Abstract:
:Sepsis is defined as the dysregulated host response to an infection resulting in life-threatening organ dysfunction. The metabolic demand from inefficiencies in anaerobic metabolism, mitochondrial and cellular dysfunction, increased cellular turnover, and free-radical damage result in the increased focus of micronutrients in sepsis as they play a pivotal role in these processes. In the present review, we will evaluate the potential role of micronutrients in sepsis, specifically, thiamine, l-carnitine, vitamin C, Se and vitamin D. Each micronutrient will be reviewed in a similar fashion, discussing its major role in normal physiology, suspected role in sepsis, use as a biomarker, discussion of the major basic science and human studies, and conclusion statement. Based on the current available data, we conclude that thiamine may be considered in all septic patients at risk for thiamine deficiency and l-carnitine and vitamin C to those in septic shock. Clinical trials are currently underway which may provide greater insight into the role of micronutrients in sepsis and validate standard utilisation.
journal_name
Nutr Res Revjournal_title
Nutrition research reviewsauthors
Belsky JB,Wira CR,Jacob V,Sather JE,Lee PJdoi
10.1017/S0954422418000124subject
Has Abstractpub_date
2018-12-01 00:00:00pages
281-290issue
2eissn
0954-4224issn
1475-2700pii
S0954422418000124journal_volume
31pub_type
杂志文章,评审abstract::The present paper provides a comprehensive review of the literature pertaining to the impact of alcohol intake on cardiovascular disease. Both cross-sectional and prospective studies have disclosed a negative association between moderate intake of alcoholic beverages and cardiovascular disease. The relationship appear...
journal_title:Nutrition research reviews
pub_type: 杂志文章
doi:10.1079/NRR200235
更新日期:2002-06-01 00:00:00
abstract::The purpose of this review is to examine the need for and appropriate level of Fe fortification of infant formula, and to assess any adverse effects of Fe fortification. The appropriate level of Fe fortification of infant formula has been established through studies of Fe absorption or erythrocyte incorporation of Fe,...
journal_title:Nutrition research reviews
pub_type: 杂志文章
doi:10.1079/095442200108729070
更新日期:2000-12-01 00:00:00
abstract::Existing reviews suggest that milk and other dairy products do not play a role in the development of obesity in childhood, but they do make an important contribution to children's nutrient intake. It is thus curious that public health advice on the consumption of dairy products for children is often perceived as uncle...
journal_title:Nutrition research reviews
pub_type: 杂志文章,评审
doi:10.1017/S0954422418000227
更新日期:2019-06-01 00:00:00
abstract::The demand for organic foods is constantly increasing mainly due to consumers' perception that they are healthier and safer than conventional foods. There is a need for information related to food safety to inform consumers of the health benefits and/or hazards of food products of both origins, in order to optimise th...
journal_title:Nutrition research reviews
pub_type: 杂志文章
doi:10.1079/NRR200361
更新日期:2003-12-01 00:00:00
abstract::The weaning transition is characterised by morphological, histological and microbial changes, often leading to weaning-associated disorders. These intestinal changes can partly be ascribed to the lack of luminal nutrition arising from the reduced feed intake common in pigs after weaning. It is increasingly becoming cl...
journal_title:Nutrition research reviews
pub_type: 杂志文章,评审
doi:10.1017/S0954422411000047
更新日期:2011-12-01 00:00:00
abstract::The micro-organisms which inhabit the human gut (i.e. the intestinal microbiota) influence numerous human biochemical pathways and physiological functions. The present review focuses on two questions, 'Are intestinal microbiota effects measurable and meaningful?' and 'What research methods and variables are influenced...
journal_title:Nutrition research reviews
pub_type: 杂志文章,评审
doi:10.1017/S0954422419000076
更新日期:2019-12-01 00:00:00
abstract::Improved domestic animal productivity is necessary in order to provide for an increasing world population over the next two to three decades and such improvement would be aided by an increase in the efficiency of nutrient utilization. This can be achieved by conventional genetic selection protocols but progress by thi...
journal_title:Nutrition research reviews
pub_type: 杂志文章
doi:10.1079/095442299108728893
更新日期:1999-06-01 00:00:00
abstract::The present review investigates the role of sleep and its alteration in triggering metabolic disorders. The reduction of the amount of time sleeping has become an endemic condition in modern society and the current literature has found important associations between sleep loss and alterations in nutritional and metabo...
