Mast cell histamine promotes the immunoregulatory activity of myeloid-derived suppressor cells.

abstract：:Polymorphonuclear leukocytes (PMNs) exert most of their physiological functions while adherent to surfaces rather than in suspension. PMN adhesion is largely dependent on the function of the beta 2 integrins, CD11a,b,c/CD18. We mimicked engagement of beta 2 integrins by antibody cross-linking of CD18 on isolated human...

journal_title：Journal of leukocyte biology

authors： Walzog B,Seifert R,Zakrzewicz A,Gaehtgens P,Ley K

更新日期：1994-11-01 00:00:00

abstract：:Regulation of macrophage PCD plays an important role in pathogenesis of leishmaniasis. However, the precise involvement of any parasite molecule in this process remains uncertain. In the current study, in silico wide analysis demonstrated that genes in the Leishmania donovani genome are highly enriched for CpG motifs,...

journal_title：Journal of leukocyte biology

authors： Das S,Ghosh AK,Singh S,Saha B,Ganguly A,Das P

更新日期：2015-02-01 00:00:00

abstract：:TLR agonists such as LPS and poly(I:C) induce expression of type I IFNs, such as IFN-α and -β, by macrophages. To examine the role of IFN-β in the induction of ISGs by LPS, we compared the ability of LPS to induce ISGF3 activity and ISG expression in bone marrow-derived macrophages from WT and Ifnb1(-/-) mice. We foun...

journal_title：Journal of leukocyte biology

authors： Sheikh F,Dickensheets H,Gamero AM,Vogel SN,Donnelly RP

更新日期：2014-10-01 00:00:00

abstract：:The synthesis and secretion of prostaglandins and leukotrienes by mouse peritoneal macrophages is under several regulatory controls. Arachidonic acid must first be released from phospholipid stores by the action of phospholipases. Macrophages have the capacity to deacylate arachidonic acid directly from the SN2 positi...

journal_title：Journal of leukocyte biology

authors： Bonney RJ,Humes JL

更新日期：1984-01-01 00:00:00

abstract：:Besides their growth-inhibiting and differentiation-inducing properties, retinoids have been shown to exert immunomodulatory and anti-inflammatory functions by mechanisms that are not well understood. Tumor necrosis factor-alpha (TNF), a cytokine produced by mononuclear phagocytes, has been shown to be an important me...

journal_title：Journal of leukocyte biology

authors： Mehta K,McQueen T,Tucker S,Pandita R,Aggarwal BB

更新日期：1994-03-01 00:00:00

abstract：:The success of using immune checkpoint inhibitors to treat cancers implies that inhibiting an immunosuppressive cytokine, such as TGF-β2, could be a strategy to develop novel adjuvants for microbial vaccines. To develop nucleic acid based TGF-β2 inhibitors, we designed three antisense oligonucleotides, designated as T...

journal_title：Journal of leukocyte biology

authors： Tu L,Sun X,Yang L,Zhang T,Zhang X,Li X,Dong B,Liu Y,Yang M,Wang L,Yu Y

更新日期：2020-11-01 00:00:00

abstract：:A sensitive in vitro assay for generation of human leukocytic pyrogen has been used to study the pathogenesis of fever accompanying administration of human alpha-interferon. Unlike other potent pyrogens, two recombinant interferon preparations tested over a wide concentration range did not stimulate release of leukocy...

journal_title：Journal of leukocyte biology

authors： Ackerman SK,Hochstein HD,Zoon K,Browne W,Rivera E,Elisberg B

更新日期：1984-07-01 00:00:00

abstract：:Endotoxin (lipopolysaccharide, LPS) is known to induce inflammatory responses, such as monocyte/macrophage adherence, migration, and accumulation. Recruitment and accumulation of macrophages during infection and inflammation are regulated by integrin-mediated cell-extracellular matrix interactions. In the present repo...

journal_title：Journal of leukocyte biology

authors： Kang YH,Lee CH,Brummel SE,Newball HH,Forrester J

更新日期：1995-04-01 00:00:00

abstract：:MMPs are generally considered to regulate degradation and remodeling of the ECM. Convincing data also implicate a role for MMPs in inflammatory conditions, such as AP, although the mechanisms are not known. The aim of this study was to define the role of MMPs in regulating activation of trypsinogen and tissue damage i...

journal_title：Journal of leukocyte biology

authors： Awla D,Abdulla A,Syk I,Jeppsson B,Regnér S,Thorlacius H

更新日期：2012-05-01 00:00:00

abstract：:The key role of TRAF6 in TLR signaling pathways is well known. More recent evidence has implicated TRAF3 as another TRAF family member important to certain TLR responses of myeloid cells. Previous studies demonstrate that TRAF3 functions are highly context-dependent, displaying receptor and cell-type specificity. We t...

