Abstract:
AIMS:To describe the 3-year progression-free survival (PFS), overall survival (OS) and disease-specific mortality in the prospective prostate cancer GESCAP cohort, as well as the progression to castration resistance in patients on hormone therapy. MATERIAL AND METHODS:Prospective, observational, epidemiological, multicentre study. Of the 4087 patients recruited, 3843 were evaluable. The variables analysed were the risk group (localized, locally advanced, lymph involvement, metastatic), age, prostate-specific antigen (PSA) levels, Gleason score and initial treatment. Kaplan Meier survival analysis, the log-rank test and the Cox model were used to evaluate the survival data. RESULTS:Three-year PFS was 81.4% and OS was 92.4%. During the 3 years of follow-up, 303 patients died (7.9%), 110 of them (36.3%) due to disease-related causes. The probability of castration resistance for all patients on hormone therapy (n=715) was 14.2%: 5%, 9.9%, 26.1% and 44.4% in localized, locally advanced, lymph involvement and metastatic cancer, respectively (log-rank P<.0001). Patients with metastases had poorer outcomes with respect to PFS, OS, disease-specific mortality and castration resistance. In the multivariate analysis, the Gleason score, PSA and presence of metastases were associated with shorter OS and PFS. CONCLUSIONS:Our study showed stratification of risk, with a more unfavourable prognosis for patients with metastases. Patients with locally advanced disease differed with respect to those with localized disease due to their higher risk as regards disease-specific mortality. (Controlled-trials.com ISRCTN19893319).
journal_name
Actas Urol Espjournal_title
Actas urologicas espanolasauthors
Cózar JM,Miñana B,Gómez-Veiga F,Rodríguez-Antolín A,Grupo Gescap.doi
10.1016/j.acuro.2018.03.004subject
Has Abstractpub_date
2019-01-01 00:00:00pages
4-11issue
1eissn
0210-4806issn
1699-7980pii
S0210-4806(18)30084-6journal_volume
43pub_type
杂志文章,多中心研究abstract:INTRODUCTION AND OBJECTIVES:The study was conducted to identify the risk factors of upper tract stone formation in patients with diversions after radical cystectomy (RC). MATERIALS AND METHODS:All patients with diversion after RC were collected in our center from January 2005 to December 2013. Three different common d...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/j.acuro.2019.04.002
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVES:The testicular tumors are frequent in the young adult, coinciding with the incorporation to the Military Service. The objective of our work is to evaluate the tumoral characteristic, its evolution with the time and the result of the treatments used in our center for this type of tumors. MATERIAL AND METHODS...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/s0210-4806(05)73275-7
更新日期:2005-05-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:Pyeloplasty has always been the treatment of choice for ureteropelvic junction obstruction at our center, where a laparoscopic approach has been used in the last 4 years to perform this procedure. Results of open pyeloplasty (OP) and laparoscopic pyeloplasty (LP) performed at our center in t...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/s0210-4806(09)72899-2
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:Analysis of the urinary excretion of cytokines in vesical carcinoma. MATERIAL AND METHOD:The study includes the results obtained in the quantification of several interleukins (IL-1, IL-2, IL-4, IL-6, INF-gamma and TNF-alpha) in urine samples corresponding to 60 patients with transitional cell carcinoma (TCC)...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract:INTRODUCTION:Primary adenocarcinoma of the seminal vesicle is an extremely rare condition. Some cases have been described in relation to congenital seminal vesicle cysts, which is often also associated with agenesia or ipsilateral renal disgenesia. The rareness of this type of lesions makes it difficult to plan a regul...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/j.acuro.2011.01.007
更新日期:2011-05-01 00:00:00
