High risk malignant gestational trophoblastic disease: experience with triple chemotherapy (MAC) in Third World circumstances.

abstract：OBJECTIVES:We aimed to evaluate whether carboplatin has a comparable efficacy with cisplatin as part of weekly concurrent chemoradiotherapy for cervical cancer (Car-RT vs. Cis-RT). METHODS:A literature search was conducted and both prospective and retrospective studies that evaluated the efficacy of Car-RT for cervica...

journal_title：Gynecologic oncology

authors： Xue R,Cai X,Xu H,Wu S,Huang H

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:To assess the utility of tumor diameter (TD) for predicting lymphatic dissemination (LD) and determining need for lymphadenectomy following diagnosis of endometrioid endometrial cancer. METHODS:Patients diagnosed with stage I-III endometrioid endometrial cancer during 2003-2013 who underwent pelvic or para-...

journal_title：Gynecologic oncology

authors： Cox Bauer CM,Greer DM,Kram JJF,Kamelle SA

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:To assess toxicity and efficacy of weekly high-dose methotrexate-etoposide (HD MTX-ETO) in high-risk gestational trophoblastic neoplasia (GTN). METHODS:Retrospective chart review of high-risk GTN patients treated with HD MTX-ETO (methotrexate 1000 mg/m² day 1, etoposide 100 mg/m² days 1 and 2, q 1 wk). RESU...

journal_title：Gynecologic oncology

authors： Han SN,Amant F,Leunen K,Devi UK,Neven P,Berteloot P,Vergote I

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:To determine the effectiveness of chemotherapy alone as postoperative adjuvant therapy for intermediate- and high-risk cervical cancer. METHODS:The study group comprised of 65 consecutive patients with stage IB or IIA squamous cell or adenosquamous cervical cancer who were initially treated with radical hyst...

journal_title：Gynecologic oncology

authors： Takeshima N,Umayahara K,Fujiwara K,Hirai Y,Takizawa K,Hasumi K

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Granulosa cell tumors of the ovary are rare, primarily treated surgically. In advanced or recurrent disease, data are inconclusive regarding the benefit of either primary or adjuvant chemotherapy. Hormonal therapy has been suggested as an alternative treatment. CASE:Our patient had three recurrences of estr...

journal_title：Gynecologic oncology

authors： Hardy RD,Bell JG,Nicely CJ,Reid GC

更新日期：2005-03-01 00:00:00

abstract：:Mixed Müllerian tumors (MMT) of the uterus are aggressive entities that result in a very poor prognosis even for patients in whom the disease is limited to the uterus. This phase II trial was undertaken in an attempt to improve overall survival as well as progression-free survival of these patients. Forty-two consecut...

journal_title：Gynecologic oncology

authors： Resnik E,Chambers SK,Carcangiu ML,Kohorn EI,Schwartz PE,Chambers JT

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVE:Microsatellite instability (MSI) is a frequent genetic event in the D-loop region (which controls mitochondrial DNA (mtDNA) replication) of mitochondrial genome of endometrial cancer. We therefore investigated the relationship between mtMSI and mtDNA content in endometrial cancer. METHODS:Tumor tissues from ...

journal_title：Gynecologic oncology

authors： Wang Y,Liu VW,Xue WC,Tsang PC,Cheung AN,Ngan HY

更新日期：2005-07-01 00:00:00

abstract：:By using monoclonal antibodies and flow cytometry, the phenotype and activation state [based on presence of interleukin 2 (IL-2) receptors] were determined on the mononuclear cell (MNC) fraction of ovarian carcinoma tissue from 12 patients. Thymidine incorporation response to IL-2 and phytohemagglutinin stimulation wa...

journal_title：Gynecologic oncology

authors： Lentz SS,McKean DJ,Kovach JS,Podratz KC

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Post-irradiation breast sarcoma is a rare and highly aggressive tumor, associated with poor prognosis. However, the mean latent periods reported for postradiation sarcomas after treatment of breast cancer ranges from 5 to 10 years. CASE:We present a rare case of fibrosarcoma of the axilla, diagnosed 23 mont...

journal_title：Gynecologic oncology

authors： Plotti F,Di Donato V,Zullo MA,Angioli R,Panici PB

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVES:Vaginal reconstruction following pelvic exenteration is an important aspect of the physical and psychological rehabilitation of women after radical surgery for pelvic malignancies. The choice of techniques is vast, and proper patient and surgical selection is important for obtaining satisfactory functional a...

journal_title：Gynecologic oncology

authors： Mirhashemi R,Averette HE,Lambrou N,Penalver MA,Mendez L,Ghurani G,Salom E

