[Biological therapy in idiopathic inflammatory myopathies].

Abstract:

:Idiopathic inflammatory myopathies are systemic, immune-mediated diseases characterized by proximal, symmetrical, progressive muscle weakness. The aim of this work is to give an overview of the biological therapy used in the treatment of idiopathic inflammatory myopathies. The authors also focus on novel results in the therapy directed against the B- and T-cells. They emphasize the importance of new trials in these diseases which may lead to the introduction of novel therapeutic options in these disorders. :Az idiopathiás inflammatorikus myopathiák szisztémás, a proximalis végtagizmok progresszív, szimmetrikus gyengeségével jellemezhető immunmediált betegségek. A szerzők áttekintést adnak a gyulladásos izombetegségek esetén alkalmazott biológiai terápiáról. Külön figyelmet fordítanak a B- és T-sejt-gátló terápia legújabb eredményeire. Rávilágítanak az új tanulmányok fontosságára ezen betegségekben. Mindez elvezethet új terápiás lehetőségek bevezetéséhez is. Orv. Hetil., 2014, 155(1), 3–10.

journal_name

Orv Hetil

journal_title

Orvosi hetilap

authors

Bodoki L,Nagy-Vincze M,Griger Z,Péter A,András C,Dankó K

doi

10.1556/OH.2014.29787

subject

Has Abstract

pub_date

2014-01-05 00:00:00

pages

3-10

issue

1

eissn

0030-6002

issn

1788-6120

pii

D143LM6630607510

journal_volume

155

pub_type

杂志文章,评审
  • [Changes in the myeloperoxidase activity of human neutrophilic granulocytes and the amount of enzyme deriving from them under the effect of estrogen].

    abstract::Free radicals which are produced constantly in the human body have a significant role in the development of atherosclerosis. The responsibility of leukocytes for vascular disease has been proved in several ways. Hormonally active women are protected much more against myocardial infarction than men, which fact can be e...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Békési G,Magyar Z,Kakucs R,Sprintz D,Kocsis I,Székács B,Fehér J

    更新日期:1999-07-18 00:00:00

  • [Long-term follow-up after tympanostomy tube insertion in children with serous otitis media].

    abstract:INTRODUCTION:The authors report about the efficacy of inserted tympanostomy tube in children with serous otitis media. AIM:The aim of the authors was to assess the status of eardrum, the function of Eustachian tube and hearing level 10 years after the use of tympanostomy tube. METHOD:Patients filled out a questionnai...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2015.30291

    authors: Fekete-Szabó G,Kiss F,Rovó L

    更新日期:2015-11-15 00:00:00

  • [Correlation between ABO and Rh blood groups, serum cholesterol and ischemic heart disease in patients undergoing coronarography].

    abstract:UNLABELLED:The associations of the ABO- and Rh-blood groups, the serum cholesterol and the extent of the coronary artery disease were examined in 653 patients who underwent coronary angiography between 1980 and 1985 in the Hungarian Institute of Cardiology. CONCLUSIONS:1. among the patients with positive coronarograph...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Tarján Z,Tonelli M,Duba J,Zorándi A

    更新日期:1995-04-09 00:00:00

  • [The role of real-time sonography in the differential diagnosis of acute appendicitis and in the detection of post-appendectomy complications].

    abstract::110 urgent sonography were performed on 101 patients with suspected acute appendicitis and on subsequent 26 patients 33 echography with suspected postappendectomy abscess. Although according to a few publications in connection with acute appendicitis there are characteristic sonographic signs, the authors didn't find ...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Regöly-Mérei J,Ihász M,Záborszky A,Dubecz S

    更新日期:1989-04-16 00:00:00

  • [Endoscopic and surgical removal of foreign bodies from the upper gastrointestinal tract].

    abstract::Results of management of 67 patients who swallowed foreign bodies are discussed. Types of foreign bodies, the importance of previous esophageal strictures, the rare diagnostic difficulties and the different clinical signs are analyzed. Authors stress that the most frequent causes of the artificial esophageal perforati...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Oláh T,Horváth OP,Szendrényi V,Selmeczi A

    更新日期:1993-02-14 00:00:00

  • [Experience with saphenous-peritoneal shunts in the treatment of intractable ascites].

