Preoperative immunonutrition decreases postoperative complications by modulating prostaglandin E2 production and T-cell differentiation in patients undergoing pancreatoduodenectomy.

Abstract:

BACKGROUND:An immune-enhancing diet has been used to alter eicosanoid synthesis, cytokine production, and immune function in an attempt to limit the undesired immune reactions after injury from surgery. This prospective randomized study was designed to investigate the effect of preoperative immunonutrition on operative complications, and the participation of prostaglandin E2 (PGE2) on T-cell differentiation in patients undergoing a severely stressful surgery. METHODS:The enrolled patients who were scheduled to undergo pancreatoduodenectomy were randomized into two groups. Patients in the immunonutrition group (n = 25) received oral supplementation containing arginine, ω-3 fatty acids, and RNA for 5 days before the procedure in addition to a 50% reduction in the amount of regular food. Patients in the control group (n = 25) received no artificial nutrition and were allowed to consume regular food before surgery. All patients received early postoperative enteral infusion of a standard formula intended to provide 25 kcal/kg/day. The primary endpoint was the rate of infectious complications; the secondary endpoint was immune responses. This study is registered with ClinicalTrials.gov (NCT01256034). RESULTS:Infectious complication rate and severity of complications (Clavien-Dindo classification) were lesser in the immunonutrition group than in the control group. mRNA expression levels of T-bet were greater in the immunonutrition group than in the control group (P < .05). Serum eicosapentaenoic acid and eicosapentaenoic acid/arachidonic acid ratios were greater in the immunonutrition group than in the control group (P < .05). The levels of plasma PGE2 were lesser in the immunonutrition group than in the control group (P < .05). CONCLUSION:Preoperative immunonutrition modulates PGE2 production and T-cell differentiation and may protect against the aggravation of operative complications in patients undergoing pancreatoduodenectomy.

journal_name

Surgery

journal_title

Surgery

authors

Aida T,Furukawa K,Suzuki D,Shimizu H,Yoshidome H,Ohtsuka M,Kato A,Yoshitomi H,Miyazaki M

doi

10.1016/j.surg.2013.05.040

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

124-33

issue

1

eissn

0039-6060

issn

1532-7361

pii

S0039-6060(13)00285-7

journal_volume

155

pub_type

杂志文章,随机对照试验

相关文献

SURGERY文献大全
  • Prospective, randomized trial of intravenous versus intraperitoneal 5-fluorouracil in patients with advanced primary colon or rectal cancer.

    abstract::No new chemotherapy agents have been developed recently that present hope for improving survival in patients with colon or rectal cancer. We undertook this study to investigate a new route of administering an old drug, 5-fluorouracil (5-FU). Sixty-six patients with advanced primary colon or rectal cancer were randomiz...

    journal_title:Surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Sugarbaker PH,Gianola FJ,Speyer JC,Wesley R,Barofsky I,Meyers CE

    更新日期:1985-09-01 00:00:00

  • Results of reoperation for hyperparathyroidism, with evaluation of preoperative localization studies.

    abstract::During the past 3 years (June, 1974, to July, 1977), 51 patients underwent reoperation for persistent or recurrent hyperparathyroidism at the Mayo Clinica. The overall success rate for cervical reoperation was 72% and for mediastinal reoperation, was 64%. Arteriography alone provided accurate preoperative localization...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Edis AJ,Sheedy PF,Beahrs OH,van Heerden JA

    更新日期:1978-09-01 00:00:00

  • Reverse electrical pacing improves intestinal absorption and transit time.

    abstract::This study evaluates the effect of reverse electrical pacing on intestinal absorption and transit time in an enterostomy model. Twenty-five male Sprague-Dawley rats (148 to 208 gm) underwent division and anastomosis of the proximal jejunum to eliminate the proximal gastroduodenal pacemaker. A 30.0 cm loop ileostomy wa...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Sawchuk A,Nogami W,Goto S,Yount J,Grosfeld JA,Lohmuller J,Grosfeld MD,Grosfeld JL

    更新日期:1986-08-01 00:00:00

  • Effect of hydroxyl radical scavenging on endotoxin-induced lung injury.

    abstract::The release of oxygen radicals, in particular the hydroxyl radical, from sequestered neutrophils produces acute lung injury after a number of insults. Our purpose was to determine whether hydroxyl radical, OH., is responsible for the lung injury from endotoxin characterized by (1) pulmonary leukostasis, (2) increased ...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Wong C,Fox R,Demling RH

    更新日期:1985-03-01 00:00:00

  • Trainee satisfaction in surgery residency programs: modern management tools ensure trainee motivation and success.