更新日期：2002-10-01 00:00:00

abstract：:It is very rare to find endometrial cancers arising within a short period following childbirth, presumably because pregnancy has a protective effect against endometrial cancer mediated by elevated secretion of progesterone. We present the case of a 30-year-old Japanese woman with stage IIIC endometrial cancer that was...

journal_title：Gynecologic oncology

authors： Kodama J,Yoshinouchi M,Miyagi Y,Kobashi Y,Kamimura S,Okuda H,Kudo T

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:To determine the feasibility of docetaxel-cisplatin combination therapy compared with docetaxel-carboplatin combination therapy as first-line chemotherapy for patients with ovarian cancer. METHODS:Fifty patients with International Federation of Gynecology and Obstetrics stage Ic-IV ovarian cancer who underwe...

journal_title：Gynecologic oncology

authors： Minagawa Y,Kigawa J,Kanamori Y,Itamochi H,Terakawa N,Okada M,Kitada F

更新日期：2006-06-01 00:00:00

abstract：:As gynecologic surgeons garnered a better understanding of various clinical-pathological prognostic factors, there evolved a number of modifications in the surgical approach allowing for more individualized therapy with less morbidity, while still retaining the curative potential of the radical vulvectomy operation. T...

journal_title：Gynecologic oncology

authors： Moore DH

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:To determine the feasibility and safety of simple extra-fascial trachelectomy plus pelvic lymphadenectomy in young patients affected by early stage cervical cancer. METHODS:We have prospectively identified all patients with early-stage cervical cancer (stages IA2-IB1) referred to our department. Inclusion cr...

journal_title：Gynecologic oncology

authors： Palaia I,Musella A,Bellati F,Marchetti C,Di Donato V,Perniola G,Benedetti Panici P

更新日期：2012-07-01 00:00:00

abstract：:Studies using serological and culture techniques indicate that chlamydial infection is frequently associated with cervical intraepithelial neoplasia (CIN). This relationship was investigated by examining a series of biopsies containing normal epithelium, non-neoplastic condylomatous epithelium, and neoplastic epitheli...

journal_title：Gynecologic oncology

authors： Mitao M,Reumann W,Winkler B,Richart RM,Fujiwara A,Crum CP

更新日期：1984-09-01 00:00:00

abstract：INTRODUCTION:We describe a case of conservatively treated endometrial endometrioid (EE) adenocarcinoma which showed an aggressive clinical outcome after pregnancy. CASE:A 30-year-old woman with a well differentiated EE adenocarcinoma decided to attempt a conservative approach and underwent progestin treatment with sub...

journal_title：Gynecologic oncology

authors： Ferrandina G,Zannoni GF,Gallotta V,Foti E,Mancuso S,Scambia G

更新日期：2005-10-01 00:00:00

abstract：:Background. Reports of supradiaphragmatic involvement of lymph nodes by serous borderline ovarian tumors are rare. Case. We describe the finding of metastatic tumor involving an internal mammary lymph node in a 74-year-old patient with serous borderline ovarian tumor. The positive lymph node was found incidentally dur...

journal_title：Gynecologic oncology

authors： Chamberlin MD,Eltabbakh GH,Mount SL,Leavitt BJ

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:Delay in diagnosis of endometrial cancer may be associated with disease progression and impact management and outcomes. Social and cultural barriers influence recognition of symptoms and self-advocacy in seeking care. Associations between social determinants of health (SDH) and disease presentation have been ...

journal_title：Gynecologic oncology

authors： Helpman L,Pond GR,Elit L,Anderson LN,Seow H

更新日期：2020-07-01 00:00:00

abstract：:A primary malignant mixed Mullerian tumor (MMMT) was found in the wall of the rectum of a 67-year-old female. The uterus, fallopian tubes, and ovaries had been previously excised for benign disease. The tumor was associated with foci of benign endometriosis. A literature review of extragenital MMMTs indicates that the...

journal_title：Gynecologic oncology

authors： Chumas JC,Thanning L,Mann WJ

更新日期：1986-02-01 00:00:00

abstract：OBJECTIVE:While there is ample literature on prognostic factors for uterine cancer, currently there are nomeans to estimate an individual's risk for recurrence or to differentiate the risk of loco-regional recurrence from distant recurrence. We addressed this gap by developing nomograms to individualize the risk of rec...

journal_title：Gynecologic oncology

authors： Kondalsamy-Chennakesavan S,Yu C,Kattan MW,Leung Y,Sykes P,Nascimento M,Nicklin J,Perrin L,Crandon A,Chetty N,Land R,Garrett A,Obermair A

