteria acclimatize to the disadvantages. The QS signals in the bacteria mainly consist of acyl-homoserine lactone, autoinducing peptide, and autoinducer-2. QS signaling ac...

journal_title：BioMed research international

authors： Jiang Q,Chen J,Yang C,Yin Y,Yao K

更新日期：2019-04-04 00:00:00

abstract：:Recombinant adeno-associated virus (AAV) vectors are powerful tools for both basic neuroscience experiments and clinical gene therapies for neurological diseases. Intravascularly administered self-complementary AAV9 vectors can cross the blood-brain barrier. However, AAV9 vectors are of limited usefulness because they...

journal_title：BioMed research international

authors： Iida A,Takino N,Miyauchi H,Shimazaki K,Muramatsu S

更新日期：2013-01-01 00:00:00

abstract：:Little is known about how small variations in ionic currents and Ca²⁺ and Na⁺ diffusion coefficients impact action potential and Ca²⁺ dynamics in rabbit ventricular myocytes. We applied sensitivity analysis to quantify the sensitivity of Shannon et al. model (Biophys. J., 2004) to 5%-10% changes in currents conductanc...

journal_title：BioMed research international

authors： Lo YH,Peachey T,Abramson D,McCulloch A,Michailova A

更新日期：2013-01-01 00:00:00

abstract：:Otitis media (OM) is a common inflammatory disease of the middle ear cavity and mainly occurs in children. As a critical regulator of inflammation response, the nuclear factor kappa B (NF-κB) pathway has been found to play an essential role in the pathogenesis of various human diseases. The aim of this study was to ex...

journal_title：BioMed research international

authors： Yang X,Zhang Q,Lu H,Wang C,Xia L

更新日期：2021-01-06 00:00:00

abstract：Background:This study is aimed at identifying unknown clinically relevant genes involved in colorectal cancer using bioinformatics analysis. Methods:Original microarray datasets GSE107499 (ulcerative colitis), GSE8671 (colorectal adenoma), and GSE32323 (colorectal cancer) were downloaded from the Gene Expression Omnib...

journal_title：BioMed research international

authors： Zhou J,Xie Z,Cui P,Su Q,Zhang Y,Luo L,Li Z,Ye L,Liang H,Huang J

更新日期：2020-05-23 00:00:00

abstract：:The objective of this study was the synthesis of folic acid- (FA-) targeted polymeric micelles of Synperonic PE/F 127-cholesteryl hemisuccinate (PF127-Chol) for specific delivery of docetaxel (DTX). Targeted or nontargeted micelles loaded with DTX were prepared via dialysis method. The effects of processing variables ...

journal_title：BioMed research international

authors： Varshosaz J,Taymouri S,Hassanzadeh F,Javanmard SH,Rostami M

更新日期：2015-01-01 00:00:00

abstract：:Upon allergen challenge, DC subsets are recruited to target sites under the influence of chemotactic agents; however, details pertinent to their trafficking remain largely unknown. We investigated the kinetic profiles of blood and skin-infiltrating DC subsets in twelve atopic subjects receiving six weekly intradermal ...

journal_title：BioMed research international

authors： Vittorakis S,Samitas K,Tousa S,Zervas E,Aggelakopoulou M,Semitekolou M,Panoutsakopoulou V,Xanthou G,Gaga M

更新日期：2014-01-01 00:00:00

abstract：:Pterospartum tridentatum and Mentha pulegium are largely used in Portuguese folk medicine to treat several human disorders and inflammatory processes but without any consistent evidence for those beneficial pointed properties. Thus, the aim of the current work is to evaluate its benefits and phytochemicals related to ...

journal_title：BioMed research international

authors： Aires A,Marrinhas E,Carvalho R,Dias C,Saavedra MJ

更新日期：2016-01-01 00:00:00

abstract：:Background. The aim of this study was to assess the effects of low concentrations of H2O2 on angiogenesis of human umbilical vein endothelial cells (HUVECs) in vitro and explore the underlying mechanisms. Methods. HUVECs were cultured and stimulated with different concentrations of H2O2. Flow cytometric analysis was u...

journal_title：BioMed research international

authors： Jiang S,Zhang D,Huang H,Lei Y,Han Y,Han W

更新日期：2017-01-01 00:00:00

abstract：:A growing body of evidence has indicated that high-fat diet-induced nonalcoholic fatty liver disease is usually accompanied by oxidized low-density lipoprotein (ox-LDL) deposited in the liver. The current study aimed to investigate the effect of quercetin on high-fat diet-induced ox-LDL accumulation in the liver and t...