    abstract:OBJECTIVE:To assess trainee satisfaction in their surgery residency with a validated instrument and identify the contributing factors. BACKGROUND:Currently, surgery is deemed unattractive by medical students and ignored by many candidates planning to enter an academic career. New insights on the rational for such lack...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2011.07.037

    authors: von Websky MW,Oberkofler CE,Rufibach K,Raptis DA,Lehmann K,Hahnloser D,Clavien PA

    更新日期:2012-11-01 00:00:00

  • Hypoglycemia after resection of pheochromocytoma.

    abstract:BACKGROUND:Hypoglycemia after resection of pheochromocytoma is a rare and poorly understood complication thought to be secondary to rebound hyperinsulinemia and increased peripheral glucose uptake. We examined the incidence of this complication and aimed to identify predisposing risk factors. METHODS:Patients who unde...

    journal_title:Surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.surg.2014.08.020

    authors: Chen Y,Hodin RA,Pandolfi C,Ruan DT,McKenzie TJ

    更新日期:2014-12-01 00:00:00

  • Differences in endothelial function and morphologic modulation between canine autogenous venous and arterial grafts: endothelium and intimal thickening.

    abstract:BACKGROUND:Late graft failure is still a problem for vascular surgeons. A previous study showed superior patency of arterial grafts compared with venous grafts. In this review we discuss the differences in functional and morphologic modulation of experimental autogenous venous and arterial grafts. RESULTS:In canine ve...

    journal_title:Surgery

    pub_type: 杂志文章,评审

    doi:10.1067/msy.2002.119797

    authors: Komori K,Inoguchi H,Kume M,Shoji T,Furuyama T

    更新日期:2002-01-01 00:00:00

  • Prognostic significance of tumor DNA content in carcinoma of the hepatic duct confluence.

    abstract:BACKGROUND:In an attempt to identify prognostic factors in carcinoma of the hepatic duct confluence, the value of tumor DNA content was studied in 58 patients with this type of malignancy. METHODS:Of 58 patients (ages 26 to 74 years) surgically treated for carcinoma of the hepatic duct confluence, tumor DNA content wa...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Sato Y,van Gulik TM,Bosma A,Lygidakis NJ,Koyama K,van der Heyde MN

    更新日期:1994-04-01 00:00:00

  • Multicenter analysis of diaphragm pacing in tetraplegics with cardiac pacemakers: positive implications for ventilator weaning in intensive care units.

    abstract:BACKGROUND:Diaphragm pacing (DP) can replace mechanical ventilation in tetraplegics and in trials has assisted respiration in amyotrophic lateral sclerosis patients. This report describes results of DP in patients with cardiac pacemakers. METHODS:Prospective, single-center and multicenter, nonrandomized, controlled, i...

    journal_title:Surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.surg.2010.07.008

    authors: Onders RP,Khansarinia S,Weiser T,Chin C,Hungness E,Soper N,Dehoyos A,Cole T,Ducko C

    更新日期:2010-10-01 00:00:00

  • Genotype-phenotype pancreatic neuroendocrine tumor relationship in multiple endocrine neoplasia type 1 patients: A 23-year experience at a single institution.

    abstract:BACKGROUND:The aim of this study was to investigate the genotype-phenotype relationship of pancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1 treated at our institution. METHODS:We conducted a retrospective chart review of all patients with multiple endocrine neoplasia type 1 treated...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2017.04.044

    authors: Christakis I,Qiu W,Hyde SM,Cote GJ,Grubbs EG,Perrier ND,Lee JE

    更新日期:2018-01-01 00:00:00

  • Reduction of polymorphonuclear leukocyte accumulations by inhibition of cyclooxygenase and thromboxane syntase in the rabbit.

    abstract::Thromboxane (Tx) inhibition prevents pulmonary leukostasis after acid aspiration. This observation prompted study of polymorphonuclear leukocyte (PMN) accumulations and products of cyclooxygenase. Experiments were conducted with a skin abrasion preparation. Five groups of six rabbits were pretreated intravenously with...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Palder SB,Huval W,Lelcuk S,Alexander F,Shepro D,Mannick JA,Hechtman HB

    更新日期:1986-01-01 00:00:00

  • CT-MIBI image fusion: a new preoperative localization technique for primary, recurrent, and persistent hyperparathyroidism.

    abstract:BACKGROUND:Successful minimally invasive or imaging-guided operations in patients with primary, recurrent, and persistent hyperparathyroidism are based on the reliability of preoperative parathyroid localization studies. The CT-MIBI image fusion promises a higher diagnostic accuracy than current imaging procedures. The...

    journal_title:Surgery

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0039-6060(03)00396-9

    authors: Profanter C,Wetscher GJ,Gabriel M,Sauper T,Rieger M,Kovacs P,Bale R,Prommegger R

    更新日期:2004-02-01 00:00:00

  • Efficacy of type-specific and cross-reactive murine monoclonal antibodies directed against endotoxin during experimental sepsis.