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:Previous studies by the Gynecologic Oncology Group have demonstrated a 7% response rate with bolus etoposide as second-line therapy in nonsquamous cell carcinoma of the cervix. Prolonged oral etoposide, which exploits the schedule dependency of this agent, has demonstrated increased activity in squamous carci...

journal_title：Gynecologic oncology

authors： Rose PG,Blessing JA,Buller RE,Mannel RS,Webster KD

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVES:To evaluate the prevalence and associated prognostic indicators in patients with vulvar carcinoma with and without evidence of perineural invasion (PNI). METHODS:A retrospective review identified 421 patients with invasive vulvar carcinoma evaluated at a single institution between 1993 and 2011. Medical rec...

journal_title：Gynecologic oncology

authors： Salcedo MP,Sood AK,Dos Reis R,Ramalingam P,Chen C,Frumovitz M,Jhingran A,Pitcher B,Ramirez PT,Schmeler KM

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:The hepatocyte growth factor (HGF) receptor c-Met plays an important role in tumor dissemination by activating mitogenic signaling pathways. The goal of this study was to investigate immunohistochemical (IHC) staining patterns of HGF and c-Met in endometrioid endometrial cancer (EC) and uterine serous cancer ...

journal_title：Gynecologic oncology

authors： Bishop EA,Lengyel ER,Yamada SD,Montag A,Temkin SM

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:To determine if the timing of normalization of CA-125 levels during primary chemotherapy for epithelial ovarian cancer (EOC) could predict survival. METHODS:Patients who reached a complete clinical response for EOC with primary taxane/platinum-based chemotherapy were eligible. Patient demographics, chemother...

journal_title：Gynecologic oncology

authors： Rocconi RP,Matthews KS,Kemper MK,Hoskins KE,Huh WK,Straughn JM Jr

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:The goal of this work was to evaluate the involvement of gonadotropins in the regulation of adhesion of human epithelial ovarian carcinoma. We studied two pathways that were previously implicated in the metastatic implantation of ovarian carcinoma to the peritoneum, namely hyaluronan-CD44 and RGD-integrin med...

journal_title：Gynecologic oncology

authors： Schiffenbauer YS,Meir G,Maoz M,Even-Ram SC,Bar-Shavit R,Neeman M

更新日期：2002-02-01 00:00:00

abstract：:Vaginal evisceration is a rare event. This case report describes a 45-year-old woman who presented 8 days following radical hysterectomy and lymph node dissection for stage 1B squamous cell carcinoma of the cervix with small bowel evisceration through the vagina. She was treated by laparotomy and resection anastamosis...

journal_title：Gynecologic oncology

authors： Dawlatly B,Lavie O,Lopes A

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVE:To design and implement a standardized postoperative voiding management protocol that accurately identifies patients with urinary retention and reduces unnecessary re-catheterization. METHODS:A postoperative voiding management protocol was designed and implemented in patients undergoing major, inpatient, non...

journal_title：Gynecologic oncology

authors： Brackmann M,Carballo E,Uppal S,Torski J,Reynolds RK,McLean K

更新日期：2020-05-01 00:00:00

abstract：:To determine the best noninvasive means of evaluating response in patients with advanced ovarian carcinoma, 50 abdominal ultrasound (US) and computed tomography (CT) scans were performed in clinically disease-free ovarian cancer patients. The scans were correlated with the results obtained at a subsequent second- or t...

journal_title：Gynecologic oncology

authors： Lund B,Jacobsen K,Rasch L,Jensen F,Olesen K,Feldt-Rasmussen K

更新日期：1990-05-01 00:00:00

abstract：:A number of chemical agents have been found to influence the proliferation, morphology, enzymatic activity, and antigen expression of neoplastic cells toward a more differentiated phenotype. We studied the effects of differentiating agents retinoic acid, sodium butyrate, and dibutyryl cyclic AMP on the expression of t...

journal_title：Gynecologic oncology

authors： Brooks SE,Timmerman J,Lau CC,Tsao SW,Knapp RC,Sheets EE

更新日期：1991-09-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to define the clinical-therapeutical approach to endometrial cancer now being followed in some of the most important centers of reference for gynecological cancer in North America by means of a questionnaire. STUDY DESIGN:The questionnaire focused on four principal areas: (1) surgic...

journal_title：Gynecologic oncology

authors： Maggino T,Romagnolo C,Landoni F,Sartori E,Zola P,Gadducci A

更新日期：1998-03-01 00:00:00