Abstract：
:Variations in the prevalence of dementia in different ethnic groups have been reported worldwide, and a number of reviews have provided a picture of epidemiological studies in dementia research. However, little is known about epidemiological studies in Chinese populations. In this review, we searched PubMed and the Web of Science for original research articles published in English up to July 2013 on the prevalence, incidence, risk factors, and prognosis of dementia in Chinese populations worldwide. Except for the prevalence, we included only population-based follow-up studies. We identified 25 studies in elderly Chinese residents in Mainland China, Hong Kong, Taiwan, and Singapore, and found a higher prevalence of dementia in Mainland China than in the other locations, which may be due to that the studies from Mainland China are more recent than those from other locations. A notable increase in incidence was observed when dementia cases were diagnosed using 10/66 diagnostic criteria compared to other criteria. Studies on risk factors for dementia were limited and mostly from Mainland China. Age, gender, education, smoking, and alcohol consumption were related to the risk of dementia in Chinese populations. Only two prognostic studies were identified, and age, gender, and residential area were related to the prognosis of dementia. In conclusion, the prevalence, incidence, and risk factors for dementia found in Chinese populations were comparable to other ethnic groups, but no conclusive results on prognosis were found. The differences in prevalence and incidence were influenced by the diagnostic criteria and the time of study. Longitudinal population-based studies on the incidence, risk factors, and prognosis of dementia in Chinese populations are required.
journal_name
Neurosci Bulljournal_title
Neuroscience bulletinauthors
Pei JJ,Giron MS,Jia J,Wang HXdoi
10.1007/s12264-013-1420-1subject
Has Abstractpub_date
2014-04-01 00:00:00pages
207-16issue
2eissn
1673-7067issn
1995-8218journal_volume
30pub_type
杂志文章,评审abstract：:The human TLX gene encodes an orphan nuclear receptor predominantly expressed in the central nervous system. Tailess and Tlx, the TLX homologues in Drosophila and mouse, play essential roles in body-pattern formation and neurogenesis during early embryogenesis and perform crucial functions in maintaining stemness and ...
journal_title：Neuroscience bulletin
pub_type： 杂志文章,评审
doi：10.1007/s12264-015-0004-7
更新日期：2016-02-01 00:00:00
abstract：:Sensory processing is strongly modulated by different brain and behavioral states, and this is based on the top-down modulation. In the olfactory system, local neural circuits in the olfactory bulb (OB) are innervated by centrifugal afferents in order to regulate the processing of olfactory information in the OB under...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-019-00385-6
更新日期：2019-08-01 00:00:00
abstract：:The local field potential (LFP) is a signal reflecting the electrical activity of neurons surrounding the electrode tip. Synchronization between LFP signals provides important details about how neural networks are organized. Synchronization between two distant brain regions is hard to detect using linear synchronizati...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-017-0175-5
更新日期：2017-12-01 00:00:00
abstract：:Neuromyelitis optica (NMO)/NMO spectrum disorder (NMOSD) is a chronic, recurrent, antibody-mediated, inflammatory demyelinating disease of the central nervous system, characterized by optic neuritis and transverse myelitis. The binding of NMO-IgG with astrocytic aquaporin-4 (AQP4) functions directly in the pathogenesi...
journal_title：Neuroscience bulletin
pub_type： 杂志文章,评审
doi：10.1007/s12264-020-00525-3
更新日期：2020-10-01 00:00:00
abstract：:Multisensory enhancement, as a facilitation phenomenon, is responsible for superior behavioral performance when an individual is responding to cross-modal versus modality-specific stimuli. However, the event-related potential (ERP) counterparts of behavioral multisensory enhancement are not well known. We recorded ERP...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-013-1386-z
更新日期：2013-12-01 00:00:00
abstract：:To investigate the behavioral and biomolecular similarity between neuralgia and depression, a trigeminal neuralgia (TN) mouse model was established by constriction of the infraorbital nerve (CION) to mimic clinical trigeminal neuropathic pain. A mouse learned helplessness (LH) model was developed to investigate inesca...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-017-0131-4
更新日期：2018-02-01 00:00:00
abstract：:The neurocircuitries that constitute the cortico-striato-thalamo-cortical (CSTC) circuit provide a framework for bridging gaps between neuroscience and executive function in attention deficit hyperactivity disorder (ADHD), but it has been difficult to identify the mechanisms for regulating emotional problems from the ...