journal_title：Journal of leukocyte biology

authors： Xie P,Poovassery J,Stunz LL,Smith SM,Schultz ML,Carlin LE,Bishop GA

更新日期：2011-12-01 00:00:00

abstract：:The absence or reduction of CFTR function causes CF and results in a pulmonary milieu characterized by bacterial colonization and unresolved inflammation. The ineffectiveness at controlling infection by species such as Pseudomonas aeruginosa suggests defects in innate immunity. Macrophages, neutrophils, and DCs have a...

journal_title：Journal of leukocyte biology

authors： Bonfield TL,Hodges CA,Cotton CU,Drumm ML

更新日期：2012-11-01 00:00:00

abstract：:The interaction between CD40 on dendritic cells (DC) and its ligand CD154 has been recognized to be an important feature in the maturation of DC. Here, we were interested in the role of CD44 a surface receptor shown to mediate cell-cell adhesion and binding to Hyaluronic acid (HA). Western blot analysis of human DC st...

journal_title：Journal of leukocyte biology

authors： Termeer C,Johannsen H,Braun T,Renkl A,Ahrens T,Denfeld RW,Lappin MB,Weiss JM,Simon JC

更新日期：2001-11-01 00:00:00

abstract：:Stromal cell-derived factor 1alpha (SDF-1alpha) is the exclusive ligand for the chemokine receptor CXCR4. This receptor plays a pivotal role in immune responses, the pathogenesis of infection such as HIV, and cellular trafficking. However, the signaling mechanisms regulating SDF-driven T cell migration are not well de...

journal_title：Journal of leukocyte biology

authors： Shahabi NA,McAllen K,Sharp BM

更新日期：2008-03-01 00:00:00

abstract：:2-Arachidonoyl-glycerol (2-AG) and arachidonyl-ethanolamide (AEA) are endocannabinoids that have been implicated in many physiologic disorders, including obesity, metabolic syndromes, hepatic diseases, pain, neurologic disorders, and inflammation. Their immunomodulatory effects are numerous and are not always mediated...

journal_title：Journal of leukocyte biology

authors： Turcotte C,Chouinard F,Lefebvre JS,Flamand N

更新日期：2015-06-01 00:00:00

abstract：:Leukocytes have been implicated to be involved in the pathogenesis of IgA nephropathy (IgAN). To clarify the precise molecular mechanism of recruitment and activation of leukocytes in the subgroups of IgAN, latent, acute, and chronic types, we studied monocyte chemotactic and activating factor (MCAF/MCP-1) and interle...

journal_title：Journal of leukocyte biology

authors： Yokoyama H,Wada T,Furuichi K,Segawa C,Shimizu M,Kobayashi K,Su S,Mukaida N,Matsushima K

更新日期：1998-04-01 00:00:00

abstract：:A murine model of allergic bronchopulmonary aspergillosis (ABPA), developed by exposure to Aspergillus fumigatus antigens, demonstrated eosinophilia of peripheral blood (PB), bone marrow (BM), and lung. The eosinophilia was abrogated by monoclonal anti-interleukin-5 (IL-5) antibody (TRFK-5) and not by an isotype contr...

journal_title：Journal of leukocyte biology

authors： Murali PS,Kumar A,Choi H,Banasal NK,Fink JN,Kurup VP

更新日期：1993-03-01 00:00:00

abstract：:The promoters of the IL-8, MCP-1, and RANTES genes contain binding sites for the redox-responsive transcription factors AP-1 and NF-kappaB, which have been shown to be important for their expression. In this overview, we present evidence from our laboratories that the stimulus-specific regulation of these chemokines b...

journal_title：Journal of leukocyte biology

authors： Roebuck KA,Carpenter LR,Lakshminarayanan V,Page SM,Moy JN,Thomas LL

更新日期：1999-03-01 00:00:00

abstract：:Several alterations in the expression of immune-related transcripts were identified recently in the degenerating retina of the retinoschisin knockout (Rs1h(-/Y)) mouse, including the strong expression of the adaptor protein Dap12. As Dap12 is found in leukocytes, we hypothesized that its disease-related expression may...

journal_title：Journal of leukocyte biology

authors： Weigelt K,Ernst W,Walczak Y,Ebert S,Loenhardt T,Klug M,Rehli M,Weber BH,Langmann T

更新日期：2007-12-01 00:00:00

abstract：:Previously, we showed that NO induces thymocyte apoptosis via a caspase-1-dependent mechanism [(1) ]. In the present study, we investigated the role of heme oxygenase, catalase, bax, and p53 in this process. The NO donor, S-nitroso-N-acetyl penicillamine (SNAP), induced DNA fragmentation in thymocytes in a time- and c...

journal_title：Journal of leukocyte biology

authors： Gordon SA,Abou-Jaoude W,Hoffman RA,McCarthy SA,Kim YM,Zhou X,Zhang XR,Simmons RL,Chen Y,Schall L,Ford HR

更新日期：2001-07-01 00:00:00

abstract：:We have shown previously that homotypic interaction of resting memory CD4 T cells with activated T cells induces the production of cytokines with immunoregulatory potential (IL-10, IL-4) from the former. Here, we analyzed the effector functions of these T cells stimulated by homotypic T cell interaction. T cells induc...

