Twenty years of protein interaction studies for biological function deciphering.

Abstract:

:Intensive methodological developments and technology innovation have been devoted to protein-protein interaction studies over 20years. Genetic indirect assays and sophisticated large scale biochemical analyses have jointly contributed to the elucidation of protein-protein interactions, still with a lot of drawbacks despite heavy investment in human resources and technologies. With the most recent developments in mass spectrometry and computational tools for studying protein content of complex samples, the initial goal of deciphering molecular bases of biological functions is now within reach. Here, we described the various steps of this process and gave examples of key milestones in this scientific story line. This article is part of a Special Issue entitled: 20years of Proteomics in memory of Viatliano Pallini. Guest Editors: Luca Bini, Juan J. Calvete, Natacha Turck, Denis Hochstrasser and Jean-Charles Sanchez.

journal_name

J Proteomics

journal_title

Journal of proteomics

authors

Legrain P,Rain JC

doi

10.1016/j.jprot.2014.03.038

subject

Has Abstract

pub_date

2014-07-31 00:00:00

pages

93-7

eissn

1874-3919

issn

1876-7737

pii

S1874-3919(14)00160-2

journal_volume

107

pub_type

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