journal_title：Neuroscience bulletin
pub_type： 杂志文章,评审
doi：10.1007/s12264-018-0214-x
更新日期：2018-06-01 00:00:00
abstract：:Objective To identify the genetype of the PS1/APP double transgenic mouse model, then to analyse the histopathological changes in the brain and compare the differences between the transgenic mice models and Abeta1-40-injected rats models of Alzheimer disease. Methods The modified congo red staining, Nissl's staining a...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVE:To determine whether the convergences of tactile information also occur at thalamic ventroposterolateral nucleus in rats, we investigated the properties of tactile responses of the thalamic ventroposterolateral nucleus in rats. METHODS:Unit responses were recorded extracellularly from thalamic ventroposterol...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-007-0045-7
更新日期：2007-09-01 00:00:00
abstract：OBJECTIVE:The literature has shown that cognitive and emotional changes may occur after chronic treatment with glucocorticoids. This might be caused by the suppressive effect of glucocorticoids on hippocampal neurogenesis and cell proliferation. Paroxetine, a selective serotonin reuptake transporter, is a commonly used...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-007-0019-9
更新日期：2007-05-01 00:00:00
abstract：:Neural stem cell is presently the research hotspot in neuroscience. Recent progress indicates that epigenetic modulation is closely related to the self-renewal and differentiation of neural stem cell. Epigenetics refer to the study of mitotical/meiotical heritage changes in gene function that cannot be explained by ch...
journal_title：Neuroscience bulletin
pub_type： 杂志文章,评审
doi：10.1007/s12264-007-0036-8
更新日期：2007-07-01 00:00:00
abstract：:Hypoxia causes depression of synaptic plasticity, hyperexcitation of neuronal networks, and the death of specific populations of neurons. However, brief episodes of hypoxia can promote the adaptation of cells. Hypoxic preconditioning is well manifested in glutamatergic neurons, while this adaptive mechanism is virtual...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-020-00480-z
更新日期：2020-07-01 00:00:00
abstract：:Parkinson disease (PD) is characterized by the selective loss of dopaminergic neurons in the substantia nigra. Although investigation in mammalian animal models of PD has enhanced our understanding of PD, the complexity of the mammalian nervous system and our inability to visualize DA neurons in vivo restricts the adv...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
abstract：:The epileptic seizure is a dynamic process involving a rapid transition from normal activity to a state of hypersynchronous neuronal discharges. Here we investigated the network properties of epileptiform discharges in hippocampal slices in the presence of high K(+) concentration (8.5 mmol/L) in the bath, and the effe...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-013-1304-4
更新日期：2013-02-01 00:00:00
abstract：:Oligodendrocytes, the myelin-forming cells for axon ensheathment in the central nervous system, are critical for maximizing and maintaining the conduction velocity of nerve impulses and proper brain function. Demyelination caused by injury or disease together with failure of myelin regeneration disrupts the rapid prop...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-013-1318-y
更新日期：2013-04-01 00:00:00
abstract：:Neuromyelitis optica (NMO) is a recurrent inflammatory disease that predominantly attacks the opticnerves and spinal cord. NMO-IgG, the specific autoantibody present in the vast majority of NMO patients, targets the astrocytic water channel protein aquaporin 4 (AQP4), and differentiates NMO from multiple sclerosis. Th...
journal_title：Neuroscience bulletin
pub_type： 杂志文章,评审
doi：10.1007/s12264-015-1552-6
更新日期：2015-12-01 00:00:00
abstract：:Protein kinase D (PKD) is an evolutionarily-conserved family of protein kinases. It has structural, regulatory, and enzymatic properties quite different from the PKC family. Many stimuli induce PKD signaling, including G-protein-coupled receptor agonists and growth factors. PKD1 is the most studied member of the famil...