journal_title：BioMed research international

authors： Liu L,Gao C,Yao P,Gong Z

更新日期：2015-01-01 00:00:00

abstract：:Protein phosphorylation is catalyzed by kinases which regulate many aspects that control death, movement, and cell growth. Identification of the phosphorylation site-specific kinase-substrate relationships (ssKSRs) is important for understanding cellular dynamics and provides a fundamental basis for further disease-re...

journal_title：BioMed research international

authors： Wang M,Wang T,Wang B,Liu Y,Li A

更新日期：2017-01-01 00:00:00

abstract：:This retrospective cohort study aims to describe characteristics of patients with MRONJ, to identify factors associated with MRONJ development, and to examine variables associated with favourable outcome. Totally 32 patients were followed and observed: 21 females and 11 males, in the age range 35-84 in the period from...

journal_title：BioMed research international

authors： Petrovic M,Jelovac DB,Antic S,Antunovic M,Lukic N,Sabani M,Mudrak J,Jezdic Z,Pucar A,Stefanovic A,Kuzmanovic C,Nikolic D,Konstantinovic V

更新日期：2019-03-18 00:00:00

abstract：:Muscle mass and strength progressively decrease with age, which results in a condition known as sarcopenia. Sarcopenia would lead to physical disability, poor quality of life, and death. Therefore, much is expected of an effective intervention for sarcopenia. Epidemiologic, clinical, and laboratory evidence suggest an...

journal_title：BioMed research international

authors： Wagatsuma A,Sakuma K

更新日期：2014-01-01 00:00:00

abstract：Objective:Cognitive impairment is considered to be an important complication of spinal cord injury (SCI), but its underlying mechanism remains unclear. The purpose of this study is to explore whether serum CCL21 can be used as a potential biomarker of cognitive impairment in SCI. Methods:In Neck-Shoulder and Lumbocrur...

journal_title：BioMed research international

authors： Chen Y,Liang L,Cao S,Hou G,Zhang Q,Ma H,Shi B

更新日期：2020-12-09 00:00:00

abstract：:The laser speckle contrast imaging (LSCI) is proved to be a reliable tool in flap monitoring in general surgery; however, it has not been evaluated in oral surgery yet. We applied the LSCI to compare the effect of a xenogeneic collagen matrix (Geistlich Mucograft®) to connective tissue grafts (CTG) on the microcircula...

journal_title：BioMed research international

authors： Molnár E,Molnár B,Lohinai Z,Tóth Z,Benyó Z,Hricisák L,Windisch P,Vág J

更新日期：2017-01-01 00:00:00

abstract：:Preformulation is an important step in the rational formulation of an active pharmaceutical ingredient (API). Micromeritics properties: bulk density (BD) and tapped density (TD), compressibility index (Carr's index), Hauser's ratio (H), and sieve analysis were performed in order to determine the best excipients to be ...

journal_title：BioMed research international

authors： Migoha CO,Ratansi M,Kaale E,Kagashe G

更新日期：2015-01-01 00:00:00

abstract：:Neoadjuvant radio(chemo)therapy is increasingly used in rectal cancer and induces a number of morphologic changes that affect prognostication after curative surgery, thereby creating new challenges for surgical pathologists, particularly in evaluating morphologic changes and tumour response to preoperative treatment. ...

journal_title：BioMed research international

authors： Hav M,Libbrecht L,Ferdinande L,Geboes K,Pattyn P,Cuvelier CA

更新日期：2015-01-01 00:00:00

abstract：:The incidence of acute kidney injury induced by contrast media (CI-AKI) is the third cause of AKI in hospitalized patients. Contrast media cause relevant alterations both in renal hemodynamics and in renal tubular cell function that lead to CI-AKI. The vasoconstriction of intrarenal vasculature is the main hemodynamic...

journal_title：BioMed research international

authors： Caiazza A,Russo L,Sabbatini M,Russo D

更新日期：2014-01-01 00:00:00

abstract：:The study of the normal function and pathology of the inner ear has unique difficulties as it is inaccessible during life and, so, conventional techniques of pathologic studies such as biopsy and surgical excision are not feasible, without further impairing function. Mathematical modelling is therefore particularly at...

journal_title：BioMed research international

authors： Bellos C,Rigas G,Spiridon IF,Bibas A,Iliopoulou D,Böhnke F,Koutsouris D,Fotiadis DI

