Cancer initiation and progression within the cancer microenvironment.

abstract：:We have compared the pattern of surface antigen expression, as detected by monoclonal antibodies (mAbs), in plasma membranes vs shed membrane vesicles of two human breast carcinoma cell lines, MCF-7 and 8701-BC. Antigen expression was detected on cells by immunofluorescence (IF) analysis, whilst, due to their small di...

journal_title：Clinical & experimental metastasis

authors： Dolo V,Adobati E,Canevari S,Picone MA,Vittorelli ML

更新日期：1995-07-01 00:00:00

abstract：:Metastatic castrate resistant prostate cancer (mCRPC) is responsible for the majority of prostate cancer deaths with the median survival after diagnosis being 2 years. The metastatic lesions often arise in the skeleton, and current treatment options are primarily palliative. Using guidelines set forth by the National ...

journal_title：Clinical & experimental metastasis

authors： Gallaher J,Cook LM,Gupta S,Araujo A,Dhillon J,Park JY,Scott JG,Pow-Sang J,Basanta D,Lynch CC

更新日期：2014-12-01 00:00:00

abstract：:Single cell progenies (SCPs) inherit biological properties from their isogenetic mother cells. If a single cancer cell can give rise to progenies, which can be passaged sustainably in vitro and produce tumor in xenotransplantation, the cell should be cancer initiating cell. CD133 (Prominin-1, Prom1) is the marker of h...

journal_title：Clinical & experimental metastasis

authors： Li G,Liu C,Yuan J,Xiao X,Tang N,Hao J,Wang H,Bian X,Deng Y,Ding Y

更新日期：2010-10-01 00:00:00

abstract：:Metastasis remains the major cause of therapeutic failure, poor prognosis and high mortality in breast and prostate cancer patients. Aberrant microenvironments including hypoxia and acidic pH are common features of most solid tumors that have been long associated with enhanced metastasis and poor patient outcomes. Nov...

journal_title：Clinical & experimental metastasis

authors： Sudhan DR,Siemann DW

更新日期：2013-10-01 00:00:00

abstract：:Radiotherapy induces untargeted effects on normal tissues such as bone marrow. So alteration of microenvironment by ionizing irradiation is supposed to influence dynamic host-cancer ecosystem affecting cancer behavior including metastasis. Herein, the incidence of lung metastasis after high-dose irradiation has been i...

journal_title：Clinical & experimental metastasis

authors： Shin JW,Son JY,Raghavendran HR,Chung WK,Kim HG,Park HJ,Jang SS,Son CG

更新日期：2011-12-01 00:00:00

abstract：:GPR56, a non-classical adhesion receptor, was previously reported to suppress tumor growth and metastasis in xenograft models using human melanoma cell lines. To understand whether GPR56 plays similar roles in the development of endogenous tumors, we analyzed cancer progression in Gpr56 (-/-) mice using a variety of t...

journal_title：Clinical & experimental metastasis

authors： Xu L,Begum S,Barry M,Crowley D,Yang L,Bronson RT,Hynes RO

更新日期：2010-04-01 00:00:00

abstract：:This study compared phenotype and behaviour of seven head and neck squamous cell carcinoma (HNSCC) cell lines and normal epithelial cells. Indications were found that in HNSCC cells: 1) loss of the cell-cell adhesion molecule E-cadherin was correlated with loss of epithelioid cell morphology but not with loss of cell-...

journal_title：Clinical & experimental metastasis

authors： Tomson AM,Scholma J,Meijer B,Koning JG,de Jong KM,van der Werf M

更新日期：1996-11-01 00:00:00

abstract：:Lymphangiogenesis plays a crucial role in promoting cancer metastasis to sentinel lymph nodes (LNs) and beyond. Increasing data have shown that simvastatin, a cholesterol-lowering medication for the prevention of cardiovascular diseases, is involved in tumor growth and dissemination, and endothelial functions. This st...

journal_title：Clinical & experimental metastasis

authors： Ji RC,Eshita Y,Kobayashi T,Hidano S,Kamiyama N,Onishi Y

更新日期：2018-12-01 00:00:00

abstract：:Aromatic polyamidines containing two, three or four benzamidine residues inhibit proteinase activity and proliferation of different human tumor cell lines, including leukemic (K562, HEL), melanoma (Colo 38) and B-lymphoid (WI-L2) cell lines. In addition, the benzamidine derivatives analysed in the present study inhibi...

journal_title：Clinical & experimental metastasis

authors： Nastruzzi C,Feriotto G,Spandidos D,Ferroni R,Guarneri M,Barbieri R,Gambari R

更新日期：1989-01-01 00:00:00

abstract：:Radiation therapy is an effective means of achieving local control in a wide range of primary tumours, with the reduction in the size of the tumour(s) thought to mediate the observed reductions in metastatic spread in clinical trials. However, there is evidence to suggest that the complex changes induced by radiation ...

