当前位置： SCI文献检索 > Advances in Experimental Medicine and Biology期刊下所有文献 > A monoclonal antibody recognizing an iscosapeptide sequence in the heavy chain of human factor XII inhibits surface-catalyzed activation.

A monoclonal antibody recognizing an iscosapeptide sequence in the heavy chain of human factor XII inhibits surface-catalyzed activation.

Abstract：

:A monoclonal antibody (mAb B7C9) to human factor XII was produced which blocked the surface mediated coagulant activity of factor XII but not the amidolysis of H-D-ProPheArg-pNA. The mAb epitope was localized to a 20 amino acid sequence of 2.5 kDa in the heavy chain of factor XII.

journal_name

Adv Exp Med Biol

journal_title

Advances in experimental medicine and biology

authors

Pixley RA,Colman RW

doi

10.1007/978-1-4615-9543-4_72

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

473-6

eissn

0065-2598

issn

2214-8019

journal_volume

247A

pub_type

杂志文章

相关文献

Advances in Experimental Medicine and Biology文献大全
  • Differential Contribution of Calcium-Activated Proteases and ER-Stress in Three Mouse Models of Retinitis Pigmentosa Expressing P23H Mutant RHO.

    abstract：:Autosomal dominant retinitis pigmentosa (adRP) is mainly caused by mutations responsible for rhodopsin (RHO) misfolding. Although it was previously proved that unfolded RHO is retained into the endoplasmatic reticulum (ER) eliciting ER-stress, consequent mechanisms underlying photoreceptor degeneration need to be furt...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章

    doi：10.1007/978-3-030-27378-1_51

    authors： Comitato A,Schiroli D,La Marca C,Marigo V

    更新日期：2019-01-01 00:00:00

  • Glycan Markers as Potential Immunological Targets in Circulating Tumor Cells.

    abstract：:We present here an experimental approach for exploring a new class of tumor biomarkers that are overexpressed by circulating tumor cells (CTCs) and are likely targetable in immunotherapy against tumor metastasis. Using carbohydrate microarrays, anti-tumor monoclonal antibodies (mAbs) were scanned against a large panel...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章,评审

    doi：10.1007/978-3-319-55947-6_15

    authors： Wang D,Wu L,Liu X

    更新日期：2017-01-01 00:00:00

  • Similarities and Differences in Psychology.

    abstract：:Addiction is marked by repeating a certain behavior while ignoring the potential physical or mental consequences. Non-substance addiction provides an ideal model for researching the emergence and development of addiction's basic mechanism. Comparative studies of substance and non-substance addiction are helpful to rev...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章,评审

    doi：10.1007/978-981-10-5562-1_6

    authors： Chen Y,Sun Y,Ai SZ,Li JJ,Lu L,Shi J

    更新日期：2017-01-01 00:00:00

  • Introduction of new crosslinks into proteins.

    abstract：:Analysis of the crosslinks epsilon-(gamma-glutamyl) lysine and epsilon- (beta-aspartyl) lysine present in treated wool has been improved by modifying the enzymic digestion. Treatment of wool with either monocarboxylic acid chlorides in dimethylsulfoxide or with 1-fluoro-2,4-dinitrobenzene in the presence of acetate co...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章

    doi：10.1007/978-1-4684-3282-4_21

    authors： Ziegler K,Schmitz I,Zahn H

    更新日期：1977-01-01 00:00:00

  • Assessment of combined thermoradiotherapy in recurrent of advanced carcinoma of the breast.

    abstract：:During 1980 to 1983, 40 patients with advanced or locally recurrent breast cancer were treated with the thermo-radiotherapy. Ten of these were primary cases and 30 recurrent. In 23 patients who had 2 to 3 lesions. Altogether there were 64 lesions treated. Combined thermo-radiotherapy was applied to the bigger lesions ...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章

    doi：10.1007/978-1-4684-5766-7_56

    authors： Li RY,Lin SY,Zhang TZ

    更新日期：1990-01-01 00:00:00

  • Application of Array Comparative Genomic Hybridization in Newborns with Multiple Congenital Anomalies.

    abstract：:Major congenital anomalies are detectable in 2-3 % of the newborn population. Some of their genetic causes are attributable to copy number variations identified by array comparative genomic hybridization (aCGH). The value of aCGH screening as a first-tier test in children with multiple congenital anomalies has been st...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章

    doi：10.1007/5584_2016_235

    authors： Szczałuba K,Nowakowska B,Sobecka K,Smyk M,Castaneda J,Klapecki J,Kutkowska-Kaźmierczak A,Śmigiel R,Bocian E,Radkowski M,Demkow U