    abstract:INTRODUCTION:The price and complication rates of pump models applied in the treatment of intractable ascites are significantly high. The development of a more simple, cheaper technique--using the biologically given venous valves--the saphenoperitoneal shunts became essential. TECHNIQUE AND RESULTS:In authors' departme...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Vizsy L,Beznicza H,Bátorfi J

    更新日期:2004-02-29 00:00:00

  • [Two-stage splenic rupture leading to the diagnosis of hepatic peliosis].

    abstract::Rare anomaly: peliosis was found in a young woman, splenectomised for rupture of the spleen. Speculations on the aetiopathogenesis of this peculiar disorder are discussed. Awareness of the pathological curiosity is also of practical relevance, because of the risk of life-threatening haemorrhagic consequences from rupt...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Gábor Z,Back F,Csiffáry D

    更新日期:1990-06-24 00:00:00

  • [Sapporo-like viruses in sporadic gastroenteritis of unknown origin].

    abstract:UNLABELLED:Sapporo-like viruses (SLVs) are members of the family Caliciviridae. The etiologic role of these viruses is evident but little is known about the incidence of acute gastroenteritis caused by them. Sapporo-like viruses have not been detected in Hungary before. METHODS:Between October and December 2000, 72 sp...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Reuter G,Farkas T,Berke T,Jiang X,Owen Matson D,Szücs G

    更新日期:2002-02-17 00:00:00

  • [Prevalence of the alpha-1 antitrypsin phenotype in Hungary].

    abstract:INTRODUCTION:Alpha-1-antitrypsin deficiency is one of the most common inherited metabolic disorders. The presence of PiZ and PiS alleles alpha-1-antitrypsin deficeing are associated with. The geographical distribution of PiZ and PiS is heterogenous in Europe. AIM:The aim of the study was to investigate the frequency o...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Szónyi L,Dobos M,Vásárhelyi B,Héninger E,Váczi Z

    更新日期:2003-04-13 00:00:00

  • [Incomplete androgen insensitivity].

    abstract::In the androgen insensitivity syndrome (AIS) the androgen effect is decreased in the fetus and the youth despite the adequate testosterone production. Usually the mutation of the androgen receptor is responsible for the disease. In the presented case the external genitalia were similar to female genitalia but masses w...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Luczay A,Sólyom J,Hiort O,Szabó E,Dobos M,Jenovári Z,Fekete G

    更新日期:2006-09-17 00:00:00

  • [Clinical significance of nodular goiter].

    abstract::The clinical characteristics of nodular goitres: relatively frequent (4-7%), diagnostic difficulties deriving from heterogeneity as well as the marked difference of treatment and prognosis. In the case of nodules the possibility of malignancy must always be considered, though the incidence is less than 5%. The pathoge...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Leövey A

    更新日期:1994-05-08 00:00:00

  • [Restricted antibody diversity after bone marrow transplantation--homogeneous immunoglobulins].

    abstract::After bone marrow transplantation, a prolonged dysregulation of humoral immunity, including restricted electrophoretic heterogeneity of serum immunoglobulins and the appearance of homogeneous immunoglobulin components, can be observed. The current study was undertaken to characterize further and define the posttranspl...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Puskás E,Hajdu M,Barta A,Sipos A,Uher F,Pálóczi K

    更新日期:2001-02-11 00:00:00

  • [Local infiltration analgesia in total joint replacement].

    abstract:INTRODUCTION:Total hip and knee replacment surgeries are characterized by severe postoperative pain. Local infiltration analgesia is proved to be very effective. However this method has not been widely used in Hungary. AIM:To evaluate the efficacy of the local infiltration analgesia with modified components in patient...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2017.30666

    authors: de Jonge T,Görgényi S,Szabó G,Torkos MB

    更新日期:2017-03-01 00:00:00

  • [A simple surgical method for removing a large floating thrombus from the ascending aorta].