abstract::Pseudoaneurism in renal grafts is a well known complication of the percutaneous biopsy. Colour Doppler has been shown to be the choice technique for their diagnosis and subsequent control, the most effective treatment being embolization. This paper presents an unusual form of pseudoaneurism in terms of its size (up to...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:To analyze the incidence of urological complications, like fistula and stenosis in our series of 282 renal transplants and their management. MATERIALS AND METHODS:Between December 1995 and October 2005, 282 adult recipients underwent renal transplant. The most common urological complication was urinary fistu...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/s0210-4806(06)73503-3
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVES:The functional symptoms of the filling phase and detrusor overactivity are two inter-related dysfunctions of the lower urinary tract. We have aimed to study the participation of the lesion of the pudendal nerve in both urinary dysfunctions. MATERIAL AND METHODS:A cross-sectional cutoff study in a series of ...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/j.acuro.2011.07.011
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:To evaluate the effect of JJ stents on SWL treatment of moderate (15-25mm) renal pelvic stones. MATERIALS AND METHODS:Between January 2016 and December 2017, a total of 152 adult patients who were planned to undergo SWL for a single radiopaque renal pelvic stone were included in the study. Patients with solita...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.acuro.2019.03.009
更新日期:2019-10-01 00:00:00
abstract:INTRODUCTION:NF-kB (p50/p65) is a transcription factor involved in TNF-α-induced cell death resistance by promoting several antiapoptotic genes. We intend to relate the expression of NF-kB (p50 and p65) with serum levels of prostate-specific antigen (PSA), both in normal males and in those with pathologic conditions of...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/j.acuro.2010.08.002
更新日期:2011-01-01 00:00:00
abstract::A prospective randomized study on 100 patients was conducted to determine the effect of the rectal digital examination on prostate specific antigen (PSA) serum concentration. The control group consisted of 50 patient, all with two PSA determinations with no urological manipulation between them. The study group had 50 ...
journal_title:Actas urologicas espanolas
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:To validate the technique of selective sentinel node biopsy for diagnosing and staging intermediate to high-risk prostate cancer by comparing the technique with conventional extended lymphadenectomy (eLFD) in a prospective, longitudinal comparative study. METHODS:We applied the technique to 45 patients. Afte...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/j.acuro.2016.06.002
更新日期:2017-01-01 00:00:00
abstract:CONTEXT:Serum testosterone is mostly bound to the sex hormone-binding globulin and albumin. A small metabolically active part is present in the form of free testosterone (FT). The relationship between serum total testosterone (TT) levels and prostate carcinogenesis is debated. Our hypothesis is that the serum FT concen...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:10.1016/j.acuro.2015.03.004
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVES:To explore the management of lower urinary tract symptoms (LUTS) in men in Spain and assess the compliance with recommendations established in the European Association of Urology (EAU) guidelines. MATERIAL AND METHODS:MERCURY was an epidemiological and cross-sectional study which involved 227 Urology Units ...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/j.acuro.2017.12.003
更新日期:2018-06-01 00:00:00
abstract::Instrumentation of lower urinary tract is a predisposing factor for the development of urinary infection. Incidence of infective complications following urethrocystoscopy has been evaluated in a multicenter, prospective, comparative and randomized study in 2,284 patients, who had a previous negative urine culture. Pat...