    更新日期：2016-01-01 00:00:00

  • Anti-neutrophil cytoplasmic antibodies in patients with systemic lupus erythematosus.

    abstract：:Autoantibodies against neutrophil cytoplasmic antigens (ANCA) are found in patients with different kinds of systemic vasculitis and glomerulonephritis, both characteristic manifestations of systemic lupus erythematosus (SLE). The present study was designed to clarify the nature of ANCA seen in SLE patients and their c...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章

    doi：10.1007/978-1-4757-9182-2_65

    authors： Waldendorf M,Schneider M

    更新日期：1993-01-01 00:00:00

  • The olivo-cerebellar system as a neural clock.

    abstract：:The cerebellum, and the olivo-cerebellar system in particular, may be the central mechanism of a neural clock that provides a rhythmic neural signal used to time motor and cognitive processes. Several independent lines of evidence support this hypothesis. First, the resting membrane potential of neurons in the inferio...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章,评审

    doi：10.1007/978-1-4939-1782-2_9

    authors： Ashe J,Bushara K

    更新日期：2014-01-01 00:00:00

  • Superoxide dismutase-1 influences the timing and post-hypoxic stability of neonatal breathing.

    abstract：:Reactive oxygen species (ROS) likely play a role in the hypoxic ventilatory response. We determined whether hypoxic responses were influenced by alterations in cellular redox status induced by reductions in superoxide dismutase-1 (SOD-1) activity, a cytosolic anti-oxidant enzyme. Using whole-body, continuous-flow plet...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章

    doi：10.1007/978-0-387-73693-8_23

    authors： Cummings KJ,Kalf D,Moore S,Miller BJ,Jirik FR,Wilson RJ

    更新日期：2008-01-01 00:00:00

  • Posttranslationally modified tubulins and other cytoskeletal proteins: their role in gametogenesis, oocyte maturation, fertilization and Pre-implantation embryo development.

    abstract：:The cytoskeleton, mainly consisting of microtubules, intermediate filaments and microfilaments, along with cytoskeleton associated and interconnecting proteins as well as the centrosome, plays enormously important roles in all stages of embryogenesis and undergoes significant changes to accommodate a diversity of cell...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章,评审

    doi：10.1007/978-1-4939-0817-2_4

    authors： Schatten H,Sun QY

    更新日期：2014-01-01 00:00:00

  • Thermal and vortical stability of purified human fibroblast interferon.

    abstract：:The loss of biological activity upon heating or agitation of human interferons is markedly altered by changing their aqueous environment. Low pH significantly stabilizes liquid fibroblast interferon at 68 degrees C and 37 degrees C whereas chaotropic salts stabilize at 68 degrees C but not at 37 degrees C; this anomal...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章

    doi：10.1007/978-1-4615-9080-4_11

    authors： Sedmak JJ,Jameson P,Grossberg SE

    更新日期：1978-01-01 00:00:00

  • Pentose Shunt, Glucose-6-Phosphate Dehydrogenase, NADPH Redox, and Stem Cells in Pulmonary Hypertension.

    abstract：:Redox signaling plays a critical role in the pathophysiology of cardiovascular diseases. The pentose phosphate pathway is a major source of NADPH redox in the cell. The activities of glucose-6-phosphate dehydrogenase (the rate-limiting enzyme in the pentose shunt) and glucose flux through the shunt pathway is increase...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章

    doi：10.1007/978-3-319-63245-2_4

    authors： Hashimoto R,Gupte S

    更新日期：2017-01-01 00:00:00

  • DNA Labeling Using DNA Methyltransferases.

    abstract：:DNA methyltransferases (MTases) uniquely combine the ability to recognize and covalently modify specific target sequences in DNA using the ubiquitous cofactor S-adenosyl-L-methionine (AdoMet). Although DNA methylation plays important roles in biological signaling, the transferred methyl group is a poor reporter and is...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章,评审

    doi：10.1007/978-3-319-43624-1_19

    authors： Tomkuvienė M,Kriukienė E,Klimašauskas S

    更新日期：2016-01-01 00:00:00

  • Mutational analysis of fusion peptide-like regions in the mouse hepatitis virus strain A59 spike protein.

    abstract：:The coronavirus peplomer protein S is responsible for attachment and fusion during viral entry as well as for the induction of cell to cell fusion. While several regions within S have been shown to influence the ability to induce fusion, the region of the protein actually responsible for fusion, the fusion peptide, ha...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章

    doi：10.1007/978-1-4615-5331-1_3

    authors： Luo ZL,Weiss SR

    更新日期：1998-01-01 00:00:00

  • Orphan opioid receptor oligonucleotides inhibit HIV-1 expression in human brain cells.

