Abstract:
:The aim of this cross-sectional study is to evaluate the factors associated with patient-reported dysphagia in patients affected by locally advanced oropharyngeal cancer (OPC) treated with definitive intensity-modulated radiation therapy (IMRT) and concurrent chemotherapy (CHT), with or without induction CHT. We evaluated 148 OPC patients treated with IMRT and concurrent CHT, without evidence of disease and who had completed their treatment since at least 6 months. At their planned follow-up visit, patients underwent clinical evaluation and completed the M.D. Anderson dysphagia inventory (MDADI) questionnaire. The association between questionnaire composite score (MDADI-CS) and different patients' and tumor's characteristics and treatments (covariates) was investigated by univariable and multivariable analyses, the latter including only covariates significant at univariable analysis. With a median time from treatment end of 30 months [range 6-74 months, interquartile range (IQR) 16-50 months], the median (IQR) MDADI-CS was 72 (63-84). The majority of patients (82.4%) had a MDADI-CS ≥ 60. At multivariable analysis, female gender, human papilloma virus (HPV)-negative status, and moderate and severe clinician-rated xerostomia were significantly associated with lower MDADI-CS. Patient-perceived dysphagia was satisfactory or acceptable in the majority of patients. HPV status and xerostomia were confirmed as important predictive factors for swallowing dysfunction after radiochemotherapy. Data regarding female gender are new and deserve further investigation.
journal_name
Dysphagiajournal_title
Dysphagiaauthors
Orlandi E,Miceli R,Infante G,Mirabile A,Alterio D,Cossu Rocca M,Denaro N,Vigna-Taglianti R,Merlotti A,Schindler A,Pizzorni N,Fallai C,Licitra L,Bossi Pdoi
10.1007/s00455-018-9913-8subject
Has Abstractpub_date
2019-02-01 00:00:00pages
52-62issue
1eissn
0179-051Xissn
1432-0460pii
10.1007/s00455-018-9913-8journal_volume
34pub_type
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