当前位置： SCI文献检索 > APPLIED MICROBIOLOGY AND BIOTECHNOLOGY期刊下所有文献 > Sodium chloride improves pullulan production by Aureobasidium pullulans but reduces the molecular weight of pullulan.

Sodium chloride improves pullulan production by Aureobasidium pullulans but reduces the molecular weight of pullulan.

Abstract：

:The effect of sodium chloride (NaCl) on pullulan production by batch culture of Aureobasidium pullulans CCTCC M 2012259 was investigated. NaCl at 3 g/L improved the pullulan titer by 26.7% but reduced the molecular weight of pullulan to only 46.8% of that obtained in the control without NaCl. In order to elucidate the physiological mechanism underlying the effect of NaCl on pullulan production, assays of key enzyme activity, gene expression, energy metabolism, and intracellular uridine diphosphate glucose (UDP-glucose) content were performed. Results indicated that NaCl increased the activities of α-phosphoglucose mutase and glucosyltransferase involved in pullulan biosynthesis, increased the activities of α-amylase being responsible for pullulan degradation, upregulated the transcriptional levels of pgm1, fks, and amy2 genes, enhanced the driving force for ATP supply, and helped to maintain intracellular UDP-glucose at a high level in A. pullulans CCTCC M 2012259. All these results illuminate the reason by which NaCl increases pullulan titer but reduces the molecular weight of pullulan.

journal_name

Appl Microbiol Biotechnol

journal_title

Applied microbiology and biotechnology

authors

Wang DH,Ni TF,Ju XM,Wei GY

doi

10.1007/s00253-018-9292-y

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

8921-8930

issue

20

eissn

0175-7598

issn

1432-0614

pii

10.1007/s00253-018-9292-y

journal_volume

102

pub_type

杂志文章

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