    abstract::To study the role of antibodies in promoting survival during gram-negative bacterial sepsis, we have developed several murine monoclonal antibodies (MAbs). One MAb (5B10) reacted in an enzyme-linked immunosorbent assay with only a single organism (Escherichia coli 0111:B4), while the other (8A1) reacted to all gram-ne...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Dunn DL,Bogard WC Jr,Cerra FB

    更新日期:1985-08-01 00:00:00

  • The biologic features of intramucosal gastric carcinoma with lymph node metastasis.

    abstract::This review concentrates on the clinicopathologic studies and molecular biologic studies of intramucosal gastric carcinomas (IMGCs) with lymph node metastasis that have been published to date. There have been several reports in which IMGCs with lymph node metastasis were compared with IMGCs without lymph node metastas...

    journal_title:Surgery

    pub_type: 杂志文章,评审

    doi:10.1067/msy.2002.119307

    authors: Kabashima A,Maehara Y,Koga T,Kakeji Y,Sugimachi K

    更新日期:2002-01-01 00:00:00

  • Treatment of benign thyroid cysts by intracystic injection of OK-432.

    abstract:BACKGROUND:Benign thyroid cysts have been successfully treated with nonoperative sclerotherapy. Although OK-432 is a safe and effective sclerosing agent used to treat benign cystic lesions, little is known about its effectiveness in thyroid cysts. This study tested the efficacy of OK-432 sclerotherapy for thyroid cysts...

    journal_title:Surgery

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.surg.2008.06.014

    authors: Roh JL,Park C 2nd

    更新日期:2008-11-01 00:00:00

  • A comparative study of postoperative complications after hepatectomy in patients with and without chronic liver disease.

    abstract:BACKGROUND:Although hepatic resection is the most reliable treatment for hepatocellular carcinoma, impaired liver function because of cirrhosis or chronic hepatitis contributes to relatively high rates of postoperative complications. We have reviewed a series of hepatectomies at our institution and investigated risk fa...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Midorikawa Y,Kubota K,Takayama T,Toyoda H,Ijichi M,Torzilli G,Mori M,Makuuchi M

    更新日期:1999-09-01 00:00:00

  • Social media is a necessary component of surgery practice.

    abstract::Social media is a necessary component of the practice of surgery. Each surgeon must embrace the power and potential of social media and serve as a guide or content expert for patients and other health care providers to facilitate and share responsible use of the various media available. Social media facilitates rapid ...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2015.06.002

    authors: Steele SR,Arshad S,Bush R,Dasani S,Cologne K,Bleier JI,Raphaeli T,Kelz RR,Society of University Surgeons' Social and Legislative Committee.

    更新日期:2015-09-01 00:00:00

  • Cutaneous thermal injury alters macromolecular permeability of rat small intestine.

    abstract::The intestinal epithelium normally provides a barrier function that prevents absorption of potentially harmful materials from the intestinal lumen. It has been postulated but never demonstrated that a cutaneous thermal injury will result in increased small-intestinal permeability. In a standardized 20% body surface ar...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Carter EA,Tompkins RG,Schiffrin E,Burke JF

    更新日期:1990-03-01 00:00:00

  • Regional oral tolerance in transgenic 2C mice.

    abstract:BACKGROUND:Antigen injected subcutaneously (SQ) results in a strong systemic immune response, whereas antigen infused orally or by the portal vein tends to induce tolerance. Nontransgenic C57BL/6J (H-2(b)), or B6, mice and transgenic 2C mice (that express a cytotoxic T cell receptor against major histocompatibility com...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2005.05.010

    authors: Margenthaler JA,Flye MW

    更新日期:2005-08-01 00:00:00

  • Continuous monitoring and control of plasma glucose during operation for removal of insulinomas.

    abstract::A glucose-controlled insulin and glucose infusion system (Biostator system, Miles Laboratories Inc., Elkhart, Ind.) was used during operation for removal of four suspected insulinomas. In two patients the Biostator system continuously monitored plasma glucose levels and, through a computer-controlled feedback mechanis...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Schwartz SS,Horwitz DL,Zehfus B,Langer BG,Kaplan E

    更新日期:1979-06-01 00:00:00

  • The use of error analysis to assess resident performance.

    abstract:BACKGROUND:The aim of this study was to assess validity of a human factors error assessment method for evaluating resident performance during a simulated operative procedure. METHODS:Seven postgraduate year 4-5 residents had 30 minutes to complete a simulated laparoscopic ventral hernia (LVH) repair on day 1 of a nati...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2015.04.010

    authors: D'Angelo AL,Law KE,Cohen ER,Greenberg JA,Kwan C,Greenberg C,Wiegmann DA,Pugh CM

