Transcription factor dosage: more or less sufficient for growth.

Abstract:

:Recent findings highlight three instances in which major aspects of plant development are controlled by dosage-dependent protein levels. In the shoot apical meristem the mobile transcription factor WUS displays an intricate function with respect to target regulation that involves WUS dosage, binding site affinity and protein dimerization. The size of the root meristem is controlled by dosage-dependent PLT protein activity. Recent identification of targets and feedbacks provide new insights and entry into possible mechanisms of dosage read-out. Finally, HD-ZIPIII dosage, enforced by a gradient of mobile miRNAs, presents a relatively unexplored case in the radial patterning of vasculature and ground tissue. We evaluate our current knowledge of these three examples and address molecular mechanisms of dosage translation where possible.

journal_name

Curr Opin Plant Biol

authors

Hofhuis HF,Heidstra R

doi

10.1016/j.pbi.2018.05.008

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

50-58

issue

Pt A

eissn

1369-5266

issn

1879-0356

pii

S1369-5266(17)30236-4

journal_volume

45

pub_type

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