[Evaluation of the efficacy of prucalopride (resolor) in the treatment of patients with chronic constipation].

Abstract:

AIM:To evaluate the efficacy of the enterokinetic prucalopride (resolor) in patients with chronic constipation. SUBJECTS:The effect of treatment with prucalopride (resolor) in 109 patients with chronic constipation was analyzed. RESULTS:The effect was noted in 82% of the patients; 61 patients were fully satisfied with treatment results. Among the adverse reactions, headache that was particularly significant on the first days of use, diarrhea, and cramping abdominal pain were reported by 35, 17, and 13% of the included patients, respectively. The authors' experience with prucalopride demonstrated that the patients with chronic constipation displayed the good efficacy of the drug in both the frequency of stool and the elimination of all other constipation symptoms (straining effort, incomplete bowel emptying sensation, solid stool, bloating), and its good tolerability. CONCLUSION:Prucalopride (resolor) exerts a predictable effect, can extend a physician's capacity to arrest chronic constipation, and, when the drug is used, requires no long-term dose adjustment.

journal_name

Ter Arkh

journal_title

Terapevticheskii arkhiv

authors

Osipenko MF,Bikbulatova EA,Skalinskaia MA,Kulygina IuA,Pankova LIu

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

60-4

issue

12

eissn

0040-3660

issn

2309-5342

journal_volume

85

pub_type

临床试验,杂志文章
  • [Prevalence of some modified cardiovascular risk factors among young students].

    abstract:AIM:To estimate the prevalence of some modified cardiovascular risk factors (RFs) among the students of two Moscow higher education institutions to further test the technology of individual medical prevention counseling. SUBJECTS AND METHODS:A questionnaire survey was conducted among 1912 first-year students (boys and...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:10.17116/terarkh201587157-63

    authors: Zvolinskaya EY,Kimicidi MG,Alexandrov AA

    更新日期:2015-01-01 00:00:00

  • [The typical features and clinical characteristics of Reiter's syndrome with a nonvenereal origin].

    abstract::Analysis of the clinical picture in 37 patients with Reiter's syndrome unrelated to venereal urethritis showed that in the majority of cases, it was preceded by acute intestinal infection which occasionally ran an unmarked course. The difficulties in diagnosing Reiter's syndrome were caused in some patients by the fac...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Ivashkin VT,Sultanov VK,Polozhentsev SD

    更新日期:1990-01-01 00:00:00

  • [Akademik Valentin Ivanovich Pokrovskiy (k 90-letiyu so dnya rozhdeniya)].

    abstract::В.И. Покровский - создатель ведущей отечественной школы по изучению инфекционных болезней и проблем эпидемиологии. Редколлегия журнала «Терапевтический архив» сердечно поздравляет юбиляра и желает ему крепкого здоровья, семейного благополучия, долгих лет жизни на благо пациентов и учеников. ...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: - -

    更新日期:2019-04-15 00:00:00

  • [Effect of trimetazidine and perindopril on myocardial function and metabolism in patients with low cardiac output during postinfarction period].

    abstract:AIM:To investigate effects of trimetazidine and perindopril on myocardial function and metabolism in patients with cardiac failure after myocardial infarction. MATERIAL AND METHODS:A comparative study was mode of the effects of 6-month therapy with perindopril, trimetazidine alone and in combination on clinical sympto...

    journal_title:Terapevticheskii arkhiv

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Shabrov AV,Arkharov IV,Burbello AT,Makhnov AP

    更新日期:2003-01-01 00:00:00

  • [The specific features of pain syndrome in patients with hemophilia].

    abstract:AIM:to study the nature of pain in hemophilic arthropathy and its prevention ways used by patients with hemophilia. SUBJECTS AND METHODS:A prospective, multicenter, cross-sectional study was conducted to interview 136 patients with hemophilia A or B. The survey included 32 points, including questions about drug and no...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章,多中心研究

    doi:10.17116/terarkh201688784-88

    authors: Levchenko OK,Shulutko EM,Zorenko VY,Galstyan GM

    更新日期:2016-01-01 00:00:00

  • [Coronary artery function and myocardial perfusion in patients with ischemic heart disease isolated and in combination with arterial hypertension].

    abstract:AIM:To characterize coronary arteries and myocardial perfusion in isolated ischemic heart disease (IHD) and IHD combined with blood hypertension (BH). MATERIALS AND METHODS:20 patients with isolated IHD and 25 patients with combined IHD have undergone coronarography, scintigraphy of the myocardium with Tc-99m, echocar...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Kuzin AI,Gabbasova LA,Volkova EG,Il'inykh DL