    更新日期:2015-11-01 00:00:00

  • Practicality of using galvanic skin response to measure intraoperative physiologic autonomic activation in operating room team members.

    abstract:BACKGROUND:Physiologic and psychological stress are commonly experienced by operating room (OR) personnel, yet there is little research about the stress levels in OR teams and their impact on performance. Previously published procedures to measure physiologic activation are invasive and impractical for the OR. The purp...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2015.04.009

    authors: Phitayakorn R,Minehart RD,Pian-Smith MC,Hemingway MW,Petrusa ER

    更新日期:2015-11-01 00:00:00

  • Pilot study of a population-based survey to assess the prevalence of surgical conditions in Uganda.

    abstract:BACKGROUND:Noncommunicable diseases, including those requiring surgical care, are increasingly straining low- and middle-income countries. Globally, 11% of all disability-adjusted life-years lost result from conditions requiring surgery; however, little is known about country-specific burden. We piloted a household-bas...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2015.05.011

    authors: Butler EK,Tran TM,Fuller AT,Makumbi F,Luboga S,Kisakye S,Haglund MM,Chipman JG,Galukande M

    更新日期:2015-09-01 00:00:00

  • Predictors of improved survival for patients with retroperitoneal sarcoma.

    abstract:BACKGROUND:Retroperitoneal sarcomas are rare tumors that can be locally aggressive with high rates of recurrence. Given that data on survival in patients with retroperitoneal sarcomas are conflicting, we sought to use a nationwide cancer database to identify factors associated with survival in patients with retroperito...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2016.05.041

    authors: Giuliano K,Nagarajan N,Canner JK,Wolfgang CL,Bivalacqua T,Terezakis S,Herman J,Schneider EB,Ahuja N

    更新日期:2016-12-01 00:00:00

  • Perfusion cholangiomanometry with papillary stimulation by dilute hydrochloric acid.

    abstract::A modification of cholangiomanometry in which the papilla of Vater was stimulated by hydrochloric acid was devised as a means to evaluate the papillary function. Manometric tracings could be classified into four patterns according to the mode of response to hydrochloric acid of the papilla. Pattern I was the type in w...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Matsushiro T,Nagashima H,Yamamoto K,Hariu T

    更新日期:1984-01-01 00:00:00

  • Physiologic response to cricopharyngeal myotomy and diverticulum suspension.

    abstract::Ten patients who had a cricopharyngeal myotomy and diverticulum suspension for pharyngoesophageal diverticulum have been studied clinically, radiologically, and manometrically. There were no deaths or morbidity and all patients have achieved marked improvement of their symptoms. Before operation all patients but one h...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Duranceau A,Rheault MJ,Jamieson GG

    更新日期:1983-10-01 00:00:00

  • Hemostasis in minimally invasive liver surgery.

    abstract::Two cases are reviewed here that highlight the utility of minimally invasive surgery (MIS) techniques in major surgery procedures involving the liver. They also demonstrate specific operative procedures once thought beyond the scope of the MIS surgeon, but they are now standard in expert hands. Improved methods for at...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2007.08.008

    authors: Saxton ML

    更新日期:2007-10-01 00:00:00

  • Impact of perioperative administration of synbiotics in patients with esophageal cancer undergoing esophagectomy: a prospective randomized controlled trial.

    abstract:BACKGROUND:The clinical value of synbiotics in patients undergoing esophagectomy remains unclear. This study investigated the effects of synbiotics on intestinal microflora and surgical outcomes in a clinical setting. METHODS:We studied 70 patients with esophageal cancer who were scheduled to undergo esophagectomy. Th...

    journal_title:Surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.surg.2012.02.021

    authors: Tanaka K,Yano M,Motoori M,Kishi K,Miyashiro I,Ohue M,Ohigashi H,Asahara T,Nomoto K,Ishikawa O

    更新日期:2012-11-01 00:00:00

  • Portopulmonary shunt by splenopneumopexy as a surgical treatment of Budd-Chiari syndrome.

    abstract::Portopulmonary shunting by splenopneumopexy was devised as a new surgical procedure for treatment of portal hypertension accompanied by Budd-Chiari syndrome. Technique of this procedure is simple and is safely performed. The remarkable portopulmonary shunts were visualized by splenoportography postoperatively. Splenic...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Akita H,Sakoda K

    更新日期:1980-01-01 00:00:00

  • Acute reversible renal failure following jejunoileal bypass for morbid obesity: a clinical and pathological (EM) study of a case.

    abstract::A patient who underwent jejunoileal bypass for morbid obesity developed servere renal failure associated with hyperoxaluria and renal oxalosis. Renal function improved and oxalate excretion decreased following hemodialysis and restoration of gastrointestinal continuity. ...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Ehlers SM,Posalaky Z,Strate RG,Quattlebaum FW

    更新日期:1977-11-01 00:00:00