Abstract:
:The return to play (RTP) process may occur during longitudinal studies tracking recovery after concussion. This factor, which is often omitted within statistical designs, could affect the fit and overall interpretation of the statistical model. This article demonstrates the difference in results and interpretation between 2 linear mixed-model designs: (1) a between-group longitudinal (GROUP) analysis and (2) a between-group longitudinal model that used an inflection point to account for changes around the time of RTP (RTP analysis). These analyses were conducted on instrumented balance data collected on 23 concussed athletes and 25 controls over 8 weeks following concussion. Total sway area and the range of mediolateral acceleration were used as outcome measures. No significant findings were found in the GROUP design for either outcome measure. In contrast, the RTP analysis revealed significant effects of time (P = .007) and RTP change (P = .007), and group*time (P = .028) and group*RTP change (P = .022) interactions for total sway area, and effects of group (P = .011), time (P = .010), and RTP change (P = .014), and group*time (P = .013) and group*RTP change interactions (P = .013) for range of mediolateral acceleration. For both outcomes, the RTP model fit the data significantly better on comparison of likelihood ratios (P ≤ .027). These results suggest that allowing for an inflection point in the statistical design may assist understanding of what happens around clinically meaningful time points. The choice of statistical model had a considerable effect on the interpretation of findings, and provokes discussion around the best method for analyzing longitudinal datasets when important clinical time points like RTP exist.
journal_name
Scand J Med Sci Sportsjournal_title
Scandinavian journal of medicine & science in sportsauthors
Parrington L,Fino NF,Fino PC,Murchison CF,Chesnutt JC,King LAdoi
10.1111/sms.13239subject
Has Abstractpub_date
2018-11-01 00:00:00pages
2436-2442issue
11eissn
0905-7188issn
1600-0838journal_volume
28pub_type
杂志文章abstract::We aimed to investigate markers of oxidative stress and levels of endogenous and dietary antioxidants in 16 elite female soccer players in response to a 90-min game (average intensity 82+/-3% HRpeak). Blood samples were taken before, immediately and 21 h after the game. Plasma-oxidized glutathione, the ratio of reduce...
journal_title:Scandinavian journal of medicine & science in sports
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journal_title:Scandinavian journal of medicine & science in sports
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journal_title:Scandinavian journal of medicine & science in sports
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journal_title:Scandinavian journal of medicine & science in sports
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journal_title:Scandinavian journal of medicine & science in sports
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更新日期:1998-08-01 00:00:00
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journal_title:Scandinavian journal of medicine & science in sports
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pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1600-0838.1999.tb00237.x
更新日期:1999-08-01 00:00:00
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doi:10.1111/j.1600-0838.2009.00902.x
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journal_title:Scandinavian journal of medicine & science in sports
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journal_title:Scandinavian journal of medicine & science in sports
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journal_title:Scandinavian journal of medicine & science in sports
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journal_title:Scandinavian journal of medicine & science in sports
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journal_title:Scandinavian journal of medicine & science in sports
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1111/sms.13556
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