    更新日期:1999-01-01 00:00:00

  • [The efficacy of high-intensity laser irradiation in the combined treatment of patients with esophageal candidiasis].

    abstract::High-intensity impulse laser radiation proved effective in 23 patients with esophageal candidiasis. The highest effect was achieved in its use with nistatin. In low laser efficacy radiation should be combined with transendoscopic administration of granulocytes concentrate. This produced clinico-endoscopic remission in...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Preobrazhenskiĭ VN,Kasatkin NN

    更新日期:1996-01-01 00:00:00

  • [The differential diagnosis of Erdheim-Chester disease and IgG4-related diseases].

    abstract::The paper describes Russia's first diagnosed case of Erdheim--Chester disease (systemic histiocytosis) in a 65-year-old man who has been long treated for Ormond's disease (idiopathic retroperitoneal fibrosis). It also gives the data available in the literature on the pathogenetic components of these diseases and on th...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:10.17116/terarkh201688570-76

    authors: Vasilyev VI,Sokol EV,Kokosadze NV,Pavlovskaya AI,Komov DV,Palshina SG,Mukhortova OV,Safonova TN

    更新日期:2016-01-01 00:00:00

  • [Use of fendivia transdermal therapeutic system in Russian patients with malignant neoplasms during palliative care: pharmacoeconomic aspects].

    abstract:AIM:To make a comparative clinical and economic assessment of a transdermal therapeutic system (TTS) for fendivia and traditional opioid analgesics in patients with malignant neoplasms (MN) during palliative care. MATERIALS AND METHODS:Pharmacoeconomic analysis of opioid analgesics used in patients with MN during anal...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Ryazhenov VV,Abuzarova GR,Gorokhova SG,Emchenko IV,Matveev NV

    更新日期:2014-01-01 00:00:00

  • [Effect of nifedipine in chronic left ventricular insufficiency in patients with post-infarction heart aneurysm].

    abstract::A study was made of a vasodilating effect of nifedipine on the hemodynamics of 30 patients with chronic postinfarction left ventricular aneurysm, with chronic cardiovascular insufficiency of the II-III degree according to NYHA. A mean value of the acontractile segment on ventriculograms was 32.5 +/- 1.7%. The main par...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Soopyl'd IuKh,Laane EIa,Uuskiula MM,Altraia EM

    更新日期:1986-01-01 00:00:00

  • [Role of AGTR1 A/C polymorphism in the development of atrial fibrillation].

    abstract:AIM:To investigate the AGTR1 A/C polymorphism associated with atrial fibrillation (AF) to form risk groups among patients who are prone to this disease. SUBJECTS AND METHODS:90 probands with a confirmed diagnosis of AF and their 144 first-, second-, and third-degree relatives were examined. These families made up a st...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:10.17116/terarkh201789948-52

    authors: Kuskaeva AV,Nikulina SY,Chernova AA,Aksyutina NV,Kuskaev AP,Cherkashina II

    更新日期:2017-01-01 00:00:00

  • [Clinical and diagnostical value of 24-hour arterial stiffness monitoring in patients with bronchial asthma].

    abstract:AIM:To evaluate 24-hour dynamics of the arterial stiffness main indicators in patients with bronchial asthma of various severity and control. MATERIALS AND METHODS:The study included 119 patients with bronchial asthma, who formed main groups: the first group 48 patients with mild and moderate asthma, the second 71 pat...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:10.26442/00403660.2020.03.000438

    authors: Karoli NA,Zarmanbetova OT,Rebrov AP

    更新日期:2020-04-27 00:00:00

  • [Antiplatelet drugs and gastrointestinal disorders: when and how effective are inhibitors of proton pump?].

    abstract::Antiplatelet drugs are essential in current treatment of coronary heart disease (CHD) but they have an adverse action--damage to gastrointestinal mucosa. Long-term administration of several medicines in CHD patients makes possible interaction of some drugs. Clinical trials show that proton pump inhibitors (PPI) reduce...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章,评审

    doi:

    authors:

    更新日期:2011-01-01 00:00:00

  • [Morphofunctional characteristics of neutrophils in patients with autoimmune thyroiditis].

    abstract:AIM:To study morphofunctional status of neutrophilic polymorphonuclear leukocytes (NPNL) in patients with chronic autoimmune thyroiditis (CAIT). MATERIAL AND METHODS:The morphofunctional status of NPNL was investigated with vital computer phasic morphometry (CPM) in 25 patients (24 females and 1 male, mean age 45.4 +/...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Rustembekova SA,Ametov AS,Vasilenko IA,Metelin VB