journal_title:Nutrition research reviews
pub_type: 杂志文章
doi:10.1017/S0954422407810651
更新日期:2007-12-01 00:00:00
abstract::The alarming prevalence of obesity has led to a better understanding of the molecular mechanisms controlling energy homeostasis. Regulation of energy intake and expenditure is more complex than previously thought, being influenced by signals from many peripheral tissues. In this sense, a wide variety of peripheral sig...
journal_title:Nutrition research reviews
pub_type: 杂志文章,评审
doi:10.1017/S0954422412000145
更新日期:2012-12-01 00:00:00
abstract::Overweight and obesity are associated with increased morbidity and mortality, although the range of body weights that is optimal for health is controversial. It is less clear whether weight loss benefits longevity and hence whether weight reduction is justified as a prime goal for all individuals who are overweight (n...
journal_title:Nutrition research reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1017/S0954422409990035
更新日期:2009-06-01 00:00:00
abstract::Androgen deprivation therapy (ADT) is used widely as part of a combined modality for the treatment of prostate cancer. However, ADT has also been associated with the development of cardiometabolic complications that can increase mortality from cardiovascular events. There is emerging evidence to suggest that ADT-relat...
journal_title:Nutrition research reviews
pub_type: 杂志文章,评审
doi:10.1017/S0954422417000087
更新日期:2017-12-01 00:00:00
abstract::Diet plays an important role in the primary and secondary prevention of cardiovascular disease. The growing perception that abnormal haemostatic processes of coagulation, platelet aggregation and fibrinolysis contribute to cardiovascular disease aetiology motivated this review on the relationships of diet, specific fo...
journal_title:Nutrition research reviews
pub_type: 杂志文章
doi:10.1079/NRR19970007
更新日期:1997-01-01 00:00:00
abstract::The cost of psychiatric illness to the UK economy was recently estimated at pound77 billion annually. Despite years of research no firm aetiological explanation exists, and with no physiological or biochemical markers diagnosis is made entirely on a behavioural basis. All current pharmacological therapies are associat...
journal_title:Nutrition research reviews
pub_type: 杂志文章
doi:10.1079/NRR2006119
更新日期:2006-06-01 00:00:00
abstract::Exercise causes a dramatic increase in energy requirements because of the metabolic needs of working muscles. Exercise-dependent factors regulate fuel use. Absolute exercise intensity determines the exercise-induced increase in energy demands, whereas exercise intensity relative to an individual's maximal aerobic capa...
journal_title:Nutrition research reviews
pub_type: 杂志文章
doi:10.1079/NRR200357
更新日期:2003-06-01 00:00:00
abstract::A food can be regarded as 'functional' if it can demonstrate a beneficial efficacy on one or more target functions in the body in a convincing way. Beyond adequate nutritional qualities, functional foods should either improve the state of health and wellbeing and/or reduce the risk of disease. Functional foods that ar...
journal_title:Nutrition research reviews
pub_type: 杂志文章,评审
doi:10.1017/S0954422409990187
更新日期:2009-12-01 00:00:00
abstract::Homelessness is present in most societies and represents a situation in which the basic needs for survival including food are often limited. It is logical to surmise that the homeless person's diet is likely to be nutritionally deficient and yet there is a relative paucity in research regarding this issue with studies...
journal_title:Nutrition research reviews
pub_type: 杂志文章,评审
doi:10.1017/S0954422416000068
更新日期:2016-12-01 00:00:00
abstract::Ruminants are recognised to suffer from Cu-responsive disorders. Present understanding of Cu transport and metabolism is limited and inconsistent across vets and veterinary professionals. There has been much progress from the studies of the 1980s and early 1990s in cellular Cu transport and liver metabolism which has ...
journal_title:Nutrition research reviews
pub_type: 杂志文章
doi:10.1017/S0954422419000180
更新日期:2020-06-01 00:00:00
abstract::Nutrition plays an important role in osteoporosis prevention and treatment. Substantial progress in both laboratory analyses and clinical use of biochemical markers has modified the strategy of anti-osteoporotic drug development. The present review examines the use of biochemical markers in clinical research aimed at ...
journal_title:Nutrition research reviews
pub_type: 杂志文章,评审
doi:10.1017/S0954422414000183
更新日期:2014-12-01 00:00:00
abstract::While medical nutrition therapy is an essential part of the care for critically ill patients, uncertainty exists about the right form, dosage, timing and route in relation to the phases of critical illness. As enteral nutrition (EN) is often withheld or interrupted during the intensive care unit (ICU) stay, combined E...