    abstract::We report the successful surgical removal of a large floating thrombus from the ascending aorta causing systemic embolization. It was diagnosed by transesophageal echocardiography (TEE), CT scan, aortography and Cardiovascular Magnetic Resonance Imaging (CMR). The free-floating, highly embolic source 2 cm distal to th...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2007.27975

    authors: Szabolcs Z,Veres G,Hüttl T,Bíró G,Tóth A,Szeberin Z,Windisch M,Acsády G

    更新日期:2007-02-25 00:00:00

  • [Subacute cutaneous lupus erythematosus based on a study of 15 cases].

    abstract::15 cases of subacute cutaneous lupus erythematosus are reported. The diagnosis was based on the presence of the typical clinical features, on the histologic and immunpathologic examination of lesional skin and on the characteristic laboratory findings. 8 patients had annular type, 4 patients had papulosquamosus type o...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Marschalkó M,Dobozy E,Daróczy J,Gyimesi E,Horváth A

    更新日期:1989-12-03 00:00:00

  • [Possibilities of doctor-patient communication - understanding patients' expectations].

    abstract:INTRODUCTION:Nowadays doctor-patient consultation is not limited to personal appointments, there are new technical possibilities to keep contact. AIM:The aim of our study was to examine the way in which the doctor and patient interact with each other between two personal consultations and how the patients would like t...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2018.31209

    authors: Molnár R,Sági Z,Fejes Z,Törőcsik K,Köves B,Paulik E

    更新日期:2018-12-01 00:00:00

  • [Level of HHV-6A antibodies in symptomless HIV infection as well as in the course of AIDS].

    abstract::HHV-6A in vitro augments expression of CD4 molecules on the surface of immune cells, facilitates HIV replication and cell death in dual infections. It is hardly known whether these processes take place in vivo; does HHV-6A enhance HIV infection and AIDS progression? To study HHV-6A fresh infections and reactivation, I...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Ongrádi J,Bánhegyi D,Maródi CL,Nagy K,Csiszár A,Horváth A

    更新日期:1999-08-22 00:00:00

  • [The Hippel-Lindau syndrome is often misdiagnosed and its frequency underestimated].

    abstract::Results of epidemiological investigations were published only recently. The syndrome is particularly seldom diagnosed if the examination program is carried out not carefully enough in the case of patients, who have to be taken into consideration on the basis of different lesions. The syndrome differs from the majority...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Neumann HP

    更新日期:1996-06-02 00:00:00

  • [Pulmonary infections following solid organ transplantation].

    abstract::Solid organ transplantation is the standard of care for selected patients with severe vital organ dysfunction. The need for immunosuppression to prevent organ rejection is a common characteristic of recipients. Immunosuppression increases the risk of infections, especially with low virulence opportunistic pathogens. I...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/OH.2012.29395

    authors: Müller V,Kováts Z,Horváth G

    更新日期:2012-06-10 00:00:00

  • [Physical measurement of the dorsal kyphosis in 14-17-year old patients with Scheuermann's disease and in matched healthy controls].

    abstract::The modified use of the Debrunner-kyphometer (a special protractor to measure the dorsal kyphosis by an objective physical method) is presented. After proving the validity and reproducibility of the measuring method, the dorsal kyphosis of patients with Scheuermann's disease and of matched healthy controls was measure...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Somhegyi A,Tóth Z,Ratkó I

    更新日期:1992-03-22 00:00:00

  • [Activity of neutral endopeptidase in serum of patients with primary biliary cirrhosis].

    abstract::Neutral endopeptidase (neprilysin; EC 3.4.24.11) is present in the brush border membrane, for example in the bile ducts. We investigated serum neprilysin activity and its correlation with cholestatic markers in patients with primary biliary cirrhosis. Sera of 39 patients with primary biliary cirrhosis (37 females, 2 m...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Horvát-Karajz K,Csepregi A,Nemesánszky E,Tulassay Z,Selmeci L,Szalay F

    更新日期:2000-04-30 00:00:00

  • [SPECT--single photon emission computer tomography. A new imaging method in isotope diagnosis].

    abstract::The paper gives an introduction to the basis and quality control of a relatively new imaging method. First the different kinds of SPECT instruments, and then the aspects of diagnostic application are described. Details are given on examinations of the central nervous system, the abdomen, the hearth and the skeletal sy...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Csernay L