    abstract：:We found that orphan opioid receptor (OR) mRNA was constitutively expressed in human fetal microglia, astrocytes, and cerebral cortical neurons. An OR antisense oligonucleotide markedly inhibited HIV-1 expression in enriched microglial cell and the mixed glial/neuronal cell cultures but not in the chronically infected...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章

    doi：10.1007/978-1-4615-5347-2_10

    authors： Chao CC,Gekker G,Sheng WS,Hu S,Loh HH,Peterson PK

    更新日期：1998-01-01 00:00:00

  • Magnetometric measurements of macrophage activity in the liver after administration of different perfluorochemicals.

    abstract：:The activity of liver macrophages was evaluated using a magnetometric method after administration of different perfluorochemicals. Following treatment with perfluoroctylbromide a significant shorter time period of diminished macrophage activity was found compared with a mixture of perfluorodecalin and perfluorotriprop...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章

    doi：10.1007/978-1-4615-2468-7_28

    authors： Koester MB,Lutz J

    更新日期：1994-01-01 00:00:00

  • Stem Cells in Alzheimer's Disease: Current Standing and Future Challenges.

    abstract：:To date, there is no definitive treatment for Alzheimer's disease (AD). The realm of stem cells is very promising in regenerative medicine, particularly for neurodegenerative diseases. Various types of stem cells have been used in preclinical/clinical trials for AD aiming the development of an elusive disease modifyin...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章,评审

    doi：10.1007/5584_2018_214

    authors： Salem H,Colpo GD,Teixeira AL

    更新日期：2018-01-01 00:00:00

  • The enthesis organ concept and its relevance to the spondyloarthropathies.

    abstract：:A characteristic feature of the spondyloarthropathies is inflammation at tendon or ligament attachment sites. This has traditionally been viewed as a focal abnormality, even though the inflammatory reaction intrinsic to enthesitis may be quite extensive. We argue that the diffuse nature of the pathology is best unders...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章,评审

    doi：10.1007/978-1-4419-0298-6_4

    authors： Benjamin M,McGonagle D

    更新日期：2009-01-01 00:00:00

  • L-tryptophan-kynurenine pathway metabolite 3-hydroxyanthranilic acid induces apoptosis in macrophage-derived cells under pathophysiological conditions.

    abstract：:Accumulation of L-kynurenine and 3-hydroxyanthranilic acid (3HAA) occurs in the monocyte-derived cells following immune stimulation, and may derive from L-tryptophan following induction of indoleamine-2,3-dioxygenase. In the present study, we evaluate the possibility that 3HAA acts as an endogenous inducer of monocyte...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章

    doi：10.1007/978-1-4615-4709-9_69

    authors： Morita T,Saito K,Takemura M,Maekawa N,Fujigaki S,Fujii H,Wada H,Takeuchi S,Noma A,Seishima M

    更新日期：1999-01-01 00:00:00

  • Modeling prolactin actions in breast cancer in vivo: insights from the NRL-PRL mouse.

    abstract：:Elevated exposure to prolactin (PRL) is epidemiologically associated with an increased risk of aggressive ER+ breast cancer. To understand the underlying mechanisms and crosstalk with other oncogenic factors, we developed the NRL-PRL mouse. In this model, mammary expression of a rat prolactin transgene raises local ex...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章

    doi：10.1007/978-3-319-12114-7_9

    authors： O'Leary KA,Shea MP,Schuler LA

    更新日期：2015-01-01 00:00:00

  • Assembly and Regulation of CRL Ubiquitin Ligases.

    abstract：:Cullin-RING ubiquitin ligases (CRLs) determine the substrate specificity of ubiquitination reactions, and substrates are recruited to the cullin core through binding to their cognate substrate receptor modules. Because a family of substrate receptors compete for the same cullin core, the assembly and activity of CRLs ...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章,评审

    doi：10.1007/978-981-15-1025-0_3

    authors： Wang K,Deshaies RJ,Liu X

    更新日期：2020-01-01 00:00:00

  • Cellular immune mechanisms in Coxsackievirus group B, type 3 induced myocarditis in Balb/C mice.

    abstract：:Coxsackie B viruses are a common cause of viral myocarditis in humans. A murine model of the human disease has been developed using Coxsackievirus group B, type 3 and inbred Balb/c mice. Infection of T lymphocyte deficient mice does not result in significant myocarditis indicating the importance of T cells in this dis...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章

    doi：10.1007/978-1-4684-4472-8_29

    authors： Huber SA,Job LP

    更新日期：1983-01-01 00:00:00

  • Role of complement in motor neuron disease: animal models and therapeutic potential of complement inhibitors.