journal_title:Nutrition research reviews
pub_type: 杂志文章
doi:10.1017/S0954422420000165
更新日期:2020-12-01 00:00:00
abstract::The primary reason for processing maize is to enhance feeding value. Total tract starch digestion is similar for coarsely processed (dry rolled, cracked) dry maize. Enhancements in starch digestion due to dry rolling maize v. feeding maize whole may be greater in light-weight calves than in yearlings, and when DM inta...
journal_title:Nutrition research reviews
pub_type: 杂志文章,评审
doi:10.1017/S0954422411000096
更新日期:2011-12-01 00:00:00
abstract::Three areas in the brain continuously generate new neurons throughout life: the subventricular zone lining the lateral ventricles, the dentate gyrus in the hippocampus and the median eminence in the hypothalamus. These areas harbour neural stem cells, which contribute to neural repair by generating daughter cells that...
journal_title:Nutrition research reviews
pub_type: 杂志文章,评审
doi:10.1017/S0954422416000081
更新日期:2016-12-01 00:00:00
abstract::Cognitive outcomes are frequently implemented as endpoints in nutrition research. To reduce the number of statistical comparisons it is commonplace for nutrition researchers to combine cognitive test results into a smaller number of broad cognitive abilities. However, there is a clear lack of understanding and consens...
journal_title:Nutrition research reviews
pub_type: 杂志文章,评审
doi:10.1017/S0954422414000158
更新日期:2014-12-01 00:00:00
abstract::Health benefits for man have been associated with conjugated linoleic acid (CLA) and dairy products are highlighted as offering the best opportunity to increase CLA consumption. CLA is synthesised in the rumen as an intermediate in the biohydrogenation of linoleic acid to stearic acid. The supplies of both intermediat...
journal_title:Nutrition research reviews
pub_type: 杂志文章
doi:10.1079/NRR200121
更新日期:2001-06-01 00:00:00
abstract::Prebiotics are non-digestible (by the host) food ingredients that have a beneficial effect through their selective metabolism in the intestinal tract. Key to this is the specificity of microbial changes. The present paper reviews the concept in terms of three criteria: (a) resistance to gastric acidity, hydrolysis by ...
journal_title:Nutrition research reviews
pub_type: 杂志文章
doi:10.1079/NRR200479
更新日期:2004-12-01 00:00:00
abstract::Wine polyphenols are considered to have beneficial effects on CHD and atherosclerosis. The consumption of red wine is high in Italy and France, approximately four times greater than that in the UK. This disparity in red wine consumption is thought to be the reason for the 'French paradox', where France was shown to ha...
journal_title:Nutrition research reviews
pub_type: 杂志文章
doi:10.1079/NRR200482
更新日期:2004-06-01 00:00:00
abstract::The metabolic syndrome (MetS) is a key indicator of two main causes of death worldwide: CVD and diabetes. The present paper aimed to perform a review of the population-based research on the association of dietary patterns and the MetS in terms of methodology and findings. For the purpose of the present study, a scopin...
journal_title:Nutrition research reviews
pub_type: 杂志文章,评审
doi:10.1017/S095442241600007X
更新日期:2016-12-01 00:00:00
abstract::The present review examines the importance of choline in dairy cow nutrition. Choline is an essential nutrient for mammals when excess methionine and folate are not available in the diet. The requirement for choline can be met by dietary choline and by transmethylation reactions. Two types of functions for choline are...
journal_title:Nutrition research reviews
pub_type: 杂志文章
doi:10.1079/NRR200247
更新日期:2002-12-01 00:00:00
abstract::In the current post-antibiotic era, botanicals represent one of the most employed nutritional strategies to sustain antibiotic-free and no-antibiotic-ever production. Botanicals can be classified either as plant extracts, meaning the direct products derived by extraction from the raw plant materials (essential oils (E...
journal_title:Nutrition research reviews
pub_type: 杂志文章
doi:10.1017/S0954422420000013
更新日期:2020-12-01 00:00:00
abstract::The ultimate goal in the design of infant formula is to achieve the outcome seen in breast fed infants. This review of lipids in infant formulas for term infants begins by referring to the lipid composition of human milk, and relates that to differences in lipid digestion and metabolism which exist between breast fed ...
journal_title:Nutrition research reviews
pub_type: 杂志文章
doi:10.1079/NRR19980018
更新日期:1998-12-01 00:00:00
abstract::CVD are the leading cause of death in women globally, with ageing associated with progressive endothelial dysfunction and increased CVD risk. Natural menopause is characterised by raised non-fasting TAG concentrations and impairment of vascular function compared with premenopausal women. However, the mechanisms underl...
journal_title:Nutrition research reviews
pub_type: 杂志文章,评审
doi:10.1017/S0954422418000033
更新日期:2018-12-01 00:00:00