    更新日期:1989-03-19 00:00:00

  • [Five-year experience with the multidisciplinary evaluation of breast lesions according to the Decker radio-pathologic correlation system].

    abstract:INTRODUCTION:Lesions identified during breast imaging often require microscopic verification. Current recommendations imply the classification of radiological, clinical, cytology and core biopsy findings into one of five predefined categories. The Decker system also includes a classification of both the correlation bet...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2017.30790

    authors: Cserni G,Ambrózay É,Serfőző O

    更新日期:2017-07-01 00:00:00

  • [Comparative studies in the diagnosis of Chlamydia trachomatis infections].

    abstract::Comparative evaluation of different methods for diagnosis of chlamydial infections was carried out. During the culture of the bacteria cycloheximide treated McCoy cell line was used, and elementary and reticulate bodies were detected by monoclonal antibodies with immunofluorescent (IF) method. Chlamydia specific IgM a...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Deák J,Nedelkovics Z,Földes J

    更新日期:1994-02-27 00:00:00

  • [Drug therapy of gastroesophageal reflux (a prospective controlled clinical trial)].

    abstract::One year follow up(1.5, 3, 6, 12 months) study was established to examine the role of several classes of drugs in the treatment of reflux disease in 40 patients on the basis of objective control parameters (pH-metry, endoscopy, histology). The therapy was initiated, respectively, the different stage of severity (Savar...

    journal_title:Orvosi hetilap

    pub_type: 临床试验,杂志文章,随机对照试验,评审

    doi:

    authors: Wittmann T,Rosztóczy A,Fehér A,Jármay K,Oláh T,Szendrényi V,Kiss I

    更新日期:1998-05-03 00:00:00

  • [Prevalence, significance and therapy of premature LH rise and peak in the In Vitro Fertilization program].

    abstract::The incidence of the premature LH-rise/peak has been analysed in view to the pregnancy rate in 139 HMG and combined Buserelin + HMG cycles of an IVF-ET/GIFT program. A premature LH-rise/peak seems to be correlated with a lower pregnancy rate; therefore the cancellation of the stimulation is recommended in these cases....

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Urbancsek J,Csömör S,Benno R,Thomas R,Sztanyik L,Klaus G

    更新日期:1990-04-29 00:00:00

  • [Psychoendocrinology of menopause].

    abstract::The possible role of of the marked changes in the regulation of female sex hormones has been implicated in the higher prevalence rate of anxiety and affective disorders in women. There is no evidence, however, for a direct relationship between specific hormone alterations and psychiatric, nosologic entities in the cri...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Arató M

    更新日期:1995-02-19 00:00:00

  • [May-Thurner syndrome].

    abstract::May-Thurner syndrome, a pelvic vein congenital anomaly is the consequence of compression of the left common iliacal vein by the overlying right common iliacal artery that results in an increased risk for ileofemoral deep vein thrombosis. Authors present a case of a young female with aberration of the pelvic vein, who ...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2011.28998

    authors: Kecskeméthy Z,Holý J

    更新日期:2011-01-23 00:00:00

  • [Chiari I. malformation, a new childhood disease?].

    abstract::From July 1, 1994 to July 1, 1997 a total of 17 children with Chiari I malformation diagnosed by MRI was seen in our hospital. Six of them underwent craniocervical decompression and tonsilar resection. The major complaints of all these children were gait ataxia and persisting (longer than 6 month) headache, and one ch...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Bognár L,Bagó A,Orbay P,Gyorsok Z,Berényi E,Kónya E,Lázár E

    更新日期:2000-03-12 00:00:00

  • Antibacterial effect of local anaesthetics

    abstract::Összefoglaló. Gyógyszereink egy részének jelentős, az eredeti alkalmazástól eltérő hatása is van. Ezek felismerése fontos, hogy elkerüljük a nem várt mellékhatásokat, vagy kihasználjuk ezeket a kedvező adottságokat. A helyi érzéstelenítők antibakteriális hatása 1909 óta ismert, de ennek több évtizeden keresztül nem tu...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2021.32002

    authors: Szabó Z,Szentkirályi É,Kovács T,Győrffy Ö,Sütő B,Bátai I,Kerényi M

    更新日期:2021-01-31 00:00:00