    更新日期:2008-01-01 00:00:00

  • [Possible ways of correcting disorders of the amino acid content of the blood serum and gastric mucosa during treatment of peptic ulcer].

    abstract::Investigations made by the authors permit the conclusion that in order to correct the disturbed amino acid content of the gastric mucosa and blood serum, mirroring the trends in the catabolic processes occurring in the body and disorder of liver amino acid-forming function, it is necessary to include the drugs elimina...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Degtiareva II,Solodova EV

    更新日期:1984-01-01 00:00:00

  • [Systolic and diastolic intraventricular asynchrony of the left ventricular myocardium in patients with pacemaker].

    abstract:AIM:To study intraventricular asynchrony and effects of pacemaker implantation on asynchrony severity in patients with rhythm and conduction disorders. MATERIAL AND METHODS:The study of 46 patients with cardiac arrhythmia (atrial fibrillation, sick sinus syndrome, AB-block of the third degree) included such examinatio...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: At'kov OIu,Popova EIu,Gorokhova SG

    更新日期:2012-01-01 00:00:00

  • [Role of uric acid in development of essential hypertension: modern conceptions].

    abstract::The article deals with current studies on the role of uric acid (UA) in development of cardiovascular diseases. The results of large prospective trials are presented which have revealed a pathogenetic role of UA in development of essential hypertension. Clinical trials demonstrated elevated concentrations of UA in hyp...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章,评审

    doi:

    authors: Polovitkina OV,Oshchepkova EV,Dmitriev VA,Titov VN

    更新日期:2011-01-01 00:00:00

  • [Regulatory R proteins and lipid peroxidation in rheumatoid arthritis].

    abstract::Levels of R proteins (RP) and activity of lipid peroxidation (LPO) were measured in 209 patients with RA. It was noted that RP levels and LPO activity correlated with the activity of inflammation. A rapid RA progression was characterized by higher RP levels and LPO activity, while polyarthritis by more intensive RP me...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Kochetova EV,Ignat'ev VK

    更新日期:1996-01-01 00:00:00

  • [Analysis of factors affecting circulation in the territory of internal carotid artery in arterial hypertension].

    abstract:AIM:To assess carotid blood flow in healthy subjects and hypertensive patients, to specify prognostic significance of factors affecting carotid circulation with use of a multivariate analysis. MATERIAL AND METHODS:Clinical examination, ultrasonic dopplerography of the internal carotid arteries (ICA), echocardiography,...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Rabinovich RM

    更新日期:2008-01-01 00:00:00

  • [Changes in the course of atherosclerosis occurring over a 25-year period in the male population of 9 cities of the CIS and Baltic countries].

    abstract::The trends in atherosclerosis presentation were followed up pathomorphologically in a two-stage epidemiological survey performed in 9 cities of CIC and Baltic states at 25-year interval. The investigations were conducted in accordance with WHO program. Stage 1 (1963-1968) covered 6121 cases, stage 2 (1985-1989) includ...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Zhdanov VS,Vikhert AM,Galakhov IE,Drobkova IP,Alekseev VP,Berdnikova NV,Volkov VA,Lifshits AM,Protsenko ES,Tushemilov OV

    更新日期:1995-01-01 00:00:00

  • [Potential of pulsed Doppler echocardiography in assessing the phasic activity of the left ventricle in patients with symptomatic arterial hypertension].

    abstract::The phasic structure of heart activity was explored in 50 patients suffering from symptomatic arterial hypertensions before and after the operative treatment with the aid of impulse Doppler echocardiography. Of these, 28 patients had renovascular hypertension (RVH), 16 primary aldosteronism (PA), and 6 pheochromocytom...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Sergakova LM,Kosmacheva ED,Ataullakhanova DM,Chikhladze NM

    更新日期:1990-01-01 00:00:00

  • [Enteral tube feeding in adult patients with cystic fibrosis and respiratory failure].

    abstract:AIM:To evaluate the efficiency of nocturnal hyperalimentation in adult patients with cystic fibrosis (CF) and respiratory failure. SUBJECTS AND METHODS:The investigation enrolled 17 patients older than 18 years (mean age, 25.6±4.2 years) diagnosed with very severe CF (forced expiratory volume in one second (FEV1), < 3...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:10.17116/terarkh2017891251-55

    authors: Krylova NA,Amelina EL,Krasovsky SA,Karchevskaya NA,Tarabrin EA,Gasanov AM,Ibragimova DF,Golovinsky SV

