Abstract：
BACKGROUND:Merkel cell carcinoma (MCC) is a rare, aggressive, neuroendocrine skin tumor with frequent local recurrence, lymph node involvement, distant metastasis, and a high mortality rate. Viscum album extracts (VAE) are a widely used adjunct in cancer treatment and show cytotoxic and immune-modulating effects. CASE PRESENTATION:A 64-year-old woman was diagnosed with a MCC of the left forearm. In the following course of 21 years, she experienced 4 episodes of lymph node relapse (axillary, submandibular, axillary, clavicular). All lesions were surgically excised. The patient declined chemotherapy and radiation and opted for adjuvant treatment with local subcutaneous VAE injections. Currently-21 years after first diagnosis and 9.5 years after the last relapse-the patient is tumor-free, in good health, and without functional limitations. CONCLUSION:The presented case shows long-time survival in a patient with MCC treated with surgery and VAE injections. The immune system plays a key role in tumorigenesis of MCC. VAE enhances several immune pathways and might therefore contribute to immunologic tumor control in MCC. The role of VAE in MCC should further be investigated.
journal_name
Complement Ther Medjournal_title
Complementary therapies in medicineauthors
Werthmann PG,Kindermann L,Kienle GSdoi
10.1016/j.ctim.2018.04.001subject
Has Abstractpub_date
2018-06-01 00:00:00pages
58-60eissn
0965-2299issn
1873-6963pii
S0965-2299(18)30197-3journal_volume
38pub_type
杂志文章abstract：:WHO Traditional Medicine Strategy 2014-23 recommended evidence-based healthcare (EBHC) education for traditional and complementary medicine (T&CM) professionals, including Chinese medicine practitioners (CMPs). We evaluated the impact of a customized educational workshop on Hong Kong CMPs' knowledge, attitude and prac...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2019.05.004
更新日期：2019-08-01 00:00:00
abstract：:Despite the recognition for rising consumption rate of traditional medicine (TRM) in health and spatio-medical literature in the global scale, the impact of location in traditional therapy use has been explored least in Ghana. This paper analysed the role of spatial variation in TRM use in Kumasi Metropolis and Sekyer...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2015.04.007
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVES:To determine the effects of Tai Chi practice on health related quality of life in patients with various chronic medical conditions. BACKGROUND:One of the characters of chronic illness is life-long condition with the deterioration in health related quality of life. Tai Chi has become a popular mind-body exer...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ctim.2014.06.003
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE:This study illustrates that direct electrical stimulation (ES) improve functional recovery and time of return to work evaluated by prognostic scoring system after ulnar nerve injury. DESIGN:The Rosén and Lundborg (R&L) protocol, Disabilities of the Arm, Shoulder and Hand (DASH) scores, and electromyography w...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2015.12.003
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVES:Focused ultrasound (FUS) techniques enable the delivery of acoustic pressure waves to a localized, specific region of anatomy, and mechanically stimulate the sonicated region when given in a train of pulses. The present pilot study examines if the pulsed application of acoustic waves focused to an acupunctur...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2014.05.010
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVES:The aim of this study is to a) investigate the headache features and level of headache severity, chronicity, and disability found within a chiropractic patient population and b) to ascertain if patient satisfaction with headache management by chiropractors is associated with headache group or reason for cons...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2019.102276
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:Diarrhea is one of the dose limiting toxicity of irinotecan. SN-38 is main irinotecan metabolite responsible for diarrhea development, which is excreted in glucuronidated form into the intestine. This study aimed to determine the effectiveness of the probiotics in the prevention of irinotecan induced diarrhea d...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2015.03.008
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVES:This qualitative study aimed to explore medical specialists' perspectives on a proposed academic integrative healthcare (IHC) centre to be established in their local district. METHODS:A convenience sample of medical specialists were recruited via direct email invitations that was augmented with snowball sam...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2020.102530
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVES:Idiopathic Environmental Intolerance (IEI) is an acquired disorder with multiple recurrent symptoms, which is associated with diverse environmental factors that are tolerated by the majority of people. IEI is an illness of uncertain aetiology, making it difficult to treat using conventional medicine. Therefo...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2012.07.005
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVES:To establish the feasibility of conducting a randomised controlled trial to evaluate the efficacy of acupuncture in the treatment of mild-to-moderate depression. Control group intervention, blinding of treatment, outcome measures and the acceptability of such a trial amongst participants were key factors to ...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2007.07.005
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate the clinical efficacy of using western anti-tinnitus therapy with or without Chai-Hu-Jia-Long-Gu-Mu-Li-Tang (CHJLGMLT) to treat patients with chronic tinnitus. METHODS:A descriptive case series with chart review was established to compare patients with chronic tinnitus ...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2015.01.002
更新日期：2015-04-01 00:00:00
abstract：OBJECTIVE:Recent studies have found that garlic supplementation can improve antioxidant status, however, there is no definitive consensus on this context. The present systematic review and meta-analysis aimed to investigate the effect of garlic supplementation on oxidative stress markers. SETTING:We searched titles, a...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,meta分析
doi：10.1016/j.ctim.2020.102385
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVE:To examine the factors correlating with repetitive use of complementary and alternative medicine (CAM). RESEARCH DESIGN:In 2006, a community-based epidemiological survey was conducted in Taiwan. A total of 2457 participants (1237 men and 1220 women) aged 18 and over participated in the study. RESULTS:From t...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2012.01.003
更新日期：2012-08-01 00:00:00
