Abstract:
:Dengue virus (DENV) is an emerging mosquito-borne human pathogen that affects millions of individuals each year by causing severe and potentially fatal syndromes. Despite intense research efforts, no approved vaccine or antiviral therapy is yet available. Overcoming this limitation requires detailed understanding of the intimate relationship between the virus and its host cell, providing the basis to devise optimal prophylactic and therapeutic treatment options. With the advent of novel high-throughput technologies including functional genomics, transcriptomics, proteomics, and lipidomics, new important insights into the DENV replication cycle and the interaction of this virus with its host cell have been obtained. In this chapter, we provide a comprehensive overview on the current status of the DENV research field, covering every step of the viral replication cycle with a particular focus on virus-host cell interaction. We will also review specific chemical inhibitors targeting cellular factors and processes of relevance for the DENV replication cycle and their possible exploitation for the development of next generation antivirals.
journal_name
Adv Virus Resjournal_title
Advances in virus researchauthors
Acosta EG,Kumar A,Bartenschlager Rdoi
10.1016/B978-0-12-800098-4.00001-5subject
Has Abstractpub_date
2014-01-01 00:00:00pages
1-109eissn
0065-3527issn
1557-8399pii
B978-0-12-800098-4.00001-5journal_volume
88pub_type
杂志文章,评审abstract::Human immunodeficiency virus type 1 (HIV-1) gives rise to a chronic infection that progressively depletes CD4(+) T lymphocytes. CD4(+) T lymphocytes play a central coordinating role in adaptive cellular and humoral immune responses, and to do so they migrate and interact within lymphoid compartments and at effector si...
journal_title:Advances in virus research
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journal_title:Advances in virus research
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journal_title:Advances in virus research
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journal_title:Advances in virus research
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journal_title:Advances in virus research
pub_type: 杂志文章,评审
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journal_title:Advances in virus research
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journal_title:Advances in virus research
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doi:10.1016/bs.aivir.2019.08.002
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journal_title:Advances in virus research
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更新日期:2020-01-01 00:00:00
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journal_title:Advances in virus research
pub_type: 杂志文章,评审
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journal_title:Advances in virus research
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journal_title:Advances in virus research
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journal_title:Advances in virus research
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journal_title:Advances in virus research
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journal_title:Advances in virus research
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journal_title:Advances in virus research
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journal_title:Advances in virus research
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journal_title:Advances in virus research
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journal_title:Advances in virus research
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更新日期:2014-01-01 00:00:00
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journal_title:Advances in virus research
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