更新日期：2014-01-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) and lung cancer, closely related to smoking, are major lung diseases affecting millions of individuals worldwide. The generated gas mixture of smoking is proved to contain about 4,500 components such as carbon monoxide, nicotine, oxidants, fine particulate matter, and aldeh...

journal_title：BioMed research international

authors： Hou W,Hu S,Li C,Ma H,Wang Q,Meng G,Guo T,Zhang J

更新日期：2019-06-24 00:00:00

abstract：:Black stain is characterized as a dark line or an incomplete coalescence of dark dots localized on the cervical third of the tooth. Over the last century, the etiology of black stain has been the subject of much debate. Most of the studies concerning this issue were conducted in pediatric population. According to the ...

journal_title：BioMed research international

authors： Żyła T,Kawala B,Antoszewska-Smith J,Kawala M

更新日期：2015-01-01 00:00:00

abstract：:There is a controversial relationship between HLA-A2 and Alzheimer's disease (AD). It has been suggested a modifier effect on the risk that depends on genetic loadings. Thus, the aims of this study were to evaluate this relationship and to reveal genes associated with both concepts the HLA-A gene and AD. Consequently,...

journal_title：BioMed research international

authors： Cifuentes RA,Murillo-Rojas J

更新日期：2014-01-01 00:00:00

abstract：Background:DNA methylation is essential for regulating gene expression, and the changes of DNA methylation status are commonly discovered in disease. Therefore, identification of differentially methylation patterns, especially differentially methylated regions (DMRs), in two different groups is important for understand...

journal_title：BioMed research international

authors： Zhang Y,Wang S,Wang X

更新日期：2018-11-18 00:00:00

abstract：:Objective. The purpose of this study was to (i) determine the cervical microbial composition in different abortion samples and to (ii) investigate the correlation between spontaneous abortion and cervical microbes in Korean women. Methods. We collected cervical swabs from women who had never undergone abortion (N = 36...

journal_title：BioMed research international

authors： Seo SS,Arokiyaraj S,Kim MK,Oh HY,Kwon M,Kong JS,Shin MK,Yu YL,Lee JK

更新日期：2017-01-01 00:00:00

abstract：:Energy dispersive X-ray spectroscopy microanalysis (EDX), scanning electron microscopy (SEM), and Archimedes' Principle were used to determine the characteristics of inorganic filler particles in five dental alginates, including Cavex ColorChange (C), Hydrogum 5 (H5), Hydrogum (H), Orthoprint (O), and Jeltrate Plus (J...

journal_title：BioMed research international

authors： Guiraldo RD,Berger SB,Consani RL,Consani S,de Carvalho RV,Lopes MB,Meneghel LL,da Silva FB,Sinhoreti MA

更新日期：2014-01-01 00:00:00

abstract：Purpose:We aimed to identify prognostic factors for survival and recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) for patients with HCC and hepatitis C virus-related cirrhosis (HCV-cirrhosis). Methods:This retrospective cohort study followed all adult patients with HCV-cirrhosis who underw...

journal_title：BioMed research international

authors： Vidal RIO,Vidal EIO,Pereira BB,Assane CC,Ribeiro A,do Nascimento EM,Romeiro FG,Ribeiro Filho J

更新日期：2020-10-17 00:00:00

abstract：:Microgravity influences cell differentiation by modifying the morphogenetic field in which stem cells are embedded. Preliminary data showed indeed that stem cells are committed to selective differentiation when exposed to real or simulated microgravity. Our study provides evidence that a similar event occurs when canc...

journal_title：BioMed research international

authors： Pisanu ME,Noto A,De Vitis C,Masiello MG,Coluccia P,Proietti S,Giovagnoli MR,Ricci A,Giarnieri E,Cucina A,Ciliberto G,Bizzarri M,Mancini R

更新日期：2014-01-01 00:00:00

abstract：:This study was designed to explore the effect of basic fibroblast growth factor (bFGF) on radiation-induced endothelial dysfunction and histological changes in the urinary bladder. bFGF was administrated to human umbilical vein cells (HUVEC) or urinary bladder immediately after radiation. Reduced expression of thrombo...

journal_title：BioMed research international

authors： Zhang S,Qiu X,Zhang Y,Fu K,Zhao X,Wu J,Hu Y,Zhu W,Guo H

更新日期：2015-01-01 00:00:00