journal_title:Actas urologicas espanolas
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1993-03-01 00:00:00
abstract:INTRODUCTION:Laparoscopic surgery through a single port is an evolution of laparoscopic surgery, possible after recent technological development of new access systems. It is an established minimally invasive technique, although its indications in the field of Urology are currently under development. MATERIAL AND METHO...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/j.acuro.2011.10.003
更新日期:2012-02-01 00:00:00
abstract::Congenital cysts in the seminal vesicle represent a rare by illustrative example of embryological malformation. They are often associated with ipsilateral urinary tract anomalies. We have analyzed the diagnostic and therapeutic schemes followed in the study of this uncommon pathology. ...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVES:To explore the links between the histological composition of the prostate and the symptoms related to the clinical BPH. MATERIAL & METHODS:The prostates of 34 patients with symptoms of BPH and 17 asymptomatic patients were biopsied. Using light microscopy, the ratio of stromal to glandular surfaces was calc...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00
abstract::Fifty-one patients with non-seminoma testicular cancer who underwent retroperitoneal ganglion dissection and 3 support cycles of chemotherapy with Cys-Platin, Vinblastine and Bleomycin. Four patients presented relapses (7.8%). Actuarial survival by 8 years was 87%, with a median of 38 months. The median survival was 4...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::Melanomas make up 2% of all body tumours, but the figure is increasing mainly in countries with longer sun hours daily. Genitourinary location is even more infrequent. That explains our clinical report when we discovered the three cases seen in our unit, one in a female urethra, one suprarenal and the third one in the...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:
更新日期:1991-07-01 00:00:00
abstract::The paper explains the results obtained in 90 female patients with stress urine incontinence (90% in grade II at medium stress) who have undergone surgery through the vagina to free the urethra, cervix vesicae and bladder, raising them with a silk transversal suture anchored to the pubourethral ligament residues as we...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:1990-09-01 00:00:00
abstract::Emphysematous cystitis constitutes an uncommon clinical radiological entity. (Approximately 160 cases in the literature). We offer five cases of emphysematous cystitis, all of which occurred in women aged 60-80 (X = 74.2). All of them except one proved to be known diabetics and the glycemia figures at the time of bein...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:
更新日期:1989-09-01 00:00:00
abstract:OBJECTIVES:Evaluation of a new mesh for incontinence (TVA/TOA) which enables the degree of tension applied during surgery to be readjusted at the post-operative stage. PATIENTS AND METHOD:62 patients treated with the TVA mesh and monitored over a 14-month period (SD 7.8, range 6-38). In 33 patients (53%) some other pe...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/s0210-4806(06)73422-2
更新日期:2006-02-01 00:00:00
abstract::Contribution of one left renal adenocarcinoma in a 54-year old women, where the initial data was the finding of erythrocytosis discovered during routine laboratory tests performed by her gynaecologist. Review of the diagnostic and therapeutic procedures followed in this case, establishing a differentiation between ery...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:1992-05-01 00:00:00
abstract:PURPOSE:Pulsed dye laser lithotripsy has shown to be an effective and safe procedure for treatment of ureteral calculi. We report our experience. MATERIAL AND METHODS:A total of 1000 patients were treated with pulsed dye laser between January 1990 and February 1996. In 450 patients the procedure was performed under ge...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::Cystadenoma of the seminal vesicles is a extremely rare pathology. To our knowledge only eight cases have been reported in the literature. We report a new case of this benign tumor, bilaterally located and incidentally found at surgery. Literature is reviewed and clinical, diagnostic and therapeutic aspects of these a...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVE:To describe the outcome of patients diagnosed of incidental prostate adenocarcinoma managed by watchful waiting. MATERIAL AND METHODS:We included patients with PSA< 4 ng/mL or higher with previous negative biopsy, who underwent surgery for BPH being diagnosed of incidental prostate adenocarcinoma. We perform...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:2010-11-01 00:00:00
abstract::Obstructive uropathy is a result of the particular tubular configuration of the urinary tract and involves virtually all its organs. This review analyses upper urinary tract obstructions as well as a number of lower urinary tract conditions whenever the circumstances of the urological disease progress so advises it. A...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:10.1016/s0210-4806(02)74311-8
更新日期:2002-11-01 00:00:00
abstract::Presentation of one case of malignant fibrohistiocytoma derived from the renal capsule. While conducting a bibliographic review the low incidence of this tumoration of renal origin was noted. The difficulties in differentiating this entity from a secondary renal invasion by a malignant fibrohistiocytoma derived from o...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVE:To determine the values of PSA in Spanish workers without history of prostate problems and compare them with other geographical latitudes. METHODS:Observational, retrospective, multicenter and population-based study, conducted between January 1 and December 31, 2006. A total of 65303 workers participated in ...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,多中心研究
doi:
更新日期:2010-09-01 00:00:00