journal_title：Journal of leukocyte biology

authors： Thümmler K,Leipe J,Ramming A,Schulze-Koops H,Skapenko A

更新日期：2010-11-01 00:00:00

abstract：:Eosinophils were isolated from peritoneal lavages of repeated horse serum-injected guinea pigs or rhesus monkeys and from peripheral blood of normal human donors. Eicosanoid metabolism and chemotaxis by these cells were studied by in vitro techniques. Upon calcium ionophore stimulation guinea pig eosinophils released ...

journal_title：Journal of leukocyte biology

authors： Sun FF,Crittenden NJ,Czuk CI,Taylor BM,Stout BK,Johnson HG

更新日期：1991-08-01 00:00:00

abstract：:G-CSF and GM-CSF play important roles in regulating neutrophil production, survival, differentiation, and function. However, we have shown previously that G-CSF/GM-CSF double-deficient [knockout (KO)] mice still develop a profound neutrophilia in bone marrow and blood after infection with Candida albicans. This findin...

journal_title：Journal of leukocyte biology

authors： Zhang HH,Basu S,Wu F,Begley CG,Saris CJ,Dunn AR,Burgess AW,Walker F

更新日期：2007-10-01 00:00:00

abstract：:This is largely a history of attempts from approximately 1960 until about 1980-81 to understand the mechanisms by which neutrophils are activated by chemotactic factors to induce chemotaxis and granule secretion. As such, it deals with the growth of our knowledge of neutrophil chemotactic factors and their receptors; ...

journal_title：Journal of leukocyte biology

authors： Becker EL

更新日期：1990-04-01 00:00:00

abstract：:On the surface of the macrophage, annexin A2 tetramer (A2t) serves as a docking protein or recognition element for bacterial and viral pathogens. Plasma levels of free A2t have been reported to increase following infection, although the mechanistic significance of this observation is unclear. Although annexin A2 had g...

journal_title：Journal of leukocyte biology

authors： Swisher JF,Khatri U,Feldman GM

更新日期：2007-11-01 00:00:00

abstract：:In this study, we demonstrate that freshly adherent bovine monocytes release tumor necrosis factor-alpha (TNF-alpha) in response to stimulation with bacterial lipopolysaccharide (LPS). TNF-alpha was detected using actinomycin D-treated WEHI-164 murine fibrosarcoma cells as targets in an 18 hr cytotoxicity assay. Doses...

journal_title：Journal of leukocyte biology

authors： Adams JL,Czuprynski CJ

更新日期：1990-12-01 00:00:00

abstract：:A role for the dietary trace mineral element selenium in the reduction of cancer incidence has been documented in numerous epidemiological and experimental studies. The precise mechanism of this antitumor effect is not well understood, but published data suggest that both inhibition of tumor cell growth and enhancemen...

journal_title：Journal of leukocyte biology

authors： Petrie HT,Klassen LW,Kay HD

更新日期：1989-03-01 00:00:00

abstract：:Highly active antiretroviral therapy (HAART) against human immunodeficiency virus type 1 (HIV-1) infection dramatically suppresses viral load, leading to marked reductions in HIV-1 associated morbidity and mortality. However, infected cell reservoirs and low-level replication persist in the face of suppressive HAART, ...

journal_title：Journal of leukocyte biology

authors： Kennedy PE,Bera TK,Wang QC,Gallo M,Wagner W,Lewis MG,Berger EA,Pastan I

更新日期：2006-11-01 00:00:00

abstract：:Epinephrine inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF) production by increasing intracellular cAMP concentrations. Because agents that increase cAMP levels can enhance TNF receptor expression in vitro, granulocyte and monocyte TNF receptors were determined by FACS-analysis in 7 normal humans...

journal_title：Journal of leukocyte biology

authors： van der Poll T,Calvano SE,Kumar A,Coyle SM,Lowry SF

更新日期：1997-02-01 00:00:00

abstract：:HIV infection causes rapid and lasting defects in the population of Vgamma2Vdelta2 T cells. To fully describe the impact of HIV, we examined PBMC samples from HIV+ patients receiving highly active antiretroviral therapy, who had displayed prolonged viral control and CD4 counts above 300 cells/mm3. We observed lower fr...

journal_title：Journal of leukocyte biology

authors： Cummings JS,Cairo C,Armstrong C,Davis CE,Pauza CD

更新日期：2008-08-01 00:00:00

abstract：:Annexin A1 is a glucocorticoid-regulated, anti-inflammatory protein, which plays an important role as an endogenous regulator of the inflammatory response. Many of these anti-inflammatory properties are retained in the N-terminal annexin A1 peptide Ac1-25, which is released from the full-length protein by a neutrophil...

journal_title：Journal of leukocyte biology

authors： Lange C,Starrett DJ,Goetsch J,Gerke V,Rescher U

更新日期：2007-12-01 00:00:00