journal_title：Neuroscience bulletin
pub_type： 杂志文章,评审
doi：10.1007/s12264-013-1403-2
更新日期：2014-06-01 00:00:00
abstract：OBJECTIVE:To investigate the correlation of perihematomal free radical level and neuronal apoptosis following the intracerebral hemorrhage (ICH). METHODS:Animals were randomly divided into 4 groups: sham operation group, model group, 1 mg/kg edaravone group, and 3 mg/kg edaravone group. Each group was then divided int...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-008-0711-4
更新日期：2008-12-01 00:00:00
abstract：:Autophagy plays a vital role in cerebral ischemia and may be a potential target for developing novel therapy for stroke. In this study, we constructed an autophagy-related pathway network by analyzing the genes related to autophagy and ischemic stroke, and the risk genes were screened. Two autophagy-related modules we...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-015-1547-3
更新日期：2015-08-01 00:00:00
abstract：:Fever is an adaptive host response coordinated by the central nervous system (CNS) during systemic immune challenge. Recent research shed light on the mechanism of fever generation, particularly the underlying neural pathways. In this review, we first briefly summarize current views on the mechanism of sensing microbi...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：
更新日期：2006-11-01 00:00:00
abstract：:Oligodendrocyte (OL) and myelin development are crucial for network integration and are associated with higher brain functions. Accumulating evidence has demonstrated structural and functional impairment of OLs and myelin in serious mental illnesses. However, whether these deficits contribute to the brain dysfunction ...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-019-00449-7
更新日期：2020-04-01 00:00:00
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journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-020-00515-5
更新日期：2020-10-01 00:00:00
abstract：:Continuous dopaminergic stimulation (CDS) is a prominent therapeutic concept for the treatment of Parkinson's disease (PD), which proposes that continuous brain dopamine-receptor stimulation, rather than intermittent doses of oral L-dopa, prevents or manages L-dopa-induced dyskinesias (LIDs). In the normal situation, ...
journal_title：Neuroscience bulletin
pub_type： 杂志文章,评审
doi：10.1007/s12264-013-1329-8
更新日期：2013-10-01 00:00:00
abstract：:General anesthesia severely affects the metabolites in the brain. Glycogen, principally stored in astrocytes and providing the short-term delivery of substrates to neurons, has been implicated as an affected molecule. However, whether glycogen plays a pivotal role in modulating anesthesia-arousal remains unclear. Here...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-020-00587-3
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:To observe the sexual differences in electrophysiological properties of neurons in the robust nucleus of the arcopallium (RA) in adult zebra finches, and to provide the direct electrophysiological evidence for the sexual dimorphism of birdsong. METHODS:Whole-cell recording was used to record the spontaneous ...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-010-1010-4
更新日期：2010-04-01 00:00:00
abstract：:Trigeminal neuropathic pain (TNP) is a significant health problem but the involved mechanism has not been completely elucidated. Toll-like receptors (TLRs) have recently been demonstrated to be expressed in the dorsal root ganglion and involved in chronic pain. Here, we show that TLR8 was persistently increased in the...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-020-00621-4
更新日期：2020-12-23 00:00:00
abstract：OBJECTIVE:It is well documented that epilepsy can increase neurogenesis in certain brain regions and cause behavioral alternations in patients and different epileptic animal models. A series of experimental studies have demonstrated that neurogenesis is regulated by various factors including glucocorticoid (CORT), whic...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-007-0012-3
更新日期：2007-03-01 00:00:00
abstract：:Recent studies have shown that the abnormal accumulation of endogenous formaldehyde could be a critical factor in age-related cognitive decline. The aim of this study was to estimate the correlation between uric formaldehyde and general cognitive abilities in a community-based elderly population, and to measure the ex...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-013-1416-x
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVE:Despite accumulating evidence on a role of immune cells and their associated chemicals in mechanisms of pain, few studies have addressed the potential role of chemokines in the descending facilitation of persistent pain. The present study was undertaken to test the hypothesis that the chemokine (C-C motif) li...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-012-1218-6
更新日期：2012-04-01 00:00:00
abstract：:The development of the nervous system is under the strict control of a number of signal transduction pathways, often interconnected. Among them, the phosphoinositide (PI) pathway and the related phospholipase C (PI-PLC) family of enzymes have been attracting much attention. Besides their well-known role in the regulat...
journal_title：Neuroscience bulletin
pub_type： 杂志文章,评审
doi：10.1007/s12264-012-1283-x
更新日期：2012-12-01 00:00:00