journal_title：Clinical & experimental metastasis

authors： Blyth BJ,Cole AJ,MacManus MP,Martin OA

更新日期：2018-04-01 00:00:00

abstract：:Tumor cells exposed to a growth stress such as low pH, glucose starvation and hypoxia have been shown to exhibit a transient increase in experimental metastatic potential, particularly when allowed to recover under normal growth conditions for a period of 24-48 h. In this study we examined whether this increase in met...

journal_title：Clinical & experimental metastasis

authors： Jang A,Hill RP

更新日期：1997-09-01 00:00:00

abstract：:The abilities of tumor cells to extravasate from the blood vessel system and to migrate through the connective tissue are prerequisites in metastasis formation. Both processes are chiefly mediated by integrins, which mediate both cell-cell and cell-matrix interactions. We investigated the role of integrin subunits in ...

journal_title：Clinical & experimental metastasis

authors： Heyder C,Gloria-Maercker E,Hatzmann W,Niggemann B,Zänker KS,Dittmar T

更新日期：2005-01-01 00:00:00

abstract：:The idea for this Special Issue originated from our recent review in Nature Reviews Clinical Oncology entitled "Does the mobilization of circulating tumour cells during cancer therapy cause metastasis?" Martin et al. (Nat Rev Clin Oncol 14:32-44, 2017). While preparing this review, it became evident that an overwhelmi...

journal_title：Clinical & experimental metastasis

authors： Martin OA,Anderson RL

更新日期：2018-04-01 00:00:00

abstract：:Recombinant murine interferon beta (MuIFN-beta) given i.v. efficiently inhibited both pulmonary arrest and formation of lung colonies of NL-17, a highly metastatic variant of mouse colon adenocarcinoma 26. NL-17 was rather resistant to MuIFN-beta in vitro and was highly resistant to natural killer cells of mice even t...

journal_title：Clinical & experimental metastasis

authors： Tsuruo T,Saito H,Watanabe M,Sugimoto Y,Yamori T,Oh-Hara T

更新日期：1990-03-01 00:00:00

abstract：:The colon carcinoma cell line HT-29 was used to explore the potential of interleukin-4 (IL-4) and tumor necrosis factor alpha (TNF-alpha) to modify integrin expression and adhesive functions of tumor cells in vitro and to examine corresponding metastatic effects in vivo. Preincubation of HT-29 cells with 100 U/ml of I...

journal_title：Clinical & experimental metastasis

authors： Herzberg F,Schöning M,Schirner M,Topp M,Thiel E,Kreuser ED

更新日期：1996-03-01 00:00:00

abstract：:In order to study the usefulness of treatment with vinblastine (VLB) in the prevention of cancer metastasis in squamous cell lung cancer, 50 patients with locoregional disease were randomized to receive either locoregional RT alone (group A) or a weekly intravenous bolus injection of VLB (6 mg/m2) concurrently with an...

journal_title：Clinical & experimental metastasis

authors： Schallier DC,De Neve WJ,De Greve JL,Van Belle SP,De Wasch GJ,Dotremont G,Storme GA

更新日期：1988-01-01 00:00:00

abstract：:Prostate cancer metastases form selectively in the bone marrow. Previously we demonstrated motility was important for the formation of primary prostatic epithelial cell colonies in bone marrow stroma (BMS) co-culture. In this study we looked at the influence of motility factors on the colony formation of epithelial ce...

journal_title：Clinical & experimental metastasis

authors： Lang SH,Clarke NW,George NJ,Testa NG

更新日期：1999-06-01 00:00:00

abstract：:Recent studies have indicated that KHT fibrosarcoma or B16 melanoma cell variants capable of forming experimental metastases in the lungs of mice after i.v. injection are created stochastically at high rates (approximately 10(-5)/cell/generation). Expression of this phenotype is unstable and hence expanding population...

journal_title：Clinical & experimental metastasis

authors： Young SD,Hill RP

更新日期：1986-07-01 00:00:00

abstract：:Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer known. IBC carries a guarded prognosis primarily due to rapid onset of disease, typically within six months, and the propensity of tumor emboli to invade the dermal lymphatics and spread systemically. Although the clinical manif...

journal_title：Clinical & experimental metastasis

authors： van Golen KL,Bao LW,Pan Q,Miller FR,Wu ZF,Merajver SD

更新日期：2002-01-01 00:00:00

abstract：:Breast cancer (BC) is the most common cancer affecting women in the United States and metastatic breast cancer is the leading cause of death. The role estradiol plays in ER-positive BC is well-documented, but the way it contributes to ER-negative BC remains unclear. In the present study, we utilized an experimental mo...