abstract：:Established in 2004, the Pediatric Complementary and Alternative Medicine Research & Education (PedCAM) Network (www.pedcam.ca) is a multidisciplinary national and international network focused on pediatric research and education with the vision of safe and effective use of complementary and alternative medicine (CAM)...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2011.03.002
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Mindful walking (MW) interventions employ mindfulness training combined with physical activity. Wearable mobile devices have been increasingly used to measure outcomes of physical activity interventions. The purpose of this study was to understand MW participants' attitudes towards MW and the use of mobile d...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2020.102640
更新日期：2020-12-31 00:00:00
abstract：OBJECTIVE:To study the effectiveness of electro-acupuncture with behavior therapy on preschool children with attention deficit hyperactivity disorder (ADHD). METHODS:180 preschool children with ADHD diagnosed by DSM-IV were classified into three subtypes: predominantly inattentive subtype (PI subtype, 60 cases), predo...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2010.08.002
更新日期：2010-10-01 00:00:00
abstract：OBJECTIVES:Cupping worldwide has been part of traditional medicine systems and is in the western world used as CAM therapy mainly for treating pain syndromes. The mode of action is up to now unclear. In order to investigate its mechanism we measured in parallel metabolic changes in the tissue under the cupping glass an...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2013.12.013
更新日期：2014-02-01 00:00:00
abstract：:The effects of three horticulture-related activities (HRAs), including floral arranging, planting, and flower pressing were compared to see if they influenced changes on a stress scale and on salivary cortisol concentrations (SCC) in maladjusted elementary school children. Twenty maladjusted elementary school children...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2018.01.004
更新日期：2018-04-01 00:00:00
abstract：:The aim of this study was to evaluate the acute effects of light-emitting diode therapy (LEDT) on cardiopulmonary adjustments and muscle oxygenation dynamics during transition to moderate exercise, as well as in glucose and lactate levels in patients with type 2 diabetes mellitus (T2DM). Sixteen individuals with T2DM ...
journal_title：Complementary therapies in medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.ctim.2018.11.015
更新日期：2019-02-01 00:00:00
abstract：:Sickle cell disease (SCD) is a genetic disorder characterized by hemolysis, end-organ damage, inflammation, and pain. Recurrent and unpredictable episodes of acute pain due to vaso-occlusive crises are a unique feature of SCD. Many patients also develop lifelong chronic pain. Opioids are the primary method of pain tre...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ctim.2020.102394
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVE:To evaluate the clinical effect of Traditional Chinese Spinal Orthopedic Manipulation (TCSOM) in treating Functional Abdominal Pain Syndrome (FAPS) in comparison with Pinaverium Bromide (Dicetel, PBD), and to assess a possible cause for FAPS. METHODS:60 cases of FAPS patients were randomly assigned to the TC...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2017.03.009
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVES:This study sought to compare the effects of multi-point ear and body acupressure on labor pain and the duration of labor active phase. DESIGN:Three-armed randomized controlled trial. SETTING:Kowsar Hospital, Qazvin, Iran. INTERVENTION:Participants in the body acupressure group received acupressure on GB21...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2020.102413
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVES:Because the use of complementary and alternative medicine (CAM) is increasing among veterans, understanding more about the characteristics of veterans who use CAM is increasingly important. Studies reporting on predictors of use almost always discuss CAM in the aggregate, yet each CAM modality represents a u...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2016.08.004
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVES:Mind-body practices (MBP), such as Yoga or Tai-Chi, have increased in popularity in the past 25 years in the US. These activities may help promote a less sedentary lifestyle and may have positive effects on health. The objective of the present study is to understand the prevalence and trends of MBP in US adu...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2020.102501
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVE:The objective was to assess the effects of massage compared to guided relaxation on stress perception and well-being among older adults. DESIGN:A randomised pilot study enrolled adults ages 60 and older to receive 50 min, twice weekly massage therapy or guided relaxation sessions. Questionnaires were adminis...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2007.01.004
更新日期：2007-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of functional-task training on activities of daily living (ADL) in people with Parkinson`s Disease. METHODS:We searched five databases (Cinahl, Embase, Medline, Pedro and CENTRAL). The included studies were assessed on therapeutic validity and risk of bias. We classified the quality of...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,meta分析
doi：10.1016/j.ctim.2018.12.008
更新日期：2019-02-01 00:00:00
abstract：:The description of individual cases is probably the most important didactic tool for teaching in medicine, especially in complementary and alternative medicine (CAM). However, only very rarely is the information provided in traditional single case reports sufficient to answer scientific questions. These reports typica...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ctim.2013.04.006
更新日期：2013-08-01 00:00:00
abstract：BACKGROUND:Although clinical trials are needed to evaluate the efficacy of liquid herbal medicinal products, design of feasible placebos that mimic the appearance, taste, and smell of such products is particularly challenging. OBJECTIVE:The design and feasibility of a liquid placebo for STW5, an herbal medicinal produ...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2012.04.003
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:Colonic diverticula develop in at least 60% of elderly patients. Less than 25% of these develop diverticulitis. Recurrent episodes are experienced by about 13% of the symptomatic patients. The effect on prevention of recurrent diverticulitis of currently used therapies is controversial. Surgical colon resect...
journal_title：Complementary therapies in medicine
pub_type： 杂志文章
doi：10.1016/j.ctim.2018.03.013
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVES:To investigate whether a footbath inhibits spasticity in the hemiplegic lower limbs of post-stroke patients. DESIGN:Randomized, controlled study. SETTING:Rehabilitation education and research hospital. INTERVENTIONS:Twenty-two post-stroke patients were randomly allocated to control or experimental groups....
journal_title：Complementary therapies in medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ctim.2014.09.006
更新日期：2014-12-01 00:00:00
