Abstract:
:Hydrogels are 3D hydrophilic polymer networks that absorb and hold huge amounts of water. Although hydrogels have traditionally been synthesized using chemical and physical methods, rapid developments in enzyme technology that, like chemical-based methods, enable the formation of stable covalent bonds are fast emerging as alternative 'green catalyst' tools. Enzymes show great potential for the synthesis of complex multifunctional wound dressing hydrogels (WDHs) ex situ and in situ as well as in acting as interactive molecules to promote the wound healing process. This review presents advances in the use of enzymes to synthesize WDHs and their fascinating role as bioactive molecules promoting the wound healing process, preventing microbial infection, and providing in situ, in-built infection-detection and diagnostic systems.
journal_name
Trends Biotechnoljournal_title
Trends in biotechnologyauthors
Guebitz GM,Nyanhongo GSdoi
10.1016/j.tibtech.2018.05.006subject
Has Abstractpub_date
2018-10-01 00:00:00pages
1040-1053issue
10eissn
0167-7799issn
1879-3096pii
S0167-7799(18)30141-0journal_volume
36pub_type
杂志文章,评审abstract::Challenges in demonstrating interchangeability and safety, as well as the ongoing evolution of regulations governing biosimilars, have meant that the development of the biosimilars industry has not been, and will not be, a carbon copy of the generics industry. Complexity in the development process reduces the cost adv...
journal_title:Trends in biotechnology
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abstract::The current productivity crisis in drug discovery has prompted the pharmaceutical industry to decentralize R&D, which is now more responsive, more flexible and better connected to research in academia and biotechnology firms. Organizational changes are also under way in academia. Universities are expanding their techn...
journal_title:Trends in biotechnology
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abstract::In Europe, in light of ethical, political and commercial pressure, every effort should be made to replace animals with alternatives (e.g. in vitro models), to reduce the number of animals used in experiments to a minimum and to refine current testing strategies in a way that ensures animals undergo minimum pain and di...
journal_title:Trends in biotechnology
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abstract::Vibrational spectroscopy using both infrared and Raman spectroscopies has been used in recent years with the aim to aid clinicians in disease diagnosis. More recently, these techniques have been applied to study stem cell differentiation and to determine stem cell presence in tissues. These studies have demonstrated t...
journal_title:Trends in biotechnology
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journal_title:Trends in biotechnology
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journal_title:Trends in biotechnology
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doi:10.1016/j.tibtech.2007.07.001
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journal_title:Trends in biotechnology
pub_type: 杂志文章,评审
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journal_title:Trends in biotechnology
pub_type: 杂志文章
doi:10.1016/j.tibtech.2004.04.015
更新日期:2004-07-01 00:00:00
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journal_title:Trends in biotechnology
pub_type: 杂志文章
doi:10.1016/j.tibtech.2016.05.001
更新日期:2017-01-01 00:00:00
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journal_title:Trends in biotechnology
pub_type: 杂志文章
doi:10.1016/j.tibtech.2015.01.002
更新日期:2015-04-01 00:00:00
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journal_title:Trends in biotechnology
pub_type: 杂志文章,评审
doi:10.1016/j.tibtech.2017.03.008
更新日期:2017-07-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/j.tibtech.2018.06.010
更新日期:2018-11-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/j.tibtech.2007.07.005
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abstract::Higher fungi with greater than 70000 species are regarded as a rich source of various natural compounds including terpenoids, the production of which represents a wide range of interest in pharmaceutical and healthcare industries. This review summarizes the current knowledge of terpenoids synthesized by higher fungi, ...
journal_title:Trends in biotechnology
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doi:10.1016/j.tibtech.2015.12.007
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abstract::Protein phosphorylation is a complex and highly dynamic process involved in numerous biological events. Abnormal phosphorylation is one of the underlying mechanisms for the development of cancer and metabolic disorders. The identification and absolute quantification of specific phospho-signatures can help elucidate pr...
journal_title:Trends in biotechnology
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abstract::Accurate diagnosis and prognosis is essential for cancer management but is subject to sampling and inter-observer error. In a recent study, Baker et al. compared Fourier transform infrared (FTIR) microspectroscopy with histological pathology to evaluate prostate tissue for disease severity. The authors found that bioc...
journal_title:Trends in biotechnology
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doi:10.1016/j.tibtech.2009.09.001
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journal_title:Trends in biotechnology
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journal_title:Trends in biotechnology
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journal_title:Trends in biotechnology
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journal_title:Trends in biotechnology
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journal_title:Trends in biotechnology
pub_type: 杂志文章,评审
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abstract::Genome engineering is crucial for answering fundamental questions about, and exploring practical applications of, microorganisms. Various microbial genome-engineering tools, including CRISPR/Cas-enhanced homologous recombination (HR), have been developed, with ever-improving simplicity, efficiency, and applicability. ...
journal_title:Trends in biotechnology
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