journal_title：Clinical & experimental metastasis

authors： Yang X,Belosay A,Du M,Fan TM,Turner RT,Iwaniec UT,Helferich WG

更新日期：2013-08-01 00:00:00

abstract：:The effects of the cyclooxygenase (COX)-2 inhibitor nimesulide on bombesin-enhanced peritoneal metastasis of azoxymethane (AOM)-induced intestinal adenocarcinomas were investigated in male Wistar rats. From the beginning of the study, the rats were given 10 weekly s.c. injections of AOM (7.4 mg/kg body weight) and s.c...

journal_title：Clinical & experimental metastasis

authors： Iishi H,Tatsuta M,Baba M,Yano H,Higashino K,Mukai M,Akedo H

更新日期：2003-01-01 00:00:00

abstract：:Evidence suggests that multiple tumors, including pancreatic adenocarcinoma, display heterogeneity in parameters that are critical for tumor formation, progression and metastasis. Understanding heterogeneity in solid tumors is increasingly providing a plethora of new diagnostic and therapeutic approaches. In this stud...

journal_title：Clinical & experimental metastasis

authors： Dembinski JL,Krauss S

更新日期：2009-01-01 00:00:00

abstract：:CD147 is expressed at low levels in normal tissues but frequently highly expressed in a wide range of tumor types such as lung, breast, and liver and therefore it is a potentially unique therapeutic target for these diverse tumor types. We previously generated a murine antibody HAb18 which suppresses matrix met al.lop...

journal_title：Clinical & experimental metastasis

authors： Wang Y,Yuan L,Yang XM,Wei D,Wang B,Sun XX,Feng F,Nan G,Wang Y,Chen ZN,Bian H

更新日期：2015-01-01 00:00:00

abstract：:Numerous cancer patients fail standard chemotherapy or develop resistance to chemotherapy during the course of treatment. The purpose of this study is to elucidate the overall response of cells obtained from cancer patients and from normal individuals to chemotherapeutic agents. We analysed the chemosensitivity of can...

journal_title：Clinical & experimental metastasis

authors： Richard C,Yau J,Th'ng JP,Duivenvoorden WC

更新日期：2006-01-01 00:00:00

abstract：:Considering recent findings that cyclooxygensase-2 (COX-2) is involved in the progression of colorectal carcinoma (CRC), the role of COX-2 in promoting invasion and angiogenesis was investigated by evaluating the relationship of COX-2 expression to various clinicopathological variables, including plasminogen activatin...

journal_title：Clinical & experimental metastasis

authors： Konno H,Baba M,Shoji T,Ohta M,Suzuki S,Nakamura S

更新日期：2002-01-01 00:00:00

abstract：:Breast cancer metastasizes to bone with high frequency and incidence. However, studies of breast cancer metastasis to bone have been limited by two factors. First, the number of models that colonize bone are limited. Second, detection of bone metastases is too insensitive or too laborious for routine, large-scale stud...

journal_title：Clinical & experimental metastasis

authors： Harms JF,Welch DR

更新日期：2003-01-01 00:00:00

abstract：:The concurrent administration of Metrazol (60 mg/kg, i.v.) to anaesthetized rats enhances the cerebral penetration of the anticancer agent razoxane. Such an enhancement leads to an increase in the therapeutic efficacy of razoxane against intracerebrally sequestered L1210 leukaemia cells in mice. The combination of Met...

journal_title：Clinical & experimental metastasis

authors： Greig N,Newell D,Hellmann K

更新日期：1984-01-01 00:00:00

abstract：:Lymph node metastasis is the main prognosis factor in a number of malignancies, including breast carcinomas. The means by which lymph node metastases arise is not fully understood, and many questions remain about their importance in the further spread of breast cancer. Nevertheless, a number of key cellular and molecu...

journal_title：Clinical & experimental metastasis

authors： Eccles S,Paon L,Sleeman J

更新日期：2007-01-01 00:00:00

abstract：:Smad interacting protein 1 (SIP1) is an epithelial-mesenchymal transition (EMT)-inducible gene that plays a key role in tumor progression in various cancers. This study seeks to clarify the clinical and biological significance of SIP1 expression, especially in intestinal type gastric cancer. We analyzed the mRNA level...

journal_title：Clinical & experimental metastasis

authors： Okugawa Y,Inoue Y,Tanaka K,Kawamura M,Saigusa S,Toiyama Y,Ohi M,Uchida K,Mohri Y,Kusunoki M

更新日期：2013-04-01 00:00:00

abstract：:The majority of patients recur after resection of colorectal liver metastases (CRLM). Patients with CRLM displaying a desmoplastic histopathological growth pattern (dHGP) have a better prognosis and lower probability of recurrence than patients with non-dHGP CRLM. The current study evaluates the impact of HGP type on ...

journal_title：Clinical & experimental metastasis

authors： Nierop PMH,Galjart B,Höppener DJ,van der Stok EP,Coebergh van den Braak RRJ,Vermeulen PB,Grünhagen DJ,Verhoef C

更新日期：2019-04-01 00:00:00