    abstract：:Amyotrophic lateral sclerosis (ALS) is one of the major forms of motor neuron disease (MND), a group of degenerative disorders causing progressive motor neuron death leading to eventual paralysis and death. The pathogenesis of MND is poorly understood and may include genetic and/or environmental factors, with a common...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章,评审

    doi：

    authors： Woodruff TM,Costantini KJ,Taylor SM,Noakes PG

    更新日期：2008-01-01 00:00:00

  • L-dopa-induced hypotension: depression of spinal sympathetic neurons by release of 5-hydroxytryptamine.

    abstract：:In studies designed to determine the respective functional roles of two bulbospinal monoaminergic pathways to sympathetic preganglionic neurons, both L-dopa and precursors of 5-HT depressed transmission through excitatory spinal reflex and bulbospinal sympathetic pathways. Transmission through spinal reflex pathways w...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章

    doi：10.1007/978-1-4684-2511-6_13

    authors： Franz DN,Neumayr RJ,Hare BD

    更新日期：1977-01-01 00:00:00

  • Fimbrial colonisation factors F18ab and F18ac of Escherichia coli isolated from pigs with postweaning diarrhea and edema disease.

    abstract：:During the last 5 years at least four new types of colonisation factors have been described in association with porcine postweaning diarrhea and edema disease strains of E. coli. Recently, evidence was presented that these fimbrial factors are closely related to each other, and therefore the common denomination F18 wa...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章

    doi：10.1007/978-1-4899-1828-4_26

    authors： Imberechts H,Bertschinger HU,Nagy B,Deprez P,Pohl P

    更新日期：1997-01-01 00:00:00

  • The Potential Role of Flavins and Retbindin in Retinal Function and Homeostasis.

    abstract：:Flavins are highly concentrated in the retina; likely because they are involved as cofactors in energy metabolism and photoreceptors have an extremely high metabolic rate. How this concentration is established is currently unknown, but photoreceptor specific proteins may exist that shuttle flavins to flavoproteins, wh...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章

    doi：10.1007/978-3-319-17121-0_85

    authors： Kelley RA,Al-Ubaidi MR,Naash MI

    更新日期：2016-01-01 00:00:00

  • Efficacy of noninvasive volume targeted ventilation in patients with chronic respiratory failure due to kyphoscoliosis.

    abstract：:Severe kyphoscoliosis can cause chronic respiratory failure. Noninvasive mechanical ventilation (NIMV) is a new optional treatment for such patients. The aim of this study was to evaluate the effectiveness of average volume-assured pressure support (AVAPS) NIMV in patients with kyphoscoliotic chronic respiratory failu...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章

    doi：10.1007/5584_2014_68

    authors： Piesiak P,Brzecka A,Kosacka M,Jankowska R

    更新日期：2015-01-01 00:00:00

  • Increased kidney metabolism as a pathway to kidney tissue hypoxia and damage: effects of triiodothyronine and dinitrophenol in normoglycemic rats.

    abstract：:Intrarenal tissue hypoxia is an acknowledged common pathway to end-stage renal disease in clinically common conditions associated with development of chronic kidney disease, such as diabetes and hypertension. In diabetic kidneys, increased oxygen metabolism mediated by mitochondrial uncoupling results in decreased kid...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章

    doi：10.1007/978-1-4614-7411-1_2

    authors： Friederich-Persson M,Persson P,Fasching A,Hansell P,Nordquist L,Palm F

    更新日期：2013-01-01 00:00:00

  • The biodistribution of radiocopper-labeled compounds.

    abstract：:Porphyrins form extremely stable chelates with Cu2+. Two copper radionuclides, 67Cu and 64Cu, have attractive nuclear decay properties for use in nuclear medicine applications. We have investigated the use of radiocopper-labeled porphyrins for localization in inflamed tissue and for attachment to antibodies for tumor ...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章

    doi：10.1007/978-1-4613-0537-8_9

    authors： Mercer-Smith JA,Cole DA,Roberts JC,Lewis D,Behr MJ,Lavallee DK

    更新日期：1989-01-01 00:00:00

  • Toxicity profile of methotrexate in rheumatoid arthritis. A preliminary survey.

    abstract：:A number of patients with rheumatoid arthritis attending the Rheumatology Clinic at St Luke's Hospital are currently receiving the drug methotrexate as a second line disease-modifying agent. A survey has been conducted to assess the toxicity profile of methotrexate in 33 of these patients who were followed up for at l...

    journal_title：Advances in experimental medicine and biology

    pub_type： 杂志文章

    doi：10.1007/978-1-4615-4857-7_55

    authors： Coleiro B,Mallia C

    更新日期：1999-01-01 00:00:00