    更新日期:2017-01-01 00:00:00

  • [Immunodiagnosis and immunotherapy of chronic nonspecific lung diseases].

    abstract::Altogether 212 patients with chronic nonspecific pulmonary diseases (CNPD) were examined. Of these, 105 patients received treatment with sodium nucleinate, 72 with levamisole, 17 with diucifon and 18 with T-activin. As compared with healthy subjects, the patients manifested significantly deviated immunological paramet...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Borisova AM

    更新日期:1985-01-01 00:00:00

  • [Organization of medical care for patients with non-ST-segment elevation acute coronary syndrome in regional vascular centers and primary vascular units in 2009-2012 (according to the data of the ACS register)].

    abstract:AIM:To study clinical characteristics of non-ST-segment elevation acute coronary syndrome (NSTEACS) and to assess the quality of medical health in patients with this condition who were treated in the regional vascular centers and primary vascular units from 48 subjects of the Russian Federation in 2009-2012. MATERIALS...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Oshchepkova EV,Dmitriev VA,Gridnev VI,Dovgalevskiĭ PIa

    更新日期:2013-01-01 00:00:00

  • [Hypotensive and diuretic effect of heparin in patients with glomerulonephritis].

    abstract::The hypotensive and diuretic properties of heparin were evaluated in 95 patients with different clinical and morphological varieties of chronic glomerulonephritis (CGN). The arterial blood pressure dropped in all the patients treated with heparin. The maximal effect was attained toward the end of heparin treatment (by...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Kutyrina IM,Nikishova TA,Tareeva IE

    更新日期:1985-01-01 00:00:00

  • Case of thrombosis of the portal vein and its branches in a patient seropositive for Borrelia antigens.

    abstract::Borreliosis after sucking ticks is an acute problem in the world. People do not go to doctors after that often, which leads to the development of various complications. Thrombosis of veins of various localization can be one of them. Thrombosis of the portal vein represents a significant problem too with high morbidity...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:10.26442/terarkh2018901179-89

    authors: Reznik EV,Prushkovskaya MP,Presnova ED,Novikova NA,Ivaschenko RA,Dedov EI,Nikitin AE,Nikitin IG

    更新日期:2018-11-22 00:00:00

  • [Current characteristics of all-cause and circulatory disease mortality in the Azerbaijan Republic].

    abstract:AIM:To prove the value of summary data from the State Statistics Commission to characterize of risk of death from circulatory system diseases (CSD). MATERIAL AND METHODS:The official data of the State Statistics Commission of the Azerbaijan Republic, which are available at its website (www.stat.gov.az), were analyzed ...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:10.17116/terarkh201688352-55

    authors: Azizov VA,Khatamzade EM

    更新日期:2016-01-01 00:00:00

  • [Highly sensitive methods for the serological,diagnosis of hepatitis B and their clinico-epidemiological significance].

    abstract::A study was made of HB-virus infection markers in 438 patients of different age with hepatitis B. Highly sensitive methods based on the test systems manufactured in this country and abroad were employed. The authors established the diagnostic importance of HBV markers, studied the prevalence of those markers in parent...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Botsvadze ESh,Aleksishvili MM,Gegeshidze TN,Mosakhlishvili NG

    更新日期:1990-01-01 00:00:00

  • [The virus-immune hypothesis for cardiac dilatation].

    abstract::The paper gives an update on the pathogenetic role of viral infection and immune mechanisms in the development of cardiac dilatation at the cellular, ultrastructural, and molecular levels. Particular attention is given to the discussion of the possible role of herpesvirus infection in the mechanisms of cardiomyocyte d...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章,评审

    doi:10.17116/terarkh2017891179-83

    authors: Kozhevnikov ML,Shipulin VM,Sukhodolo IV

    更新日期:2017-01-01 00:00:00

  • [State of lipid peroxidation, blood antioxidant defense in patients with myocardial infarction aggravated by circulatory insufficiency].

    abstract:AIM:To study free radical processes in patients with myocardial infarction (MI) aggravated by heart failure. MATERIAL AND METHODS:Forty seven patients taken to the clinic within the first 5 hours of MI were examined. The patients were divided into 2 groups: 1) those with left ventricular failure-complicated IM (n = 25...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Tarasov NI,Tepliakov AT,Malakhovich EV,Stepacheva TA,Fedosova NN,Kaliuzhin VV,Pushnikova EIu

    更新日期:2002-01-01 00:00:00